Getting Surprising Answers to Unasked Questions.

The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell (2002) 9.92

The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol (2010) 6.63

Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell (2004) 6.44

System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol (2007) 6.23

SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68

Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat Genet (2006) 5.08

Mammalian genes are transcribed with widely different bursting kinetics. Science (2011) 4.08

Integration of microRNA miR-122 in hepatic circadian gene expression. Genes Dev (2009) 3.64

Crosstalk between components of circadian and metabolic cycles in mammals. Cell Metab (2011) 3.31

Circadian rhythms: mechanisms and therapeutic implications. Annu Rev Pharmacol Toxicol (2007) 3.19

Rhythms of mammalian body temperature can sustain peripheral circadian clocks. Curr Biol (2002) 3.05

The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification. Cell Metab (2006) 3.00

REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol (2009) 2.76

The mammalian circadian timing system: from gene expression to physiology. Chromosoma (2004) 2.67

Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell (2010) 2.52

PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science (2005) 2.29

Properties, entrainment, and physiological functions of mammalian peripheral oscillators. J Biol Rhythms (2006) 2.21

The period length of fibroblast circadian gene expression varies widely among human individuals. PLoS Biol (2005) 2.13

Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles. PLoS Biol (2012) 2.12

The loss of circadian PAR bZip transcription factors results in epilepsy. Genes Dev (2004) 1.92

Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally. Science (2012) 1.91

Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor. Genes Dev (2008) 1.78

Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock. Neuron (2002) 1.72

Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity. Cell (2013) 1.71

Circadian gene expression is resilient to large fluctuations in overall transcription rates. EMBO J (2008) 1.61

Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillators. Genes Dev (2012) 1.48

Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms. Proc Natl Acad Sci U S A (2006) 1.40

Physiology. Proteasomes keep the circadian clock ticking. Science (2007) 1.08

Circadian gene expression in cultured cells. Methods Enzymol (2005) 1.07

Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity. Proc Natl Acad Sci U S A (2011) 1.05

Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome. Mol Cell (2012) 1.01

Origins and consequences of transcriptional discontinuity. Curr Opin Cell Biol (2011) 0.97

Real-time recording of circadian liver gene expression in freely moving mice reveals the phase-setting behavior of hepatocyte clocks. Genes Dev (2013) 0.93

A CLOCK-less clock. Trends Cell Biol (2006) 0.93

Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF. Am J Physiol Regul Integr Comp Physiol (2010) 0.92

REV-ERBs: more than the sum of the individual parts. Cell Metab (2012) 0.83

Body temperature cycles: gatekeepers of circadian clocks. Cell Cycle (2013) 0.81

Circadian glucose homeostasis requires compensatory interference between brain and liver clocks. Proc Natl Acad Sci U S A (2008) 0.81

Orphan nuclear receptors, molecular clockwork, and the entrainment of peripheral oscillators. Novartis Found Symp (2003) 0.80

CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions. EMBO Rep (2012) 0.79

Shedding new light on circadian clocks. Elife (2013) 0.78

Physiology. Feeding the clock. Science (2009) 0.77

Circadian cell-cycle progression: Cracking open the gate. Cell (2010) 0.76

In Vitro Screening for Regulated Transcription Factors with Differential Display of DNA-Binding Proteins (DDDP). CSH Protoc (2008) 0.76

Transcription factor loading: please take my place! Cell (2011) 0.75

The ticking tail: daily oscillations in mRNA poly(A) tail length drive circadian cycles in protein synthesis. Genes Dev (2012) 0.75

Glucocorticoid rhythm renders female mice more daring. Cell (2013) 0.75

[The inter-individual variability of circadian period length in human skin cells]. Med Sci (Paris) (2006) 0.75

Otto Naegeli Award 2002 honors the work of Prof. Walter Wahli. Swiss Med Wkly (2002) 0.75

[Circadian metabolism of medicaments: an important Geneva discovery]. Rev Med Suisse (2006) 0.75