Published in Cancer Res on March 15, 2007
Microenvironmental regulation of metastasis. Nat Rev Cancer (2008) 15.76
Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 13.41
Imaging in the era of molecular oncology. Nature (2008) 11.10
Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell (2009) 8.54
Microenvironmental regulation of tumor progression and metastasis. Nat Med (2013) 8.37
Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer (2013) 6.13
The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol (2012) 6.07
Trophic macrophages in development and disease. Nat Rev Immunol (2009) 5.37
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell (2009) 4.73
Tumor-associated macrophages: from mechanisms to therapy. Immunity (2014) 4.69
Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol (2009) 4.39
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20
Intravital imaging of metastatic behavior through a mammary imaging window. Nat Methods (2008) 4.13
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. J Cell Biol (2009) 4.04
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer (2013) 4.02
Tumors as organs: complex tissues that interface with the entire organism. Dev Cell (2010) 3.98
The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96
Balancing forces: architectural control of mechanotransduction. Nat Rev Mol Cell Biol (2011) 3.87
A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One (2009) 3.86
Aligned collagen is a prognostic signature for survival in human breast carcinoma. Am J Pathol (2011) 3.70
Chemotaxis in cancer. Nat Rev Cancer (2011) 3.68
Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice. J Clin Invest (2008) 3.37
Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol (2011) 3.36
Differential macrophage programming in the tumor microenvironment. Trends Immunol (2012) 3.18
Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe. Am J Pathol (2009) 3.09
Cancer: Inflaming metastasis. Nature (2009) 3.09
Macrophages define the invasive microenvironment in breast cancer. J Leukoc Biol (2008) 3.02
Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev (2008) 2.95
Macrophages in tumor microenvironments and the progression of tumors. Clin Dev Immunol (2012) 2.94
Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol (2010) 2.79
A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell (2008) 2.65
Immune surveillance: a balance between protumor and antitumor immunity. Curr Opin Genet Dev (2008) 2.62
Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation (2010) 2.53
Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clin Cancer Res (2009) 2.41
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech (2008) 2.34
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci U S A (2012) 2.29
Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. J Cell Biol (2007) 2.26
Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer Res (2009) 2.25
Immune cell promotion of metastasis. Nat Rev Immunol (2015) 2.15
Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat Rev Cancer (2014) 2.00
Crossing the endothelial barrier during metastasis. Nat Rev Cancer (2013) 2.00
Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci (2011) 2.00
Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res (2011) 1.99
Leukocyte composition of human breast cancer. Proc Natl Acad Sci U S A (2011) 1.97
The epithelial-mesenchymal transition (EMT) phenomenon. Ann Oncol (2010) 1.96
Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer. Cancer Microenviron (2010) 1.96
Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment. Clin Exp Immunol (2012) 1.90
Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell (2014) 1.88
Leukocytes in mammary development and cancer. Cold Spring Harb Perspect Biol (2011) 1.88
Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA. Cancer Discov (2015) 1.82
High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors. Am J Pathol (2009) 1.80
Forcing form and function: biomechanical regulation of tumor evolution. Trends Cell Biol (2010) 1.77
In vivo imaging in cancer. Cold Spring Harb Perspect Biol (2010) 1.76
Tumor-associated macrophages as major players in the tumor microenvironment. Cancers (Basel) (2014) 1.74
Cancer and inflammation: promise for biologic therapy. J Immunother (2010) 1.72
Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions. Curr Biol (2012) 1.70
Initial steps of metastasis: cell invasion and endothelial transmigration. Mutat Res (2011) 1.67
Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J Immunol (2009) 1.64
Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration. Sci Signal (2014) 1.60
The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12. Cancer Res (2009) 1.56
The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor-associated macrophages. Biomed Res Int (2012) 1.53
High-resolution multiphoton imaging of tumors in vivo. Cold Spring Harb Protoc (2011) 1.52
Intravital microscopy: a novel tool to study cell biology in living animals. Histochem Cell Biol (2010) 1.51
Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res (2013) 1.51
Lessons in signaling and tumorigenesis from polyomavirus middle T antigen. Microbiol Mol Biol Rev (2009) 1.48
Monomeric red fluorescent proteins with a large Stokes shift. Proc Natl Acad Sci U S A (2010) 1.47
Modeling metastasis in the mouse. Curr Opin Pharmacol (2010) 1.46
Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: contrasting, overlapping and compensatory functions. Biochim Biophys Acta (2009) 1.46
Macrophage polarization in health and disease. ScientificWorldJournal (2011) 1.46
Metastasis: tumor cells becoming MENAcing. Trends Cell Biol (2010) 1.44
Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. J Biol Chem (2013) 1.44
A microfluidic device for label-free, physical capture of circulating tumor cell clusters. Nat Methods (2015) 1.43
Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers. Cell Adh Migr (2012) 1.41
Coherent anti-Stokes Raman scattering imaging of lipids in cancer metastasis. BMC Cancer (2009) 1.41
An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. Cancer Res (2010) 1.39
Interaction of tumor cells with the microenvironment. Cell Commun Signal (2011) 1.38
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol Cancer Res (2013) 1.38
Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis. Oncogene (2012) 1.37
Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer. Am J Transl Res (2012) 1.37
Dendra2 photoswitching through the Mammary Imaging Window. J Vis Exp (2009) 1.36
Intravital microscopy: new insights into metastasis of tumors. J Cell Sci (2011) 1.36
Imaging cell biology in live animals: ready for prime time. J Cell Biol (2013) 1.35
Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer. Cell Cycle (2011) 1.34
Mechanisms of metastasis. Breast Cancer Res (2008) 1.34
Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proc Natl Acad Sci U S A (2010) 1.33
Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation. Oncogene (2013) 1.32
Imaging hallmarks of cancer in living mice. Nat Rev Cancer (2014) 1.32
Tumor-infiltrating immune cells promoting tumor invasion and metastasis: existing theories. J Cancer (2013) 1.31
Macrophages in breast cancer: do involution macrophages account for the poor prognosis of pregnancy-associated breast cancer? J Mammary Gland Biol Neoplasia (2009) 1.31
Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle. Neoplasia (2009) 1.28
Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors. Breast Cancer Res (2010) 1.24
Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clin Exp Metastasis (2011) 1.23
Multiparametric classification links tumor microenvironments with tumor cell phenotype. PLoS Biol (2014) 1.22
Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors. Intravital (2013) 1.22
The pathology of EMT in mouse mammary tumorigenesis. J Mammary Gland Biol Neoplasia (2010) 1.21
CSF-1 receptor structure/function in MacCsf1r-/- macrophages: regulation of proliferation, differentiation, and morphology. J Leukoc Biol (2008) 1.19
The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy. Oncotarget (2015) 1.18
Metastasis suppressor genes at the interface between the environment and tumor cell growth. Int Rev Cell Mol Biol (2011) 1.18
Reprogramming multipotent tumor cells with the embryonic neural crest microenvironment. Dev Dyn (2008) 1.18
Microenvironmental regulation of metastasis. Nat Rev Cancer (2008) 15.76
Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell (2006) 13.79
Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 13.41
Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science (2010) 12.15
Distinct role of macrophages in different tumor microenvironments. Cancer Res (2006) 9.29
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature (2011) 8.62
Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol (2003) 8.61
A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science (2012) 8.42
Macrophage biology in development, homeostasis and disease. Nature (2013) 8.28
A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res (2004) 7.56
Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res (2006) 6.52
Intravital imaging of cell movement in tumours. Nat Rev Cancer (2003) 6.35
Origin of the lamina propria dendritic cell network. Immunity (2009) 5.95
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity (2013) 5.47
Langerhans cells arise from monocytes in vivo. Nat Immunol (2006) 5.46
Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1. Nature (2005) 5.29
The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med (2009) 4.79
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol (2005) 4.75
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res (2005) 4.33
Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta (2006) 4.27
Intravital imaging of metastatic behavior through a mammary imaging window. Nat Methods (2008) 4.13
A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood (2002) 4.06
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res (2004) 4.04
CSF-1 regulation of the wandering macrophage: complexity in action. Trends Cell Biol (2004) 4.02
Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Res (2002) 3.95
Cell migration in tumors. Curr Opin Cell Biol (2005) 3.88
A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One (2009) 3.86
The cofilin pathway in breast cancer invasion and metastasis. Nat Rev Cancer (2007) 3.71
Colony-stimulating factor-1 in immunity and inflammation. Curr Opin Immunol (2005) 3.67
Tumor-associated macrophages press the angiogenic switch in breast cancer. Cancer Res (2007) 3.49
PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells. Proc Natl Acad Sci U S A (2008) 3.35
Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex. Curr Biol (2002) 3.06
The great escape: when cancer cells hijack the genes for chemotaxis and motility. Annu Rev Cell Dev Biol (2005) 2.97
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J Cell Biol (2009) 2.90
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A (2010) 2.89
Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A (2010) 2.87
Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis. Curr Biol (2006) 2.86
Classifying collective cancer cell invasion. Nat Cell Biol (2012) 2.83
M-CSF instructs myeloid lineage fate in single haematopoietic stem cells. Nature (2013) 2.74
Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J Leukoc Biol (2010) 2.71
Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med (2012) 2.69
IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity (2013) 2.69
A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell (2008) 2.65
The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors. J Cell Biol (2006) 2.59
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. J Cell Biol (2004) 2.55
Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature (2004) 2.49
Probing the microenvironment of mammary tumors using multiphoton microscopy. J Mammary Gland Biol Neoplasia (2006) 2.40
A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization. EMBO J (2002) 2.39
The macrophage growth factor CSF-1 in mammary gland development and tumor progression. J Mammary Gland Biol Neoplasia (2002) 2.37
Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans. Sci Transl Med (2013) 2.37
Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Dev Dyn (2006) 2.35
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation (2004) 2.35
A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol (2011) 2.34
Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene (2003) 2.27
Cofilin takes the lead. J Cell Sci (2005) 2.27
Genomic profiling of microRNAs and messenger RNAs reveals hormonal regulation in microRNA expression in human endometrium. Biol Reprod (2009) 2.26
Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. J Cell Biol (2007) 2.26
Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer Res (2009) 2.25
Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc Natl Acad Sci U S A (2012) 2.24
Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors. Cancer Res (2007) 2.24
Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease. Immunity (2003) 2.20
Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis. Cancer Res (2006) 2.17
Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice. Cancer Res (2004) 2.12
Directed cell invasion and migration during metastasis. Curr Opin Cell Biol (2011) 2.12
Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge. J Cell Sci (2002) 2.11
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol (2011) 2.09
Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Nature (2008) 2.06
Tumor cells caught in the act of invading: their strategy for enhanced cell motility. Trends Cell Biol (2005) 2.04
Cell motility and cytoskeletal regulation in invasion and metastasis. J Mammary Gland Biol Neoplasia (2007) 2.03
Visualization of mRNA translation in living cells. J Cell Biol (2006) 2.03
Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci (2011) 2.00
The cofilin activity cycle in lamellipodia and invadopodia. J Cell Biochem (2009) 1.99
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity (2012) 1.98
Localization of all seven messenger RNAs for the actin-polymerization nucleator Arp2/3 complex in the protrusions of fibroblasts. J Cell Sci (2005) 1.95
Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol (2006) 1.95
Functions of cofilin in cell locomotion and invasion. Nat Rev Mol Cell Biol (2013) 1.95
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol (2007) 1.93
Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy. BMC Biotechnol (2005) 1.93