Published in Nature on July 13, 2011
MicroRNA biogenesis pathways in cancer. Nat Rev Cancer (2015) 2.67
Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing. Cell (2013) 2.03
The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo. Cell (2012) 1.84
The Menu of Features that Define Primary MicroRNAs and Enable De Novo Design of MicroRNA Genes. Mol Cell (2015) 1.69
Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Cell (2012) 1.57
Human RNA methyltransferase BCDIN3D regulates microRNA processing. Cell (2012) 1.46
MicroRNA biogenesis: regulating the regulators. Crit Rev Biochem Mol Biol (2012) 1.41
Circulating microRNAs as novel and sensitive biomarkers of acute myocardial Infarction. Clin Biochem (2012) 1.24
In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs. RNA (2012) 1.20
Common and distinct patterns of terminal modifications to mirtrons and canonical microRNAs. RNA (2011) 1.20
The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution. PLoS Pathog (2012) 1.16
The role of Dicer protein partners in the processing of microRNA precursors. PLoS One (2011) 1.15
Evolution of animal and plant dicers: early parallel duplications and recurrent adaptation of antiviral RNA binding in plants. Mol Biol Evol (2012) 1.14
The double-stranded RNA binding domain of human Dicer functions as a nuclear localization signal. RNA (2013) 1.11
Mammalian 5'-capped microRNA precursors that generate a single microRNA. Cell (2013) 1.10
Evidence for a cytoplasmic microprocessor of pri-miRNAs. RNA (2012) 1.10
Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour. Nat Commun (2014) 1.08
Substrate-specific structural rearrangements of human Dicer. Nat Struct Mol Biol (2013) 1.08
Clinical applications of microRNAs. F1000Res (2013) 1.07
Coordinated activities of human dicer domains in regulatory RNA processing. J Mol Biol (2012) 1.07
From guide to target: molecular insights into eukaryotic RNA-interference machinery. Nat Struct Mol Biol (2015) 1.06
Biogenesis of mammalian microRNAs: a global view. Genomics Proteomics Bioinformatics (2012) 1.04
Ribonuclease III mechanisms of double-stranded RNA cleavage. Wiley Interdiscip Rev RNA (2013) 1.04
DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. Nat Struct Mol Biol (2012) 1.03
pre-miRNA profiles obtained through application of locked nucleic acids and deep sequencing reveals complex 5'/3' arm variation including concomitant cleavage and polyuridylation patterns. Nucleic Acids Res (2011) 1.02
A simple method for analyzing actives in random RNAi screens: introducing the "H Score" for hit nomination & gene prioritization. Comb Chem High Throughput Screen (2012) 1.00
Pol III Promoters to Express Small RNAs: Delineation of Transcription Initiation. Mol Ther Nucleic Acids (2014) 0.99
A MicroRNA precursor surveillance system in quality control of MicroRNA synthesis. Mol Cell (2014) 0.98
The Path to microRNA Therapeutics in Psychiatric and Neurodegenerative Disorders. Front Genet (2012) 0.98
A comprehensive analysis of precursor microRNA cleavage by human Dicer. RNA (2012) 0.97
Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis. Proc Natl Acad Sci U S A (2016) 0.95
Regulation of microRNA biogenesis and turnover by animals and their viruses. Cell Mol Life Sci (2013) 0.95
Synthetic pre-microRNAs reveal dual-strand activity of miR-34a on TNF-α. RNA (2013) 0.95
Drosha as an interferon-independent antiviral factor. Proc Natl Acad Sci U S A (2014) 0.94
miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Mol Ther (2015) 0.94
Preferential star strand biogenesis of pre-miR-24-2 targets PKC-alpha and suppresses cell survival in MCF-7 breast cancer cells. Mol Carcinog (2012) 0.94
Computational prediction of the localization of microRNAs within their pre-miRNA. Nucleic Acids Res (2013) 0.94
An arrayed genome-scale lentiviral-enabled short hairpin RNA screen identifies lethal and rescuer gene candidates. Assay Drug Dev Technol (2012) 0.92
Targetome profiling, pathway analysis and genetic association study implicate miR-202 in lymphomagenesis. Cancer Epidemiol Biomarkers Prev (2013) 0.92
The evolution of microRNA pathway protein components in Cnidaria. Mol Biol Evol (2013) 0.92
Systematic analysis of RNAi reports identifies dismal commonality at gene-level and reveals an unprecedented enrichment in pooled shRNA screens. Comb Chem High Throughput Screen (2013) 0.91
Testing hypotheses on the rate of molecular evolution in relation to gene expression using microRNAs. Proc Natl Acad Sci U S A (2011) 0.90
A phosphate-binding pocket within the platform-PAZ-connector helix cassette of human Dicer. Mol Cell (2014) 0.90
Distinct substrate specificities of Arabidopsis DCL3 and DCL4. Nucleic Acids Res (2013) 0.89
Analysis of Nearly One Thousand Mammalian Mirtrons Reveals Novel Features of Dicer Substrates. PLoS Comput Biol (2015) 0.89
Down-regulation of the antisense mitochondrial non-coding RNAs (ncRNAs) is a unique vulnerability of cancer cells and a potential target for cancer therapy. J Biol Chem (2014) 0.88
PHDcleav: a SVM based method for predicting human Dicer cleavage sites using sequence and secondary structure of miRNA precursors. BMC Bioinformatics (2013) 0.88
MicroRNA Machinery Genes as Novel Biomarkers for Cancer. Front Oncol (2014) 0.88
RNA Binding Proteins in the miRNA Pathway. Int J Mol Sci (2015) 0.88
MiRmat: mature microRNA sequence prediction. PLoS One (2012) 0.88
Genetic variants in microRNA genes: impact on microRNA expression, function, and disease. Front Genet (2015) 0.87
Signaling-mediated regulation of MicroRNA processing. Cancer Res (2015) 0.87
A meta-analysis revealed insights into the sources, conservation and impact of microRNA 5'-isoforms in four model species. Nucleic Acids Res (2013) 0.87
A microRNA processing defect in smokers' macrophages is linked to SUMOylation of the endonuclease DICER. J Biol Chem (2014) 0.87
Ensemble analysis of primary microRNA structure reveals an extensive capacity to deform near the Drosha cleavage site. Biochemistry (2013) 0.87
A prokaryotic twist on argonaute function. Life (Basel) (2015) 0.86
A central role for the primary microRNA stem in guiding the position and efficiency of Drosha processing of a viral pri-miRNA. RNA (2014) 0.86
Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor. Mol Cell (2015) 0.86
Embedding siRNA sequences targeting apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy. Mol Ther (2012) 0.86
Drosophila dicer-2 cleavage is mediated by helicase- and dsRNA termini-dependent states that are modulated by Loquacious-PD. Mol Cell (2015) 0.84
Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain. EMBO J (2014) 0.84
Versatile microRNA biogenesis in animals and their viruses. RNA Biol (2014) 0.84
The host Integrator complex acts in transcription-independent maturation of herpesvirus microRNA 3' ends. Genes Dev (2015) 0.84
Plant dicer-like proteins: double-stranded RNA-cleaving enzymes for small RNA biogenesis. J Plant Res (2016) 0.84
miRNA Control of Tissue Repair and Regeneration. Am J Pathol (2015) 0.83
Nucleotide sequence of miRNA precursor contributes to cleavage site selection by Dicer. Nucleic Acids Res (2015) 0.83
Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules. RNA (2013) 0.83
Transposable-element associated small RNAs in Bombyx mori genome. PLoS One (2012) 0.83
Small-RNA asymmetry is directly driven by mammalian Argonautes. Nat Struct Mol Biol (2015) 0.83
The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities. Nucleic Acids Res (2015) 0.83
Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors. Nucleic Acids Res (2014) 0.83
Molecular characteristics and efficacy of 16D10 siRNAs in inhibiting root-knot nematode infection in transgenic grape hairy roots. PLoS One (2013) 0.82
Biogenesis and regulation of the let-7 miRNAs and their functional implications. Protein Cell (2015) 0.82
Phylogenetic analysis of the endoribonuclease Dicer family. PLoS One (2014) 0.82
New insights into the promoterless transcription of DNA coligo templates by RNA polymerase III. Transcription (2014) 0.82
Deep Sequencing Insights in Therapeutic shRNA Processing and siRNA Target Cleavage Precision. Mol Ther Nucleic Acids (2014) 0.81
Global identification of target recognition and cleavage by the Microprocessor in human ES cells. Nucleic Acids Res (2014) 0.81
Improved nucleic acid descriptors for siRNA efficacy prediction. Nucleic Acids Res (2012) 0.81
Acetylation of drosha on the N-terminus inhibits its degradation by ubiquitination. PLoS One (2013) 0.81
Dicer-related helicase 3 forms an obligate dimer for recognizing 22G-RNA. Nucleic Acids Res (2014) 0.81
LBSizeCleav: improved support vector machine (SVM)-based prediction of Dicer cleavage sites using loop/bulge length. BMC Bioinformatics (2016) 0.81
Dysregulation of microRNA biosynthesis enzyme Dicer plays an important role in gastric cancer progression. Int J Clin Exp Pathol (2014) 0.80
RNaseIII and T4 polynucleotide Kinase sequence biases and solutions during RNA-seq library construction. Biol Direct (2013) 0.80
Messages on small RNA duplexes in plants. J Plant Res (2016) 0.80
Three-dimensionally designed protein-responsive RNA devices for cell signaling regulation. Nucleic Acids Res (2012) 0.79
Biogenesis and mechanism of action of small non-coding RNAs: insights from the point of view of structural biology. Int J Mol Sci (2012) 0.79
The microRNAs in an ancient protist repress the variant-specific surface protein expression by targeting the entire coding sequence. PLoS Pathog (2014) 0.79
Optimization and comparison of knockdown efficacy between polymerase II expressed shRNA and artificial miRNA targeting luciferase and Apolipoprotein B100. BMC Biotechnol (2012) 0.79
Genome wide screening of RNAi factors of Sf21 cells reveal several novel pathway associated proteins. BMC Genomics (2014) 0.79
Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells. Nucleic Acids Res (2014) 0.78
Guidelines for the optimal design of miRNA-based shRNAs. Methods (2016) 0.78
Identification of loop nucleotide polymorphisms affecting microRNA processing and function. Mol Cells (2013) 0.78
miRVaS: a tool to predict the impact of genetic variants on miRNAs. Nucleic Acids Res (2015) 0.78
A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis. Cell Cycle (2014) 0.78
Identification of germline DICER1 mutations and loss of heterozygosity in familial Wilms tumour. J Med Genet (2015) 0.77
Concise review: new frontiers in microRNA-based tissue regeneration. Stem Cells Transl Med (2014) 0.77
Asymmetric bulges and mismatches determine 20-nt microRNA formation in plants. RNA Biol (2015) 0.77
A Single RNaseIII Domain Protein from Entamoeba histolytica Has dsRNA Cleavage Activity and Can Help Mediate RNAi Gene Silencing in a Heterologous System. PLoS One (2015) 0.77
Ewing's Sarcoma: Development of RNA Interference-Based Therapy for Advanced Disease. ISRN Oncol (2012) 0.77
Human RNAi pathway: crosstalk with organelles and cells. Funct Integr Genomics (2013) 0.77
The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49
MicroRNA genes are transcribed by RNA polymerase II. EMBO J (2004) 20.65
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
MicroRNA maturation: stepwise processing and subcellular localization. EMBO J (2002) 19.47
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell (2006) 11.98
The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev (2004) 11.58
Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature (2011) 10.16
Human embryonic stem cells express a unique set of microRNAs. Dev Biol (2004) 8.87
Messenger-RNA-binding proteins and the messages they carry. Nat Rev Mol Cell Biol (2002) 8.81
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell (2008) 8.32
Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70
Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature (2005) 7.12
Processing of intronic microRNAs. EMBO J (2007) 6.32
TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell (2009) 5.99
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature (2008) 5.78
Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem Biol (2004) 5.44
Structure of the guide-strand-containing argonaute silencing complex. Nature (2008) 5.36
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature (2009) 5.24
miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol (2008) 4.81
The role of PACT in the RNA silencing pathway. EMBO J (2006) 4.53
Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell (2005) 4.11
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature (2012) 4.08
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell (2013) 3.97
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell (2013) 3.92
Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch. Nature (2006) 3.90
Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell (2006) 3.87
Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense. Genes Dev (2006) 3.77
Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. J Am Chem Soc (2004) 3.74
Posttranscriptional crossregulation between Drosha and DGCR8. Cell (2009) 3.54
Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer. Nucleic Acids Res (2009) 3.44
Recognition of small interfering RNA by a viral suppressor of RNA silencing. Nature (2003) 3.36
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold. J Am Chem Soc (2006) 3.26
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature (2009) 3.13
TRIM24 links a non-canonical histone signature to breast cancer. Nature (2010) 2.99
Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science (2010) 2.98
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature (2008) 2.86
Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell (2011) 2.68
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature (2013) 2.67
Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. Mol Cell (2006) 2.63
Ribozymes, riboswitches and beyond: regulation of gene expression without proteins. Nat Rev Genet (2007) 2.52
Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kinetics. J Am Chem Soc (2003) 2.52
Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat Struct Mol Biol (2005) 2.50
Human microRNA prediction through a probabilistic co-learning model of sequence and structure. Nucleic Acids Res (2005) 2.48
Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. Mol Cell (2007) 2.47
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell (2010) 2.44
Structural insights into amino acid binding and gene control by a lysine riboswitch. Nature (2008) 2.41
Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K. Cell (2009) 2.39
Structure of yeast Argonaute with guide RNA. Nature (2012) 2.38
Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell (2012) 2.38
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat Struct Mol Biol (2006) 2.29
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc (2007) 2.26
Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants. Cell (2012) 2.19
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol (2011) 2.18
Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nat Struct Mol Biol (2010) 2.13
The RNA-binding protein repertoire of embryonic stem cells. Nat Struct Mol Biol (2013) 2.12
Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution. Nucleic Acids Res (2007) 2.09
Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs. Cell (2012) 2.09
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Nature (2012) 2.07
Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Nat Struct Mol Biol (2008) 2.00
Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter. Nat Chem Biol (2005) 2.00
Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution. Nucleic Acids Res (2006) 1.98
Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing. Nucleic Acids Res (2006) 1.97
DNA architecture: from G to Z. Curr Opin Struct Biol (2006) 1.97
Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch. Nature (2009) 1.90
Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion. PLoS Biol (2006) 1.89
RNA-Puzzles: a CASP-like evaluation of RNA three-dimensional structure prediction. RNA (2012) 1.88
Concerted motions in HIV-1 TAR RNA may allow access to bound state conformations: RNA dynamics from NMR residual dipolar couplings. J Mol Biol (2002) 1.86
Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell (2013) 1.82
Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature (2013) 1.82
A poised chromatin platform for TGF-β access to master regulators. Cell (2011) 1.81
A site-specific low-enrichment (15)N,(13)C isotope-labeling approach to unambiguous NMR spectral assignments in nucleic acids. J Am Chem Soc (2002) 1.77
Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers. J Am Chem Soc (2009) 1.74
Crystal structure of human DGCR8 core. Nat Struct Mol Biol (2007) 1.74
An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase. Proc Natl Acad Sci U S A (2005) 1.71
The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure. PLoS Biol (2006) 1.70
Modifications of small RNAs and their associated proteins. Cell (2010) 1.69
Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1. Structure (2010) 1.67
Structural insights into ligand recognition by a sensing domain of the cooperative glycine riboswitch. Mol Cell (2010) 1.66
DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. Nature (2012) 1.65
Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation. Science (2012) 1.64
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res (2012) 1.64
Activation and intrinsic gamma-secretase activity of presenilin 1. Proc Natl Acad Sci U S A (2010) 1.62
Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation. Nat Cell Biol (2012) 1.60
Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Structure (2009) 1.59
LIN28A is a suppressor of ER-associated translation in embryonic stem cells. Cell (2012) 1.58
Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets. Structure (2003) 1.56
Short structured RNAs with low GC content are selectively lost during extraction from a small number of cells. Mol Cell (2012) 1.56
Berberine inhibits angiogenic potential of Hep G2 cell line through VEGF down-regulation in vitro. J Gastroenterol Hepatol (2011) 1.55
Structural and functional insights into Dom34, a key component of no-go mRNA decay. Mol Cell (2007) 1.54
Genome-wide transcriptome profiling reveals the functional impact of rare de novo and recurrent CNVs in autism spectrum disorders. Am J Hum Genet (2012) 1.52
(3 + 1) Assembly of three human telomeric repeats into an asymmetric dimeric G-quadruplex. J Am Chem Soc (2005) 1.51
The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA. Nature (2016) 1.50
Lutein: more than just a filter for blue light. Prog Retin Eye Res (2012) 1.49
Metabolite recognition principles and molecular mechanisms underlying riboswitch function. Annu Rev Biophys (2012) 1.47