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P Angel

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 1987 20.61
2 Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 1991 6.89
3 DNA binding of the glucocorticoid receptor is not essential for survival. Cell 1998 6.40
4 12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region. Mol Cell Biol 1987 4.86
5 Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 1987 4.56
6 Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature 1989 4.42
7 ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J 1995 4.28
8 Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell 1989 4.17
9 Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev 1999 3.51
10 Comparison of human stromelysin and collagenase by cloning and sequence analysis. Biochem J 1986 3.31
11 Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J 1993 3.28
12 Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein. EMBO J 1993 2.83
13 Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol 1990 2.73
14 Posttranscriptional regulation of c-fos mRNA expression. Nucleic Acids Res 1987 2.66
15 Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 1995 2.64
16 Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts. Mol Cell Biol 1986 2.63
17 Structure and chromosomal localization of the functional intronless human JUN protooncogene. Proc Natl Acad Sci U S A 1988 2.51
18 c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin. Cell 2000 2.35
19 Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J 2001 2.34
20 Different requirements for formation of Jun: Jun and Jun: Fos complexes. Genes Dev 1989 2.22
21 The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res 1996 2.09
22 Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Science 1997 1.93
23 UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. EMBO J 1993 1.86
24 The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription. Oncogene 1989 1.78
25 The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep 2001 1.76
26 Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1. EMBO J 1992 1.74
27 Fos is an essential component of the mammalian UV response. EMBO J 1995 1.73
28 The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells. Mol Cell Biol 1991 1.59
29 JunB is essential for mammalian placentation. EMBO J 1999 1.57
30 AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element. J Biol Chem 2001 1.51
31 Modulation of AP-1/ATF transcription factor activity by the adenovirus-E1A oncogene products. Bioessays 1995 1.50
32 The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin. J Cell Biol 1999 1.48
33 Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell Growth Differ 1995 1.46
34 Autocrine growth and anchorage independence: two complementing Jun-controlled genetic programs of cellular transformation. Genes Dev 1998 1.42
35 Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone. Oncogene 1999 1.38
36 Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response. Photochem Photobiol 1992 1.37
37 The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Mol Cell Biol 1997 1.36
38 Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein. J Biol Chem 1994 1.24
39 Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J 1997 1.23
40 Structural organization and chromosomal localization of the mouse collagenase type I gene. Biochem J 1995 1.22
41 Collagenase-3 (MMP-13) and integral membrane protein 2a (Itm2a) are marker genes of chondrogenic/osteoblastic cells in bone formation: sequential temporal, and spatial expression of Itm2a, alkaline phosphatase, MMP-13, and osteocalcin in the mouse. J Bone Miner Res 2000 1.22
42 Adenovirus E1A negatively and positively modulates transcription of AP-1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun. EMBO J 1993 1.20
43 Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation. Carcinogenesis 1994 1.19
44 Identification of novel tumour-associated genes differentially expressed in the process of squamous cell cancer development. Oncogene 2006 1.19
45 Organotypic cocultures with genetically modified mouse fibroblasts as a tool to dissect molecular mechanisms regulating keratinocyte growth and differentiation. J Invest Dermatol 2001 1.19
46 c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents. Mol Cell Biol 2000 1.18
47 The mammalian genetic stress response. Adv Enzyme Regul 1986 1.17
48 A switch region determines the cell type-specific positive or negative action of YY1 on the activity of the human papillomavirus type 18 promoter. J Virol 1995 1.08
49 Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1 beta or phorbol ester. Biochem Biophys Res Commun 1987 1.06
50 Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1-binding site. Mol Endocrinol 1990 1.05
51 The glucocorticoid receptor synergizes with Jun homodimers to activate AP-1-regulated promoters lacking GR binding sites. Chem Senses 1995 1.01
52 Induction of the AP-1 members c-Jun and JunB by TGF-beta/Smad suppresses early Smad-driven gene activation. Oncogene 2001 1.00
53 p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV. J Biol Chem 2000 0.98
54 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced gene sequences in human primary diploid fibroblasts and their expression in SV40-transformed fibroblasts. J Cell Biochem 1985 0.97
55 JNK/SAPK activity contributes to TRAIL-induced apoptosis. Cell Death Differ 1999 0.97
56 A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs. Mol Cell Biol 2000 0.96
57 Is restricting tobacco sales the answer to adolescent smoking? Prev Med 2003 0.90
58 Localisation of matrix metalloproteinases and TIMP-2 in resorbing mouse bone. Cell Tissue Res 2000 0.89
59 Gene structure and expression analysis of the epidermal growth factor receptor, transforming growth factor-alpha, myc, jun, and metallothionein in human ovarian carcinomas. Classification of malignant phenotypes. Cancer 1993 0.87
60 FRMD3, a novel putative tumour suppressor in NSCLC. Oncogene 2007 0.87
61 Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro. Nucleic Acids Res 1997 0.87
62 Mutation of a phosphorylation site in the DNA-binding domain is required for redox-independent transactivation of AP1-dependent genes by v-Jun. Oncogene 1993 0.86
63 Altered AP-1/ATF complexes in adenovirus-E1-transformed cells due to EIA-dependent induction of ATF3. Oncogene 1996 0.86
64 Keratinocyte-specific onset of serine protease BSSP expression in experimental carcinogenesis. J Invest Dermatol 2001 0.86
65 Both ATF-2 and c-Jun are phosphorylated by stress-activated protein kinases in response to UV irradiation. Immunobiology 1995 0.86
66 JNK/SAPK activity is not sufficient for anticancer therapy-induced apoptosis involving CD95-L, TRAIL and TNF-alpha. Int J Cancer 1999 0.86
67 NFkappaB activation is required for interferon regulatory factor-1-mediated interferon beta induction. Eur J Biochem 1999 0.84
68 Targets for signal-transducing protein kinases. Cold Spring Harb Symp Quant Biol 1988 0.83
69 A common intermediary factor (p52/54) recognizing "acidic blob"-type domains is required for transcriptional activation by the Jun proteins. Mol Cell Biol 1992 0.83
70 The catalytic domain of activated collagenase I (MMP-1) is absolutely required for interaction with its specific inhibitor, tissue inhibitor of metalloproteinases-1 (TIMP-1). Eur J Biochem 1997 0.83
71 Expression of the recessive glomerulosclerosis gene Mpv17 regulates MMP-2 expression in fibroblasts, the kidney, and the inner ear of mice. Mol Biol Cell 1998 0.83
72 Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases. Cell Regul 1990 0.81
73 Transcriptional control of human papillomavirus type 18 oncogene expression in different cell lines: role of transcription factor YY1. Virus Genes 1995 0.80
74 Expression of collagenase-3 (MMP-13) in c-fos-induced osteosarcomas and chondrosarcomas is restricted to a subset of cells of the osteo-/chondrogenic lineage. Differentiation 2001 0.79
75 Evaluation of dental restorations: a comparative study between clinical and digital photographic assessments. Oper Dent 2013 0.79
76 DNA-binding activity of Jun is increased through its interaction with Fos. J Cell Biochem 1990 0.79
77 TAp63alpha indirectly regulates a cutaneous HPV promoter through complex formation with Jun family members. Oncogene 2006 0.78
78 Characterization of mammary epithelial cell line HC11 using the NIA 15k gene array reveals potential regulators of the undifferentiated and differentiated phenotypes. Differentiation 2009 0.76
79 c-jun expression and growth stimulation in human ovarian carcinoma cell lines following exposure to cytokines. Int J Cancer 1995 0.75
80 Signal transduction into the nucleus: fifth colloquium on cellular signal transduction. Heidelberg, Germany, January 1996. J Cancer Res Clin Oncol 1996 0.75
81 Amplification of the expression of major histocompatibility class-I antigens by inducers of differentiation and gamma interferon in murine and human solid tumor-cell lines. Int J Oncol 1993 0.75
82 Ovarian adenocarcinomas express members of different cytokine pathways - analysis and quantification of transcripts from the tgf-alpha and m-csf fms pathways and the transcription factor cjun. Int J Oncol 1993 0.75
83 [The family of the addict: critical review of the literature]. Psychiatr Enfant 1983 0.75
84 Drug addicts attending specialised institutions: towards a drug addiction data bank? Drug Alcohol Depend 1991 0.75
85 Expression of human collagenase I (MMP-1) and TIMP-1 in a baculovirus-based expression system. Methods Mol Biol 2001 0.75