Published in Science on August 02, 2001
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev (2001) 21.82
Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14
MicroRNA genes are transcribed by RNA polymerase II. EMBO J (2004) 20.65
Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol (2009) 19.99
MicroRNA maturation: stepwise processing and subcellular localization. EMBO J (2002) 19.47
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev (2002) 19.24
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J (2001) 12.88
Genetic and functional diversification of small RNA pathways in plants. PLoS Biol (2004) 12.21
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol (2005) 12.12
The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev (2004) 11.58
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71
Endogenous and silencing-associated small RNAs in plants. Plant Cell (2002) 10.07
Computational identification of Drosophila microRNA genes. Genome Biol (2003) 9.86
A combined computational-experimental approach predicts human microRNA targets. Genes Dev (2004) 9.82
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev (2004) 9.32
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci U S A (2003) 8.73
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci U S A (2002) 8.57
Sequence-specific inhibition of small RNA function. PLoS Biol (2004) 7.98
Sequence requirements for micro RNA processing and function in human cells. RNA (2003) 7.46
Post-transcriptional regulation of microRNA expression. RNA (2006) 6.76
Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J (2002) 6.65
Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev (2002) 6.43
Processing of intronic microRNAs. EMBO J (2007) 6.32
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33
Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev (2005) 5.29
Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A (2002) 5.05
The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution. Nat Struct Mol Biol (2008) 4.88
Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc Natl Acad Sci U S A (2001) 4.79
Ribonuclease activity and RNA binding of recombinant human Dicer. EMBO J (2002) 4.73
A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev (2007) 4.69
A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev (2005) 4.55
Carbodiimide-mediated cross-linking of RNA to nylon membranes improves the detection of siRNA, miRNA and piRNA by northern blot. Nucleic Acids Res (2007) 4.54
Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet (2010) 4.27
MicroRNAs: key regulators of stem cells. Nat Rev Mol Cell Biol (2009) 4.26
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov (2010) 4.25
Critical roles for Dicer in the female germline. Genes Dev (2007) 4.23
Comparative genomics and evolution of proteins involved in RNA metabolism. Nucleic Acids Res (2002) 4.00
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J (2004) 3.57
RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast. Proc Natl Acad Sci U S A (2002) 3.52
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med (2008) 3.45
Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. J Virol (2002) 3.42
miRNP:mRNA association in polyribosomes in a human neuronal cell line. RNA (2004) 3.39
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Mol Cell (2008) 3.37
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33
ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos. Proc Natl Acad Sci U S A (2002) 3.09
MicroRNA biogenesis and function in plants. FEBS Lett (2005) 3.02
Micro-RNAs: small is plentiful. J Cell Biol (2002) 2.95
Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science (2010) 2.66
Molecular mechanism of RNA silencing suppression mediated by p19 protein of tombusviruses. EMBO J (2004) 2.65
RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes Dev (2002) 2.61
Distinct phases of siRNA synthesis in an endogenous RNAi pathway in C. elegans soma. Mol Cell (2010) 2.57
Human microRNA prediction through a probabilistic co-learning model of sequence and structure. Nucleic Acids Res (2005) 2.48
Exploring systemic RNA interference in insects: a genome-wide survey for RNAi genes in Tribolium. Genome Biol (2008) 2.25
RNA interference: biology, mechanism, and applications. Microbiol Mol Biol Rev (2003) 2.19
An antiviral role for the RNA interference machinery in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2005) 2.16
RNA interference in human cells is restricted to the cytoplasm. RNA (2002) 2.16
Transcriptional silencing of a transgene by RNAi in the soma of C. elegans. Genes Dev (2005) 2.16
How does RNA editing affect dsRNA-mediated gene silencing? Cold Spring Harb Symp Quant Biol (2006) 2.12
RNA silencing of single and multiple members in a gene family of rice. Plant Physiol (2005) 2.10
Redundancy of the two dicer genes in transgene-induced posttranscriptional gene silencing in Neurospora crassa. Mol Cell Biol (2004) 2.10
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A (2006) 2.04
SHORT INTEGUMENTS1/SUSPENSOR1/CARPEL FACTORY, a Dicer homolog, is a maternal effect gene required for embryo development in Arabidopsis. Plant Physiol (2002) 2.04
RNA silencing and the mobile silencing signal. Plant Cell (2002) 2.03
Inhibition of microRNA function by antimiR oligonucleotides. Silence (2012) 2.02
Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing. Nucleic Acids Res (2006) 1.97
Dicer is required for chromosome segregation and gene silencing in fission yeast cells. Proc Natl Acad Sci U S A (2002) 1.97
RNAi is antagonized by A-->I hyper-editing. EMBO Rep (2001) 1.86
Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression. Nat Methods (2009) 1.82
Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell (2012) 1.81
MicroRNAs in gene regulation: when the smallest governs it all. J Biomed Biotechnol (2006) 1.76
The role of miRNAs in regulating gene expression networks. J Mol Biol (2013) 1.74
Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using Tat- or CCR5-specific small interfering RNAs expressed from a lentivirus vector. J Virol (2003) 1.73
26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2009) 1.71
Structure of a yeast RNase III dsRBD complex with a noncanonical RNA substrate provides new insights into binding specificity of dsRBDs. Structure (2011) 1.69
A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe. Genes Dev (2004) 1.69
The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Curr Biol (2011) 1.66
Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III. Proc Natl Acad Sci U S A (2004) 1.66
Using RNA interference to identify genes required for RNA interference. Proc Natl Acad Sci U S A (2002) 1.63
Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis. J Cell Biol (2008) 1.60
Effects of length and location on the cellular response to double-stranded RNA. Microbiol Mol Biol Rev (2004) 1.57
West Nile virus infection of Drosophila melanogaster induces a protective RNAi response. Virology (2008) 1.56
Comprehensive thermodynamic analysis of 3' double-nucleotide overhangs neighboring Watson-Crick terminal base pairs. Nucleic Acids Res (2006) 1.54
Requirement for the ERI/DICER complex in endogenous RNA interference and sperm development in Caenorhabditis elegans. Genetics (2009) 1.52
Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. RNA (2007) 1.51
Small RNAs: keeping stem cells in line. Cell (2008) 1.51
MiR-200, a new star miRNA in human cancer. Cancer Lett (2013) 1.50
An RIG-I-Like RNA helicase mediates antiviral RNAi downstream of viral siRNA biogenesis in Caenorhabditis elegans. PLoS Pathog (2009) 1.49
Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA. Nucleic Acids Res (2003) 1.47
Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans. PLoS Genet (2006) 1.47
Inter- and intra-combinatorial regulation by transcription factors and microRNAs. BMC Genomics (2007) 1.45
Hepatic function is preserved in the absence of mature microRNAs. Hepatology (2009) 1.44
Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets. Blood (2016) 1.42
The microRNA-17-92 family of microRNA clusters in development and disease. Cancer J (2012) 1.42
MiRFinder: an improved approach and software implementation for genome-wide fast microRNA precursor scans. BMC Bioinformatics (2007) 1.42
MicroRNA biogenesis: regulating the regulators. Crit Rev Biochem Mol Biol (2012) 1.41
dsRNA binding properties of RDE-4 and TRBP reflect their distinct roles in RNAi. J Mol Biol (2008) 1.39
Noncanonical cytoplasmic processing of viral microRNAs. RNA (2010) 1.38
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (1998) 72.56
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31
Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science (2001) 31.33
RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev (2001) 26.16
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell (2001) 25.86
RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell (2000) 20.32
A species of small antisense RNA in posttranscriptional gene silencing in plants. Science (1999) 19.34
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature (2000) 19.15
The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell (1999) 13.48
Specific interference by ingested dsRNA. Nature (1998) 11.82
Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell (2000) 11.44
An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus. Cell (2000) 10.42
Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD. Cell (1999) 9.01
RNA interference--2001. Genes Dev (2001) 7.68
EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans. Curr Biol (2000) 7.16
Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase. Nature (1999) 6.02
Double-stranded RNA as a template for gene silencing. Cell (2000) 5.42
Regulation of gene expression: possible role of repetitive sequences. Science (1979) 5.34
Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference. Mol Cell (2000) 5.18
SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis. EMBO J (2001) 4.89
RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc Natl Acad Sci U S A (1998) 4.63
RNAi in C. elegans: soaking in the genome sequence. Science (1998) 4.39
Genetic requirements for inheritance of RNAi in C. elegans. Science (2000) 4.04
Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes. Nat Genet (2000) 3.79
A genetic link between co-suppression and RNA interference in C. elegans. Nature (2000) 3.67
Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase. Science (1999) 3.36
A new marker for mosaic analysis in Caenorhabditis elegans indicates a fusion between hyp6 and hyp7, two major components of the hypodermis. Genetics (1998) 2.67
A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans. Science (2000) 2.52
Biological catalysis by RNA. Annu Rev Biochem (1986) 5.69
RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase. Nature (1996) 4.04
A developmentally regulated activity that unwinds RNA duplexes. Cell (1987) 3.79
Preferential selection of adenosines for modification by double-stranded RNA adenosine deaminase. EMBO J (1994) 3.75
Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA. EMBO J (1998) 3.23
Double-stranded RNA adenosine deaminases ADAR1 and ADAR2 have overlapping specificities. Biochemistry (2000) 2.85
Biased hypermutation of viral RNA genomes could be due to unwinding/modification of double-stranded RNA. Cell (1989) 2.54
A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans. Science (2000) 2.52
A standardized nomenclature for adenosine deaminases that act on RNA. RNA (1997) 2.50
The mechanism of adenosine to inosine conversion by the double-stranded RNA unwinding/modifying activity: a high-performance liquid chromatography-mass spectrometry analysis. Biochemistry (1991) 2.08
Long RNA hairpins that contain inosine are present in Caenorhabditis elegans poly(A)+ RNA. Proc Natl Acad Sci U S A (1999) 2.08
The importance of internal loops within RNA substrates of ADAR1. J Mol Biol (1999) 1.98
Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA. Nature (1984) 1.96
Purification of the Xenopus laevis double-stranded RNA adenosine deaminase. J Biol Chem (1994) 1.73
A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing. RNA (2000) 1.71
Detection of inosine in messenger RNA by inosine-specific cleavage. Biochemistry (1997) 1.62
Hepatitis delta virus RNA editing is highly specific for the amber/W site and is suppressed by hepatitis delta antigen. Mol Cell Biol (1998) 1.53
RNA interference. The short answer. Nature (2001) 1.53
Ribozyme inhibitors: deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor. Biochemistry (1986) 1.48
In vitro analysis of the binding of ADAR2 to the pre-mRNA encoding the GluR-B R/G site. RNA (2000) 1.47
Dual structural and functional phenotypes of the porcine aortic valve interstitial population: characteristics of the leaflet myofibroblast. J Surg Res (1994) 1.42
Analysis of Xenopus dsRNA adenosine deaminase cDNAs reveals similarities to DNA methyltransferases. RNA (1997) 1.23
Effect of growth factors on cell proliferation and epithelialization in human skin. J Surg Res (1995) 1.22
Tripartite differentiation in a carcinoma of the duodenum. Cancer (1994) 1.18
A minor fraction of basic fibroblast growth factor mRNA is deaminated in Xenopus stage VI and matured oocytes. RNA (1999) 1.16
The cytoplasm of Xenopus oocytes contains a factor that protects double-stranded RNA from adenosine-to-inosine modification. Mol Cell Biol (1994) 1.16
Deamination of mammalian glutamate receptor RNA by Xenopus dsRNA adenosine deaminase: similarities to in vivo RNA editing. RNA (1995) 1.13
NF-kappaB activation and susceptibility to apoptosis after polyamine depletion in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol (2001) 1.13
Inhibition of polyamine synthesis induces p53 gene expression but not apoptosis. Am J Physiol (1999) 1.11
Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation. Am J Physiol Cell Physiol (2001) 1.09
Differentiated intestinal epithelial cells exhibit increased migration through polyamines and myosin II. Am J Physiol (1999) 1.05
A Xenopus zinc finger protein that specifically binds dsRNA and RNA-DNA hybrids. J Mol Biol (1997) 1.04
H+ back diffusion interferes with intrinsic reactive regulation of esophageal mucosal blood flow. Surgery (1984) 0.97
Expression of the transforming growth factor-beta gene during growth inhibition following polyamine depletion. Am J Physiol (1998) 0.95
Bile acid efflux precedes mucosal barrier disruption in the rabbit esophagus. Am J Physiol (1984) 0.91
Caenorhabditis elegans mRNAs that encode a protein similar to ADARs derive from an operon containing six genes. Nucleic Acids Res (1999) 0.90
Hazards of nonoperative therapy of hepatic injury in children. J Trauma (1984) 0.88
Esophageal mucosal blood flow: a central role for calcitonin gene-related peptide. Surgery (1994) 0.87
Subsets of the zinc finger motifs in dsRBP-ZFa can bind double-stranded RNA. Biochemistry (1999) 0.86
Bile acid accumulation by rabbit esophageal mucosa. Dig Dis Sci (1986) 0.86
Video. Chopstick surgery: a novel technique enables use of the Da Vinci Robot to perform single-incision laparoscopic surgery. Surg Endosc (2010) 0.85
Expression of the TGF-beta receptor gene and sensitivity to growth inhibition following polyamine depletion. Am J Physiol Cell Physiol (2000) 0.84
Sucralfate prevents experimental peptic esophagitis in rabbits. Gastroenterology (1985) 0.84
Bile salt stimulates intestinal epithelial cell migration through TGFbeta after wounding. J Surg Res (2001) 0.84
Intestinal epithelial cell regulation of macrophage and lymphocyte interleukin 10 expression. Arch Surg (1997) 0.82
Lipid solubilization during bile salt-induced esophageal mucosal barrier disruption in the rabbit. J Lab Clin Med (1987) 0.81
Femur fracture induces site-specific changes in T-cell immunity. J Surg Res (1999) 0.81
Epidermal growth factor primes intestinal epithelial cells for proliferative effect of insulin-like growth factor I. Dig Dis Sci (1994) 0.80
Nitric oxide mediates the blood flow response to intravenous adenosine in the rabbit. Circ Shock (1994) 0.80
Retroperitoneal follicular dendritic cell sarcoma presenting as secondary amyloidosis. Surgery (2001) 0.80
Advanced proximal colon cancer. Surg Endosc (2001) 0.80
Deriving indicators for breast conserving surgery using finite element analysis. Comput Methods Biomech Biomed Engin (2013) 0.80
Gastric remnant carcinoma: reevaluation of screening endoscopy. Surg Endosc (2001) 0.80
Nitric oxide regulates basal but not capsaicin-, CGRP-, or bile salt-stimulated rabbit esophageal mucosal blood flow. Ann Surg (1995) 0.79
Synergistic induction of ornithine decarboxylase by asparagine and gut peptides in intestinal crypt cells. Am J Physiol (1998) 0.79
Adenosine: differential effect on blood flow to subregions of the upper gastrointestinal tract. J Surg Res (1994) 0.79
Intraluminal pCO2: a reliable indicator of intestinal ischemia. J Surg Res (1985) 0.78
Adenine nucleotide depletion in cryopreserved human cardiac valves: the "stunned" leaflet interstitial cell population. Cryobiology (1995) 0.78
Matrix alters the proliferative response of enterocytes to growth factors. Am J Surg (1996) 0.78
Anatomic and physiologic characteristics of transplanted fetal rat intestine. Ann Surg (1984) 0.77
Interstitial cellular and matrix restoration of cardiac valves after cryopreservation. J Thorac Cardiovasc Surg (1999) 0.77
Role of transforming growth factor-beta in growth and injury response of the pancreatic duct epithelium in vitro. J Gastrointest Surg (2000) 0.77
Protein kinase C inhibits epidermal growth factor receptor phosphorylation in enterocytes. J Surg Res (1997) 0.76
Extracellular matrix modulates enterocyte growth via downregulation of c-jun but is independent of p21 and p27 expression. J Gastrointest Surg (2000) 0.76
Epithelial-matrix interactions : laminin downregulates enterocyte EGF receptor and IGF-I receptor expression. J Surg Res (1996) 0.76
Extracellular matrix composition influences insulinlike growth factor I receptor expression in rat IEC-18 cells. Gastroenterology (1993) 0.75
Acute effects of bile acids on the pancreatic duct epithelium in vitro. J Surg Res (1998) 0.75
The pancreatic duct epithelium in vitro: bile acid injury and the effect of epidermal growth factor. Surgery (1997) 0.75
Kinetics of splenocyte interleukin-4 production after injury and lethal endotoxin challenge. J Surg Res (1997) 0.75
Esophageal blood flow in the rabbit: response to calcium channel blockers. Surgery (1989) 0.75
Somatostatin analog: effects on hypergastrinemia and hypercalcitoninemia. Surgery (1986) 0.75
RNA editing. Splicing: the new edition. Nature (1991) 0.75
RNA editing. Physarum--C the difference? Nature (1991) 0.75
Use of the radiolabeled murine monoclonal antibody, 111In-CYT-103, in the management of colon cancer. Am J Surg (1993) 0.75
Blood flow to transplanted fetal rat intestine. J Surg Res (1986) 0.75
Early and late VEPs for reading stimuli are altered by common binocular misalignments. Psychophysiology (1993) 0.75