Published in Oncogene on March 27, 2017
The hallmarks of cancer. Cell (2000) 113.05
The basics of epithelial-mesenchymal transition. J Clin Invest (2009) 32.82
Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet (2000) 24.22
Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution. Science (1995) 12.94
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell (1994) 11.73
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell (1994) 8.65
Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem (2001) 7.03
The multiple faces of caveolae. Nat Rev Mol Cell Biol (2007) 6.85
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J Biol Chem (1998) 6.26
Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res (2006) 5.90
Role of caveolae and caveolins in health and disease. Physiol Rev (2004) 4.55
PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell (2008) 4.42
Caveolin-1 in oncogenic transformation, cancer, and metastasis. Am J Physiol Cell Physiol (2005) 3.20
Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells. Oncogene (1998) 2.59
Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol (2008) 2.57
UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells. Proc Natl Acad Sci U S A (1996) 2.37
Caveolin-1 in tumor progression: the good, the bad and the ugly. Cancer Metastasis Rev (2008) 2.05
Elevated expression of caveolin is associated with prostate and breast cancer. Clin Cancer Res (1998) 1.95
Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. Implications for transcription-coupled DNA repair. J Biol Chem (1998) 1.87
Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity. Cancer Res (2000) 1.86
Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation. J Cell Biol (2010) 1.83
Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. Cancer Res (2008) 1.82
Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation. Am J Pathol (2002) 1.78
Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. Am J Pathol (2001) 1.67
Correlative evidence that prostate cancer cell-derived caveolin-1 mediates angiogenesis. Hum Pathol (2007) 1.66
Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. J Biol Chem (2004) 1.43
Elevated expression of caveolin-1 in adenocarcinoma of the colon. Am J Clin Pathol (2001) 1.41
Second cysteine-rich region of epidermal growth factor receptor contains targeting information for caveolae/rafts. J Biol Chem (2002) 1.39
A role for caveolae in cell migration. FASEB J (2004) 1.38
The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1). J Biol Chem (2012) 1.38
Identification of differentially expressed genes in pulmonary adenocarcinoma by using cDNA array. Oncogene (2002) 1.38
Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Biochem J (2011) 1.34
Reduction of caveolin 1 gene expression in lung carcinoma cell lines. Biochem Biophys Res Commun (1999) 1.34
Caveolin-1 overexpression is associated with aggressive prostate cancer recurrence. Prostate (2007) 1.29
N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis. EMBO Mol Med (2012) 1.24
Caveats of caveolin-1 in cancer progression. Cancer Lett (2008) 1.21
E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription. Mol Cell Biol (2007) 1.17
The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways. Antioxid Redox Signal (2012) 1.09
KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer. J Biol Chem (2011) 1.07
Caveolin-1 secreting LNCaP cells induce tumor growth of caveolin-1 negative LNCaP cells in vivo. Int J Cancer (2008) 1.06
Overexpression of caveolin-1 in experimental colon adenocarcinomas and human colon cancer cell lines. Oncol Rep (2004) 1.03
The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4. J Cell Sci (2014) 1.01
Caveolin-1, a metastasis-related gene that promotes cell survival in prostate cancer. Apoptosis (1999) 0.96
The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling. Biochem Biophys Res Commun (2010) 0.96
Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway. Mol Pharmacol (2012) 0.96
The iron-regulated metastasis suppressor, Ndrg-1: identification of novel molecular targets. Biochim Biophys Acta (2008) 0.95
The metastasis suppressor, N-myc downregulated gene 1 (NDRG1), is a prognostic biomarker for human colorectal cancer. PLoS One (2013) 0.95
The caveolin-1 connection to cell death and survival. Curr Mol Med (2013) 0.94
Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis (2013) 0.93
Comparing the scoring mechanisms of p16INK4a immunohistochemistry based on independent nucleic stains and independent cytoplasmic stains in distinguishing between endocervical and endometrial adenocarcinomas in a tissue microarray study. Arch Gynecol Obstet (2009) 0.91
N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression. Cancer Res (2009) 0.91
Caveolae and caveolae-like membrane domains in cellular signaling and disease: identification of downstream targets for the tumor suppressor protein caveolin-1. Biol Res (2002) 0.89
Is caveolin-1 a viable therapeutic target to reduce cancer metastasis? Expert Opin Ther Targets (2006) 0.83
Expression of caveolin-1 is correlated with lung adenocarcinoma proliferation, migration, and invasion. Med Oncol (2015) 0.79
Caveolin-1 and doxorubicin-induced P-glycoprotein modulate plasma cholesterol membrane accessibility in erythrolymphoblastic cell line. Anticancer Res (2010) 0.76