Published in Nat Rev Mol Cell Biol on March 01, 2017
Cellular motility driven by assembly and disassembly of actin filaments. Cell (2003) 26.05
Reconstitution of actin-based motility of Listeria and Shigella using pure proteins. Nature (1999) 8.61
Head to tail polymerization of actin. J Mol Biol (1976) 7.14
Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility. J Cell Biol (1997) 7.10
Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. Curr Biol (1999) 6.24
The ARP2/3 complex: an actin nucleator comes of age. Nat Rev Mol Cell Biol (2006) 6.04
Proteins of the ADF/cofilin family: essential regulators of actin dynamics. Annu Rev Cell Dev Biol (1999) 5.76
The lamellipodium: where motility begins. Trends Cell Biol (2002) 5.70
Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proc Natl Acad Sci U S A (1999) 5.62
Stress fibers are generated by two distinct actin assembly mechanisms in motile cells. J Cell Biol (2006) 5.54
Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J Cell Biol (2003) 5.06
Mechanism of actin-based motility. Science (2001) 5.04
Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin. Mol Cell (2006) 4.88
Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function. J Cell Biol (1997) 4.54
Life at the leading edge. Cell (2011) 4.42
Control of the assembly of ATP- and ADP-actin by formins and profilin. Cell (2006) 4.37
How profilin promotes actin filament assembly in the presence of thymosin beta 4. Cell (1993) 4.20
Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis. Cell (2004) 4.01
Myosin II functions in actin-bundle turnover in neuronal growth cones. Nat Cell Biol (2006) 3.91
Negative regulation of fibroblast motility by Ena/VASP proteins. Cell (2000) 3.89
Shaping cups into phagosomes and macropinosomes. Nat Rev Mol Cell Biol (2008) 3.62
Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. Nat Cell Biol (2001) 3.51
Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell (2004) 3.48
Unleashing formins to remodel the actin and microtubule cytoskeletons. Nat Rev Mol Cell Biol (2009) 3.45
Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling. Nature (1999) 3.44
Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts. Cell (1994) 3.42
Actin filament organization in the fish keratocyte lamellipodium. J Cell Biol (1995) 3.20
Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol Biol Cell (2004) 3.15
Quantitative analysis of the effect of Acanthamoeba profilin on actin filament nucleation and elongation. Biochemistry (1984) 3.15
Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis. Cell (2012) 2.98
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell (2004) 2.96
Actin polymerization-driven molecular movement of mDia1 in living cells. Science (2004) 2.80
Characterization of actin filament severing by actophorin from Acanthamoeba castellanii. J Cell Biol (1991) 2.77
Putting a new twist on actin: ADF/cofilins modulate actin dynamics. Trends Cell Biol (1999) 2.69
A biomimetic motility assay provides insight into the mechanism of actin-based motility. J Cell Biol (2003) 2.67
Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals. Nat Cell Biol (1999) 2.65
Individual actin filaments in a microfluidic flow reveal the mechanism of ATP hydrolysis and give insight into the properties of profilin. PLoS Biol (2011) 2.59
Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments. Biochemistry (1993) 2.49
The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins. Nat Cell Biol (2000) 2.46
Control of actin dynamics in cell motility. J Mol Biol (1997) 2.45
Spatial and temporal relationships between actin-filament nucleation, capping, and disassembly. Curr Biol (2007) 2.44
Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes. Mol Biol Cell (2006) 2.36
The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration. J Cell Biol (2012) 2.34
Arp2/3 complex interactions and actin network turnover in lamellipodia. EMBO J (2008) 2.30
Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3. Nat Cell Biol (2000) 2.29
Actin-based movement of Listeria monocytogenes: actin assembly results from the local maintenance of uncapped filament barbed ends at the bacterium surface. J Cell Biol (1995) 2.27
New insights into the regulation and cellular functions of the ARP2/3 complex. Nat Rev Mol Cell Biol (2012) 2.25
pH control of actin polymerization by cofilin. J Biol Chem (1985) 2.25
Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide. Curr Biol (1999) 2.21
Virulent Burkholderia species mimic host actin polymerases to drive actin-based motility. Cell (2015) 2.20
FMNL2 drives actin-based protrusion and migration downstream of Cdc42. Curr Biol (2012) 2.18
Cofilin dissociates Arp2/3 complex and branches from actin filaments. Curr Biol (2009) 1.98
Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. J Cell Biol (2008) 1.95
Cofilin promotes stimulus-induced lamellipodium formation by generating an abundant supply of actin monomers. J Cell Biol (2007) 1.93
Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility. Nat Cell Biol (2010) 1.91
Partial purification and characterization of an actin depolymerizing factor from brain. FEBS Lett (1980) 1.91
Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation. EMBO J (2008) 1.90
Tracking retrograde flow in keratocytes: news from the front. Mol Biol Cell (2005) 1.88
Transients and relaxation kinetics of enzyme reactions. Annu Rev Biochem (1971) 1.88
Kinetic analysis of the interaction of actin-depolymerizing factor (ADF)/cofilin with G- and F-actins. Comparison of plant and human ADFs and effect of phosphorylation. J Biol Chem (1998) 1.85
Interaction of actin monomers with Acanthamoeba actophorin (ADF/cofilin) and profilin. J Biol Chem (1998) 1.79
Interaction of thymosin beta 4 with muscle and platelet actin: implications for actin sequestration in resting platelets. Biochemistry (1992) 1.73
ADF/cofilin use an intrinsic mode of F-actin instability to disrupt actin filaments. J Cell Biol (2003) 1.68
INF2 is an endoplasmic reticulum-associated formin protein. J Cell Sci (2009) 1.67
Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways. Dev Cell (2014) 1.66
Spire and Formin 2 synergize and antagonize in regulating actin assembly in meiosis by a ping-pong mechanism. PLoS Biol (2014) 1.62
Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex. Dev Cell (2014) 1.61
WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond. Trends Cell Biol (2010) 1.58
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence. Nat Rev Mol Cell Biol (2014) 1.58
Analysis of the function of Spire in actin assembly and its synergy with formin and profilin. Mol Cell (2007) 1.57
Equilibrium of the actin-tropomyosin interaction. J Mol Biol (1979) 1.56
Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex. Proc Natl Acad Sci U S A (2011) 1.56
Cofilin tunes the nucleotide state of actin filaments and severs at bare and decorated segment boundaries. Curr Biol (2011) 1.55
Spatial organization of intracellular communication: insights from imaging. Nat Rev Mol Cell Biol (2010) 1.55
The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes. Curr Biol (1999) 1.53
Profilin plays a role in cell elongation, cell shape maintenance, and flowering in Arabidopsis. Plant Physiol (2000) 1.53
Silencing profilin-1 inhibits endothelial cell proliferation, migration and cord morphogenesis. J Cell Sci (2006) 1.52
Accelerated actin filament polymerization from microtubule plus ends. Science (2016) 1.45
Uncoupling actin filament fragmentation by cofilin from increased subunit turnover. J Mol Biol (2000) 1.43
F- and G-actin concentrations in lamellipodia of moving cells. PLoS One (2009) 1.41
Synergy between actin depolymerizing factor/cofilin and profilin in increasing actin filament turnover. J Biol Chem (1998) 1.41
Use of fluorescently labelled deoxyribonuclease I to spatially measure G-actin levels in migrating and non-migrating cells. Cell Motil Cytoskeleton (2002) 1.40
Effects of profilin and profilactin on actin structure and function in living cells. J Cell Biol (1992) 1.39
Profilin-1 is a negative regulator of mammary carcinoma aggressiveness. Br J Cancer (2007) 1.39
Rho GTPase signalling in cell migration. Curr Opin Cell Biol (2015) 1.38
Homeostatic actin cytoskeleton networks are regulated by assembly factor competition for monomers. Curr Biol (2014) 1.38
Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins. J Biol Chem (1993) 1.33
GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation. Curr Biol (2010) 1.33
Mutational analysis of an actin-binding site of cofilin and characterization of chimeric proteins between cofilin and destrin. J Biol Chem (1992) 1.32
Arp2 depletion inhibits sheet-like protrusions but not linear protrusions of fibroblasts and lymphocytes. Cell Motil Cytoskeleton (2008) 1.31
Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins. J Cell Physiol (2009) 1.30
The polarization defect of Wiskott-Aldrich syndrome macrophages is linked to dislocalization of the Arp2/3 complex. J Immunol (2000) 1.30
Actin filament remodeling by actin depolymerization factor/cofilin. Proc Natl Acad Sci U S A (2010) 1.28
Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells. Nat Cell Biol (2015) 1.27
Unraveling the enigma: progress towards understanding the coronin family of actin regulators. Trends Cell Biol (2011) 1.26
Profilin is predominantly associated with monomeric actin in Acanthamoeba. J Cell Sci (1999) 1.24
Filopodia initiation: focus on the Arp2/3 complex and formins. Cell Adh Migr (2011) 1.23
PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity. EMBO J (2011) 1.22
Assembly of filopodia by the formin FRL2 (FMNL3). Cytoskeleton (Hoboken) (2010) 1.20
Brain-derived neurotrophic factor regulation of retinal growth cone filopodial dynamics is mediated through actin depolymerizing factor/cofilin. J Neurosci (2004) 1.20