Published in Cell on September 09, 2010
Circadian integration of metabolism and energetics. Science (2010) 6.86
Central and peripheral circadian clocks in mammals. Annu Rev Neurosci (2012) 4.73
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50
Clocks not winding down: unravelling circadian networks. Nat Rev Mol Cell Biol (2010) 2.95
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab (2011) 2.94
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. Genes Dev (2012) 2.82
Circadian topology of metabolism. Nature (2012) 2.63
Metabolic regulation of epigenetics. Cell Metab (2012) 2.55
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature (2011) 2.34
Molecular architecture of the mammalian circadian clock. Trends Cell Biol (2013) 2.26
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85
Clocks, metabolism, and the epigenome. Mol Cell (2012) 1.84
Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillators. Genes Dev (2012) 1.48
Metabolism and the circadian clock converge. Physiol Rev (2013) 1.47
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab (2015) 1.38
O-GlcNAcylation, novel post-translational modification linking myocardial metabolism and cardiomyocyte circadian clock. J Biol Chem (2011) 1.36
Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides. Cell Metab (2014) 1.29
Biochemical analysis of the canonical model for the mammalian circadian clock. J Biol Chem (2011) 1.27
Jumonji domain protein JMJD5 functions in both the plant and human circadian systems. Proc Natl Acad Sci U S A (2010) 1.25
bHLH-PAS proteins in cancer. Nat Rev Cancer (2013) 1.23
Tuning the mammalian circadian clock: robust synergy of two loops. PLoS Comput Biol (2011) 1.18
Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab (2013) 1.16
NAD+ as a signaling molecule modulating metabolism. Cold Spring Harb Symp Quant Biol (2012) 1.12
Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21. Proc Natl Acad Sci U S A (2014) 1.10
Circadian regulation of metabolism. J Endocrinol (2014) 1.08
Circadian clocks and metabolism. Handb Exp Pharmacol (2013) 1.07
Circadian control of glucose metabolism. Mol Metab (2014) 1.05
Small molecule modifiers of circadian clocks. Cell Mol Life Sci (2012) 1.03
Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation. Aging (Albany NY) (2011) 0.98
Nutrient sensing and the circadian clock. Trends Endocrinol Metab (2012) 0.98
The circadian epigenome: how metabolism talks to chromatin remodeling. Curr Opin Cell Biol (2013) 0.98
Protein acetylation in metabolism - metabolites and cofactors. Nat Rev Endocrinol (2015) 0.97
The circadian clock transcriptional complex: metabolic feedback intersects with epigenetic control. Ann N Y Acad Sci (2012) 0.96
PARPs and ADP-Ribosylation: 50 Years … and Counting. Mol Cell (2015) 0.95
Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG). ACS Chem Biol (2012) 0.95
Nutrients, Clock Genes, and Chrononutrition. Curr Nutr Rep (2014) 0.95
AMPK at the crossroads of circadian clocks and metabolism. Mol Cell Endocrinol (2012) 0.94
Real-time recording of circadian liver gene expression in freely moving mice reveals the phase-setting behavior of hepatocyte clocks. Genes Dev (2013) 0.93
USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals. J Biol Chem (2012) 0.92
Physiological responses to food intake throughout the day. Nutr Res Rev (2014) 0.92
Disturbances in the murine hepatic circadian clock in alcohol-induced hepatic steatosis. Sci Rep (2014) 0.92
Circadian rhythms: Redox redux. Nature (2011) 0.91
Functional Aspects of PARP1 in DNA Repair and Transcription. Biomolecules (2012) 0.91
Metabolic and nontranscriptional circadian clocks: eukaryotes. Annu Rev Biochem (2014) 0.91
Transcriptional roles of PARP1 in cancer. Mol Cancer Res (2014) 0.91
Circadian rhythms in urinary functions: possible roles of circadian clocks? Int Neurourol J (2011) 0.89
Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol Aspects Med (2013) 0.89
Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4. PLoS One (2013) 0.88
New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases. Chem Rev (2015) 0.88
Impact of nutrients on circadian rhythmicity. Am J Physiol Regul Integr Comp Physiol (2014) 0.87
The role of circadian clocks in metabolic disease. Yale J Biol Med (2012) 0.87
Circadian autophagy rhythm: a link between clock and metabolism? Trends Endocrinol Metab (2012) 0.87
The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice. PLoS One (2014) 0.87
A one and a two … expanding roles for poly(ADP-ribose) polymerases in metabolism. Cell Metab (2011) 0.85
Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J Biol Chem (2014) 0.85
Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription. Proc Natl Acad Sci U S A (2014) 0.85
Circadian clocks in fuel harvesting and energy homeostasis. Cold Spring Harb Symp Quant Biol (2011) 0.84
The Molecular Circadian Clock and Alcohol-Induced Liver Injury. Biomolecules (2015) 0.84
Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue. Nat Commun (2016) 0.83
Shifting the feeding of mice to the rest phase creates metabolic alterations, which, on their own, shift the peripheral circadian clocks by 12 hours. Proc Natl Acad Sci U S A (2015) 0.83
SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism. Genome Integr (2013) 0.82
Manipulating the circadian and sleep cycles to protect against metabolic disease. Front Endocrinol (Lausanne) (2015) 0.82
Analysis of poly(ADP-Ribose) polymerases in Arabidopsis telomere biology. PLoS One (2014) 0.81
A metabolic-transcriptional network links sleep and cellular energetics in the brain. Pflugers Arch (2011) 0.80
Molecular clocks in pharmacology. Handb Exp Pharmacol (2013) 0.80
NAD(+) maintenance attenuates light induced photoreceptor degeneration. Exp Eye Res (2012) 0.80
Metabolism as an integral cog in the mammalian circadian clockwork. Crit Rev Biochem Mol Biol (2013) 0.80
Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism. Biology (Basel) (2015) 0.80
Genetic insights on sleep schedules: this time, it's PERsonal. Trends Genet (2012) 0.79
Modelling and analysis of the feeding regimen induced entrainment of hepatocyte circadian oscillators using petri nets. PLoS One (2015) 0.79
Proteomics and circadian rhythms: it's all about signaling! Proteomics (2014) 0.79
PARP around the clock. Cell (2010) 0.79
Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism. Am J Physiol Heart Circ Physiol (2016) 0.78
Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP). J Biol Chem (2013) 0.78
Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures. Endocr Rev (2016) 0.78
The PXDLS linear motif regulates circadian rhythmicity through protein-protein interactions. Nucleic Acids Res (2014) 0.77
Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders. Clin Transl Med (2016) 0.77
The circadian coordination of cell biology. J Cell Biol (2016) 0.77
Cancer Clocks Out for Lunch: Disruption of Circadian Rhythm and Metabolic Oscillation in Cancer. Front Cell Dev Biol (2016) 0.76
Circadian rhythms: PARP1 feeds into clocks. Nat Rev Mol Cell Biol (2010) 0.76
Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock. Nat Commun (2016) 0.76
Cross-talk between circadian clocks, sleep-wake cycles, and metabolic networks: Dispelling the darkness. Bioessays (2016) 0.76
The biological clock and the molecular basis of lysosomal storage diseases. JIMD Rep (2015) 0.76
PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. Mol Cell (2017) 0.75
Solving the mystery of human sleep schedules one mutation at a time. Crit Rev Biochem Mol Biol (2013) 0.75
Nutrition and the circadian system. Br J Nutr (2016) 0.75
Epigenetic Control of Circadian Clock Operation during Development. Genet Res Int (2012) 0.75
Physiological processes underlying organ injury in alcohol abuse. Am J Physiol Endocrinol Metab (2016) 0.75
Circadian Oscillations of NADH Redox State Using a Heterologous Metabolic Sensor in Mammalian Cells. J Biol Chem (2016) 0.75
Non-thermal plasma-induced apoptosis is modulated by ATR- and PARP1-mediated DNA damage responses and circadian clock. Oncotarget (2016) 0.75
Transcriptional repression of mitochondrial function in aging: a novel role for the silencing mediator of retinoid and thyroid hormone receptors co-repressor. Antioxid Redox Signal (2012) 0.75
O-GlcNAcylation of a circadian clock protein: dPER taking its sweet time. Genes Dev (2012) 0.75
Modulating NAD(+) metabolism, from bench to bedside. EMBO J (2017) 0.75
Transcriptome genetics using second generation sequencing in a Caucasian population. Nature (2010) 14.85
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell (2002) 9.92
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol (2010) 6.63
Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell (2004) 6.44
System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol (2007) 6.23
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
Patterns of cis regulatory variation in diverse human populations. PLoS Genet (2012) 5.28
Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat Genet (2006) 5.08
Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies. Bioinformatics (2010) 4.56
Mammalian genes are transcribed with widely different bursting kinetics. Science (2011) 4.08
Integration of microRNA miR-122 in hepatic circadian gene expression. Genes Dev (2009) 3.64
The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci (2008) 3.56
Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? Microbiol Mol Biol Rev (2006) 3.31
Crosstalk between components of circadian and metabolic cycles in mammals. Cell Metab (2011) 3.31
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat Struct Mol Biol (2009) 3.26
Circadian rhythms: mechanisms and therapeutic implications. Annu Rev Pharmacol Toxicol (2007) 3.19
Rhythms of mammalian body temperature can sustain peripheral circadian clocks. Curr Biol (2002) 3.05
The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification. Cell Metab (2006) 3.00
ATR prohibits replication catastrophe by preventing global exhaustion of RPA. Cell (2013) 2.99
Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver. PLoS Biol (2011) 2.94
REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol (2009) 2.76
The mammalian circadian timing system: from gene expression to physiology. Chromosoma (2004) 2.67
Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription. Science (2013) 2.66
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell (2012) 2.53
PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science (2005) 2.29
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation. Mol Cell (2008) 2.29
Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites. Nucleic Acids Res (2009) 2.22
Properties, entrainment, and physiological functions of mammalian peripheral oscillators. J Biol Rhythms (2006) 2.21
The period length of fibroblast circadian gene expression varies widely among human individuals. PLoS Biol (2005) 2.13
Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles. PLoS Biol (2012) 2.12
Multiple mechanistically distinct functions of SAGA at the PHO5 promoter. Mol Cell Biol (2003) 2.07
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem (2005) 1.93
Inheritance of silent rDNA chromatin is mediated by PARP1 via noncoding RNA. Mol Cell (2012) 1.93
The loss of circadian PAR bZip transcription factors results in epilepsy. Genes Dev (2004) 1.92
Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally. Science (2012) 1.91
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells. Proc Natl Acad Sci U S A (2011) 1.81
Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1. J Biol Chem (2003) 1.79
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol (2009) 1.79
Rare and common regulatory variation in population-scale sequenced human genomes. PLoS Genet (2011) 1.79
Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor. Genes Dev (2008) 1.78
Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J (2004) 1.74
Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length. Nucleic Acids Res (2007) 1.73
Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock. Neuron (2002) 1.72
Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity. Cell (2013) 1.71
HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination. Nat Neurosci (2011) 1.67
PARP1 ADP-ribosylates lysine residues of the core histone tails. Nucleic Acids Res (2010) 1.64
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair. Nucleic Acids Res (2004) 1.63
Circadian gene expression is resilient to large fluctuations in overall transcription rates. EMBO J (2008) 1.61
SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310. J Cell Sci (2010) 1.60
Arginine methylation regulates DNA polymerase beta. Mol Cell (2006) 1.57
Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses. Mol Cell (2013) 1.52
Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillators. Genes Dev (2012) 1.48
Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. Nat Struct Mol Biol (2013) 1.47
The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. EMBO J (2010) 1.40
Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms. Proc Natl Acad Sci U S A (2006) 1.40
SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis. Eur Heart J (2010) 1.40
PARP-1 and gene regulation: progress and puzzles. Mol Aspects Med (2013) 1.39
The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. J Biol Chem (2012) 1.32
Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Res (2008) 1.32
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase. Oncogene (2003) 1.30
The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity. J Mol Biol (2005) 1.25
Histone acetyl transferases: a role in DNA repair and DNA replication. J Mol Med (Berl) (2002) 1.24
Acetylation regulates the DNA end-trimming activity of DNA polymerase beta. Mol Cell (2002) 1.22
Histone ADP-ribosylation in DNA repair, replication and transcription. Trends Cell Biol (2011) 1.20
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Ann Rheum Dis (2011) 1.19
Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice. J Clin Invest (2004) 1.17
Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes. Mol Cell (2012) 1.17
Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. J Mol Biol (2008) 1.17
Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation. Int J Biochem Cell Biol (2008) 1.16
Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function. FASEB J (2009) 1.15
Allelic mapping bias in RNA-sequencing is not a major confounder in eQTL studies. Genome Biol (2014) 1.12
Localized insulin-like growth factor I delivery to enhance new bone formation. Bone (2003) 1.12
Physiology. Proteasomes keep the circadian clock ticking. Science (2007) 1.08
Circadian gene expression in cultured cells. Methods Enzymol (2005) 1.07
PARP1 is required for adhesion molecule expression in atherogenesis. Cardiovasc Res (2007) 1.06
The post-genomic era of interactive proteomics: facts and perspectives. Proteomics (2002) 1.06
NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells. Biol Chem (2005) 1.06
Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity. Proc Natl Acad Sci U S A (2011) 1.05
Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging. Aging (Albany NY) (2009) 1.05
Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression. BMC Genomics (2010) 1.05
Sex-biased genetic effects on gene regulation in humans. Genome Res (2012) 1.05
Methylation of DNA polymerase beta by protein arginine methyltransferase 1 regulates its binding to proliferating cell nuclear antigen. FASEB J (2006) 1.04
Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression. Mol Cancer Res (2008) 1.03
Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic field. Nucleic Acids Res (2006) 1.01
p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization. J Cell Sci (2009) 1.01
Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome. Mol Cell (2012) 1.01
MYBBP1a is a novel repressor of NF-kappaB. J Mol Biol (2006) 0.99
ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation. FASEB J (2012) 0.98
An epigenetic code for DNA damage repair pathways? Biochem Cell Biol (2005) 0.98
Origins and consequences of transcriptional discontinuity. Curr Opin Cell Biol (2011) 0.97
Genetic and epigenetic regulation of human lincRNA gene expression. Am J Hum Genet (2013) 0.97
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. Biotechniques (2007) 0.96
Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia. Cancer Res (2010) 0.94