Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers.

PubWeight™: 1.95‹?› | Rank: Top 2%

🔗 View Article (PMC 2483518)

Published in J Cell Biol on July 28, 2008

Authors

Hao Yuan Kueh1, Guillaume T Charras, Timothy J Mitchison, William M Brieher

Author Affiliations

1: Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

Articles citing this

A nucleator arms race: cellular control of actin assembly. Nat Rev Mol Cell Biol (2010) 5.33

ADF/cofilin: a functional node in cell biology. Trends Cell Biol (2010) 3.95

Structural plasticity in actin and tubulin polymer dynamics. Science (2009) 2.45

N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway. Nat Cell Biol (2011) 1.92

Coronin switches roles in actin disassembly depending on the nucleotide state of actin. Mol Cell (2009) 1.69

Cofilin tunes the nucleotide state of actin filaments and severs at bare and decorated segment boundaries. Curr Biol (2011) 1.55

The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility. Nature (2009) 1.53

Actin remodeling by ADF/cofilin is required for cargo sorting at the trans-Golgi network. J Cell Biol (2009) 1.51

Dynamic stabilization of actin filaments. Proc Natl Acad Sci U S A (2008) 1.50

Antenna Mechanism of Length Control of Actin Cables. PLoS Comput Biol (2015) 1.41

Analysis of turnover dynamics of the submembranous actin cortex. Mol Biol Cell (2013) 1.38

Overlapping and distinct functions for cofilin, coronin and Aip1 in actin dynamics in vivo. J Cell Sci (2010) 1.35

Loss of Aip1 reveals a role in maintaining the actin monomer pool and an in vivo oligomer assembly pathway. J Cell Biol (2010) 1.33

Arabidopsis actin depolymerizing factor4 modulates the stochastic dynamic behavior of actin filaments in the cortical array of epidermal cells. Plant Cell (2011) 1.30

Unraveling the enigma: progress towards understanding the coronin family of actin regulators. Trends Cell Biol (2011) 1.26

Actin dynamics and endocytosis in yeast and mammals. Curr Opin Biotechnol (2010) 1.23

Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast. J Biol Chem (2011) 1.17

Roles of ADF/cofilin in actin polymerization and beyond. F1000 Biol Rep (2010) 1.15

Srv2/cyclase-associated protein forms hexameric shurikens that directly catalyze actin filament severing by cofilin. Mol Biol Cell (2012) 1.14

Role of focal adhesions and mechanical stresses in the formation and progression of the lamellipodium-lamellum interface [corrected]. Biophys J (2009) 1.14

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. Cancer Res (2013) 1.12

Actin dynamics: from nanoscale to microscale. Annu Rev Biophys (2010) 1.09

Evolutionary selection of new breast cancer cell-targeting peptides and phages with the cell-targeting peptides fully displayed on the major coat and their effects on actin dynamics during cell internalization. Mol Pharm (2010) 1.08

Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b. J Exp Med (2011) 1.07

Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos. J Cell Sci (2011) 1.07

An order of magnitude faster AIP1-associated actin disruption than nucleation by the Arp2/3 complex in lamellipodia. PLoS One (2009) 1.06

Turnover of branched actin filament networks by stochastic fragmentation with ADF/cofilin. Mol Biol Cell (2011) 1.01

Inside view of cell locomotion through single-molecule: fast F-/G-actin cycle and G-actin regulation of polymer restoration. Proc Jpn Acad Ser B Phys Biol Sci (2010) 1.00

Actin and endocytosis in budding yeast. Genetics (2015) 0.99

Single-molecule imaging of a three-component ordered actin disassembly mechanism. Nat Commun (2015) 0.98

A pharmacological cocktail for arresting actin dynamics in living cells. Mol Biol Cell (2011) 0.97

Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway. J Cell Sci (2009) 0.96

Functional surfaces on the actin-binding protein coronin revealed by systematic mutagenesis. J Biol Chem (2010) 0.96

Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A. Proc Natl Acad Sci U S A (2014) 0.95

Aip1 destabilizes cofilin-saturated actin filaments by severing and accelerating monomer dissociation from ends. Curr Biol (2014) 0.94

Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins. Nat Commun (2015) 0.90

Actin cytoskeletal defects in immunodeficiency. Immunol Rev (2013) 0.90

T cell activation requires force generation. J Cell Biol (2016) 0.88

Quantitative analysis of actin turnover in Listeria comet tails: evidence for catastrophic filament turnover. Biophys J (2010) 0.87

The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation. Mol Biol Cell (2010) 0.87

Determinants of fluidlike behavior and effective viscosity in cross-linked actin networks. Biophys J (2014) 0.85

Actin kinetics shapes cortical network structure and mechanics. Sci Adv (2016) 0.85

Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells. Biochem Biophys Res Commun (2009) 0.84

Mechanisms of actin disassembly. Mol Biol Cell (2013) 0.84

Robust organizational principles of protrusive biopolymer networks in migrating living cells. PLoS One (2011) 0.83

Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity. Elife (2015) 0.83

Coronin Enhances Actin Filament Severing by Recruiting Cofilin to Filament Sides and Altering F-Actin Conformation. J Mol Biol (2015) 0.81

Modeling the synergy of cofilin and Arp2/3 in lamellipodial protrusive activity. Biophys J (2013) 0.81

The two actin-interacting protein 1 genes have overlapping and essential function for embryonic development in Caenorhabditis elegans. Mol Biol Cell (2011) 0.81

A continuum model of actin waves in Dictyostelium discoideum. PLoS One (2013) 0.80

Actin dynamics and cofilin-actin rods in alzheimer disease. Cytoskeleton (Hoboken) (2016) 0.80

Combinatorial genetic analysis of a network of actin disassembly-promoting factors. Cytoskeleton (Hoboken) (2015) 0.79

Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction. PLoS One (2013) 0.79

A phenomenological density-scaling approach to lamellipodial actin dynamics(†). Interface Focus (2014) 0.79

Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse. Cell Mol Life Sci (2014) 0.79

Correlative nanoscale imaging of actin filaments and their complexes. Nanoscale (2013) 0.79

Coronin-1A: immune deficiency in humans and mice. J Clin Immunol (2015) 0.78

Plasma membrane calcium ATPase activity is regulated by actin oligomers through direct interaction. J Biol Chem (2013) 0.78

Global treadmilling coordinates actin turnover and controls the size of actin networks. Nat Rev Mol Cell Biol (2017) 0.75

Platelet WDR1 suppresses platelet activity and associates with cardiovascular disease. Blood (2016) 0.75

Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells. PLoS One (2016) 0.75

ADF/Cofilin Accelerates Actin Dynamics by Severing Filaments and Promoting Their Depolymerization at Both Ends. Curr Biol (2017) 0.75

Articles cited by this

Cellular motility driven by assembly and disassembly of actin filaments. Cell (2003) 26.05

Atomic model of the actin filament. Nature (1990) 11.33

Purification of muscle actin. Methods Enzymol (1982) 9.11

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A (1996) 8.53

Rate constants for the reactions of ATP- and ADP-actin with the ends of actin filaments. J Cell Biol (1986) 7.79

Two distinct actin networks drive the protrusion of migrating cells. Science (2004) 7.69

Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmilling. J Cell Biol (1985) 7.25

Head to tail polymerization of actin. J Mol Biol (1976) 7.14

Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility. J Cell Biol (1997) 7.10

The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization. Nature (1992) 5.84

Listeria monocytogenes moves rapidly through the host-cell cytoplasm by inducing directional actin assembly. Proc Natl Acad Sci U S A (1990) 5.45

Cofilin promotes actin polymerization and defines the direction of cell motility. Science (2004) 5.12

Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J Cell Biol (2003) 5.06

Mechanism of actin-based motility. Science (2001) 5.04

Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin. Mol Cell (2006) 4.88

Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function. J Cell Biol (1997) 4.54

Latrunculins--novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D. Cell Motil Cytoskeleton (1989) 4.27

Single-molecule speckle analysis of actin filament turnover in lamellipodia. Science (2002) 4.27

Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides. J Cell Biol (1996) 3.97

Host cell actin assembly is necessary and likely to provide the propulsive force for intracellular movement of Listeria monocytogenes. Infect Immun (1992) 3.13

Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex. Curr Biol (2002) 3.06

Behaviour of microtubules and actin filaments in living Drosophila embryos. Development (1988) 2.87

Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science (2006) 2.85

Cytochalasin B and the structure of actin gels. J Mol Biol (1979) 2.81

Actin polymerization-driven molecular movement of mDia1 in living cells. Science (2004) 2.80

Characterization of actin filament severing by actophorin from Acanthamoeba castellanii. J Cell Biol (1991) 2.77

Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J Cell Sci (2001) 2.74

Myosin-II-dependent localization and dynamics of F-actin during cytokinesis. Curr Biol (2005) 2.68

Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cell (2007) 2.59

Defining protein interactions with yeast actin in vivo. Nat Struct Biol (1995) 2.52

Mechanism of interaction of Acanthamoeba actophorin (ADF/Cofilin) with actin filaments. J Biol Chem (1999) 2.48

Dendritic organization of actin comet tails. Curr Biol (2001) 2.43

Effects of CapZ, an actin capping protein of muscle, on the polymerization of actin. Biochemistry (1989) 2.38

Actin-based movement of Listeria monocytogenes: actin assembly results from the local maintenance of uncapped filament barbed ends at the bacterium surface. J Cell Biol (1995) 2.27

Aip1p interacts with cofilin to disassemble actin filaments. J Cell Biol (1999) 2.22

Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits. EMBO J (1991) 2.20

Actin-dependent regulation of neurotransmitter release at central synapses. Neuron (2000) 2.15

Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. J Cell Biol (2006) 2.07

Direct electron microscopic visualization of barbed end capping and filament cutting by intestinal microvillar 95-kdalton protein (villin): a new actin assembly assay using the Limulus acrosomal process. J Cell Biol (1983) 1.99

Cofilin promotes stimulus-induced lamellipodium formation by generating an abundant supply of actin monomers. J Cell Biol (2007) 1.93

The ADF/cofilin family: actin-remodeling proteins. Genome Biol (2002) 1.83

Coordinated regulation of actin filament turnover by a high-molecular-weight Srv2/CAP complex, cofilin, profilin, and Aip1. Curr Biol (2003) 1.78

The structural basis for the intrinsic disorder of the actin filament: the "lateral slipping" model. J Cell Biol (1991) 1.77

Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing. J Cell Biol (2006) 1.70

The isolated comet tail pseudopodium of Listeria monocytogenes: a tail of two actin filament populations, long and axial and short and random. J Cell Biol (1997) 1.69

Cofilin recruitment and function during actin-mediated endocytosis dictated by actin nucleotide state. J Cell Biol (2007) 1.63

Aip1 and cofilin promote rapid turnover of yeast actin patches and cables: a coordinated mechanism for severing and capping filaments. Mol Biol Cell (2006) 1.62

The actin-interacting protein AIP1 is essential for actin organization and plant development. Curr Biol (2004) 1.60

F-actin binding is essential for coronin 1B function in vivo. J Cell Sci (2007) 1.55

The Caenorhabditis elegans unc-78 gene encodes a homologue of actin-interacting protein 1 required for organized assembly of muscle actin filaments. J Cell Biol (2001) 1.52

Xenopus actin-interacting protein 1 (XAip1) enhances cofilin fragmentation of filaments by capping filament ends. J Biol Chem (2002) 1.50

Actin filaments play a critical role in insulin-induced exocytotic recruitment but not in endocytosis of GLUT4 in isolated rat adipocytes. Biochem J (2000) 1.44

Microscopic evidence that actin-interacting protein 1 actively disassembles actin-depolymerizing factor/Cofilin-bound actin filaments. J Biol Chem (2004) 1.37

Biomolecular mimicry in the actin cytoskeleton: mechanisms underlying the cytotoxicity of kabiramide C and related macrolides. Proc Natl Acad Sci U S A (2003) 1.33

Cofilin (ADF) affects lateral contacts in F-actin. J Mol Biol (2004) 1.24

Compare and contrast actin filaments and microtubules. Mol Biol Cell (1992) 1.19

The kinetics of cytochalasin D binding to monomeric actin. J Biol Chem (1986) 1.05

Biochemical and genetic analyses provide insight into the structural and mechanistic properties of actin filament disassembly by the Aip1p cofilin complex in Saccharomyces cerevisiae. Genetics (2007) 0.95

SnapShot: actin regulators I. Cell (2007) 0.94

Cytochalasin D and latrunculin affect chromosome behaviour during meiosis in crane-fly spermatocytes. Chromosome Res (1998) 0.90

Articles by these authors

Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science (2003) 12.41

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63

A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A (2008) 10.09

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature (2009) 5.55

Multidimensional drug profiling by automated microscopy. Science (2004) 5.45

Self- and actin-templated assembly of Mammalian septins. Dev Cell (2002) 4.48

A standardized kinesin nomenclature. J Cell Biol (2004) 4.43

Reassembly of contractile actin cortex in cell blebs. J Cell Biol (2006) 4.31

Single-molecule speckle analysis of actin filament turnover in lamellipodia. Science (2002) 4.27

Animal cytokinesis: from parts list to mechanisms. Annu Rev Biochem (2006) 4.23

Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell (2004) 3.51

Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell (2009) 3.44

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol (2004) 3.39

Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell (2013) 3.26

Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol (2007) 3.17

Poly(ADP-ribose) is required for spindle assembly and structure. Nature (2004) 3.11

Life and times of a cellular bleb. Biophys J (2007) 3.05

Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics. J Cell Biol (2003) 3.01

EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. Mol Biol Cell (2002) 2.92

Determining the position of the cell division plane. Nature (2003) 2.80

Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nat Cell Biol (2005) 2.70

Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell (2004) 2.51

Structural plasticity in actin and tubulin polymer dynamics. Science (2009) 2.45

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes. Proc Natl Acad Sci U S A (2011) 2.44

Anillin binds nonmuscle myosin II and regulates the contractile ring. Mol Biol Cell (2004) 2.33

Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton. Chem Biol (2002) 2.28

EB1 targets to kinetochores with attached, polymerizing microtubules. Mol Biol Cell (2002) 2.27

Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos. Curr Biol (2002) 2.27

Force and length in the mitotic spindle. Curr Biol (2009) 2.11

Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A (2004) 2.08

A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods. BMC Biotechnol (2004) 2.08

Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. J Cell Biol (2006) 2.07

The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles. J Cell Biol (2004) 2.06

A quantitative analysis of contractility in active cytoskeletal protein networks. Biophys J (2008) 2.05

Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nat Cell Biol (2007) 2.01

Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res (2011) 1.99

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov (2009) 1.95

The force-velocity relationship for the actin-based motility of Listeria monocytogenes. Curr Biol (2003) 1.94

Evidence for an upper limit to mitotic spindle length. Curr Biol (2008) 1.94

Cell polarization during monopolar cytokinesis. J Cell Biol (2008) 1.92

Small molecule screening by imaging. Curr Opin Chem Biol (2006) 1.90

Structural insights into yeast septin organization from polarized fluorescence microscopy. Nature (2006) 1.83

The cytoplasm of living cells behaves as a poroelastic material. Nat Mater (2013) 1.80

Slide-and-cluster models for spindle assembly. Curr Biol (2007) 1.79

An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell (2003) 1.76

A model for cleavage plane determination in early amphibian and fish embryos. Curr Biol (2010) 1.72

Nonredundant functions of Kinesin-13s during meiotic spindle assembly. Curr Biol (2007) 1.69

A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii. Proc Natl Acad Sci U S A (2004) 1.64

Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex. J Cell Biol (2004) 1.62

Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chem Biol (2002) 1.58

XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly. Curr Biol (2004) 1.56

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell (2011) 1.53

Noble metals strip peptides from class II MHC proteins. Nat Chem Biol (2006) 1.53

Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Mol Cancer Ther (2008) 1.53

KIF4 regulates midzone length during cytokinesis. Curr Biol (2011) 1.51

Midbody assembly and its regulation during cytokinesis. Mol Biol Cell (2012) 1.50

Dynamic stabilization of actin filaments. Proc Natl Acad Sci U S A (2008) 1.50

How does a millimeter-sized cell find its center? Cell Cycle (2009) 1.48

The microtubule-destabilizing kinesin XKCM1 is required for chromosome positioning during spindle assembly. Curr Biol (2002) 1.46

A new method reveals microtubule minus ends throughout the meiotic spindle. J Cell Biol (2006) 1.46

Microtubule plus-end dynamics in Xenopus egg extract spindles. Mol Biol Cell (2004) 1.45

Compression regulates mitotic spindle length by a mechanochemical switch at the poles. Curr Biol (2009) 1.44

Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell division. Biochemistry (2004) 1.44

Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol (2005) 1.43

Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. Biochemistry (2004) 1.40

High-content screening and profiling of drug activity in an automated centrosome-duplication assay. Chembiochem (2005) 1.38

NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Mol Biol Cell (2006) 1.37

Deformations within moving kinetochores reveal different sites of active and passive force generation. Science (2012) 1.36

Characterizing the mechanics of cultured cell monolayers. Proc Natl Acad Sci U S A (2012) 1.36

The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. J Biol Chem (2003) 1.29

Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest. PLoS One (2010) 1.28

Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL. Cancer Res (2011) 1.27

Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules. Curr Biol (2009) 1.27

A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes. Curr Biol (2005) 1.26

α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction. J Cell Biol (2012) 1.22

Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. Mol Biol Cell (2009) 1.20

Animal cell hydraulics. J Cell Sci (2009) 1.19

Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity. Curr Biol (2009) 1.19

Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC Chem Biol (2006) 1.19

Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked. Curr Biol (2004) 1.19

Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics (2009) 1.18

Mammalian septins nomenclature. Mol Biol Cell (2002) 1.16

A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly. J Cell Sci (2008) 1.15

Symmetry of septin hourglass and ring structures. J Mol Biol (2007) 1.13

Anticancer flavonoids are mouse-selective STING agonists. ACS Chem Biol (2013) 1.12

Micron-scale coherence in interphase chromatin dynamics. Proc Natl Acad Sci U S A (2013) 1.11

Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament. J Mol Biol (2007) 1.11

Cyclase-associated protein (CAP) acts directly on F-actin to accelerate cofilin-mediated actin severing across the range of physiological pH. J Biol Chem (2012) 1.09

Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly. Mol Biol Cell (2009) 1.08

Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos. J Cell Sci (2011) 1.07

Rapid de-localization of actin leading edge components with BDM treatment. BMC Cell Biol (2003) 1.07

The first World Cell Race. Curr Biol (2012) 1.07

The natural product cucurbitacin E inhibits depolymerization of actin filaments. ACS Chem Biol (2012) 1.05

Directly probing the mechanical properties of the spindle and its matrix. J Cell Biol (2010) 1.05

Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis. Mol Biol Cell (2012) 1.05

A novel action of histone deacetylase inhibitors in a protein aggresome disease model. Curr Biol (2004) 1.03

Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm. Curr Biol (2008) 0.99

Imaging burst kinetics and spatial coordination during serial killing by single natural killer cells. Proc Natl Acad Sci U S A (2013) 0.98