Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.

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Published in Sci Rep on March 27, 2017

Authors

Javad Alizadeh1,2, Amir A Zeki3, Nima Mirzaei1, Sandipan Tewary1, Adel Rezaei Moghadam1,2, Aleksandra Glogowska1, Pandian Nagakannan4, Eftekhar Eftekharpour4, Emilia Wiechec5, Joseph W Gordon1,6, Fred Y Xu7, Jared T Field8, Ken Y Yoneda3, Nicholas J Kenyon3, Mohammad Hashemi9, Grant M Hatch7, Sabine Hombach-Klonisch1, Thomas Klonisch1, Saeid Ghavami1,2,10

Author Affiliations

1: Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
2: Biology of Breathing Theme, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada.
3: Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, Davis, CA, USA.
4: Department of Physiology and Pathophysiology, Regenerative Medicine, Program and Spinal Cord research Center, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
5: Department of Clinical and Experimental Moledicine, Division of Otorhinolaryngology, Linköping University, 581-85, Linköping, Sweden.
6: College of Nursing and Children's Hospital Research Institute of Manitoba, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
7: DREAM, Children's Hospital Research Institute of Manitoba, Center for Research and Treatment of Atherosclerosis and Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada.
8: Department of Biological Sciences, Faculty of Science, University of Manitoba, Winnipeg, Canada.
9: Department of Clinical Biochemistry, Zehedan University of Medical Sciences, Zahedan, Iran.
10: Health Policy Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.

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