Published in Curr Biol on August 08, 2006
A tense situation: forcing tumour progression. Nat Rev Cancer (2009) 7.80
Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol (2009) 4.39
Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Rev (2009) 4.36
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. J Cell Biol (2009) 4.04
Chemotaxis in cancer. Nat Rev Cancer (2011) 3.68
Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization. Biophys J (2008) 3.49
Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol (2009) 3.09
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J Cell Biol (2009) 2.90
The actin cytoskeleton in cancer cell motility. Clin Exp Metastasis (2008) 2.82
Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression. Cold Spring Harb Perspect Biol (2011) 2.48
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA. J Cell Biol (2008) 2.39
A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol (2011) 2.34
Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. J Cell Biol (2007) 2.26
Directed cell invasion and migration during metastasis. Curr Opin Cell Biol (2011) 2.12
Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel. Proc Natl Acad Sci U S A (2011) 1.98
Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy. Cold Spring Harb Protoc (2011) 1.95
Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels. J Exp Med (2009) 1.83
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J Cell Biol (2010) 1.79
In situ force mapping of mammary gland transformation. Integr Biol (Camb) (2011) 1.78
Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev (2007) 1.77
Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility. J Cell Biol (2006) 1.76
In vivo imaging in cancer. Cold Spring Harb Perspect Biol (2010) 1.76
An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Res (2011) 1.75
Movers and shakers: cell cytoskeleton in cancer metastasis. Br J Pharmacol (2014) 1.74
RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol (2012) 1.69
Visualizing extravasation dynamics of metastatic tumor cells. J Cell Sci (2010) 1.67
Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy. EMBO Rep (2012) 1.66
At the leading edge of three-dimensional cell migration. J Cell Sci (2013) 1.66
Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species. Am J Pathol (2010) 1.65
Cell migration and invasion assays as tools for drug discovery. Pharmaceutics (2011) 1.60
STRIPAK components determine mode of cancer cell migration and metastasis. Nat Cell Biol (2014) 1.59
Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Mol Cell Biol (2008) 1.57
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis. Mol Biol Cell (2011) 1.54
The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells. Cell Mol Life Sci (2009) 1.52
High-resolution multiphoton imaging of tumors in vivo. Cold Spring Harb Protoc (2011) 1.52
Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity (2012) 1.50
Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks. Am J Physiol Cell Physiol (2014) 1.50
Cellular traction stresses increase with increasing metastatic potential. PLoS One (2012) 1.50
Retracted Formin-like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer. Cancer Sci (2015) 1.46
Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion. J Mammary Gland Biol Neoplasia (2011) 1.37
Self-organization of engineered epithelial tubules by differential cellular motility. Proc Natl Acad Sci U S A (2009) 1.36
Intravital microscopy: new insights into metastasis of tumors. J Cell Sci (2011) 1.36
MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices. J Cell Sci (2009) 1.33
Imaging hallmarks of cancer in living mice. Nat Rev Cancer (2014) 1.32
Biomechanical regulation of cell orientation and fate. Oncogene (2008) 1.31
Contractile forces in tumor cell migration. Eur J Cell Biol (2008) 1.31
Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices. Methods Mol Biol (2009) 1.27
The role of the tissue microenvironment in the regulation of cancer cell motility and invasion. Cell Commun Signal (2010) 1.27
A molecular switch for the orientation of epithelial cell polarization. Dev Cell (2014) 1.27
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp Cell Res (2008) 1.22
Multiparametric classification links tumor microenvironments with tumor cell phenotype. PLoS Biol (2014) 1.22
Dendritic cells control fibroblastic reticular network tension and lymph node expansion. Nature (2014) 1.19
3D collagen alignment limits protrusions to enhance breast cancer cell persistence. Biophys J (2014) 1.19
Signaling inputs to invadopodia and podosomes. J Cell Sci (2013) 1.18
Metastasis suppressor genes at the interface between the environment and tumor cell growth. Int Rev Cell Mol Biol (2011) 1.18
Intravital imaging illuminates transforming growth factor beta signaling switches during metastasis. Cancer Res (2010) 1.18
Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid model. Clin Exp Metastasis (2013) 1.18
RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation. Nat Cell Biol (2011) 1.17
The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis. J Biol Chem (2010) 1.17
Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis. Cancer Metastasis Rev (2012) 1.17
Tumor cell migration in complex microenvironments. Cell Mol Life Sci (2012) 1.16
Epigenetic disruption of cadherin-11 in human cancer metastasis. J Pathol (2012) 1.14
Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments. Nat Commun (2016) 1.13
The potential of optical proteomic technologies to individualize prognosis and guide rational treatment for cancer patients. Target Oncol (2009) 1.10
Myosin IIA dependent retrograde flow drives 3D cell migration. Biophys J (2010) 1.09
Shining new light on 3D cell motility and the metastatic process. Trends Cell Biol (2009) 1.09
Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. Nat Commun (2014) 1.08
FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration. Mol Biol Cell (2012) 1.08
RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res (2012) 1.05
Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment. Biochem J (2011) 1.05
Tumour cell invasion: an emerging role for basal epithelial cell extrusion. Nat Rev Cancer (2014) 1.03
Rho-regulated myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation. Development (2009) 1.03
I'm coming to GEF you: Regulation of RhoGEFs during cell migration. Cell Adh Migr (2014) 1.02
Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity. PLoS One (2012) 1.02
Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells. PLoS One (2010) 1.01
Regulation of ROCK activity in cancer. J Histochem Cytochem (2012) 1.01
From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity. J Cell Biol (2009) 1.01
DIAPH3 governs the cellular transition to the amoeboid tumour phenotype. EMBO Mol Med (2012) 1.01
Mechanism of a flow-gated angiogenesis switch: early signaling events at cell-matrix and cell-cell junctions. Integr Biol (Camb) (2012) 1.00
Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis. Hum Mol Genet (2012) 0.98
Diverse roles for the paxillin family of proteins in cancer. Genes Cancer (2012) 0.98
Controlling matrix stiffness and topography for the study of tumor cell migration. Cell Adh Migr (2012) 0.95
Pigment epithelium-derived factor blocks tumor extravasation by suppressing amoeboid morphology and mesenchymal proteolysis. Neoplasia (2011) 0.95
RhoA/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility. Clin Exp Metastasis (2011) 0.94
Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities. Oncogene (2013) 0.94
Mechanobiology of tumor invasion: engineering meets oncology. Crit Rev Oncol Hematol (2011) 0.94
Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis. Exp Cell Res (2009) 0.93
Dynamic regulation of ROCK in tumor cells controls CXCR4-driven adhesion events. J Cell Sci (2010) 0.93
Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8. Clin Exp Metastasis (2010) 0.92
Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo. PLoS One (2013) 0.92
The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition. Sci Rep (2014) 0.92
The process of macrophage migration promotes matrix metalloproteinase-independent invasion by tumor cells. J Immunol (2011) 0.91
Matrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasion. Lab Invest (2013) 0.90
Actin binding proteins: their ups and downs in metastatic life. Cell Adh Migr (2013) 0.90
Bi-directional signaling: extracellular matrix and integrin regulation of breast tumor progression. Crit Rev Eukaryot Gene Expr (2013) 0.90
Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination. J Natl Cancer Inst (2015) 0.89
Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion. PLoS One (2011) 0.89
KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis. Mol Ther (2014) 0.89
LAMC2 enhances the metastatic potential of lung adenocarcinoma. Cell Death Differ (2015) 0.88
Polychlorinated biphenyls (PCBs) enhance metastatic properties of breast cancer cells by activating Rho-associated kinase (ROCK). PLoS One (2010) 0.87
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol (2007) 7.20
Rac activation and inactivation control plasticity of tumor cell movement. Cell (2008) 6.01
Cofilin promotes actin polymerization and defines the direction of cell motility. Science (2004) 5.12
Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol (2009) 4.39
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res (2005) 4.33
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res (2004) 4.04
Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A. Cancer Cell (2011) 4.02
Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Res (2002) 3.95
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell (2007) 3.89
Chemotaxis in cancer. Nat Rev Cancer (2011) 3.68
ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. Cancer Cell (2003) 3.28
Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol (2009) 3.09
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet (2011) 2.99
Classifying collective cancer cell invasion. Nat Cell Biol (2012) 2.83
The actin cytoskeleton in cancer cell motility. Clin Exp Metastasis (2008) 2.82
ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma. Cancer Cell (2011) 2.77
A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell (2008) 2.65
The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors. J Cell Biol (2006) 2.59
Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol (2010) 2.58
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat Cell Biol (2013) 2.58
EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. J Cell Biol (2007) 2.48
Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clin Cancer Res (2009) 2.41
Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions. J Exp Med (2010) 2.37
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci U S A (2012) 2.29
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nat Cell Biol (2008) 2.27
Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer Res (2009) 2.25
Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors. Cancer Res (2007) 2.24
Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis. Cancer Res (2006) 2.17
Tumor cells caught in the act of invading: their strategy for enhanced cell motility. Trends Cell Biol (2005) 2.04
Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci (2011) 2.00
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res (2013) 1.92
Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures. Science (2005) 1.92
Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes. J Pathol (2013) 1.86
Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions. Nat Cell Biol (2013) 1.84
Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis. Cancer Res (2004) 1.81
GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice. Cancer Res (2002) 1.77
A photoswitchable orange-to-far-red fluorescent protein, PSmOrange. Nat Methods (2011) 1.69
Deficits in axonal transport precede ALS symptoms in vivo. Proc Natl Acad Sci U S A (2010) 1.66
Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines. Cancer Res (2007) 1.65
Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J Immunol (2009) 1.64
Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Metastasis (2008) 1.64
Intravital imaging reveals transient changes in pigment production and Brn2 expression during metastatic melanoma dissemination. Cancer Res (2009) 1.63
Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells. J Cell Sci (2006) 1.55
New dimensions in cell migration. Nat Rev Mol Cell Biol (2012) 1.46
Cancer dissemination--lessons from leukocytes. Dev Cell (2010) 1.46
Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Cancer Res (2009) 1.45
Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Res (2012) 1.43
The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration. J Cell Sci (2007) 1.34
Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast Cancer Res (2011) 1.33
Melanoma invasion - current knowledge and future directions. Pigment Cell Res (2007) 1.33
Mechanisms and cellular roles of local protein synthesis in mammalian cells. Curr Opin Cell Biol (2008) 1.31
Cell communication networks in cancer invasion. Curr Opin Cell Biol (2011) 1.31
Breast cancer cells isolated by chemotaxis from primary tumors show increased survival and resistance to chemotherapy. Cancer Res (2004) 1.31
Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors. Breast Cancer Res (2010) 1.24
Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clin Exp Metastasis (2011) 1.23
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp Cell Res (2008) 1.22
Tumor cell migration in three dimensions. Methods Enzymol (2006) 1.18
Intravital imaging illuminates transforming growth factor beta signaling switches during metastasis. Cancer Res (2010) 1.18
RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation. Nat Cell Biol (2011) 1.17
AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res (2010) 1.17
ZBP1 enhances cell polarity and reduces chemotaxis. J Cell Sci (2007) 1.11
Reconstitution of in vivo macrophage-tumor cell pairing and streaming motility on one-dimensional micro-patterned substrates. Intravital (2012) 1.10
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. J Cell Sci (2007) 1.07
Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse. BMC Biotechnol (2003) 1.05
In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion. J Cell Sci (2012) 1.05
A new chemotaxis device for cell migration studies. Integr Biol (Camb) (2010) 1.04
Imaging tumor cell movement in vivo. Curr Protoc Cell Biol (2007) 1.02
Mutant torsinA, which causes early-onset primary torsion dystonia, is redistributed to membranous structures enriched in vesicular monoamine transporter in cultured human SH-SY5Y cells. Mov Disord (2005) 1.00
Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis. Int J Cancer (2014) 0.98
Immunization with neurofilament light protein induces spastic paresis and axonal degeneration in Biozzi ABH mice. J Neuropathol Exp Neurol (2007) 0.98
Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer. Breast Cancer Res (2012) 0.96
Wiskott-Aldrich syndrome protein regulates leukocyte-dependent breast cancer metastasis. Cell Rep (2013) 0.92
Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells. Cell Motil Cytoskeleton (2004) 0.91
Arkadia regulates tumor metastasis by modulation of the TGF-β pathway. Cancer Res (2013) 0.91
An in vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction. Methods Mol Biol (2014) 0.86
A new strategy for caging proteins regulated by kinases. J Am Chem Soc (2002) 0.86
A FRET-facilitated photoswitching using an orange fluorescent protein with the fast photoconversion kinetics. J Am Chem Soc (2012) 0.86
Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells. Proc Natl Acad Sci U S A (2013) 0.85
Imaging tumor cell movement in vivo. Curr Protoc Cell Biol (2013) 0.83
Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]. BMC Dev Biol (2009) 0.83
Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis (2013) 0.80
Metastatic cells: moving onco-targets. Oncotarget (2014) 0.78
Imaging real-time gene expression in living yeast. CSH Protoc (2007) 0.77
Integrin-independent movement of immune cells. F1000 Biol Rep (2009) 0.77
Correlated immunohistochemical and cytological assays for the prediction of hematogenous dissemination of breast cancer. J Histochem Cytochem (2012) 0.76
An open data ecosystem for cell migration research. Trends Cell Biol (2014) 0.76
3-D individual cell based computational modeling of tumor cell-macrophage paracrine signaling mediated by EGF and CSF-1 gradients. Integr Biol (Camb) (2015) 0.75
Imaging real-time gene expression in living systems with single-transcript resolution: image analysis of single mRNA transcripts. CSH Protoc (2007) 0.75
Imaging Real-Time Gene Expression in Living Systems with Single-Transcript Resolution: Single mRNA Particle Tracking with ImageJ-Based Analysis. CSH Protoc (2007) 0.75
Erik Sahai: getting the whole picture of metastasis. Interview by Sedwick Caitlin. J Cell Biol (2011) 0.75
Imaging real-time gene expression in Mammalian cells with single-transcript resolution. CSH Protoc (2007) 0.75
Imaging real-time gene expression in living systems with single-transcript resolution: construct design and imaging system setup. CSH Protoc (2007) 0.75
Chris Marshall (1949-2015)--a personal reflection and tribute. J Cell Sci (2015) 0.75