Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28388673)

Published in PLoS One on April 07, 2017

Authors

Friedrich Hahn1, Adrian Schmalen1, Christian Setz1, Melanie Friedrich1, Stefan Schlößer1, Julia Kölle1, Robert Spranger1, Pia Rauch1, Kirsten Fraedrich1, Tatjana Reif1, Julia Karius-Fischer1, Ashok Balasubramanyam2, Petra Henklein3, Torgils Fossen4, Ulrich Schubert1

Author Affiliations

1: Institute of Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
2: Translational Metabolism Unit, Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, Texas, United States of America.
3: Institute of Biochemistry, Charité Universitätsmedizin-Berlin, Berlin, Germany.
4: Department of Chemistry and Centre for Pharmacy, University of Bergen, Bergen, Norway.

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J Virol (1986) 37.70

Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science (1984) 33.32

Complete nucleotide sequence of the AIDS virus, HTLV-III. Nature (1985) 30.62

HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science (1996) 21.81

Genome engineering using the CRISPR-Cas9 system. Nat Protoc (2013) 15.98

In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity. J Virol (1988) 12.52

High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science (1993) 12.22

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell (2001) 12.00

The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy. Biochemistry (1992) 9.40

HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress. Nat Med (2001) 8.38

BRENDA, enzyme data and metabolic information. Nucleic Acids Res (2002) 7.92

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Proc Natl Acad Sci U S A (1994) 7.85

Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides. Gene (1995) 7.42

p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease. J Virol (1995) 6.87

Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods (2002) 6.67

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature (2011) 5.68

Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: identification of replication-competent and -defective viral genomes. J Virol (1991) 5.56

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A (2003) 5.44

Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. Immunogenetics (1985) 5.30

Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis. J Virol (1993) 5.30

The stoichiometry of Gag protein in HIV-1. Nat Struct Mol Biol (2004) 4.91

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res (2011) 4.90

Equine infectious anemia virus utilizes a YXXL motif within the late assembly domain of the Gag p9 protein. J Virol (1997) 4.08

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem (1998) 3.77

Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages. J Virol (2006) 3.59

Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains. Cell Host Microbe (2009) 3.58

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol (2002) 3.45

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature (2006) 3.21

HIV-1 assembly, budding, and maturation. Cold Spring Harb Perspect Med (2012) 3.17

Characterization of novel safe lentiviral vectors derived from simian immunodeficiency virus (SIVmac251) that efficiently transduce mature human dendritic cells. Gene Ther (2000) 2.95

Exact prediction of a natural T cell epitope. Eur J Immunol (1991) 2.90

Ubiquitin is covalently attached to the p6Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12Gag protein of Moloney murine leukemia virus. J Virol (1998) 2.77

The p6gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particles. J Virol (1995) 2.64

A rapid method for the construction of synthetic genes using the polymerase chain reaction. Biotechniques (1990) 2.64

JCat: a novel tool to adapt codon usage of a target gene to its potential expression host. Nucleic Acids Res (2005) 2.60

ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. Science (2012) 2.59

Human immunodeficiency virus type 1 neutralization measured by flow cytometric quantitation of single-round infection of primary human T cells. J Virol (2002) 2.44

Ubiquitination of HIV-1 and MuLV Gag. Virology (2000) 2.33

Augmentation of virus secretion by the human immunodeficiency virus type 1 Vpu protein is cell type independent and occurs in cultured human primary macrophages and lymphocytes. J Virol (1995) 2.27

The Vif protein of human and simian immunodeficiency viruses is packaged into virions and associates with viral core structures. J Virol (1995) 2.25

The envelope glycoprotein of human immunodeficiency virus type 2 enhances viral particle release: a Vpu-like factor? J Virol (1996) 2.21

Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J Virol (2003) 2.02

Multivesicular body morphogenesis. Annu Rev Cell Dev Biol (2012) 1.92

Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesis. Cell Host Microbe (2008) 1.91

Membrane fission reactions of the mammalian ESCRT pathway. Annu Rev Biochem (2013) 1.91

Construction and characterization of a stable full-length macrophage-tropic HIV type 1 molecular clone that directs the production of high titers of progeny virions. AIDS Res Hum Retroviruses (1996) 1.74

Human-immunodeficiency-virus-type-1-encoded Vpu protein is phosphorylated by casein kinase II. Eur J Biochem (1992) 1.70

Virus budding and the ESCRT pathway. Cell Host Microbe (2013) 1.70

Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase. J Biol Chem (1998) 1.60

Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism. J Virol (2002) 1.53

Molecular Epidemiology of HIV Type 1 in Ecuador, Peru, Bolivia, Uruguay, and Argentina. AIDS Res Hum Retroviruses (2002) 1.50

Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases. J Biol Chem (2004) 1.50

A conserved LXXLF sequence is the major determinant in p6gag required for the incorporation of human immunodeficiency virus type 1 Vpr. J Virol (1996) 1.47

Detection of plasma viremia in human immunodeficiency virus-infected individuals at all clinical stages. J Clin Microbiol (1993) 1.40

Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides. J Immunol (1999) 1.37

Assembly PCR oligo maker: a tool for designing oligodeoxynucleotides for constructing long DNA molecules for RNA production. Nucleic Acids Res (2005) 1.35

Regulation of virus release by the macrophage-tropic human immunodeficiency virus type 1 AD8 isolate is redundant and can be controlled by either Vpu or Env. J Virol (1999) 1.31

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry (2005) 1.26

Resistance to nucleoside analog reverse transcriptase inhibitors mediated by human immunodeficiency virus type 1 p6 protein. J Virol (2001) 1.22

Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. J Biol Chem (2009) 1.20

HIV-1 assembly, release and maturation. Nat Rev Microbiol (2015) 1.18

Cleavage of p15 protein in vitro by human immunodeficiency virus type 1 protease is RNA dependent. J Virol (1994) 1.18

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature (2014) 1.17

Molecular characterization of human and bovine endothelin converting enzyme (ECE-1). FEBS Lett (1994) 1.16

Analysis of human immunodeficiency virus type 1 Gag ubiquitination. J Virol (2005) 1.15

Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues. J Biol Chem (1994) 1.13

Covalent modification of human immunodeficiency virus type 1 p6 by SUMO-1. J Virol (2005) 1.11

Analysis of insertions and deletions in the gag p6 region of diverse HIV type 1 strains. AIDS Res Hum Retroviruses (2004) 1.05

The late-domain-containing protein p6 is the predominant phosphoprotein of human immunodeficiency virus type 1 particles. J Virol (2002) 1.04

Solution structure of the human immunodeficiency virus type 1 p6 protein. J Biol Chem (2005) 1.04

Production of an antigenic peptide by insulin-degrading enzyme. Nat Immunol (2010) 1.02

Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses. AIDS (2002) 1.02

Molecular cloning and characterization of viruses isolated from chimpanzees with pathogenic human immunodeficiency virus type 1 infections. J Virol (1998) 0.98

Dysregulation of glucose metabolism in HIV patients: epidemiology, mechanisms, and management. Endocrine (2011) 0.96

Amino acid insertions near Gag cleavage sites restore the otherwise compromised replication of human immunodeficiency virus type 1 variants resistant to protease inhibitors. J Virol (2004) 0.95

Structural characterization of the HIV-1 Vpr N terminus: evidence of cis/trans-proline isomerism. J Biol Chem (2003) 0.94

Amyloid beta accumulation in HIV-1-infected brain: The role of the blood brain barrier. IUBMB Life (2012) 0.91

Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly. Retrovirology (2011) 0.90

Targeting HIV-1 Gag into the defective ribosomal product pathway enhances MHC class I antigen presentation and CD8+ T cell activation. J Immunol (2008) 0.90

Comprehensive mutational analysis reveals p6Gag phosphorylation to be dispensable for HIV-1 morphogenesis and replication. J Virol (2012) 0.87

Structure, function, and regulation of insulin-degrading enzyme. Vitam Horm (2009) 0.86

HIV-1 p6 - a structured to flexible multifunctional membrane-interacting protein. Biochim Biophys Acta (2012) 0.85

The PTAP sequence within the p6 domain of human immunodeficiency virus type 1 Gag regulates its ubiquitination and MHC class I antigen presentation. J Immunol (2011) 0.82

Correlation between changes in plasma HIV RNA levels and in plasma infectivity in response to antiretroviral therapy. AIDS Res Hum Retroviruses (1997) 0.82

Elucidation of the Molecular Mechanism Driving Duplication of the HIV-1 PTAP Late Domain. J Virol (2015) 0.82

Insulin-like growth factor 1 and insulin inhibit HIV type 1 replication in cultured cells. AIDS Res Hum Retroviruses (1995) 0.80

Analysis of PTAP duplications in the gag p6 region of subtype C HIV type 1. AIDS Res Hum Retroviruses (2005) 0.79

Mutation of the highly conserved Ser-40 of the HIV-1 p6 gag protein to Phe causes the formation of a hydrophobic patch, enhances membrane association, and polyubiquitination of Gag. Viruses (2014) 0.79

Solution structure of the equine infectious anemia virus p9 protein: a rationalization of its different ALIX binding requirements compared to the analogous HIV-p6 protein. BMC Struct Biol (2009) 0.77

Glutamic Acid Residues in HIV-1 p6 Regulate Virus Budding and Membrane Association of Gag. Viruses (2016) 0.76