Published in PLoS One on July 05, 2017
Hallmarks of cancer: the next generation. Cell (2011) 140.01
DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83
Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med (1995) 26.60
Autophagy as a regulated pathway of cellular degradation. Science (2000) 17.27
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature (2009) 10.59
MAP kinase signalling pathways in cancer. Oncogene (2007) 8.52
Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal (2012) 5.65
Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science (1994) 5.54
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11
Endoplasmic reticulum stress triggers autophagy. J Biol Chem (2006) 5.05
Cancer Statistics, 2017. CA Cancer J Clin (2017) 4.77
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A (2004) 3.93
Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ (2007) 3.50
SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell (2008) 3.32
Emerging regulation and functions of autophagy. Nat Cell Biol (2013) 3.24
SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci (2009) 2.80
Autophagy and human diseases. Cell Res (2013) 2.17
Control of the autophagy maturation step by the MAPK ERK and p38: lessons from environmental carcinogens. Autophagy (2007) 1.50
Catalase gene C-262T polymorphism: importance in ulcerative colitis. J Gastroenterol Hepatol (2013) 1.49
Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol Cancer (2015) 1.39
Regulation of FoxO transcription factors by acetylation and protein-protein interactions. Biochim Biophys Acta (2011) 1.38
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol (2011) 1.35
Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the α-tubulin tyrosination cycle. Cancer Res (2011) 1.28
DNA methylation, nuclear structure, gene expression and cancer. J Cell Biochem Suppl (2000) 1.27
CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer. Urology (2008) 1.24
SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress. Stem Cells (2014) 1.19
Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress. Autophagy (2012) 1.17
Gene expression of antioxidative enzymes in the human heart: increased expression of catalase in the end-stage failing heart. Circulation (2000) 1.14
Discovery of epigenetically masked tumor suppressor genes in endometrial cancer. Mol Cancer Res (2005) 1.12
Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin. J Invest Dermatol (1996) 1.08
MAP Kinases and Prostate Cancer. J Signal Transduct (2011) 1.06
Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagy. Cell Death Differ (2012) 1.01
Catalase overexpression in mammary cancer cells leads to a less aggressive phenotype and an altered response to chemotherapy. Biochem Pharmacol (2011) 0.98
Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle. Angiogenesis (2013) 0.97
Autophagy in cancer. F1000Prime Rep (2015) 0.96
Regulation and function of FoxO transcription factors in normal and cancer stem cells: what have we learned? Curr Drug Targets (2011) 0.95
DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage. Cancer Sci (2005) 0.93
Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma. Int J Cancer (2005) 0.93
Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells. Drug Des Devel Ther (2015) 0.92
Promoter hypermethylation of CCNA1, RARRES1, and HRASLS3 in nasopharyngeal carcinoma. Oral Oncol (2007) 0.88
Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1. Cancer Res Treat (2015) 0.84
Epigenetics in breast and prostate cancer. Methods Mol Biol (2015) 0.79
Multifaceted Modulation of SIRT1 in Cancer and Inflammation. Crit Rev Oncog (2015) 0.79
Differential effects of superoxide dismutase and superoxide dismutase/catalase mimetics on human breast cancer cells. Breast Cancer Res Treat (2015) 0.76