The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection.

PubWeight™: 3.22‹?› | Rank: Top 1%

🔗 View Article (PMC 253569)

Published in J Virol on December 01, 1988

Authors

E K Wagner1, W M Flanagan, G Devi-Rao, Y F Zhang, J M Hill, K P Anderson, J G Stevens

Author Affiliations

1: Department of Molecular Biology and Biochemistry, University of California, Irvine 92717.

Articles citing this

Herpes simplex virus latency-associated transcript is a stable intron. Proc Natl Acad Sci U S A (1991) 3.87

Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency. J Virol (1992) 3.56

The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency. J Virol (1993) 3.43

Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus. J Virol (1989) 3.39

Human herpesviruses: a consideration of the latent state. Microbiol Rev (1989) 3.15

Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells. J Virol (1992) 3.10

Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect. J Virol (1994) 3.07

The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency. J Virol (1994) 2.94

EBV gene expression in an NPC-related tumour. EMBO J (1989) 2.94

The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency. J Virol (1997) 2.55

Experimental investigation of herpes simplex virus latency. Clin Microbiol Rev (1997) 2.53

Molecular analysis of herpes simplex virus type 1 during epinephrine-induced reactivation of latently infected rabbits in vivo. J Virol (1994) 2.41

A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1. J Virol (1997) 2.35

Expression of a herpes simplex virus 1 open reading frame antisense to the gamma(1)34.5 gene and transcribed by an RNA 3' coterminal with the unspliced latency-associated transcript. J Virol (1994) 2.34

A novel class of transcripts expressed with late kinetics in the absence of ICP4 spans the junction between the long and short segments of the herpes simplex virus type 1 genome. J Virol (1993) 2.28

Herpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia. J Virol (1994) 2.27

Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts. J Virol (1991) 2.20

Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse. Proc Natl Acad Sci U S A (1989) 2.05

The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript. J Virol (1996) 1.93

A herpes simplex virus type 1 mutant containing a nontransinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia. J Virol (1990) 1.91

A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats. J Virol (1994) 1.86

Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1. J Virol (1990) 1.85

Herpes simplex virus type 1 latency-associated transcription plays no role in establishment or maintenance of a latent infection in murine sensory neurons. J Virol (1989) 1.85

A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection. J Virol (1990) 1.83

Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1. J Virol (1992) 1.79

Identification of a promoter mapping within the reiterated sequences that flank the herpes simplex virus type 1 UL region. J Virol (1993) 1.77

Expression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigs. J Exp Med (1995) 1.63

Herpes simplex virus type 1 and bovine herpesvirus 1 latency. Clin Microbiol Rev (2003) 1.62

Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue culture. J Virol (2001) 1.55

Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain. J Virol (1994) 1.51

A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1. J Virol (1996) 1.51

Identification of a novel latency-specific splice donor signal within the herpes simplex virus type 1 2.0-kilobase latency-associated transcript (LAT): translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT. J Virol (1991) 1.49

Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency. J Virol (1996) 1.48

PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant. J Virol (1994) 1.45

The characteristic site-specific reactivation phenotypes of HSV-1 and HSV-2 depend upon the latency-associated transcript region. J Exp Med (1996) 1.41

An antigen encoded by the latency-associated transcript in neuronal cell cultures latently infected with herpes simplex virus type 1. J Virol (1991) 1.41

Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment. PLoS Pathog (2016) 1.39

Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses. J Virol (1990) 1.35

Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene alpha 0 accumulate in the cytoplasm of infected cells. Proc Natl Acad Sci U S A (1996) 1.35

The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine. J Virol (1997) 1.33

Herpes simplex virus type 1 latency-associated transcript expression protects trigeminal ganglion neurons from apoptosis. J Virol (2005) 1.27

Long-term promoter activity during herpes simplex virus latency. J Virol (1994) 1.27

A major portion of the latent pseudorabies virus genome is transcribed in trigeminal ganglia of pigs. J Virol (1990) 1.25

The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation. J Virol (1996) 1.25

The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2. J Virol (1993) 1.25

Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear. J Virol (1996) 1.23

The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. J Virol (2011) 1.18

Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency. J Virol (1994) 1.15

Human cytomegalovirus 5-kilobase immediate-early RNA is a stable intron. J Virol (2004) 1.15

The nucleotide sequence, 5' end, promoter domain, and kinetics of expression of the gene encoding the herpes simplex virus type 2 latency-associated transcript. J Virol (1991) 1.14

Localization of cis-acting sequence requirements in the promoter of the latency-associated transcript of herpes simplex virus type 1 required for cell-type-specific activity. J Virol (1992) 1.13

Selection of a nonconsensus branch point is influenced by an RNA stem-loop structure and is important to confer stability to the herpes simplex virus 2-kilobase latency-associated transcript. J Virol (1997) 1.11

Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region. J Virol (1993) 1.11

Effect of the transcription start region of the herpes simplex virus type 1 latency-associated transcript promoter on expression of productively infected neurons in vivo. J Virol (1994) 1.08

Structural and kinetic analyses of herpes simplex virus type 1 latency-associated transcripts in human trigeminal ganglia and in cell culture. J Clin Invest (1990) 1.08

Isolation and characterization of a functional cDNA encoding ICP0 from herpes simplex virus type 1. J Virol (1991) 1.06

Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycle. Interdiscip Perspect Infect Dis (2010) 1.05

The locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice. J Virol (2005) 1.04

Alternative splicing of the latency-related transcript of bovine herpesvirus 1 yields RNAs containing unique open reading frames. J Virol (1998) 1.03

Downstream regulatory elements increase acute and latent herpes simplex virus type 2 latency-associated transcript expression but do not influence recurrence phenotype or establishment of latency. J Virol (1996) 1.03

Two small RNAs encoded within the first 1.5 kilobases of the herpes simplex virus type 1 latency-associated transcript can inhibit productive infection and cooperate to inhibit apoptosis. J Virol (2009) 1.02

Effect of genomic location on expression of beta-galactosidase mRNA controlled by the herpes simplex virus type 1 UL38 promoter. J Virol (1992) 1.00

Herpes simplex virus genome replication and transcription during induced reactivation in the rabbit eye. J Virol (1997) 0.97

The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia. J Virol (1997) 0.97

Marek's disease virus latency-associated transcripts belong to a family of spliced RNAs that are antisense to the ICP4 homolog gene. J Virol (1997) 0.96

Analysis of protein expression from within the region encoding the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1. J Virol (2001) 0.96

Cellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice. J Neurovirol (2008) 0.93

The 2-kilobase intron of the herpes simplex virus type 1 latency-associated transcript has a half-life of approximately 24 hours in SY5Y and COS-1 cells. J Virol (2002) 0.93

Herpes simplex virus type 1 strain KOS-63 does not cause acute or recurrent ocular disease and does not reactivate ganglionic latency in vivo. Acta Neuropathol (1994) 0.88

The stable 2.0-kilobase intron of the herpes simplex virus type 1 latency-associated transcript does not function as an antisense repressor of ICP0 in nonneuronal cells. J Virol (2003) 0.86

Genetic studies exposing the splicing events involved in herpes simplex virus type 1 latency-associated transcript production during lytic and latent infection. J Virol (1999) 0.86

The herpes simplex virus type 1 locus that encodes the latency-associated transcript enhances the frequency of encephalitis in male BALB/c mice. J Virol (2005) 0.86

Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice. J Virol (2000) 0.84

Interactions between herpesvirus entry mediator (TNFRSF14) and latency-associated transcript during herpes simplex virus 1 latency. J Virol (2013) 0.83

Small non-coding RNAs encoded within the herpes simplex virus type 1 latency associated transcript (LAT) cooperate with the retinoic acid inducible gene I (RIG-I) to induce beta-interferon promoter activity and promote cell survival. Virus Res (2013) 0.82

HSV-1 latent rabbits shed viral DNA into their saliva. Virol J (2012) 0.82

Update on emerging antivirals for the management of herpes simplex virus infections: a patenting perspective. Recent Pat Antiinfect Drug Discov (2013) 0.81

Identification of a novel herpes simplex virus type 1 transcript and protein (AL3) expressed during latency. J Gen Virol (2009) 0.80

Bovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting Apoptosis. J Cell Death (2013) 0.79

Enhancer and long-term expression functions of herpes simplex virus type 1 latency-associated promoter are both located in the same region. J Virol (2001) 0.78

The half-life of the HSV-1 1.5-kb LAT intron is similar to the half-life of the 2.0-kb LAT intron. J Neurovirol (2013) 0.76

Prevention of vaginal and rectal herpes simplex virus type 2 transmission in mice: mechanism of antiviral action. Int J Nanomedicine (2016) 0.75

Articles cited by this

A membrane-filter technique for the detection of complementary DNA. Biochem Biophys Res Commun (1966) 71.25

A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. Gene (1982) 59.01

Transcription termination and 3' processing: the end is in site! Cell (1985) 17.46

Detection of mrnas in sea urchin embryos by in situ hybridization using asymmetric RNA probes. Dev Biol (1984) 12.47

RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science (1987) 11.14

Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase. Proc Natl Acad Sci U S A (1985) 6.48

Steps in the processing of Ad2 mRNA: poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing. Cell (1978) 6.36

Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1. J Virol (1987) 5.45

Detection of herpes simplex virus type 1 transcripts during latent infection in mice. J Virol (1987) 5.12

Physical characterization of the herpes simplex virus latency-associated transcript in neurons. J Virol (1988) 4.85

Latent herpes simplex virus in human trigeminal ganglia. Detection of an immediate early gene "anti-sense" transcript by in situ hybridization. N Engl J Med (1987) 4.57

Characterization of the IE110 gene of herpes simplex virus type 1. J Gen Virol (1986) 4.19

A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state. Virology (1988) 3.11

Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection. J Virol (1988) 2.80

Continued expression of a poly(A)+ transcript of herpes simplex virus type 1 in trigeminal ganglia of latently infected mice. J Virol (1987) 2.78

Quantitation of herpes simplex virus type 1 RNA in infected HeLa cells. J Virol (1977) 2.76

Translational regulation of expression of the bacteriophage T4 lysozyme gene. Nucleic Acids Res (1986) 2.45

Functional and molecular analyses of the avirulent wild-type herpes simplex virus type 1 strain KOS. J Virol (1986) 2.41

Isolation and localization of herpes simplex virus type 1 mRNA abundant before viral DNA synthesis. J Virol (1979) 2.16

Prominence of the herpes simplex virus latency-associated transcript in trigeminal ganglia from seropositive humans. J Infect Dis (1988) 2.00

Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins. J Virol (1986) 1.92

Adrenergically induced recurrent HSV-1 corneal epithelial lesions. Curr Eye Res (1987) 1.31

Spontaneous ocular shedding of HSV-1 in latently infected rabbits. Invest Ophthalmol Vis Sci (1985) 1.18

The effect of elevated levels of herpes simplex virus alpha-gene products on the expression of model early and late genes in vivo. Virology (1987) 1.11

Articles by these authors

RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science (1987) 11.14

Latent herpes simplex virus in spinal ganglia of mice. Science (1971) 7.04

Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra-axonal transport of infection. Infect Immun (1973) 5.29

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature (1994) 5.12

Physical characterization of the herpes simplex virus latency-associated transcript in neurons. J Virol (1988) 4.85

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature (1992) 4.12

Viral DNA synthesis is required for the efficient expression of specific herpes simplex virus type 1 mRNA species. Virology (1980) 4.05

Characterization of herpes simplex virus type 1 RNA present in the absence of de novo protein synthesis. J Virol (1980) 4.01

Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology (1990) 4.00

Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science (1996) 3.74

Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus. J Virol (1989) 3.39

Latent herpes simplex virus from trigeminal ganglia of rabbits with recurrent eye infection. Nat New Biol (1972) 3.23

Human herpesviruses: a consideration of the latent state. Microbiol Rev (1989) 3.15

Mesenteric Chyladenectasis: Report of a Case. Am J Pathol (1937) 3.13

A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state. Virology (1988) 3.11

Detailed characterization of the mRNA mapping in the HindIII fragment K region of the herpes simplex virus type 1 genome. J Virol (1981) 3.10

Evidence that neurons harbor latent herpes simplex virus. Infect Immun (1974) 3.03

Herpes simplex virus type 1 HindIII fragment L encodes spliced and complementary mRNA species. J Virol (1981) 2.97

Latent herpes simplex virus and the nervous system,. Curr Top Microbiol Immunol (1975) 2.71

Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem (2000) 2.70

Variable-sized free episomes of Shope papilloma virus DNA are present in all non-virus-producing neoplasms and integrated episomes are detected in some. Proc Natl Acad Sci U S A (1982) 2.65

Restriction of herpes simplex virus by macrophages. An analysis of the cell-virus interaction. J Exp Med (1971) 2.61

Latent herpes simplex virus in the central nervous system of rabbits and mice. J Exp Med (1973) 2.48

Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats. Proc Natl Acad Sci U S A (1989) 2.43

Functional and molecular analyses of the avirulent wild-type herpes simplex virus type 1 strain KOS. J Virol (1986) 2.41

Molecular analysis of herpes simplex virus type 1 during epinephrine-induced reactivation of latently infected rabbits in vivo. J Virol (1994) 2.41

Effect of cytosine arabinoside on viral-specific protein synthesis in cells infected with herpes simplex virus. J Virol (1975) 2.40

Biological characterization of a herpes simplex virus intertypic recombinant which is completely and specifically non-neurovirulent. Virology (1983) 2.32

Characterization of a major late herpes simplex virus type 1 mRNA. J Virol (1981) 2.29

Herpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia. J Virol (1994) 2.27

Amiodarone: clinical efficacy and toxicity in 96 patients with recurrent, drug-refractory arrhythmias. Circulation (1983) 2.24

Isolation and localization of herpes simplex virus type 1 mRNA. J Virol (1979) 2.23

Physical location of a herpes simplex virus type-1 gene function(s) specifically associated with a 10 million-fold increase in HSV neurovirulence. Virology (1983) 2.19

Isolation and localization of herpes simplex virus type 1 mRNA abundant before viral DNA synthesis. J Virol (1979) 2.16

Replication of varicella-zoste virus in cell culture: an ultrastructural study. J Ultrastruct Res (1970) 1.99

Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors. Br J Pharmacol (1988) 1.96

A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation. J Virol (1996) 1.94

Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins. J Virol (1986) 1.92

Low-temperature in situ large strain plasticity of ceramic SiC nanowires and its atomic-scale mechanism. Nano Lett (2007) 1.91

Maintenance of latent herpetic infection: an apparent role for anti-viral IgG. J Immunol (1974) 1.91

A comparison of T-wave alternans, signal averaged electrocardiography and programmed ventricular stimulation for arrhythmia risk stratification. J Am Coll Cardiol (2000) 1.89

A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells. Nucleic Acids Res (1999) 1.85

Herpes simplex virus type 1 latency-associated transcription plays no role in establishment or maintenance of a latent infection in murine sensory neurons. J Virol (1989) 1.85

Two colinear and spliced viral transcripts are present in non-virus-producing benign and malignant neoplasms induced by the shope (rabbit) papilloma virus. J Virol (1982) 1.83

Pathways of viral gene expression during acute neuronal infection with HSV-1. Virology (1992) 1.81

Effect of phorbol 12-myristate 13-acetate and its analogue 4 alpha-phorbol 12,13-didecanoate on protein phosphorylation and lysosomal enzyme release in rabbit neutrophils. J Biol Chem (1984) 1.80

Pathogenesis of herpetic encephalitis in mice after ophthalmic inoculation. J Infect Dis (1974) 1.80

Immunosuppression reactivates and disseminates latent murine cytomegalovirus. J Gen Virol (1977) 1.79

L-asparaginase therapy for leukemia and other malignant neoplasms. Remission in human leukemia. JAMA (1967) 1.78

Latency competence of thirteen HSV-1 temperature-sensitive mutants. J Gen Virol (1980) 1.75

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death Differ (2013) 1.73

Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells. Proc Natl Acad Sci U S A (2000) 1.71

Strain specificity of spontaneous and adrenergically induced HSV-1 ocular reactivation in latently infected rabbits. Curr Eye Res (1987) 1.70

Specific roles of alpha-toxin and beta-toxin during Staphylococcus aureus corneal infection. Infect Immun (1997) 1.69

A helix-loop-helix transcription factor-like gene is located at the mi locus. J Biol Chem (1993) 1.66

Further properties of the diamine oxidase of pea seedlings. Biochem J (1964) 1.63

The regional distribution and cellular localization of iron in the rat brain. Neuroscience (1984) 1.62

Pharmacokinetics of methamphetamine self-administered to human subjects by smoking S-(+)-methamphetamine hydrochloride. Drug Metab Dispos (1993) 1.61

Responses of group III and IV muscle afferents to dynamic exercise. J Appl Physiol (1985) (1997) 1.60

Changes in nuclear basic proteins during pseudorabies virus infection. J Virol (1969) 1.60

The effect of pregnancy and menstruation on the size of the spleen. J Physiol (1928) 1.58

A latent, nonpathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons. Neuron (1990) 1.57

New procedures for purification of L-asparaginase with high yield from Escherichia coli. J Bacteriol (1968) 1.55

Temperature-sensitive mutants of herpes simplex virus differ in the capacity to establish latent infections in mice. Virology (1977) 1.54

Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome. J Pharmacol Exp Ther (2001) 1.52

Role of iron and ferritin in MR imaging of the brain: a study in primates at different field strengths. Radiology (1990) 1.51

Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region. Antimicrob Agents Chemother (1993) 1.51

Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40. Science (1991) 1.49

Nature of the scrapie agent: evidence against a viroid. J Virol (1974) 1.48

Latent infection can be established with drastically restricted transcription and replication of the HSV-1 genome. Virology (1993) 1.48

Latent herpes simplex virus. Isolation from rabbit trigeminal ganglia between episodes of recurrent ocular infection. Arch Ophthalmol (1972) 1.48

Rescue of a herpes simplex virus type 1 neurovirulence function with a cloned DNA fragment. J Virol (1985) 1.45

Virus-induced modification of the host cell is required for expression of the bacterial chloramphenicol acetyltransferase gene controlled by a late herpes simplex virus promoter (VP5). J Virol (1985) 1.45

Corneal virulence of Staphylococcus aureus: roles of alpha-toxin and protein A in pathogenesis. Infect Immun (1994) 1.45

ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways. Cancer Res (2001) 1.44

Latent herpetic infections following experimental viraemia. J Gen Virol (1976) 1.44

Modification by adoptive humoral immunity of murine cytomegalovirus infection. J Infect Dis (1981) 1.43

Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity. Proc Natl Acad Sci U S A (1986) 1.43

The characteristic site-specific reactivation phenotypes of HSV-1 and HSV-2 depend upon the latency-associated transcript region. J Exp Med (1996) 1.41

Genetic and biological analyses of a herpes simplex virus intertypic recombinant reduced specifically for neurovirulence. J Virol (1987) 1.40

Two avirulent herpes simplex viruses generate lethal recombinants in vivo. Science (1986) 1.40

Multiple copies of Shope virus DNA are present in cells of benign and malignant non-virus-producing neoplasms. J Virol (1979) 1.39

Rhabdomyolysis and a "greenhouse effect". Lancet (1990) 1.38

A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA. Proc Natl Acad Sci U S A (1996) 1.38

Time-saving formats for patient care planning in outpatient surgery units. J Post Anesth Nurs (1991) 1.37

Quantitation and kinetics of induced HSV-1 ocular shedding. Curr Eye Res (1986) 1.36

Molecular and biological characterization of a herpes simplex virus type 1 (HSV-1) neuroinvasiveness gene. J Exp Med (1990) 1.36

Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution. Proc Natl Acad Sci U S A (1985) 1.35

Posttranscriptional block to synthesis of a human adenovirus capsid protein in abortively infected monkey cells. J Mol Appl Genet (1983) 1.34

HSV-1 shedding by lontophoresis of 6-hydroxydopamine followed by topical epinephrine. Invest Ophthalmol Vis Sci (1983) 1.31

Ocular herpes simplex virus reactivation in mice latently infected with latency-associated transcript mutants. Invest Ophthalmol Vis Sci (1991) 1.30