Published in J Natl Cancer Inst on January 08, 2008
Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20,536 high-risk individuals: a randomised controlled trial. Lancet (2011) 5.08
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
Statin use and risk of prostate cancer: a meta-analysis of observational studies. PLoS One (2012) 1.74
Association between plasma cholesterol and prostate cancer in the PSA era. Int J Cancer (2008) 1.70
Prospective analysis of association between use of statins or other lipid-lowering agents and colorectal cancer risk. Ann Epidemiol (2011) 1.57
Statin use and cancer risk: a comprehensive review. Expert Opin Drug Saf (2010) 1.56
Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer. Breast Cancer Res Treat (2010) 1.42
Statins and colorectal cancer. Clin Gastroenterol Hepatol (2012) 1.36
Beyond aspirin-cancer prevention with statins, metformin and bisphosphonates. Nat Rev Clin Oncol (2013) 1.20
Anticancer activity of the cholesterol exporter ABCA1 gene. Cell Rep (2012) 1.14
HMG CoA reductase inhibitors, NSAIDs and risk of glioma. Int J Cancer (2012) 1.10
Statin use and risk of hepatocellular carcinoma. Eur J Epidemiol (2013) 1.04
Long-term use of valproic acid in US veterans is associated with a reduced risk of smoking-related cases of head and neck cancer. Cancer (2014) 1.01
Cardiovascular medication use and risk for colorectal cancer. Cancer Epidemiol Biomarkers Prev (2008) 0.99
Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins. Am J Cancer Res (2011) 0.97
The associations between statin use and prostate cancer screening, prostate size, high-grade prostatic intraepithelial neoplasia (PIN), and prostate cancer. Cancer Causes Control (2010) 0.97
Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs. J Med Chem (2010) 0.96
Obesity and cancer: mechanistic insights from transdisciplinary studies. Endocr Relat Cancer (2015) 0.96
Simvastatin does not affect vitamin d status, but low vitamin d levels are associated with dyslipidemia: results from a randomised, controlled trial. Int J Endocrinol (2009) 0.96
Epidemiologic characteristics and risk factors for renal cell cancer. Clin Epidemiol (2009) 0.95
Statin use and risk of lung cancer: a meta-analysis of observational studies and randomized controlled trials. PLoS One (2013) 0.93
Statins and cancers. Contemp Oncol (Pozn) (2014) 0.93
Statins and the risk of lung cancer: a meta-analysis. PLoS One (2013) 0.92
Statin use is not associated with reduced risk of skin cancer: a meta-analysis. Br J Cancer (2013) 0.89
Metabolic changes during ovarian cancer progression as targets for sphingosine treatment. Exp Cell Res (2013) 0.88
Statins and the risk of colorectal cancer: an updated systematic review and meta-analysis of 40 studies. World J Gastroenterol (2014) 0.87
Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. Br J Pharmacol (2009) 0.87
Atorvastatin induces apoptosis in vitro and slows growth of tumor xenografts but not polyp formation in MIN mice. Dig Dis Sci (2010) 0.85
Minimal detection bias in the inverse association between statin drug use and advanced prostate cancer risk: a simulation study. Cancer Epidemiol (2010) 0.85
Association between statin use and risk for keratinocyte carcinoma in the veterans affairs topical tretinoin chemoprevention trial. Ann Intern Med (2009) 0.85
Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. Sci Rep (2014) 0.85
Cholesterol and benign prostate disease. Differentiation (2011) 0.85
Association between statin use and cancer: data mining of a spontaneous reporting database and a claims database. Int J Med Sci (2015) 0.84
Atorvastatin and fluvastatin are associated with dose-dependent reductions in cirrhosis and hepatocellular carcinoma, among patients with hepatitis C virus: Results from ERCHIVES. Hepatology (2016) 0.84
Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. Curr Breast Cancer Rep (2014) 0.83
Statin use and risk of basal cell carcinoma. J Am Acad Dermatol (2009) 0.82
Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. PLoS One (2012) 0.82
Role of serum cholesterol and statin use in the risk of prostate cancer detection and tumor aggressiveness. Int J Mol Sci (2014) 0.81
Reply to Comment on 'Statin use and all-cancer survival: prospective results from the Women's Health Initiative'. Br J Cancer (2016) 0.78
Re: The association between statins and cancer incidence in a veterans population. J Natl Cancer Inst (2008) 0.78
Lipid metabolic pathways as lung cancer therapeutic targets: a computational study. Int J Mol Med (2011) 0.77
Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death. Oncotarget (2016) 0.77
Simvastatin Treatment Does Not Affect Serum Vitamin D Concentrations in Patients with Dyslipidemia: A Randomized Double-blind Placebo-controlled Cross-over Trial. Int J Prev Med (2016) 0.77
Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. Oncotarget (2015) 0.76
The Effect of Atorvastatin on Breast Cancer Biomarkers in High-Risk Women. Cancer Prev Res (Phila) (2016) 0.75
Can statins reduce risk of lung cancer, especially among elderly people? A meta-analysis. Chin J Cancer Res (2013) 0.75
Evidence for Detection Bias by Medication Use in a Cohort Study of Breast Cancer Survivors. Am J Epidemiol (2017) 0.75
Critical role of toxicologic pathology in a short-term screen for carcinogenicity. J Toxicol Pathol (2016) 0.75
Re: The association between statins and cancer incidence in a veterans population. J Natl Cancer Inst (2008) 0.75
Metabolic profiling of cholesterol and sex steroid hormones to monitor urological diseases. Endocr Relat Cancer (2016) 0.75
Statins improve survival by inhibiting spontaneous metastasis and tumor growth in a mouse melanoma model. Am J Cancer Res (2015) 0.75
Statin Use in Prostate Cancer: An Update. Nutr Metab Insights (2016) 0.75
Impact of Statins on Gene Expression in Human Lung Tissues. PLoS One (2015) 0.75
Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells. Sci Rep (2017) 0.75
Potentiating NK cell activity by combination of Rosuvastatin and Difluoromethylornithine for effective chemopreventive efficacy against Colon Cancer. Sci Rep (2016) 0.75
Bisphosphonates: beyond prevention of bone metastases. J Natl Cancer Inst (2011) 0.75
Transcriptional profiling of breast cancer cells in response to mevinolin: Evidence of cell cycle arrest, DNA degradation and apoptosis. Int J Oncol (2016) 0.75
Statin use and endometrial cancer risk: a meta-analysis. Oncotarget (2017) 0.75
A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med (2005) 17.32
Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2008) 13.35
Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA (2005) 12.09
Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2011) 11.02
Adverse events associated with testosterone administration. N Engl J Med (2010) 10.94
Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA (2005) 9.03
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 8.32
C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men. Circulation (2008) 7.33
Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med (2010) 6.48
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation (2007) 6.34
Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med (2007) 6.29
Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect. Am J Epidemiol (2005) 6.20
Migraine and risk of cardiovascular disease in women. JAMA (2006) 6.16
Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med (2009) 6.16
C-reactive protein and the risk of developing hypertension. JAMA (2003) 5.75
Laboratory-based versus non-laboratory-based method for assessment of cardiovascular disease risk: the NHANES I Follow-up Study cohort. Lancet (2008) 5.49
Measures of obesity and cardiovascular risk among men and women. J Am Coll Cardiol (2008) 5.28
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2012) 4.40
Rates and outcomes of primary and revision total hip replacement in the United States medicare population. J Bone Joint Surg Am (2003) 4.38
Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res (2003) 4.15
A comprehensive care management program to prevent chronic obstructive pulmonary disease hospitalizations: a randomized, controlled trial. Ann Intern Med (2012) 4.10
New models for large prospective studies: is there a better way? Am J Epidemiol (2012) 3.85
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis. Lancet Oncol (2008) 3.62
Comparison of self-report, hospital discharge codes, and adjudication of cardiovascular events in the Women's Health Initiative. Am J Epidemiol (2004) 3.53
Therapies for active rheumatoid arthritis after methotrexate failure. N Engl J Med (2013) 3.51
A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch Intern Med (2007) 3.37
A prospective study of plasma selenium levels and prostate cancer risk. J Natl Cancer Inst (2004) 3.32
Relationship of physical activity vs body mass index with type 2 diabetes in women. JAMA (2004) 3.31
Anticoagulant use for atrial fibrillation in the elderly. J Am Geriatr Soc (2004) 3.13
Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer. J Natl Cancer Inst (2002) 3.03
Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT). J Natl Cancer Inst (2005) 2.99
Association of hospital and surgeon volume of total hip replacement with functional status and satisfaction three years following surgery. Arthritis Rheum (2003) 2.98
Body mass index and the risk of stroke in men. Arch Intern Med (2002) 2.90
Relation between modifiable lifestyle factors and lifetime risk of heart failure. JAMA (2009) 2.90
A prospective cohort study of cancer incidence following the diagnosis of Parkinson's disease. Cancer Epidemiol Biomarkers Prev (2007) 2.77
Prospective study of body mass index and risk of stroke in apparently healthy women. Circulation (2005) 2.73
Inhibition of clinical benefits of aspirin on first myocardial infarction by nonsteroidal antiinflammatory drugs. Circulation (2003) 2.73
Proton pump inhibitors and risk for recurrent Clostridium difficile infection. Arch Intern Med (2010) 2.71
Exceptional longevity in men: modifiable factors associated with survival and function to age 90 years. Arch Intern Med (2008) 2.67
Egg consumption in relation to cardiovascular disease and mortality: the Physicians' Health Study. Am J Clin Nutr (2008) 2.61
Genome-wide association study identifies new prostate cancer susceptibility loci. Hum Mol Genet (2011) 2.51
Migraine and risk of cardiovascular disease in men. Arch Intern Med (2007) 2.49
Migraine, vascular risk, and cardiovascular events in women: prospective cohort study. BMJ (2008) 2.48
Cardiovascular risk prediction in diabetic men and women using hemoglobin A1c vs diabetes as a high-risk equivalent. Arch Intern Med (2011) 2.43
A prospective study of body mass index and the risk of developing hypertension in men. Am J Hypertens (2007) 2.43
Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals. Lancet (2013) 2.37
Practitioner-level determinants of inappropriate prostate-specific antigen screening. Arch Intern Med (2007) 2.34
Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. JAMA (2008) 2.32
Association between body mass index and CKD in apparently healthy men. Am J Kidney Dis (2005) 2.30
Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes. Am J Clin Nutr (2010) 2.25
Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome: meta-analysis with estimates of risk and benefit. Ann Intern Med (2005) 2.22
A prospective study of plasma C-peptide and colorectal cancer risk in men. J Natl Cancer Inst (2004) 2.22
A prospective study of plasma vitamin D metabolites, vitamin D receptor polymorphisms, and prostate cancer. PLoS Med (2007) 2.20
A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians' Health Study II. Arch Intern Med (2007) 2.20
Body mass index and vigorous physical activity and the risk of heart failure among men. Circulation (2008) 2.19
Department of Veterans Affairs Cooperative Studies Program Clinical Trial comparing combined warfarin and aspirin with aspirin alone in survivors of acute myocardial infarction: primary results of the CHAMP study. Circulation (2002) 2.16
Fish consumption, omega-3 fatty acids and risk of heart failure: a meta-analysis. Clin Nutr (2012) 2.14
Egg consumption and risk of type 2 diabetes in men and women. Diabetes Care (2008) 2.14
Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst (2008) 2.07
Healthy lifestyle and the risk of stroke in women. Arch Intern Med (2006) 2.02
Incidence of cardiovascular disease and cancer in advanced age: prospective cohort study. BMJ (2008) 2.01
Manganese superoxide dismutase polymorphism, prediagnostic antioxidant status, and risk of clinical significant prostate cancer. Cancer Res (2005) 1.98
Vitamin supplement use in a low-risk population of US male physicians and subsequent cardiovascular mortality. Arch Intern Med (2002) 1.97
Alcohol consumption and the risk of hypertension in women and men. Hypertension (2008) 1.96
Genome-wide association study of glioma and meta-analysis. Hum Genet (2012) 1.96
An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation. BMC Bioinformatics (2004) 1.95
Geographic patterns in overall and specific cardiovascular disease incidence in apparently healthy men in the United States. Stroke (2007) 1.91
A point-of-care clinical trial comparing insulin administered using a sliding scale versus a weight-based regimen. Clin Trials (2011) 1.91
Evaluation of a generalizable approach to clinical information retrieval using the automated retrieval console (ARC). J Am Med Inform Assoc (2010) 1.89
Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Arch Intern Med (2010) 1.88
Nut consumption and risk of hypertension in US male physicians. Clin Nutr (2008) 1.88
Cholesterol and the risk of renal dysfunction in apparently healthy men. J Am Soc Nephrol (2003) 1.87
Topical tretinoin therapy and all-cause mortality. Arch Dermatol (2009) 1.85
Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. Proc Natl Acad Sci U S A (2009) 1.81
Relation of vigorous exercise to risk of atrial fibrillation. Am J Cardiol (2009) 1.79
Flavonoid intake and the risk of cardiovascular disease in women. Am J Clin Nutr (2003) 1.79
Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study. Arch Ophthalmol (2008) 1.74
Nut consumption and decreased risk of sudden cardiac death in the Physicians' Health Study. Arch Intern Med (2002) 1.73
Alcohol consumption and risk of heart failure in the Physicians' Health Study I. Circulation (2006) 1.68
Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Gut (2012) 1.66
Randomized clinical trial of quick-release bromocriptine among patients with type 2 diabetes on overall safety and cardiovascular outcomes. Diabetes Care (2010) 1.65
Smoking and risk of hemorrhagic stroke in women. Stroke (2003) 1.63
Age-related cataract in a randomized trial of vitamins E and C in men. Arch Ophthalmol (2010) 1.60
Statin use and fracture risk: study of a US veterans population. Arch Intern Med (2005) 1.58
Chronic disease in men with newly diagnosed cancer: a nested case-control study. Am J Epidemiol (2010) 1.58
Dyslipidemia and the risk of incident hypertension in men. Hypertension (2005) 1.54
Comparison of interleukin-6 and C-reactive protein for the risk of developing hypertension in women. Hypertension (2006) 1.53
Change in use of gadolinium-enhanced magnetic resonance studies in kidney disease patients after US Food and Drug Administration warnings: a cross-sectional study of Veterans Affairs Health Care System data from 2005-2008. Am J Kidney Dis (2010) 1.52
Measuring clinically important changes with patient-oriented questionnaires. Med Care (2002) 1.50
Statins and prostate cancer diagnosis and grade in a veterans population. J Natl Cancer Inst (2011) 1.49
Incidence and remaining lifetime risk of Parkinson disease in advanced age. Neurology (2009) 1.48