Published in Proc Natl Acad Sci U S A on April 16, 1996
Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc Natl Acad Sci U S A (1998) 3.26
The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation. Immunity (2001) 1.98
A new peptide vector for efficient delivery of oligonucleotides into mammalian cells. Nucleic Acids Res (1997) 1.67
cAMP acts as a second messenger in pollen tube growth and reorientation. Proc Natl Acad Sci U S A (2001) 1.41
Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus. Nucleic Acids Res (1998) 1.22
Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells. Proc Natl Acad Sci U S A (1998) 1.21
Inhibition of human telomerase by 2'-O-methyl-RNA. Proc Natl Acad Sci U S A (1998) 1.09
Oligodeoxynucleotides containing C-7 propyne analogs of 7-deaza-2'-deoxyguanosine and 7-deaza-2'-deoxyadenosine. Nucleic Acids Res (1996) 1.00
A cytosine analog that confers enhanced potency to antisense oligonucleotides. Proc Natl Acad Sci U S A (1999) 1.00
Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotides. Nucleic Acids Res (2004) 0.98
A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy. J Clin Invest (1999) 0.97
Ultrasmall gold nanoparticles as carriers for nucleus-based gene therapy due to size-dependent nuclear entry. ACS Nano (2014) 0.94
Chemical activation of lipoplexes formed from DNA and a redox-active, ferrocene-containing cationic lipid. Bioconjug Chem (2008) 0.92
Effects of oligonucleotide length, mismatches and mRNA levels on C-5 propyne-modified antisense potency. Nucleic Acids Res (1996) 0.89
Addition of ascorbic acid to the extracellular environment activates lipoplexes of a ferrocenyl lipid and promotes cell transfection. J Control Release (2011) 0.88
Oligonucleotides tethered to a short polyguanylic acid stretch are targeted to macrophages: enhanced antiviral activity of a vesicular stomatitis virus-specific antisense oligonucleotide. Antimicrob Agents Chemother (1999) 0.87
Targeted delivery of oligodeoxynucleotides to parenchymal liver cells in vivo. Biochem J (1999) 0.86
Polymeric nucleic acid vehicles exploit active interorganelle trafficking mechanisms. ACS Nano (2012) 0.85
Optimizing cationic and neutral lipids for efficient gene delivery at high serum content. J Gene Med (2014) 0.85
Condensation of oligonucleotides assembled into nicked and gapped duplexes: potential structures for oligonucleotide delivery. Nucleic Acids Res (2005) 0.83
The spherulites(TM): a promising carrier for oligonucleotide delivery. Nucleic Acids Res (2000) 0.82
Inhibition of gene expression by anti-sense C-5 propyne oligonucleotides detected by a reporter enzyme. Biochem J (1999) 0.80
Transferrin-associated lipoplexes as gene delivery systems: relevance of mode of preparation and biophysical properties. J Membr Biol (2008) 0.75
SupraMolecular BioVectors (SMBV) improve antisense inhibition of erbB-2 expression. Br J Cancer (1998) 0.75
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A (1992) 35.45
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci U S A (1987) 18.91
Theory of self-assembly of lipid bilayers and vesicles. Biochim Biophys Acta (1977) 3.49
Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol Pharmacol (1992) 3.42
Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J Biol Chem (1994) 3.41
Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. Proc Natl Acad Sci U S A (1989) 3.28
Gene inhibition using antisense oligodeoxynucleotides. Nature (1994) 3.26
Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides microinjected into mammalian cells. Nucleic Acids Res (1993) 2.72
A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem Biophys Res Commun (1991) 2.72
Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines. Science (1993) 2.56
Gene transfer with synthetic cationic amphiphiles: prospects for gene therapy. Bioconjug Chem (1995) 2.46
Current concepts in antisense drug design. J Med Chem (1993) 2.28
Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters. J Biol Chem (1994) 2.00
Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides. J Immunol (1994) 1.59
Inverted micellar intermediates and the transitions between lamellar, cubic, and inverted hexagonal lipid phases. I. Mechanism of the L alpha----HII phase transitions. Biophys J (1986) 1.36
Phosphatidylethanolamine liposomes: drug delivery, gene transfer and immunodiagnostic applications. Biochim Biophys Acta (1992) 1.21
Use of an antisense oligonucleotide to inhibit expression of a mutated human procollagen gene (COL1A1) in transfected mouse 3T3 cells. Biochemistry (1993) 1.03
Membrane fusion. Subcell Biochem (1985) 0.94
Luminescent reporter gene assays for luciferase and beta-galactosidase using a liquid scintillation counter. Biotechniques (1993) 0.91
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature (1994) 5.12
Physical characterization of the herpes simplex virus latency-associated transcript in neurons. J Virol (1988) 4.85
Synthesis of DNA via deoxynucleoside H-phosphonate intermediates. Nucleic Acids Res (1986) 4.24
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature (1992) 4.12
Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions. Infect Immun (1982) 4.02
Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science (1996) 3.74
Dialkylformamidines: depurination resistant N6-protecting group for deoxyadenosine. Nucleic Acids Res (1983) 3.62
The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection. J Virol (1988) 3.22
Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release (2001) 2.84
Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides microinjected into mammalian cells. Nucleic Acids Res (1993) 2.72
Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem (2000) 2.70
Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines. Science (1993) 2.56
New chemical methods for synthesizing polynucleotides. Nucleic Acids Symp Ser (1980) 2.32
Current concepts in antisense drug design. J Med Chem (1993) 2.28
Triple helix formation inhibits transcription elongation in vitro. Proc Natl Acad Sci U S A (1991) 2.28
Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides? J Med Chem (1996) 2.08
High incidence of erythromycin-resistant streptococci in Taiwan. Antimicrob Agents Chemother (1997) 1.97
Role of streptococcal pyrogenic exotoxin B in the mouse model of group A streptococcal infection. Infect Immun (1998) 1.84
Potent and selective inhibition of gene expression by an antisense heptanucleotide. Nat Biotechnol (1996) 1.74
The surgical management of orbitofacial dermoids in the pediatric patient. Plast Reconstr Surg (1993) 1.73
Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells. Proc Natl Acad Sci U S A (2000) 1.71
Hybridization triggered cross-linking of deoxyoligonucleotides. Nucleic Acids Res (1986) 1.69
Targeting human papillomavirus type 16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine human papillomavirus type 16 E7-expressing tumors. Hum Gene Ther (1999) 1.63
Targeted random mutagenesis: the use of ambiguously synthesized oligonucleotides to mutagenize sequences immediately 5' of an ATG initiation codon. Nucleic Acids Res (1983) 1.60
Chemical synthesis and biological studies on mutated gene-control regions. Cold Spring Harb Symp Quant Biol (1983) 1.55
Effect of group A streptococcal cysteine protease on invasion of epithelial cells. Infect Immun (1998) 1.54
Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40. Science (1991) 1.49
An anti-parallel triple helix motif with oligodeoxynucleotides containing 2'-deoxyguanosine and 7-deaza-2'-deoxyxanthosine. Nucleic Acids Res (1993) 1.47
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. J Med Chem (1998) 1.46
ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways. Cancer Res (2001) 1.44
Oligonucleotide-mediated triple helix formation using an N3-protonated deoxycytidine analog exhibiting pH-independent binding within the physiological range. Proc Natl Acad Sci U S A (1992) 1.44
Abnormal head MRI in a neurologically normal boy with hypomelanosis of Ito. Am J Med Genet (1996) 1.44
Antigen-specific immunotherapy for murine lung metastatic tumors expressing human papillomavirus type 16 E7 oncoprotein. Int J Cancer (1998) 1.38
Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity. J Biol Chem (2000) 1.26
p27(kip1) acts as a downstream effector of and is coexpressed with the beta1C integrin in prostatic adenocarcinoma. J Clin Invest (1999) 1.19
Site and mechanism of antisense inhibition by C-5 propyne oligonucleotides. Biochemistry (1995) 1.18
Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo. Biochemistry (1996) 1.17
In pursuit of antisense. Nature (1996) 1.15
Hybridization and dissociation rates of phosphodiester or modified oligodeoxynucleotides with RNA at near-physiological conditions. Nucleic Acids Res (1991) 1.14
In vitro synergism between cefotaxime and minocycline against Vibrio vulnificus. Antimicrob Agents Chemother (1997) 1.08
Double-stranded RNA poses puzzle. Nature (1998) 1.08
Wound complications of abdominoplasty in obese patients. Ann Plast Surg (1999) 1.06
The detection of mutants in mice by electrophoresis: results of a model induction experiment with procarbazine. Genetics (1981) 1.05
Triplex formation by oligonucleotides containing 5-(1-propynyl)-2'-deoxyuridine: decreased magnesium dependence and improved intracellular gene targeting. Biochemistry (1999) 1.04
Inhibition of human immunodeficiency virus type-1 env expression by C-5 propyne oligonucleotides specific for Rev-response element stem-loop V. Biochemistry (1994) 1.01
Oligodeoxynucleotides containing C-7 propyne analogs of 7-deaza-2'-deoxyguanosine and 7-deaza-2'-deoxyadenosine. Nucleic Acids Res (1996) 1.00
A cytosine analog that confers enhanced potency to antisense oligonucleotides. Proc Natl Acad Sci U S A (1999) 1.00
Cell-surface-associated nucleic acid in tumorigenic cells made visible with platinum-pyrimidine complexes by electron microscopy. Proc Natl Acad Sci U S A (1975) 1.00
Potassium-resistant triple helix formation and improved intracellular gene targeting by oligodeoxyribonucleotides containing 7-deazaxanthine. Nucleic Acids Res (1997) 0.99
Antisense technology and prospects for therapy of viral infections and cancer. Mol Med Today (1997) 0.98
Regulation of the interleukin-2 gene. Chem Immunol (1992) 0.97
CD8+ T cells, NK cells and IFN-gamma are important for control of tumor with downregulated MHC class I expression by DNA vaccination. Gene Ther (2003) 0.97
Apert syndrome: quantitative assessment by CT scan of presenting deformity and surgical results after first-stage reconstruction. Plast Reconstr Surg (1994) 0.96
Cleavage of single stranded oligonucleotides by EcoRI restriction endonuclease. Nucleic Acids Res (1987) 0.96
Recombinant human stem cell factor, a c-kit ligand, stimulates hematopoiesis in primates. Blood (1991) 0.96
Potent and selective gene inhibition using antisense oligodeoxynucleotides. Mol Cell Biochem (1997) 0.95
Effect of sodium intake on single nephron glomerular filtration rate and sodium reabsorption in experimental uremia. Kidney Int (1975) 0.95
Folate-mediated drug delivery: effect of alternative conjugation chemistry. J Drug Target (1999) 0.95
YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Br J Pharmacol (2014) 0.95
Development of a population-based microsimulation model of osteoarthritis in Canada. Osteoarthritis Cartilage (2009) 0.93
In utero brachial artery thrombosis: limb salvage with postnatal urokinase infusion. Ann Plast Surg (1995) 0.93
Nuclease recognition of an alternating structure in a d(AT)14 plasmid insert. Nucleic Acids Res (1986) 0.93
Development of antisense therapeutics. Implications for cancer gene therapy. Ann N Y Acad Sci (1994) 0.93
Fatty acid synthetases from Euglena gracilis. Separation of component activities of the ACP-dependent fatty acid synthetase and partial purification of the beta-ketoacyl-ACP synthetase. J Biol Chem (1980) 0.92
Chromosome 22q11.2 deletion in a boy with Opitz (G/BBB) syndrome. Am J Med Genet (1996) 0.92
Probing structural factors stabilizing antisense oligonucleotide duplexes: NMR studies of a DNA.DNA duplex containing a formacetal linkage. Biochemistry (1992) 0.91
Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: toward perfection of rates of time-dependent inhibition by using ligand-binding energies. Biochemistry (1995) 0.91
Effects of oligonucleotide length, mismatches and mRNA levels on C-5 propyne-modified antisense potency. Nucleic Acids Res (1996) 0.89
Endogenous retroviral envelope antigen in plasma cells. J Immunol (1981) 0.89
Antisense gene inhibition by C-5-substituted deoxyuridine-containing oligodeoxynucleotides. Biochemistry (1997) 0.88
Biomechanical performance of powder-free examination gloves. J Emerg Med (1999) 0.87
Mechanisms of premature closure of cranial sutures. Childs Nerv Syst (1999) 0.86
Induction of HSP70 is associated with vincristine resistance in heat-shocked 9L rat brain tumour cells. Br J Cancer (1992) 0.85
Arteriovenous fistula of the scalp after hair transplantation treated by endovascular embolization. Ann Plast Surg (1994) 0.84
Matrix-assisted laser desorption mass spectrometric analysis of a pegylated recombinant protein. Biotechniques (1994) 0.84
Metopic synostosis: quantitative assessment of presenting deformity and surgical results based on CT scans. Plast Reconstr Surg (1994) 0.84
Induction of heat-shock response and alterations of protein phosphorylation by a novel topoisomerase II inhibitor, withangulatin A, in 9L rat brain tumor cells. J Cell Physiol (1991) 0.83
Substantial decrease of heat shock protein 90 in ventricular tissues of two sudden-death pigs with hypertrophic cardiomyopathy. FASEB J (1996) 0.83
Immunogenicity of thrombopoietin mimetic peptide GW395058 in BALB/c mice and New Zealand white rabbits: evaluation of the potential for thrombopoietin neutralizing antibody production in man. Stem Cells (1999) 0.83
Successful excision of a large immature teratoma involving the cranial base: report of a case with long-term follow-up. Neurosurgery (1998) 0.82
The effect of a biodegradable contraceptive capsule (Capronor) containing levonorgestrel on gonadotropin, estrogen, and progesterone levels. Am J Obstet Gynecol (1983) 0.82
Gastrointestinal neuropathy in familial amyloidosis. Report of a case with severe diarrhea without steatorrhea or malabsorption. Am J Gastroenterol (1973) 0.82
Frontonasal dysplasia in two successive generations. Am J Med Genet (1993) 0.81
Folate copolymer-mediated transfection of cultured cells. Bioconjug Chem (2000) 0.81
[A case of vivax malaria with thrombocytopenia suggesting immunological mechanisms]. Rinsho Ketsueki (1993) 0.81
Sagittal synostosis: quantitative assessment of presenting deformity and surgical results based on CT scans. Plast Reconstr Surg (1993) 0.81
Sagittal synostosis. Neurosurg Focus (2000) 0.81
17 beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5 alpha-reductase 1. Biochemistry (1994) 0.81
Hydration changes implicated in the remarkable temperature-dependent membrane permeation of cyclosporin A. Biochemistry (2000) 0.81
Recurrent lambdoid synostosis within two families. Am J Med Genet (1995) 0.80
Elucidation of gene function using C-5 propyne antisense oligonucleotides. Nat Biotechnol (1996) 0.80
Glycosuria and tubular glycogen deposition. Nephron (1974) 0.80