Published in Nat Cell Biol on August 01, 2007
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Repair of strand breaks by homologous recombination. Cold Spring Harb Perspect Biol (2013) 1.96
An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway. Nat Struct Mol Biol (2010) 1.92
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Choreography of recombination proteins during the DNA damage response. DNA Repair (Amst) (2009) 1.40
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The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol (2011) 1.18
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A biochemically defined system for coding joint formation in V(D)J recombination. Mol Cell (2008) 1.13
An end-joining repair mechanism in Escherichia coli. Proc Natl Acad Sci U S A (2010) 1.13
Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks. Nucleic Acids Res (2011) 1.12
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance. Oncogene (2013) 1.11
NHEJ and its backup pathways in chromosomal translocations. Nat Struct Mol Biol (2010) 1.11
The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment. Oncogene (2012) 1.11
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Charity begins at home: non-coding RNA functions in DNA repair. Nat Rev Mol Cell Biol (2013) 1.05
ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks. PLoS Genet (2010) 0.99
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Effect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line. Mol Cell Biol (2009) 0.98
Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. J Cell Biol (2014) 0.97
Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining. Nucleic Acids Res (2014) 0.96
PARP1 is required for chromosomal translocations. Blood (2013) 0.96
Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts. PLoS One (2012) 0.92
Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks. PLoS One (2013) 0.92
Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair. DNA Repair (Amst) (2011) 0.92
Terminal deoxynucleotidyl transferase requires KU80 and XRCC4 to promote N-addition at non-V(D)J chromosomal breaks in non-lymphoid cells. Nucleic Acids Res (2012) 0.91
Induction of chromosomal translocations in mouse and human cells using site-specific endonucleases. J Natl Cancer Inst Monogr (2008) 0.91
Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks. Mol Cell (2016) 0.88
Mechanisms of telomere loss and their consequences for chromosome instability. Front Oncol (2012) 0.87
MRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patens. Nucleic Acids Res (2011) 0.87
The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations. Cancer Genet Cytogenet (2010) 0.86
Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase. Nucleic Acids Res (2008) 0.83
Faithful after break-up: suppression of chromosomal translocations. Cell Mol Life Sci (2009) 0.82
The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line. PLoS Genet (2013) 0.81
Whole genome sequence analysis links chromothripsis to EGFR, MDM2, MDM4, and CDK4 amplification in glioblastoma. Oncoscience (2015) 0.80
Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks. Nucleic Acids Res (2015) 0.80
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PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells. DNA Repair (Amst) (2011) 0.76
53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks. PLoS Genet (2016) 0.75
PREVENTING THE CHROMOSOMAL TRANSLOCATIONS THAT CAUSE CANCER. Trans Am Clin Climatol Assoc (2016) 0.75
Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1. Sci Rep (2017) 0.75
Dealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair. EMBO Rep (2009) 0.75
Drugging the Cancers Addicted to DNA Repair. J Natl Cancer Inst (2017) 0.75
PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. Nat Commun (2017) 0.75
Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol (2003) 6.49
The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28
Positional stability of single double-strand breaks in mammalian cells. Nat Cell Biol (2007) 4.35
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29
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Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur J Immunol (2002) 2.57
Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations. DNA Repair (Amst) (2006) 2.52
Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA. J Biol Chem (1996) 2.40
A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair. Blood (2005) 1.78
Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures. DNA Repair (Amst) (2006) 1.76
Restraining the V(D)J recombinase. Nat Rev Immunol (2003) 1.56
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell (2006) 7.33
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol (2010) 5.35
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell (2011) 4.41
Positional stability of single double-strand breaks in mammalian cells. Nat Cell Biol (2007) 4.35
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev (2007) 4.16
Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol Cell Biol (2004) 3.96
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A (2005) 3.93
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature (2005) 3.90
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell (2012) 3.26
A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation. Cell (2011) 3.08
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol (2008) 3.07
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
Chromosomal translocations induced at specified loci in human stem cells. Proc Natl Acad Sci U S A (2009) 2.73
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation. Nat Struct Mol Biol (2010) 2.65
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet (2012) 2.63
Distinct properties of the XY pseudoautosomal region crucial for male meiosis. Science (2011) 2.43
DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation. PLoS Genet (2011) 2.22
Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase. Methods Enzymol (2006) 2.21
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science (2011) 2.17
Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. PLoS Genet (2009) 2.15
Androgen receptor signaling regulates DNA repair in prostate cancers. Cancer Discov (2013) 2.15
Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. Mol Cell Biol (2005) 2.13
Collaboration and competition between DNA double-strand break repair pathways. FEBS Lett (2010) 2.11
Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions. Proc Natl Acad Sci U S A (2006) 2.10
Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J (2006) 2.09
Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science (2004) 2.03
Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cells. DNA Repair (Amst) (2006) 2.03
Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc Natl Acad Sci U S A (2005) 2.03
Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res (2005) 2.02
ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair. J Biol Chem (2002) 1.97
E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks. Proc Natl Acad Sci U S A (2008) 1.97
Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability. Oncogene (2004) 1.95
An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway. Nat Struct Mol Biol (2010) 1.92
Chromosomal translocation mechanisms at intronic alu elements in mammalian cells. Mol Cell (2005) 1.84
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature (2011) 1.80
Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene (2004) 1.79
A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair. Blood (2005) 1.78
Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev (2004) 1.77
Homeostatic control of recombination is implemented progressively in mouse meiosis. Nat Cell Biol (2012) 1.73
An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucleic Acids Res (2002) 1.70
Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J (2003) 1.68
ATM controls meiotic double-strand-break formation. Nature (2011) 1.68
The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol (2011) 1.67
Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks. Mol Cell Biol (2003) 1.65
ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes. PLoS Genet (2008) 1.61
Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis. PLoS Genet (2010) 1.54
Cancer translocations in human cells induced by zinc finger and TALE nucleases. Genome Res (2013) 1.44
Numerical constraints and feedback control of double-strand breaks in mouse meiosis. Genes Dev (2013) 1.43
Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1. Nat Cell Biol (2011) 1.40
Measuring recombination proficiency in mouse embryonic stem cells. Methods Mol Biol (2005) 1.39
BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks. Mol Cell Biol (2003) 1.34
Evolutionary conservation of meiotic DSB proteins: more than just Spo11. Genes Dev (2010) 1.33
Homologous recombination deficiency leads to profound genetic instability in cells derived from Xrcc2-knockout mice. Cancer Res (2003) 1.32
Alternative pathways for the repair of RAG-induced DNA breaks. Mol Cell Biol (2006) 1.32
Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication. Nat Struct Mol Biol (2011) 1.29
Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase. Proc Natl Acad Sci U S A (2013) 1.27
Comprehensive, fine-scale dissection of homologous recombination outcomes at a hot spot in mouse meiosis. Mol Cell (2010) 1.21
The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells. Carcinogenesis (2005) 1.21
DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity. Cell Cycle (2009) 1.18
Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. PLoS Genet (2010) 1.16
Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks. Oncogene (2002) 1.15
Mechanisms of recombination between diverged sequences in wild-type and BLM-deficient mouse and human cells. Mol Cell Biol (2010) 1.12
Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1). Proc Natl Acad Sci U S A (2011) 1.11
Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends. Mol Cell Biol (2005) 1.09
Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells. Proc Natl Acad Sci U S A (2011) 1.09
Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state. Cell Rep (2013) 1.07
Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. PLoS Genet (2011) 1.02
Loss of 53BP1 is a gain for BRCA1 mutant cells. Cancer Cell (2010) 1.01
RECQ1 plays a distinct role in cellular response to oxidative DNA damage. DNA Repair (Amst) (2012) 1.00
Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells. Mol Cell Biol (2004) 0.98
Molecular cross-talk among chromosome fragility syndromes. Genes Dev (2004) 0.96
Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair. J Biol Chem (2007) 0.95
Homologous recombination assay for interstrand cross-link repair. Methods Mol Biol (2011) 0.95
Gene conversion is strongly induced in human cells by double-strand breaks and is modulated by the expression of BCL-x(L). Cancer Res (2002) 0.94
Meiotic crossover hotspots contained in haplotype block boundaries of the mouse genome. Proc Natl Acad Sci U S A (2007) 0.93
Reduced repair of DNA double-strand breaks by homologous recombination in a DNA ligase I-deficient human cell line. DNA Repair (Amst) (2005) 0.91
Induction of chromosomal translocations in mouse and human cells using site-specific endonucleases. J Natl Cancer Inst Monogr (2008) 0.91
The tricky path to recombining X and Y chromosomes in meiosis. Ann N Y Acad Sci (2012) 0.90
Retracted Triplex-forming oligonucleotide-orthophenanthroline conjugates for efficient targeted genome modification. Proc Natl Acad Sci U S A (2008) 0.90
Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells. Nucleic Acids Res (2013) 0.90
Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition. PLoS One (2012) 0.89
p21 promotes error-free replication-coupled DNA double-strand break repair. Nucleic Acids Res (2012) 0.89
Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells. PLoS Genet (2011) 0.88
Mice deficient for the type II topoisomerase-like DNA transesterase Spo11 show normal immunoglobulin somatic hypermutation and class switching. Eur J Immunol (2002) 0.87
The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations. Cancer Genet Cytogenet (2010) 0.86
DNA ligase III: a spotty presence in eukaryotes, but an essential function where tested. Cell Cycle (2011) 0.86
Isolation of meiotic recombinants from mouse sperm. Methods Mol Biol (2011) 0.86
Preaching about the converted: how meiotic gene conversion influences genomic diversity. Ann N Y Acad Sci (2012) 0.85
Attenuating homologous recombination stimulates an AID-induced antileukemic effect. J Exp Med (2013) 0.85
Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo. Mol Immunol (2008) 0.85
Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex. Nucleic Acids Res (2012) 0.85
Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis. PLoS Genet (2013) 0.84