Published in Front Cell Dev Biol on March 23, 2017
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Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
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Nitric oxide and peroxynitrite in health and disease. Physiol Rev (2007) 15.49
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 12.91
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature (2009) 10.59
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol (2003) 9.14
Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science (1995) 8.17
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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev (2011) 5.26
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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab (2006) 4.64
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab (2010) 4.14
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Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes (2006) 3.85
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature (2012) 3.85
The structure of a domain common to archaebacteria and the homocystinuria disease protein. Trends Biochem Sci (1997) 3.74
Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase. J Biol Chem (1998) 3.53
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes (2009) 3.39
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett (1987) 3.04
Cellular stress responses: cell survival and cell death. Int J Cell Biol (2010) 2.74
Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro. J Biol Chem (2006) 2.69
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The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex. Mol Cell Biol (1997) 2.42
AMPK beta subunit targets metabolic stress sensing to glycogen. Curr Biol (2003) 2.19
Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem (2007) 2.12
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Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. J Biol Chem (1998) 1.92
Generation of reactive oxygen species, lipid peroxidation, and human sperm function. Biol Reprod (1989) 1.91
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The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase. Biochim Biophys Acta (1989) 1.76
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Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling. Chem Biol (2014) 1.75
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A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias. Curr Biol (2003) 1.71
Neither LKB1 nor AMPK are the direct targets of metformin. Gastroenterology (2006) 1.63
AMPKalpha1 regulates the antioxidant status of vascular endothelial cells. Biochem J (2009) 1.55
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Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway. Mol Pharmacol (2009) 1.45
Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism. Arterioscler Thromb Vasc Biol (2007) 1.44
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Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. Diabetes (2009) 1.39
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. Biochem J (2008) 1.38
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Three models of free radical-induced cell injury. Chem Biol Interact (1989) 1.35
AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3. Biochem Pharmacol (2006) 1.35
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The effect of reactive oxygen species on equine sperm motility, viability, acrosomal integrity, mitochondrial membrane potential, and membrane lipid peroxidation. J Androl (2001) 1.26
FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts. J Biol Chem (2008) 1.25
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The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior. J Biol Chem (2008) 1.19
AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases. Biochim Biophys Acta (2011) 1.18
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Metabolic regulation is important for spermatogenesis. Nat Rev Urol (2012) 1.11
AMPK: regulating energy balance at the cellular and whole body levels. Physiology (Bethesda) (2014) 1.06
AMP-activated protein kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression. J Pharmacol Sci (2008) 1.04
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Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase. J Biomed Sci (2011) 1.03
A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism. FEBS Lett (2008) 1.02
AMP-activated protein kinase rescues the angiogenic functions of endothelial progenitor cells via manganese superoxide dismutase induction in type 1 diabetes. Am J Physiol Endocrinol Metab (2011) 0.97
Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis. Hum Mol Genet (2012) 0.94
Brain mitochondrial dysfunction in aging, neurodegeneration, and Parkinson's disease. Front Aging Neurosci (2010) 0.93
Endurance training activates AMP-activated protein kinase, increases expression of uncoupling protein 2 and reduces insulin secretion from rat pancreatic islets. J Endocrinol (2011) 0.92
Hormonal control of Sertoli cell metabolism regulates spermatogenesis. Cell Mol Life Sci (2012) 0.90
The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells. Free Radic Biol Med (2009) 0.89
Effects of resveratrol analogs on steroidogenesis and mitochondrial function in rat Leydig cells in vitro. J Appl Toxicol (2009) 0.85
The AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside, regulates lactate production in rat Sertoli cells. J Mol Endocrinol (2007) 0.84
The 5'-AMP-Activated Protein Kinase (AMPK) Is Involved in the Augmentation of Antioxidant Defenses in Cryopreserved Chicken Sperm. PLoS One (2015) 0.82
Functional significance of the pentose phosphate pathway and glutathione reductase in the antioxidant defenses of human sperm. Biol Reprod (2004) 0.80
Inactivation of AMPKα1 induces asthenozoospermia and alters spermatozoa morphology. Endocrinology (2012) 0.79
AMP-activated kinase, AMPK, is involved in the maintenance of plasma membrane organization in boar spermatozoa. Biochim Biophys Acta (2013) 0.79
Honey and metformin ameliorated diabetes-induced damages in testes of rat; correlation with hormonal changes. Iran J Reprod Med (2013) 0.79
Effect of metformin on the fertilizing ability of mouse spermatozoa. Cryobiology (2014) 0.79
Bioenergetics of mammalian sperm capacitation. Biomed Res Int (2014) 0.78
Protective effect of resveratrol on biomarkers of oxidative stress induced by iron/ascorbate in mouse spermatozoa. Nutrients (2014) 0.78
AMP-activated kinase AMPK is expressed in boar spermatozoa and regulates motility. PLoS One (2012) 0.78
Central role of 5'-AMP-activated protein kinase in chicken sperm functions. Biol Reprod (2014) 0.77
AMPK up-activation reduces motility and regulates other functions of boar spermatozoa. Mol Hum Reprod (2014) 0.77
4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways. Toxicology (2016) 0.77
The insulin sensitiser metformin regulates chicken Sertoli and germ cell populations. Reproduction (2016) 0.76
Sex-specific regulation of AMP-activated protein kinase (AMPK) in the Pacific oyster Crassostrea gigas. Biol Reprod (2013) 0.76
Protective features of resveratrol on human spermatozoa cryopreservation may be mediated through 5' AMP-activated protein kinase activation. Andrology (2016) 0.76
Use of hypometabolic TRIS extenders and high cooling rate refrigeration for cryopreservation of stallion sperm: presence and sensitivity of 5' AMP-activated protein kinase (AMPK). Cryobiology (2014) 0.76
Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality. Mol Cell Endocrinol (2016) 0.75
AMP-activated kinase in human spermatozoa: identification, intracellular localization, and key function in the regulation of sperm motility. Asian J Androl (2016) 0.75
[Metformin improves epididymal sperm quality and antioxidant function of the testis in diet-induced obesity rats]. Zhonghua Nan Ke Xue (2012) 0.75