Published in Nature on December 10, 1985
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MYC on the path to cancer. Cell (2012) 8.65
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Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci (2010) 6.30
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Nucleotide sequence of the human N-myc gene. Proc Natl Acad Sci U S A (1986) 2.99
Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas. Proc Natl Acad Sci U S A (1986) 2.66
The GLI-Kruppel family of human genes. Mol Cell Biol (1988) 2.52
Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung. Proc Natl Acad Sci U S A (1987) 2.50
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Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification. Proc Natl Acad Sci U S A (1989) 2.25
Neoplastic transformation by the human gene N-myc. Mol Cell Biol (1987) 2.17
Human proto-oncogene N-myc encodes nuclear proteins that bind DNA. Mol Cell Biol (1986) 2.15
Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40. Proc Natl Acad Sci U S A (1988) 2.15
Human small-cell lung cancers show amplification and expression of the N-myc gene. Proc Natl Acad Sci U S A (1986) 1.96
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A genetic linkage map of 27 loci from PND to FY on the short arm of human chromosome I. Am J Hum Genet (1988) 1.92
The erg gene: a human gene related to the ets oncogene. Proc Natl Acad Sci U S A (1987) 1.90
Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Mol Cell Biol (1993) 1.79
Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing. Mol Cell Biol (1988) 1.78
c-myc down-regulates class I HLA expression in human melanomas. EMBO J (1988) 1.72
Structure and expression of the murine L-myc gene. EMBO J (1987) 1.64
An overview of MYC and its interactome. Cold Spring Harb Perspect Med (2014) 1.53
Copy number analysis identifies novel interactions between genomic loci in ovarian cancer. PLoS One (2010) 1.50
N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization. J Cell Biol (1988) 1.47
Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer. Mol Cell Biol (1988) 1.45
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L-myc cooperates with ras to transform primary rat embryo fibroblasts. Mol Cell Biol (1988) 1.43
myc family oncogene amplification in tumor cell lines established from small cell lung cancer patients and its relationship to clinical status and course. J Clin Invest (1987) 1.43
Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. J Invest Dermatol (2008) 1.42
IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression. EMBO J (1989) 1.42
Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells. Mol Cell Biol (1992) 1.39
Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer. J Clin Invest (1990) 1.38
Expression and activity of L-Myc in normal mouse development. Mol Cell Biol (1996) 1.36
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Distal deletion of chromosome Ip in ductal carcinoma of the breast. Am J Hum Genet (1989) 1.25
Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. EMBO J (1997) 1.25
Contrasting expression patterns of three members of the myc family of protooncogenes in the developing and adult mouse kidney. J Cell Biol (1991) 1.23
Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression. Proc Natl Acad Sci U S A (1989) 1.21
XB130, a novel adaptor protein, promotes thyroid tumor growth. Am J Pathol (2010) 1.21
The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs. Mol Cell Biol (1988) 1.18
Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner. Proc Natl Acad Sci U S A (1995) 1.14
Genetic mapping of a locus for multiple epiphyseal dysplasia (EDM2) to a region of chromosome 1 containing a type IX collagen gene. Am J Hum Genet (1994) 1.12
A translocated human c-myc oncogene is altered in a conserved coding sequence. Proc Natl Acad Sci U S A (1986) 1.12
MYC and metabolism on the path to cancer. Semin Cell Dev Biol (2015) 1.09
Cellular myc (c-myc) in fish (rainbow trout): its relationship to other vertebrate myc genes and to the transforming genes of the MC29 family of viruses. Proc Natl Acad Sci U S A (1986) 1.08
Human cancer and cellular oncogenes. Biochem J (1987) 1.07
Myc: the beauty and the beast. Genes Cancer (2010) 1.07
Close correlation between restriction fragment length polymorphism of the L-MYC gene and metastasis of human lung cancer to the lymph nodes and other organs. Proc Natl Acad Sci U S A (1988) 1.04
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L-Myc protein synthesis is initiated by internal ribosome entry. RNA (2004) 1.03
A fusion protein formed by L-myc and a novel gene in SCLC. EMBO J (1991) 1.03
Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis. Biochim Biophys Acta (2014) 1.02
Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo. EMBO J (1995) 1.02
Differential regulation of the N-myc gene in transfected cells and transgenic mice. Mol Cell Biol (1990) 1.02
B-myc inhibits neoplastic transformation and transcriptional activation by c-myc. Mol Cell Biol (1993) 1.01
Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One (2012) 1.01
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers. Am J Pathol (2002) 1.00
Pks, a raf-related sequence in humans. Proc Natl Acad Sci U S A (1986) 1.00
Regulation of N-myc gene expression: use of an adenovirus vector to demonstrate posttranscriptional control. Mol Cell Biol (1990) 1.00
IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis. EMBO J (1990) 1.00
Structural alteration in the MYB protooncogene and deletion within the gene encoding alpha-type protein kinase C in human melanoma cell lines. Proc Natl Acad Sci U S A (1988) 1.00
Nucleotide sequence of the coding region of the mouse N-myc gene. EMBO J (1986) 1.00
v-Ha-ras oncogene insertion: a model for tumor progression of human small cell lung cancer. Proc Natl Acad Sci U S A (1988) 0.99
Differential expression of myc, max and RB1 genes in human gliomas and glioma cell lines. Br J Cancer (1994) 0.98
Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors. Neoplasia (2006) 0.97
Isolation and structural analysis of a 1.2-megabase N-myc amplicon from a human neuroblastoma. Mol Cell Biol (1992) 0.95
Antisense c-myc effects on preimplantation mouse embryo development. Proc Natl Acad Sci U S A (1992) 0.95
v-rasH induces non-small cell phenotype, with associated growth factors and receptors, in a small cell lung cancer cell line. J Clin Invest (1990) 0.95
Excision of N-myc from chromosome 2 in human neuroblastoma cells containing amplified N-myc sequences. Mol Cell Biol (1990) 0.95
Mechanism of endogenous myc gene down-regulation in E mu-N-myc tumors. Mol Cell Biol (1991) 0.95
Structure and expression of B-myc, a new member of the myc gene family. Mol Cell Biol (1988) 0.93
Abnormal distribution of c-myc oncogene product in familial adenomatous polyposis. J Clin Pathol (1987) 0.93
Mitochondrial acetylation and diseases of aging. J Aging Res (2011) 0.91
Molecular characterization of a novel amplicon at 1q21-q22 frequently observed in human sarcomas. Br J Cancer (1998) 0.91
Cooperation of c-raf-1 and c-myc protooncogenes in the neoplastic transformation of simian virus 40 large tumor antigen-immortalized human bronchial epithelial cells. Proc Natl Acad Sci U S A (1989) 0.90
Genomic and gene expression profiling of minute alterations of chromosome arm 1p in small-cell lung carcinoma cells. Br J Cancer (2005) 0.90
Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas. Am J Pathol (2003) 0.90
Sustained expression of the human protooncogene MYCN rescues rat embryo cells from senescence. Proc Natl Acad Sci U S A (1988) 0.89
Differential patterns of DNA binding by myc and max proteins. Proc Natl Acad Sci U S A (1993) 0.88
MYC-y mice: from tumour initiation to therapeutic targeting of endogenous MYC. Mol Oncol (2013) 0.88
Acidosis decreases c-Myc oncogene expression in human lymphoma cells: a role for the proton-sensing G protein-coupled receptor TDAG8. Int J Mol Sci (2013) 0.87
Cellular oncogenes in neoplasia. J Clin Pathol (1987) 0.87
Rapid phosphorylation of the L-myc protein induced by phorbol ester tumor promoters and serum. EMBO J (1989) 0.87
Oncogene expression in vivo by ovarian adenocarcinomas and mixed-mullerian tumors. Yale J Biol Med (1990) 0.86
Oncogenes and tumor-suppressor genes. Environ Health Perspect (1991) 0.86
Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors. Proc Natl Acad Sci U S A (2016) 0.86
MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation. Cell Death Differ (2017) 0.85
Resistance to anticancer drugs in NIH3T3 cells transfected with c-myc and/or c-H-ras genes. Br J Cancer (1991) 0.85
Transcriptional activation and DNase I hypersensitive sites are associated with selective expression of the gastrin-releasing peptide gene. J Clin Invest (1988) 0.85
Expression of a fms-related oncogene in carcinogen-induced neoplastic epithelial cells. Proc Natl Acad Sci U S A (1987) 0.84
Control of growth and squamous differentiation in normal human bronchial epithelial cells by chemical and biological modifiers and transferred genes. Environ Health Perspect (1989) 0.84
Relationship of myc protein expression to the phenotype and to the growth potential of HOC-7 ovarian cancer cells. Br J Cancer (1992) 0.83
From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers. J Thorac Oncol (2015) 0.82
Application of a high throughput method of biomarker discovery to improvement of the EarlyCDT(®)-Lung Test. PLoS One (2012) 0.82
Functional analysis of microRNA and transcription factor synergistic regulatory network based on identifying regulatory motifs in non-small cell lung cancer. BMC Syst Biol (2013) 0.82
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Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature (2001) 10.96
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The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma. Cell (1983) 8.54
p53: a frequent target for genetic abnormalities in lung cancer. Science (1989) 7.51
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell (1985) 7.29
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science (1987) 6.89
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IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res (1998) 5.41
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