Published in Intravital on January 06, 2015
Two-photon laser scanning fluorescence microscopy. Science (1990) 43.55
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med (2004) 41.02
Tissue cells feel and respond to the stiffness of their substrate. Science (2005) 23.42
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer (2003) 22.78
Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer (2002) 17.49
Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell (2009) 14.40
Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer (2009) 14.17
The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev (1989) 13.15
Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol (2009) 9.87
A tense situation: forcing tumour progression. Nat Rev Cancer (2009) 7.80
Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res (2007) 6.60
Collagen reorganization at the tumor-stromal interface facilitates local invasion. BMC Med (2006) 6.44
Intravital imaging of cell movement in tumours. Nat Rev Cancer (2003) 6.35
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat Med (2003) 5.50
Interpreting second-harmonic generation images of collagen I fibrils. Biophys J (2004) 4.74
Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence. Proc Natl Acad Sci U S A (2002) 4.73
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol (2003) 4.24
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. J Cell Biol (2009) 4.04
Mammographic breast density as an intermediate phenotype for breast cancer. Lancet Oncol (2005) 3.99
Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Res (2002) 3.95
Connective tissue polarity. Optical second-harmonic microscopy, crossed-beam summation, and small-angle scattering in rat-tail tendon. Biophys J (1986) 3.78
Aligned collagen is a prognostic signature for survival in human breast carcinoma. Am J Pathol (2011) 3.70
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol (2006) 3.55
Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization. Biophys J (2008) 3.49
Tensile mechanical properties of three-dimensional type I collagen extracellular matrices with varied microstructure. J Biomech Eng (2002) 3.48
Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell (2011) 3.37
Optical sectioning microscopy. Nat Methods (2005) 3.32
Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage. Oncogene (2009) 3.17
Scaling down imaging: molecular mapping of cancer in mice. Nat Rev Cancer (2002) 3.04
Macrophages define the invasive microenvironment in breast cancer. J Leukoc Biol (2008) 3.02
A cancer cell metalloprotease triad regulates the basement membrane transmigration program. Genes Dev (2006) 2.78
High-resolution nonlinear optical imaging of live cells by second harmonic generation. Biophys J (1999) 2.74
Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation (2010) 2.53
Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Dev Dyn (2006) 2.35
Multiphoton microscopy in biological research. Curr Opin Chem Biol (2001) 2.27
Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc Natl Acad Sci U S A (2011) 2.27
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2. Nat Med (2011) 2.12
Alterations of the extracellular matrix in ovarian cancer studied by Second Harmonic Generation imaging microscopy. BMC Cancer (2010) 2.09
In vivo detection of apoptosis. J Nucl Med (2008) 1.99
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol (2013) 1.93
Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1. Proc Natl Acad Sci U S A (2009) 1.84
Phase Matching considerations in Second Harmonic Generation from tissues: Effects on emission directionality, conversion efficiency and observed morphology. Opt Commun (2008) 1.79
Association between mammographic breast density and breast cancer tumor characteristics. Cancer Epidemiol Biomarkers Prev (2005) 1.69
Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy. Am Surg (2005) 1.65
Association of an extracellular matrix gene cluster with breast cancer prognosis and endocrine therapy response. Clin Cancer Res (2008) 1.61
Discrimination of basal cell carcinoma from normal dermal stroma by quantitative multiphoton imaging. Opt Lett (2006) 1.61
Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging. Histochem Cell Biol (2008) 1.55
Positive margin rates following breast-conserving surgery for stage I-III breast cancer: palpable versus nonpalpable tumors. J Surg Res (2012) 1.53
In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. Nat Methods (2009) 1.48
Missing the target: matrix metalloproteinase antitargets in inflammation and cancer. Trends Pharmacol Sci (2013) 1.47
Lysophosphatidic acid promotes matrix metalloproteinase (MMP) activation and MMP-dependent invasion in ovarian cancer cells. Cancer Res (2001) 1.45
Second harmonic properties of tumor collagen: determining the structural relationship between reactive stroma and healthy stroma. Opt Express (2008) 1.40
Intravital microscopy: new insights into metastasis of tumors. J Cell Sci (2011) 1.36
Strategies for high-resolution imaging of epithelial ovarian cancer by laparoscopic nonlinear microscopy. Transl Oncol (2010) 1.31
Endogenous optical biomarkers of ovarian cancer evaluated with multiphoton microscopy. Cancer Epidemiol Biomarkers Prev (2007) 1.31
Assessing margin status. Surg Oncol (1999) 1.27
The relationship between surgical factors and margin status after breast-conservation surgery for early stage breast cancer. Am J Surg (2008) 1.19
Intravital imaging of stromal cell dynamics in tumors. Curr Opin Genet Dev (2009) 1.16
Stiff collagen matrices increase tumorigenic prolactin signaling in breast cancer cells. J Biol Chem (2013) 1.15
Prospective randomized study comparing cryo-assisted and needle-wire localization of ultrasound-visible breast tumors. Am J Surg (2006) 1.14
Second-harmonic generation in collagen as a potential cancer diagnostic parameter. J Biomed Opt (2008) 1.08
Matrix metalloproteinase-2 contributes to cancer cell migration on collagen. Cancer Res (2005) 1.07
Imaging tumor cell movement in vivo. Curr Protoc Cell Biol (2007) 1.02
Structural changes in mixed Col I/Col V collagen gels probed by SHG microscopy: implications for probing stromal alterations in human breast cancer. Biomed Opt Express (2011) 1.01
Intra-operative assessment of excision margins using breast imprint and scrape cytology. Breast (2005) 1.00
Second harmonic generation reveals matrix alterations during breast tumor progression. J Biomed Opt (2013) 0.99
Analysis of collagen fibre shape changes in breast cancer. Phys Med Biol (2008) 0.98
Stromal matrix metalloprotease-13 knockout alters Collagen I structure at the tumor-host interface and increases lung metastasis of C57BL/6 syngeneic E0771 mammary tumor cells. BMC Cancer (2013) 0.91
The antidepressant desipramine and α2-adrenergic receptor activation promote breast tumor progression in association with altered collagen structure. Cancer Prev Res (Phila) (2013) 0.88
Application of intravital microscopy in studies of tumor microcirculation. J Biomed Opt (2010) 0.86
Measurement of the ratio of forward-propagating to back-propagating second harmonic signal using a single objective. Opt Express (2010) 0.84
Tumor-associated macrophages and stromal TNF-α regulate collagen structure in a breast tumor model as visualized by second harmonic generation. J Biomed Opt (2013) 0.84
Medical imaging techniques in the evaluation of strategies for therapeutic angiogenesis. Curr Pharm Des (2002) 0.84