Published in J Biol Chem on July 11, 2006
Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev (2009) 6.46
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev (2011) 5.26
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J (2007) 4.48
Structure of mammalian AMPK and its regulation by ADP. Nature (2011) 4.27
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem (2008) 4.16
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol (2011) 3.28
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. EMBO J (2009) 2.88
SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. Circulation (2016) 2.71
SNF1/AMPK pathways in yeast. Front Biosci (2008) 2.70
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem (2007) 2.54
Nutritional control of growth and development in yeast. Genetics (2012) 2.33
Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance. Nat Neurosci (2014) 2.22
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol (Oxf) (2009) 2.13
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci U S A (2006) 2.03
AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J Biol Chem (2008) 2.02
AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci (2010) 1.95
AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol (2010) 1.93
Autophagy regulation by nutrient signaling. Cell Res (2013) 1.81
JNK3 perpetuates metabolic stress induced by Aβ peptides. Neuron (2012) 1.80
MAP kinase pathways: the first twenty years. Biochim Biophys Acta (2006) 1.65
Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase. Mol Cell Biol (2007) 1.62
Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry. Genes Dev (2013) 1.57
The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation. Neuron (2013) 1.43
Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. J Biol Chem (2007) 1.42
Effects of AMP-activated protein kinase in cerebral ischemia. J Cereb Blood Flow Metab (2009) 1.40
A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. PLoS Pathog (2010) 1.39
AMP-activated protein kinase regulation and biological actions in the heart. Circ Res (2012) 1.33
AMP-activated protein kinase, stress responses and cardiovascular diseases. Clin Sci (Lond) (2012) 1.29
AMPK at the nexus of energetics and aging. Cell Metab (2014) 1.28
AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol (2009) 1.27
AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes (2014) 1.25
Maternal obesity, inflammation, and fetal skeletal muscle development. Biol Reprod (2009) 1.25
Therapeutic targeting of autophagy in disease: biology and pharmacology. Pharmacol Rev (2013) 1.25
Bioenergy sensing in the brain: the role of AMP-activated protein kinase in neuronal metabolism, development and neurological diseases. Cell Cycle (2011) 1.24
Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J Physiol (2008) 1.23
Nitrogen availability and TOR regulate the Snf1 protein kinase in Saccharomyces cerevisiae. Eukaryot Cell (2006) 1.17
AMP-activated kinase restricts Rift Valley fever virus infection by inhibiting fatty acid synthesis. PLoS Pathog (2012) 1.14
New therapeutic agents in diabetic nephropathy. Korean J Intern Med (2017) 1.11
AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases. J Lipid Res (2012) 1.10
Arabidopsis protein kinases GRIK1 and GRIK2 specifically activate SnRK1 by phosphorylating its activation loop. Plant Physiol (2009) 1.09
TAK1 control of cell death. Cell Death Differ (2014) 1.09
Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems. Free Radic Biol Med (2012) 1.07
AMPK: regulating energy balance at the cellular and whole body levels. Physiology (Bethesda) (2014) 1.06
AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals. Cell Death Dis (2012) 1.05
Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem (2010) 1.05
Suppression of Tak1 promotes prostate tumorigenesis. Cancer Res (2012) 1.04
Phosphorylation of yeast hexokinase 2 regulates its nucleocytoplasmic shuttling. J Biol Chem (2012) 1.04
Targeting AMPK for cardiac protection: opportunities and challenges. J Mol Cell Cardiol (2010) 1.04
IRE1-dependent activation of AMPK in response to nitric oxide. Mol Cell Biol (2011) 1.00
Defective myofibroblast formation from mesenchymal stem cells in the aging murine heart rescue by activation of the AMPK pathway. Am J Pathol (2011) 1.00
AMP-activated protein kinase inhibits vascular smooth muscle cell proliferation and migration and vascular remodeling following injury. Am J Physiol Heart Circ Physiol (2012) 1.00
Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations. Rev Diabet Stud (2009) 0.98
Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase. J Biol Chem (2010) 0.98
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases. Front Plant Sci (2014) 0.98
Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer. Trends Pharmacol Sci (2015) 0.96
LKB1 and AMPK differentially regulate pancreatic β-cell identity. FASEB J (2014) 0.96
Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity. Biochem Biophys Res Commun (2009) 0.95
SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals. Neuron (2013) 0.95
Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase. J Biol Chem (2008) 0.95
LKB1 and AMPK regulate synaptic remodeling in old age. Nat Neurosci (2014) 0.95
AMPK: energy sensor and survival mechanism in the ischemic heart. Trends Endocrinol Metab (2015) 0.94
AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF. J Biol Chem (2010) 0.94
AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability. World J Gastroenterol (2010) 0.92
Current understanding of metformin effect on the control of hyperglycemia in diabetes. J Endocrinol (2016) 0.92
Protective effects of AMP-activated protein kinase in the cardiovascular system. J Cell Mol Med (2010) 0.91
The transcriptional activity of Gli1 is negatively regulated by AMPK through Hedgehog partial agonism in hepatocellular carcinoma. Int J Mol Med (2014) 0.91
LKB1 and AMP-activated protein kinase: regulators of cell polarity. Genes Cells (2012) 0.91
Protein kinase A contributes to the negative control of Snf1 protein kinase in Saccharomyces cerevisiae. Eukaryot Cell (2011) 0.91
Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry. Structure (2013) 0.91
LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia. Mol Metab (2015) 0.90
Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription. Int J Biol Sci (2011) 0.90
Role of AMP-activated protein kinase in the control of appetite. J Neuroendocrinol (2008) 0.89
Activated protein C: a potential cardioprotective factor against ischemic injury during ischemia/reperfusion. Am J Transl Res (2009) 0.88
Function of the master energy regulator adenosine monophosphate-activated protein kinase in stroke. J Neurosci Res (2013) 0.88
AMPK-NF-κB axis in the photoreceptor disorder during retinal inflammation. PLoS One (2014) 0.87
Targeting the LKB1 tumor suppressor. Curr Drug Targets (2014) 0.87
Cross-phosphorylation between Arabidopsis thaliana sucrose nonfermenting 1-related protein kinase 1 (AtSnRK1) and its activating kinase (AtSnAK) determines their catalytic activities. J Biol Chem (2010) 0.87
Perivascular fat, AMP-activated protein kinase and vascular diseases. Br J Pharmacol (2014) 0.86
Germline ablation of VGF increases lipolysis in white adipose tissue. J Endocrinol (2012) 0.85
AMPK-Dependent Metabolic Regulation by PPAR Agonists. PPAR Res (2010) 0.85
Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells. Stem Cell Res Ther (2015) 0.85
Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases. J Med Chem (2014) 0.84
AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain. Exp Neurobiol (2012) 0.84
The interplay of AMP-activated protein kinase and androgen receptor in prostate cancer cells. J Cell Physiol (2014) 0.84
Minireview: hey U(PS): metabolic and proteolytic homeostasis linked via AMPK and the ubiquitin proteasome system. Mol Endocrinol (2014) 0.83
Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix. J Biol Chem (2009) 0.83
Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase. Arch Biochem Biophys (2009) 0.83
Inhibition of vascular smooth muscle growth via signaling crosstalk between AMP-activated protein kinase and cAMP-dependent protein kinase. Front Physiol (2012) 0.83
Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection. Sci Rep (2015) 0.83
Activation of the AMP-activated protein kinase-p38 MAP kinase pathway mediates apoptosis induced by conjugated linoleic acid in p53-mutant mouse mammary tumor cells. Cell Signal (2009) 0.82
AMPK as a potential anticancer target - friend or foe? Curr Pharm Des (2014) 0.82
Targeted therapies of the LKB1/AMPK pathway for the treatment of insulin resistance. Future Med Chem (2010) 0.82
Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One (2013) 0.81
Regulation of AMP-activated protein kinase by natural and synthetic activators. Acta Pharm Sin B (2015) 0.81
Regulation and function of AMPK in physiology and diseases. Exp Mol Med (2016) 0.80
Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death. Oncotarget (2015) 0.79
Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia. PLoS One (2012) 0.79
Chicoric acid is an antioxidant molecule that stimulates AMP kinase pathway in L6 myotubes and extends lifespan in Caenorhabditis elegans. PLoS One (2013) 0.79
Suppression of Kaposi's Sarcoma-Associated Herpesvirus Infection and Replication by 5'-AMP-Activated Protein Kinase. J Virol (2016) 0.79
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol (2003) 9.14
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab (2005) 7.15
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci U S A (2003) 4.87
SNF1/AMPK pathways in yeast. Front Biosci (2008) 2.70
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol (2002) 2.20
Regulation of snf1 protein kinase in response to environmental stress. J Biol Chem (2007) 1.81
Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast. J Biol Chem (2005) 1.64
Evaluation of the efficacy and cross-protectivity of recent human and swine vaccines against the pandemic (H1N1) 2009 virus infection. PLoS One (2009) 1.42
Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. Nat Biotechnol (2013) 1.38
Pak1 protein kinase regulates activation and nuclear localization of Snf1-Gal83 protein kinase. Mol Cell Biol (2004) 1.30
Cyclic AMP-dependent protein kinase regulates the subcellular localization of Snf1-Sip1 protein kinase. Mol Cell Biol (2004) 1.23
Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol (2003) 1.22
Repressors Nrg1 and Nrg2 regulate a set of stress-responsive genes in Saccharomyces cerevisiae. Eukaryot Cell (2005) 1.19
Mucosal immunization with surface-displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in mice. J Virol (2006) 1.12
Roles of two protein phosphatases, Reg1-Glc7 and Sit4, and glycogen synthesis in regulation of SNF1 protein kinase. Proc Natl Acad Sci U S A (2011) 1.01
Std1p (Msn3p) positively regulates the Snf1 kinase in Saccharomyces cerevisiae. Genetics (2003) 0.96
Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase. J Biol Chem (2008) 0.95
Regulation of the nucleocytoplasmic distribution of Snf1-Gal83 protein kinase. Eukaryot Cell (2006) 0.95
Role of Tos3, a Snf1 protein kinase kinase, during growth of Saccharomyces cerevisiae on nonfermentable carbon sources. Eukaryot Cell (2005) 0.95
Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding. Structure (2007) 0.94
Nrg1 and nrg2 transcriptional repressors are differently regulated in response to carbon source. Eukaryot Cell (2004) 0.94
Mutations in the gal83 glycogen-binding domain activate the snf1/gal83 kinase pathway by a glycogen-independent mechanism. Mol Cell Biol (2004) 0.93
Reversible pulmonary hypertension in adolescent with left atrial myxoma. J Cardiovasc Ultrasound (2011) 0.92
Identification of a novel one-carbon metabolism regulon in Saccharomyces cerevisiae. J Biol Chem (2003) 0.92
Heterotrimer-independent regulation of activation-loop phosphorylation of Snf1 protein kinase involves two protein phosphatases. Proc Natl Acad Sci U S A (2012) 0.91
Yap1 accumulates in the nucleus in response to carbon stress in Saccharomyces cerevisiae. Eukaryot Cell (2003) 0.90
Genetic characterization and pathogenicity assessment of highly pathogenic H5N1 avian influenza viruses isolated from migratory wild birds in 2011, South Korea. Virus Res (2011) 0.86
Interaction of SNF1 protein kinase with its activating kinase Sak1. Eukaryot Cell (2011) 0.85
Alterations at dispersed sites cause phosphorylation and activation of SNF1 protein kinase during growth on high glucose. J Biol Chem (2011) 0.85
Characterization of a thermostable D-stereospecific alanine amidase from Brevibacillus borstelensis BCS-1. Appl Environ Microbiol (2003) 0.83
A specific catalytic subunit isoform of protein kinase CK2 is required for phosphorylation of the repressor Nrg1 in Saccharomyces cerevisiae. Curr Genet (2006) 0.83
New biological functions and applications of high-molecular-mass poly-gamma-glutamic acid. Chem Biodivers (2010) 0.83
Characterization of Symbiobacterium toebii, an obligate commensal thermophile isolated from compost. Extremophiles (2002) 0.83
Biochemical and functional studies on the regulation of the Saccharomyces cerevisiae AMPK homolog SNF1. Biochem Biophys Res Commun (2010) 0.82
Ptc1 protein phosphatase 2C contributes to glucose regulation of SNF1/AMP-activated protein kinase (AMPK) in Saccharomyces cerevisiae. J Biol Chem (2013) 0.81
Inactivation of tyrosine phenol-lyase by Pictet-Spengler reaction and alleviation by T15A mutation on intertwined N-terminal arm. FEBS J (2006) 0.80
Isolation of a Δ5 desaturase gene from Euglena gracilis and functional dissection of its HPGG and HDASH motifs. Lipids (2012) 0.80
Expression and characterization of a novel enantioselective lipase from Acinetobacter species SY-01. Biochimie (2003) 0.79
Coordinated change of a ratio of methylated H3-lysine 4 or acetylated H3 to acetylated H4 and DNA methylation is associated with tissue-specific gene expression in cloned pig. Exp Mol Med (2007) 0.79
Snf1 is a regulator of lipid accumulation in Yarrowia lipolytica. Appl Environ Microbiol (2013) 0.79
Development of bioreactor system for L-tyrosine synthesis using thermostable tyrosine phenol-lyase. J Microbiol Biotechnol (2007) 0.78
Analysis of transcriptional repression by Mig1 in Saccharomyces cerevisiae using a reporter assay. Methods Enzymol (2003) 0.78
Functional and structural characterization of thermostable D-amino acid aminotransferases from Geobacillus spp. Appl Environ Microbiol (2006) 0.78
Evaluation of the efficacy of a pre-pandemic H5N1 vaccine (MG1109) in mouse and ferret models. J Microbiol (2012) 0.78
Simultaneous improvement of catalytic activity and thermal stability of tyrosine phenol-lyase by directed evolution. FEBS J (2009) 0.77
Anomalous origin of the left coronary artery from the pulmonary artery initially visualized by echocardiography and multidetector computed tomography coronary angiography. J Cardiovasc Ultrasound (2012) 0.75