The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27938414)

Published in Acta Neuropathol Commun on December 09, 2016

Authors

Diana F Lázaro1, Mariana Castro Dias1, Anita Carija2, Susanna Navarro2, Carolina Silva Madaleno3, Sandra Tenreiro3, Salvador Ventura2, Tiago F Outeiro4,5,6

Author Affiliations

1: Department of Neurodegeneration and Restorative Research, University Medical Center Göttingen, Waldweg 33, 37073, Göttingen, Germany.
2: Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.
3: Chronic Disease Research Center (CEDOC), NOVA Medical School, Campo dos Mártires da Pátria, 130, 1169-056, Lisbon, Portugal.
4: Department of Neurodegeneration and Restorative Research, University Medical Center Göttingen, Waldweg 33, 37073, Göttingen, Germany. touteir@gwdg.de.
5: Chronic Disease Research Center (CEDOC), NOVA Medical School, Campo dos Mártires da Pátria, 130, 1169-056, Lisbon, Portugal. touteir@gwdg.de.
6: Max Planck Institute for Experimental Medicine, Göttingen, Germany. touteir@gwdg.de.

Articles cited by this

Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res (1992) 34.33

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science (1997) 28.30

Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging (2002) 22.40

Alpha-synuclein in Lewy bodies. Nature (1997) 20.83

alpha-Synuclein locus triplication causes Parkinson's disease. Science (2003) 20.20

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet (1998) 12.92

Aggresomes: a cellular response to misfolded proteins. J Cell Biol (1998) 11.24

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol (2004) 9.62

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc Natl Acad Sci U S A (1998) 8.41

Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci (1993) 7.92

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (2006) 7.72

Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res (2004) 7.06

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med (2008) 6.90

Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem (2003) 6.84

alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol (2002) 6.64

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell (2005) 6.31

Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet (2004) 5.06

Misfolded proteins partition between two distinct quality control compartments. Nature (2008) 4.75

Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science (2003) 4.45

In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A (2011) 4.38

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci (1988) 4.36

Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. Dev Cell (2007) 4.26

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J Neurosci (2000) 3.90

Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation. J Histochem Cytochem (1989) 3.26

α-Synuclein: membrane interactions and toxicity in Parkinson's disease. Annu Rev Cell Dev Biol (2010) 2.93

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci (2006) 2.85

The many faces of α-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci (2013) 2.78

Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates. Methods Enzymol (2005) 2.49

Formation of toxic oligomeric alpha-synuclein species in living cells. PLoS One (2008) 2.35

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion. J Biol Chem (2002) 2.19

100 years of Lewy pathology. Nat Rev Neurol (2012) 2.15

Translation initiator EIF4G1 mutations in familial Parkinson disease. Am J Hum Genet (2011) 2.00

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons. Neuroscience (2001) 1.80

G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome. Ann Neurol (2013) 1.77

A novel α-synuclein missense mutation in Parkinson disease. Neurology (2013) 1.74

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease. Mov Disord (2013) 1.64

Accumulation of phosphorylated alpha-synuclein in aging human brain. J Neuropathol Exp Neurol (2003) 1.59

Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death. J Neurol Sci (2006) 1.52

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity. J Mol Biol (2006) 1.47

Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells. J Biol Chem (2002) 1.44

Lewy-body formation is an aggresome-related process: a hypothesis. Lancet Neurol (2004) 1.41

Novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology. Neurobiol Aging (2014) 1.38

Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity. Proc Natl Acad Sci U S A (2012) 1.23

Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: 'permissive templating' as a general mechanism underlying neurodegeneration. Biochem Soc Trans (2005) 1.20

Golgi apparatus and neurodegenerative diseases. Int J Dev Neurosci (2008) 1.16

Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease. Acta Neuropathol (2006) 1.15

Alpha-synuclein biology in Lewy body diseases. Alzheimers Res Ther (2014) 1.09

The role of innate and adaptive immunity in Parkinson's disease. J Parkinsons Dis (2013) 1.03

Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration. J Parkinsons Dis (2013) 1.02

The newly discovered Parkinson's disease associated Finnish mutation (A53E) attenuates α-synuclein aggregation and membrane binding. Biochemistry (2014) 0.98

N-terminal acetylation stabilizes N-terminal helicity in lipid- and micelle-bound α-synuclein and increases its affinity for physiological membranes. J Biol Chem (2013) 0.97

Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease. PLoS Genet (2014) 0.96

Genetics and epigenetics of Parkinson's disease. ScientificWorldJournal (2012) 0.95

Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J (2012) 0.93

Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation. PLoS Genet (2014) 0.90

Link between the SNCA gene and parkinsonism. Neurobiol Aging (2014) 0.90

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease. J Exp Med (2016) 0.87

Synphilin suppresses α-synuclein neurotoxicity in a Parkinson's disease Drosophila model. Genesis (2011) 0.86

Propagation of host disease to grafted neurons: accumulating evidence. Exp Neurol (2009) 0.85

Thioflavin-T excimer formation upon interaction with amyloid fibers. Chem Commun (Camb) (2013) 0.83

Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells. J Biol Chem (2015) 0.82

Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. J Biol Chem (2015) 0.78

The A53E α-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture. Neurosci Lett (2015) 0.76

Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Hum Mol Genet (2015) 0.76

Recent onset disequilibrium mimicking acute vestibulopathy in early multiple sclerosis. Am J Otolaryngol (2014) 0.76