Published in Proc Natl Acad Sci U S A on January 01, 1988
The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins. Proc Natl Acad Sci U S A (1998) 2.50
Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteins. Proc Natl Acad Sci U S A (1998) 2.41
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome. Proc Natl Acad Sci U S A (1992) 2.26
Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis. Proc Natl Acad Sci U S A (1990) 1.82
The Drosophila gene coding for the alpha subunit of a stimulatory G protein is preferentially expressed in the nervous system. Proc Natl Acad Sci U S A (1989) 1.05
The GNAS Locus: Quintessential Complex Gene Encoding Gsalpha, XLalphas, and other Imprinted Transcripts. Curr Genomics (2007) 0.97
Mutations in pseudohypoparathyroidism 1a and pseudopseudohypoparathyroidism in ethnic Chinese. PLoS One (2014) 0.82
Aberrant splicing of Gs alpha transcript in transformed human astroglial and glioblastoma cell lines. Nucleic Acids Res (1992) 0.75
A case report of a 14 year old male with pseudohypoparathyroidism associated with multiple hormonal resistance. Indian J Clin Biochem (2014) 0.75
Differential expression of guanosine triphosphate binding proteins in men at high and low risk for the future development of alcoholism. J Clin Invest (1994) 0.75
G-protein Stimulatory α Subunit Is Involved in Osteogenic Activity in Osteoblastic Cell Line SaOS-2 Cells. Clin Pediatr Endocrinol (2006) 0.75
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci U S A (1980) 109.70
"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. Anal Biochem (1984) 66.58
Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol Cell Biol (1983) 11.06
G proteins and dual control of adenylate cyclase. Cell (1984) 11.05
G proteins: a family of signal transducers. Annu Rev Cell Biol (1986) 5.38
Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. J Biol Chem (1987) 4.60
Pseudo-pseudohypoparathyroidism. Trans Assoc Am Physicians (1952) 3.44
The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor. Cell (1983) 2.62
Human cDNA clones for four species of G alpha s signal transduction protein. Proc Natl Acad Sci U S A (1986) 2.38
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase. Science (1985) 2.35
Resistance to multiple hormones in patients with pseudohypoparathyroidism. Association with deficient activity of guanine nucleotide regulatory protein. Am J Med (1983) 2.14
Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A (1986) 2.03
Defect of receptor-cyclase coupling protein in psudohypoparathyroidism. N Engl J Med (1980) 1.68
Deficient activity of guanine nucleotide regulatory protein in erythrocytes from patients with pseudohypoparathyroidism. Biochem Biophys Res Commun (1980) 1.54
Gene conversion in salt-losing congenital adrenal hyperplasia with absent complement C4B protein. J Clin Endocrinol Metab (1986) 1.52
Activity of the stimulatory guanine nucleotide-binding protein is reduced in erythrocytes from patients with pseudohypoparathyroidism and pseudopseudohypoparathyroidism: biochemical, endocrine, and genetic analysis of Albright's hereditary osteodystrophy in six kindreds. J Clin Endocrinol Metab (1986) 1.38
Fibroblast defect in pseudohypoparathyroidism, type I: reduced activity of receptor-cyclase coupling protein. J Clin Endocrinol Metab (1981) 1.02
Restriction maps and restriction fragment length polymorphisms of the human 21-hydroxylase genes. Biochem Biophys Res Commun (1986) 1.00
Novel S49 lymphoma variants with aberrant cyclic AMP metabolism. Mol Pharmacol (1981) 1.00
Deficient guanine nucleotide regulatory unit activity in cultured fibroblast membranes from patients with pseudohypoparathyroidism type I. a cause of impaired synthesis of 3',5'-cyclic AMP by intact and broken cells. J Clin Invest (1983) 0.99
Pseudohypoparathyroidism: inheritance of deficient receptor-cyclase coupling activity. Proc Natl Acad Sci U S A (1981) 0.97
Deficient activity of receptor-cyclase coupling protein in platelets of patients with pseudohypoparathyroidism. J Clin Endocrinol Metab (1980) 0.95
Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism. J Clin Invest (1983) 0.92
Mental deficiency in pseudohypoparathyroidism type I is associated with Ns-protein deficiency. Ann Intern Med (1986) 0.91
Deficient activity of receptor-cyclase coupling protein is transformed lymphoblasts of patients with pseudohypoparathyroidism, type I. J Clin Endocrinol Metab (1982) 0.90
Infantile hypothyroidism in two sibs: an unusual presentation of pseudohypoparathyroidism type Ia. J Pediatr (1985) 0.88
Pseudohypoparathyroidism. Annu Rev Med (1983) 0.87
The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism. J Clin Endocrinol Metab (1985) 0.85
Olfactory dysfunction in humans with deficient guanine nucleotide-binding protein. Nature (1986) 0.85
Father to son transmission of decreased Ns activity in pseudohypoparathyroidism type Ia. J Clin Endocrinol Metab (1984) 0.82
Differential diagnosis in young women with oligomenorrhea and the pseudo-pseudohypoparathyroidism variant of Albright's hereditary osteodystrophy. Am J Med Genet (1985) 0.78
An evolutionary trace method defines binding surfaces common to protein families. J Mol Biol (1996) 9.31
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (2000) 6.93
G proteins: a family of signal transducers. Annu Rev Cell Biol (1986) 5.38
GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature (1989) 5.03
Two G protein oncogenes in human endocrine tumors. Science (1990) 4.46
Modulation of inflammation and immunity by cyclic AMP. Science (1974) 4.31
Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature (1993) 3.57
The role of cyclic 3',5' adenosine monophosphate in the specific cytolytic activity of lymphocytes. J Immunol (1972) 3.51
Spatial control of actin polymerization during neutrophil chemotaxis. Nat Cell Biol (1999) 3.45
A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature (1999) 3.22
Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature (1994) 3.21
Sleep disturbance as the hallmark of posttraumatic stress disorder. Am J Psychiatry (1989) 3.18
Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright's hereditary osteodystrophy. N Engl J Med (1990) 3.09
Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. Proc Natl Acad Sci U S A (1999) 2.73
A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A (1997) 2.70
Pharmacologic control of allergic histamine release in vitro: evidence for an inhibitory role of 3',5'-adenosine monophosphate in human leukocytes. J Immunol (1972) 2.70
Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature (1992) 2.62
Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell (1999) 2.61
Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol (2000) 2.59
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature (1996) 2.55
Histamine augments leukocyte adenosine 3',5'-monophosphate and blocks antigenic histamine release. Science (1971) 2.47
ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors. J Biol Chem (1984) 2.39
Lipid modifications of trimeric G proteins. J Biol Chem (1995) 2.39
Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function. Nature (1994) 2.36
Cyclic 3',5'-adenosine monophosphate in the human lukocyte: synthesis, degradation, andeffects n neutrophil candidacidal activity. J Clin Invest (1971) 2.35
Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors. Cell (1993) 2.34
Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.34
Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc Natl Acad Sci U S A (1990) 2.31
A guanine nucleotide-sensitive adenylate cyclase in the yeast Saccharomyces cerevisiae. J Biol Chem (1983) 2.31
Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes. Diabetes Obes Metab (2010) 2.30
Activation and depalmitoylation of Gs alpha. Cell (1994) 2.29
Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin. J Biol Chem (1984) 2.17
Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase. J Clin Invest (1973) 2.16
Rejection of ascites tumor allografts. I. Isolation, characterization, and in vitro reactivity of peritoneal lymphoid effector cells from BALB-c mice immune to EL4 leukosis. J Exp Med (1972) 2.13
Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase. J Biol Chem (1978) 2.12
Separate GTP binding and GTPase activating domains of a G alpha subunit. Science (1993) 2.08
Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A (1986) 2.03
Adenyl cyclase in human leukocytes: evidence for activation by separate beta adrenergic and prostaglandin receptors. J Pharmacol Exp Ther (1971) 2.02
Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. J Biol Chem (1993) 2.02
Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs. Proc Natl Acad Sci U S A (1997) 1.99
cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J Biol Chem (1994) 1.98
Hemolytic plaque formation by leukocytes in vitro. Control by vasoactive hormones. J Clin Invest (1974) 1.98
Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol. J Biol Chem (2000) 1.96
Mutations in the GTP-binding site of GS alpha alter stimulation of adenylyl cyclase. J Biol Chem (1989) 1.95
Effects of cholera toxin on in vitro models of immediate and delayed hypersensitivity. Further evidence for the role of cyclic adenosine 3',5'-monophosphate. J Clin Invest (1973) 1.94
Neurons undergo apoptosis in animal and cell culture models of diabetes. Neurobiol Dis (1999) 1.89
Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity. J Cell Biol (1992) 1.88
Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Commun (1989) 1.88
Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation. Nature (1991) 1.87
Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart. J Clin Invest (1988) 1.85
Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains. Protein Eng (1989) 1.76
Selection of a variant lymphoma cell deficient in adenylate cyclase. Science (1975) 1.76
An 18,000 molecular weight polypeptide induces early events and stimulates DNA synthesis in cultured cells. Proc Natl Acad Sci U S A (1976) 1.74
Biochemical defects in ABCR protein variants associated with human retinopathies. Nat Genet (2000) 1.73
Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin. Science (1997) 1.71
Purification and characterization of a naturally occurring vascular endothelial growth factor.placenta growth factor heterodimer. J Biol Chem (1995) 1.68
Defect of receptor-cyclase coupling protein in psudohypoparathyroidism. N Engl J Med (1980) 1.68
Efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes. Diabetes Obes Metab (2010) 1.67
The effects of a series of prostaglandins on in vitro models of the allergic response and cellular immunity. Prostaglandins (1972) 1.67
Chronic treatment with finasteride daily does not affect spermatogenesis or semen production in young men. J Urol (1999) 1.67
Identification of receptor contact site involved in receptor-G protein coupling. Nature (1988) 1.65
An antigenic determinant of cytotoxic lymphocytes. Transplantation (1973) 1.65
Influence of cholera toxin on the regulation of adenylate cyclase by GTP. Biochem Biophys Res Commun (1977) 1.59
A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways. Mol Endocrinol (1992) 1.59
Primary structure of bovine pituitary secretory protein I (chromogranin A) deduced from the cDNA sequence. Proc Natl Acad Sci U S A (1987) 1.58
Isolation of the gene encoding adenylate cyclase in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1985) 1.58
Cholera toxin induces cAMP-independent degradation of Gs. J Biol Chem (1989) 1.57
Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts. J Clin Invest (1994) 1.57
GTP-binding proteins. One molecular machine can transduce diverse signals. Nature (1986) 1.56
Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes. J Exp Med (1985) 1.54
G-protein diseases furnish a model for the turn-on switch. Nature (1998) 1.54
Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin. J Biol Chem (1982) 1.53
Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth. Science (1975) 1.51
A mutation that prevents GTP-dependent activation of the alpha chain of Gs. Nature (1988) 1.50
Receptors for histamine can be detected on the surface of selected leukocytes. Science (1972) 1.46
Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency. Diabetes Obes Metab (2008) 1.44
Somatic genetic analysis of cyclic AMP action: selection of unresponsive mutants. J Cell Physiol (1975) 1.44
Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C. J Biol Chem (1992) 1.43
Safety and efficacy of treatment with sitagliptin or glipizide in patients with type 2 diabetes inadequately controlled on metformin: a 2-year study. Int J Clin Pract (2010) 1.43
The expanding spectrum of G protein diseases. N Engl J Med (1999) 1.41
A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival. Neuron (2001) 1.41
A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells. Proc Natl Acad Sci U S A (1991) 1.40
Familial isolated hypoparathyroidism: a molecular genetic analysis of 8 families with 23 affected persons. Medicine (Baltimore) (1986) 1.40
Specific leukocyte receptors for small endogenous hormones. Detection by cell binding to insolubilized hormone preparations. J Clin Invest (1973) 1.39
Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing. J Biol Chem (2000) 1.38
Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. J Biol Chem (1999) 1.36
Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients. Am J Transplant (2008) 1.36
A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells. Proc Natl Acad Sci U S A (1975) 1.36
Activation-induced subcellular redistribution of Gs alpha. Mol Biol Cell (1996) 1.36
Carboxyl terminal domain of Gs alpha specifies coupling of receptors to stimulation of adenylyl cyclase. Science (1988) 1.35
Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems. Proc Natl Acad Sci U S A (1986) 1.35
Biochemical characterization of three stimulatory GTP-binding proteins. The large and small forms of Gs and the olfactory-specific G-protein, Golf. J Biol Chem (1990) 1.35
Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide. Proc Natl Acad Sci U S A (1990) 1.34