Published in FEBS Lett on July 03, 2003
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 12.91
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J (2004) 10.82
Molecular mediators of hepatic steatosis and liver injury. J Clin Invest (2004) 9.40
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer (2009) 8.43
AMP-activated protein kinase--development of the energy sensor concept. J Physiol (2006) 4.93
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest (2004) 4.54
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J (2005) 4.31
5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol (2006) 4.28
Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci U S A (2007) 4.24
Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20
Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol (2008) 3.07
The tuberous sclerosis complex. Ann N Y Acad Sci (2010) 2.51
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad Sci U S A (2004) 2.48
Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells. Circulation (2008) 2.48
Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell Signal (2009) 2.11
AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J (2009) 2.09
Coupling oxidative signals to protein phosphorylation via methionine oxidation in Arabidopsis. Biochem J (2009) 1.97
The role of adiponectin in cancer: a review of current evidence. Endocr Rev (2012) 1.78
Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio. Free Radic Biol Med (2009) 1.78
Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle. J Physiol (2006) 1.69
Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis. Br J Pharmacol (2008) 1.67
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature (2014) 1.63
Benefits of lifestyle modification in NAFLD. Gut (2007) 1.59
AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K(+) channels. J Cell Physiol (2007) 1.58
Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Commun (2008) 1.54
Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase. J Biol Chem (2010) 1.52
AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model. Nutr Metab (Lond) (2006) 1.49
MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis. Mol Cell Biol (2006) 1.48
SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. J Pharmacol Exp Ther (2010) 1.47
Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis. Mol Cell Biol (2009) 1.41
Proteomics of Breast Muscle Tissue Associated with the Phenotypic Expression of Feed Efficiency within a Pedigree Male Broiler Line: I. Highlight on Mitochondria. PLoS One (2016) 1.41
Compound C inhibits hypoxic activation of HIF-1 independent of AMPK. FEBS Lett (2007) 1.39
Molecular paleontology and complexity in the last eukaryotic common ancestor. Crit Rev Biochem Mol Biol (2013) 1.39
A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. PLoS Pathog (2010) 1.39
Energy metabolism, fuel selection and body weight regulation. Int J Obes (Lond) (2008) 1.39
Histological evaluation of AMPK signalling in primary breast cancer. BMC Cancer (2009) 1.38
5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK. Biochem J (2005) 1.35
p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Cell Metab (2012) 1.35
LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition. Br J Cancer (2009) 1.33
Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A. Cancer Discov (2012) 1.33
Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy. Mol Cancer (2007) 1.31
Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance. Endocrinology (2008) 1.29
Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling. Mol Biol Cell (2007) 1.28
STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice. J Clin Invest (2010) 1.23
Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization. Diabetes (2009) 1.23
Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. Cancer Res (2008) 1.20
Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol (2010) 1.20
Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice. J Physiol (2007) 1.19
AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress. J Biol Chem (2010) 1.19
Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. Proc Natl Acad Sci U S A (2007) 1.18
Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress. Cell Signal (2010) 1.13
Control of ATP homeostasis during the respiro-fermentative transition in yeast. Mol Syst Biol (2010) 1.13
Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells. Diabetes (2009) 1.13
AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex. J Biol Chem (2009) 1.12
Oligomycin-induced bioenergetic adaptation in cancer cells with heterogeneous bioenergetic organization. J Biol Chem (2010) 1.11
AMP-activated protein kinase: the guardian of cardiac energy status. J Clin Invest (2004) 1.11
Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium. J Immunol (2011) 1.09
Acute exercise activates AMPK and eNOS in the mouse aorta. Am J Physiol Heart Circ Physiol (2011) 1.08
Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: involvement of P2 receptors and adenosine transporters. Circ Res (2006) 1.08
LKB1 and AMPK and the regulation of skeletal muscle metabolism. Curr Opin Clin Nutr Metab Care (2008) 1.07
MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma. Int J Oncol (2011) 1.07
AMPK: regulating energy balance at the cellular and whole body levels. Physiology (Bethesda) (2014) 1.06
Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism. Endocrinology (2012) 1.05
Central exercise action increases the AMPK and mTOR response to leptin. PLoS One (2008) 1.05
The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: implication for Krabbe disease. J Neurochem (2008) 1.05
Regulation of mTORC1 signaling by pH. PLoS One (2011) 1.04
Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain. Mol Cancer (2008) 1.04
Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit. EMBO J (2007) 1.03
AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR. Am J Physiol Cell Physiol (2009) 1.02
Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases. Dis Model Mech (2014) 1.02
Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). Dose Response (2014) 1.00
Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line. Int J Clin Exp Pathol (2010) 0.99
Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations. Rev Diabet Stud (2009) 0.98
Metabolic rate regulates L1 longevity in C. elegans. PLoS One (2012) 0.98
Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro. J Neurosci Methods (2007) 0.98
AMP-activated protein kinase activation during cardioplegia-induced hypoxia/reoxygenation injury attenuates cardiomyocytic apoptosis via reduction of endoplasmic reticulum stress. Mediators Inflamm (2011) 0.98
AMP-activated protein kinase alpha2 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function. Diabetes (2007) 0.97
Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K. Am J Physiol Cell Physiol (2009) 0.95
Acute modulation of sugar transport in brain capillary endothelial cell cultures during activation of the metabolic stress pathway. J Biol Chem (2010) 0.95
Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity. Biochem Biophys Res Commun (2009) 0.95
Establishing a relationship between prolactin and altered fatty acid β-oxidation via carnitine palmitoyl transferase 1 in breast cancer cells. BMC Cancer (2011) 0.95
A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats. J Physiol Biochem (2012) 0.94
Resveratrol ameliorates high glucose-induced protein synthesis in glomerular epithelial cells. Cell Signal (2009) 0.94
Anti-obesity effects of Lysimachia foenum-graecum characterized by decreased adipogenesis and regulated lipid metabolism. Exp Mol Med (2011) 0.92
Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation. J Biol Chem (2011) 0.92
AMPK regulates metabolic actions of glucocorticoids by phosphorylating the glucocorticoid receptor through p38 MAPK. Mol Endocrinol (2010) 0.92
Stretch-induced activation of AMP kinase in the lung requires dystroglycan. Am J Respir Cell Mol Biol (2008) 0.91
Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways. PLoS One (2014) 0.91
AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol (2013) 0.90
AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol (2013) 0.90
Activation of AMP-activated protein kinase is essential for lysophosphatidic acid-induced cell migration in ovarian cancer cells. J Biol Chem (2011) 0.90
Controls of Nuclear Factor-Kappa B Signaling Activity by 5'-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells. Int Neurourol J (2016) 0.89
Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice. World J Gastroenterol (2008) 0.88
A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation. Brain Res (2007) 0.88
Rosiglitazone and fenofibrate improve insulin sensitivity of pre-diabetic OLETF rats by reducing malonyl-CoA levels in the liver and skeletal muscle. Life Sci (2009) 0.87
Regulation of facilitative glucose transporters and AKT/MAPK/PRKAA signaling via estradiol and progesterone in the mouse uterine epithelium. Biol Reprod (2009) 0.87
5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase. Mol Cancer (2010) 0.87
Prolyl hydroxylase-dependent modulation of eukaryotic elongation factor 2 activity and protein translation under acute hypoxia. J Biol Chem (2012) 0.86
Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. Invest Ophthalmol Vis Sci (2011) 0.86
Molecular mechanisms of chromium in alleviating insulin resistance. J Nutr Biochem (2012) 0.86
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab (2005) 8.30
AMP-activated protein kinase--development of the energy sensor concept. J Physiol (2006) 4.93
AMPK is a direct adenylate charge-regulated protein kinase. Science (2011) 3.58
β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc Natl Acad Sci U S A (2010) 2.28
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). J Cell Sci (2002) 1.79
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias. Curr Biol (2003) 1.71
Analysis of the LKB1-STRAD-MO25 complex. J Cell Sci (2004) 1.65
Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency. Am J Hum Genet (2005) 1.51
AMPK functions as an adenylate charge-regulated protein kinase. Trends Endocrinol Metab (2012) 1.44
Effect of iodine on mercury concentrations in dental-unit wastewater. Dent Mater (2005) 1.40
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. Biochem J (2008) 1.38
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. J Biol Chem (2010) 1.30
Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells. J Physiol (2005) 1.26
High-density SNP genotyping of tomato (Solanum lycopersicum L.) reveals patterns of genetic variation due to breeding. PLoS One (2012) 1.22
The Tomato Yellow Leaf Curl Virus resistance genes Ty-1 and Ty-3 are allelic and code for DFDGD-class RNA-dependent RNA polymerases. PLoS Genet (2013) 1.20
Walking, running and the evolution of short toes in humans. J Exp Biol (2009) 1.15
AMPK structure and regulation from three angles. Structure (2007) 1.13
PD98059 and U0126 activate AMP-activated protein kinase by increasing the cellular AMP:ATP ratio and not via inhibition of the MAP kinase pathway. FEBS Lett (2005) 1.03
Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function. FASEB J (2009) 0.99
Transgenic resistance confers effective field level control of bacterial spot disease in tomato. PLoS One (2012) 0.99
Isolation of a gene encoding a 1,2-diacylglycerol-sn-acetyl-CoA acetyltransferase from developing seeds of Euonymus alatus. J Biol Chem (2004) 0.99
Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase. Pediatr Res (2007) 0.97
Chromosomal rearrangements between tomato and Solanum chilense hamper mapping and breeding of the TYLCV resistance gene Ty-1. Plant J (2011) 0.96
A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes. Dev Biol (2002) 0.93
Ca2+/Calmodulin-dependent protein kinase kinase beta is regulated by multisite phosphorylation. J Biol Chem (2011) 0.88
SnRK1 from Arabidopsis thaliana is an atypical AMPK. Plant J (2015) 0.83
A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits. J Biol Chem (2007) 0.81
Renal metastasis of head and neck squamous cell carcinoma with inferior vena caval thrombus. J Urol (2004) 0.81
Racial disparities in emergency general surgery: Do differences in outcomes persist among universally insured military patients? J Trauma Acute Care Surg (2016) 0.78
The feline thyroid gland: a model for endocrine disruption by polybrominated diphenyl ethers (PBDEs)? J Toxicol Environ Health A (2012) 0.77
Rethinking Priorities: Cost of Complications After Elective Colectomy. Ann Surg (2016) 0.76
Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models. PLoS One (2014) 0.76
Design and synthesis of potent carboxylic acid DGAT1 inhibitors with high cell permeability. Bioorg Med Chem Lett (2011) 0.75
The Need to Consider Longer-term Outcomes of Care: Racial/Ethnic Disparities Among Adult and Older Adult Emergency General Surgery Patients at 30, 90, and 180 Days. Ann Surg (2016) 0.75
Select metal and metalloid surveillance of free-ranging Eastern box turtles from Illinois and Tennessee (Terrapene carolina carolina). Ecotoxicology (2015) 0.75
Three-region perfusion strategy for aortic arch reconstruction in the Norwood. Ann Thorac Surg (2011) 0.75
Polyaromatic hydrocarbons and elements in sediments associated with a suburban railway. Environ Monit Assess (2015) 0.75
The Association Between Medicare Eligibility and Gains in Access to Rehabilitative Care: A National Regression Discontinuity Assessment of Patients Ages 64 Versus 65 Years. Ann Surg (2017) 0.75
Epidemiologic Characteristics of Pediatric Trauma Patients Receiving Prehospital Care in Kigali, Rwanda. Pediatr Emerg Care (2017) 0.75
Comparison of chlorine and chloramine in the release of mercury from dental amalgam. Sci Total Environ (2008) 0.75
Progress in achieving universal access to surgical care: An update and a path forward. Bull Am Coll Surg (2016) 0.75