Published in Science on December 01, 2000
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
Apoptosis: a review of programmed cell death. Toxicol Pathol (2007) 17.92
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59
Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06
Autophagy in cell death: an innocent convict? J Clin Invest (2005) 10.70
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
Autophagy: molecular machinery for self-eating. Cell Death Differ (2005) 8.46
Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev (2007) 7.41
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol (2011) 7.40
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A (2005) 7.21
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35
Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun (2005) 6.31
Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol Cell Biol (2001) 6.05
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol (2007) 5.78
Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci U S A (2001) 5.59
Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol (2005) 5.21
Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest (2007) 5.17
Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci U S A (2006) 4.81
Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell (2007) 4.55
Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell (2002) 4.49
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J Cell Biol (2007) 4.30
Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole. J Cell Biol (2001) 4.25
Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc Natl Acad Sci U S A (2004) 4.20
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol (2008) 4.19
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest (2008) 4.09
Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. J Biol Chem (2001) 3.90
Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway. J Biol Chem (2004) 3.86
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci U S A (2009) 3.84
Immune activation in brain aging and neurodegeneration: too much or too little? Neuron (2009) 3.76
Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc Natl Acad Sci U S A (2005) 3.75
Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell (2005) 3.71
Autophagy in the eukaryotic cell. Eukaryot Cell (2002) 3.61
Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci U S A (2005) 3.55
Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A (2007) 3.37
DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J Cell Biol (2002) 3.32
Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress. Eukaryot Cell (2002) 3.21
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem (2010) 3.16
The target of rapamycin (TOR) proteins. Proc Natl Acad Sci U S A (2001) 3.16
Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway. Mol Cell (2001) 3.12
The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell (2007) 3.10
Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol (2013) 3.07
Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat Cell Biol (2009) 3.05
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J Clin Invest (2009) 3.01
The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene (2008) 2.94
Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae. Mol Biol Cell (2004) 2.84
Mitophagy in yeast occurs through a selective mechanism. J Biol Chem (2008) 2.80
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell (2003) 2.72
Death begets failure in the heart. J Clin Invest (2005) 2.72
Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes (2011) 2.72
Autophagy is an immediate macrophage response to Legionella pneumophila. Cell Microbiol (2005) 2.68
Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail Rev (2007) 2.67
The molecular mechanism of autophagy. Mol Med (2003) 2.63
Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy (2010) 2.62
Unconventional secretion of Acb1 is mediated by autophagosomes. J Cell Biol (2010) 2.58
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
Nutrient-sensing mechanisms and pathways. Nature (2015) 2.46
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol (2006) 2.45
Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum (2010) 2.43
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell (2008) 2.38
A role for Rab5 in structuring the endoplasmic reticulum. J Cell Biol (2007) 2.34
Role of Unc51.1 and its binding partners in CNS axon outgrowth. Genes Dev (2004) 2.34
Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae. Proc Natl Acad Sci U S A (2007) 2.27
Role of LAMP-2 in lysosome biogenesis and autophagy. Mol Biol Cell (2002) 2.25
TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth. J Cell Biol (2006) 2.24
Autophagosome supports coxsackievirus B3 replication in host cells. J Virol (2008) 2.24
Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris. Mol Biol Cell (2001) 2.21
Autophagy in ischemic heart disease. Circ Res (2009) 2.20
High-mobility group box 1, oxidative stress, and disease. Antioxid Redox Signal (2011) 2.19
A Salmonella protein causes macrophage cell death by inducing autophagy. J Cell Biol (2003) 2.15
Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology (2011) 2.15
Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways. Gastroenterology (2010) 2.13
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol (2010) 2.12
Specific iron chelators determine the route of ferritin degradation. Blood (2009) 2.10
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci (2011) 2.09
Autophagy links inflammasomes to atherosclerotic progression. Cell Metab (2012) 2.08
Efficient cross-presentation depends on autophagy in tumor cells. Cancer Res (2008) 2.05
A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell (2009) 2.04
Disruption of mitochondrial networks by the human cytomegalovirus UL37 gene product viral mitochondrion-localized inhibitor of apoptosis. J Virol (2003) 2.03
Antibacterial effects of vitamin D. Nat Rev Endocrinol (2011) 2.03
A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. EMBO J (2004) 1.99
Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol (2011) 1.97
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev (2014) 1.96
The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway. Autophagy (2011) 1.93
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One (2010) 1.92
ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem (2010) 1.91
PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep (2009) 1.89
Mitochondria-ros crosstalk in the control of cell death and aging. J Signal Transduct (2011) 1.89
Autophagy and mistargeting of therapeutic enzyme in skeletal muscle in Pompe disease. Mol Ther (2006) 1.88
Autophagy contributes to leaf starch degradation. Plant Cell (2013) 1.85
Liver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury. J Clin Invest (2002) 1.84
Manipulation of rab GTPase function by intracellular bacterial pathogens. Microbiol Mol Biol Rev (2007) 1.82
Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis. Gut (2014) 1.79
Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases. Brain Pathol (2003) 1.75
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy (2008) 1.74
Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript. Free Radic Biol Med (2006) 1.73
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest (2013) 1.72
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Hum Mol Genet (2011) 1.72
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48
Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62
Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett (1993) 13.48
A protein conjugation system essential for autophagy. Nature (1998) 12.71
Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (1997) 11.48
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem (1998) 10.77
Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol (2000) 9.61
Formation process of autophagosome is traced with Apg8/Aut7p in yeast. J Cell Biol (1999) 9.33
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature (1999) 9.29
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem (2000) 8.68
Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J Cell Biol (1992) 8.33
Vacuolar import of proteins and organelles from the cytoplasm. Annu Rev Cell Dev Biol (1999) 7.75
The mitochondrial permeability transition pore and its role in cell death. Biochem J (1999) 7.72
The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J Cell Biol (2000) 7.48
Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature (1995) 7.05
The PI3K-PDK1 connection: more than just a road to PKB. Biochem J (2000) 7.00
Autophagy and related mechanisms of lysosome-mediated protein degradation. Trends Cell Biol (1994) 6.88
Phosphorylation and activation of p70s6k by PDK1. Science (1998) 6.53
Isolation of autophagocytosis mutants of Saccharomyces cerevisiae. FEBS Lett (1994) 6.35
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature (2000) 6.34
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J (1998) 6.28
Studies on the mechanisms of autophagy: formation of the autophagic vacuole. J Cell Biol (1990) 5.79
Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). Nature (2000) 5.71
Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome. J Cell Biol (1997) 5.57
Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene (1997) 5.53
Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway. J Cell Biol (1995) 5.41
A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. J Biol Chem (1998) 5.07
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr Biol (1998) 5.04
Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole. Proc Natl Acad Sci U S A (1996) 4.97
TOR signalling and control of cell growth. Curr Opin Cell Biol (1997) 4.86
Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway. J Biol Chem (1996) 4.85
Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Mol Biol Cell (1999) 4.68
The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta (1998) 4.50
Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole. EMBO J (1998) 4.38
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem (1995) 4.36
A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc Natl Acad Sci U S A (2000) 4.33
Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways. J Cell Biol (2000) 4.30
A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole. J Cell Biol (1997) 4.16
Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. EMBO J (1999) 3.97
The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways. J Biol Chem (2000) 3.97
Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem (1998) 3.93
Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism. J Cell Biol (1997) 3.81
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol (1997) 3.80
Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution. Mol Cell Neurosci (1999) 3.78
The GTPase Ypt7p of Saccharomyces cerevisiae is required on both partner vacuoles for the homotypic fusion step of vacuole inheritance. EMBO J (1995) 3.76
Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast. EMBO J (1999) 3.70
Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu Rev Biochem (2000) 3.44
GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28. EMBO J (2000) 3.39
Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways. Mol Biol Cell (1999) 3.30
Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion. Mol Cell (2000) 3.30
A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole. Mol Biol Cell (1997) 3.27
Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J Biol Chem (2000) 3.25
Transport of a large oligomeric protein by the cytoplasm to vacuole protein targeting pathway. J Cell Biol (1997) 3.05
Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homolog, function together in yeast vacuolar protein trafficking. Mol Cell Biol (1998) 2.80
Divergent modes of autophagy in the methylotrophic yeast Pichia pastoris. J Cell Sci (1995) 2.74
Akt signaling: linking membrane events to life and death decisions. Science (1997) 2.74
Peroxisome degradation in Saccharomyces cerevisiae is dependent on machinery of macroautophagy and the Cvt pathway. J Cell Sci (1999) 2.62
Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein. Mol Biol Cell (1999) 2.48
Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase. Genes Dev (1994) 2.43
Do all programmed cell deaths occur via apoptosis? Proc Natl Acad Sci U S A (1993) 2.35
Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways. Mol Biol Cell (2000) 2.33
Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun (1998) 2.31
Purification and characterization of autophagosomes from rat hepatocytes. Biochem J (1998) 2.20
Guanine nucleotide exchange on heterotrimeric Gi3 protein controls autophagic sequestration in HT-29 cells. J Biol Chem (1996) 2.14
Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. J Cell Biol (1998) 2.13
Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J Cell Sci (2000) 2.10
Vam3p, a new member of syntaxin related protein, is required for vacuolar assembly in the yeast Saccharomyces cerevisiae. J Cell Sci (1997) 2.05
Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion. Mol Biol Cell (2000) 1.95
Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. Br J Haematol (1997) 1.87
Lysosomes, a meeting point of proteins, chaperones, and proteases. J Mol Med (Berl) (1998) 1.59
Acidification of vacuoles is required for autophagic degradation in the yeast, Saccharomyces cerevisiae. J Biochem (1997) 1.57
Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast. FEBS Lett (1998) 1.55
Autophagy. Subcell Biochem (1996) 1.45
Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases. Neuroscience (1999) 1.34
The age-related accumulation of protein carbonyl in rat liver correlates with the age-related decline in liver proteolytic activities. J Gerontol A Biol Sci Med Sci (1999) 1.30
Composition and assembly of the yeast vacuolar H(+)-ATPase complex. J Exp Biol (2000) 1.24
Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity. Biochem J (1992) 1.21
Disappearance of Rohon-Beard neurons from the spinal cord of larval Xenopus laevis. J Comp Neurol (1987) 1.19
Signal transduction pathways in macroautophagy. Cell Signal (1997) 1.16
Concepts of cell death and application to carcinogenesis. Toxicol Pathol (1997) 0.99
Batten's disease: clues to neuronal protein catabolism in lysosomes. J Neurosci Res (2000) 0.93
Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol Cell Biol (1988) 13.27
A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast. J Cell Biol (1995) 12.18
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell (2001) 9.08
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science (1993) 7.86
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J (1998) 7.68
The fungal vacuole: composition, function, and biogenesis. Microbiol Rev (1990) 6.98
Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell (1994) 6.57
Suppressor mutations that restore export of a protein with a defective signal sequence. Cell (1981) 6.33
Mechanisms of protein localization. Microbiol Rev (1983) 6.12
Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Cell (1998) 6.07
Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease. Cell (1987) 5.92
Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant. J Cell Biol (1991) 5.76
Isolation of yeast mutants defective in protein targeting to the vacuole. Proc Natl Acad Sci U S A (1986) 5.71
Intracellular sorting and processing of a yeast vacuolar hydrolase: proteinase A propeptide contains vacuolar targeting information. Mol Cell Biol (1988) 5.42
Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol Cell Biol (1990) 5.25
Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase. EMBO J (1989) 5.12
The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell (1994) 5.10
Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p. EMBO J (1997) 5.05
Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting. J Cell Biol (1988) 4.90
Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant. Mol Biol Cell (1996) 4.71
Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast. Mol Biol Cell (1996) 4.58
A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol (1998) 4.41
Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic (2000) 4.17
A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole. J Cell Biol (1997) 4.16
Phosphoinositides as regulators in membrane traffic. Science (1996) 4.13
The amino terminus of the yeast F1-ATPase beta-subunit precursor functions as a mitochondrial import signal. J Cell Biol (1986) 4.07
Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains. Mol Cell (1998) 4.01
An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast. Proc Natl Acad Sci U S A (1983) 3.95
Characterization of a component of the yeast secretion machinery: identification of the SEC18 gene product. Mol Cell Biol (1988) 3.74
New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion. J Cell Biol (2000) 3.69
Mutations affecting localization of an Escherichia coli outer membrane protein, the bacteriophage lambda receptor. J Mol Biol (1980) 3.62
Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. J Cell Biol (1997) 3.61
The role of phosphoinositides in membrane transport. Curr Opin Cell Biol (2001) 3.57
The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex. J Cell Biol (1989) 3.55
A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. EMBO J (1993) 3.49
Sequence analysis of mutations that prevent export of lambda receptor, an Escherichia coli outer membrane protein. Nature (1980) 3.36
Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast. J Cell Biol (1994) 3.32
The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell (1997) 3.30
Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion. Mol Cell (2000) 3.30
A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole. Mol Biol Cell (1997) 3.27
Yeast vacuolar proenzymes are sorted in the late Golgi complex and transported to the vacuole via a prevacuolar endosome-like compartment. J Cell Biol (1993) 3.25
Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. J Cell Biol (1998) 3.24
Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J Cell Biol (1995) 3.16
Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat Cell Biol (2001) 3.14
Intracellular targeting and import of an F1-ATPase beta-subunit-beta-galactosidase hybrid protein into yeast mitochondria. Proc Natl Acad Sci U S A (1984) 3.02
Receptor-mediated protein sorting to the vacuole in yeast: roles for a protein kinase, a lipid kinase and GTP-binding proteins. Annu Rev Cell Dev Biol (1995) 2.93
A mechanism of protein localization: the signal hypothesis and bacteria. J Cell Biol (1980) 2.91
VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins. EMBO J (1994) 2.90
Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics. Mol Biol Cell (2000) 2.87
Localization and processing of outer membrane and periplasmic proteins in Escherichia coli strains harboring export-specific suppressor mutations. J Biol Chem (1982) 2.85
A previously unidentified gene in the spc operon of Escherichia coli K12 specifies a component of the protein export machinery. Cell (1982) 2.84
Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homolog, function together in yeast vacuolar protein trafficking. Mol Cell Biol (1998) 2.80
Cytoplasm to vacuole trafficking of aminopeptidase I requires a t-SNARE-Sec1p complex composed of Tlg2p and Vps45p. EMBO J (1999) 2.77
Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells. J Cell Biol (1995) 2.74
Phosphoinositide signaling and the regulation of membrane trafficking in yeast. Trends Biochem Sci (2000) 2.72
Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities. J Biol Chem (1994) 2.66
Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast. Mol Biol Cell (1995) 2.64
A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole. Cell (1991) 2.64
A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. J Cell Biol (1996) 2.62
Mutations in the VPS45 gene, a SEC1 homologue, result in vacuolar protein sorting defects and accumulation of membrane vesicles. J Cell Sci (1994) 2.61
Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component. EMBO J (1997) 2.60
The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization. Mol Biol Cell (1995) 2.50
The VPS16 gene product associates with a sedimentable protein complex and is essential for vacuolar protein sorting in yeast. J Biol Chem (1993) 2.50
Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. J Cell Biol (1998) 2.43
A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation. Mol Cell Biol (1991) 2.38
Mutations altering the cellular localization of the phage lambda receptor, an Escherichia coli outer membrane protein. Proc Natl Acad Sci U S A (1978) 2.37
Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis. Mol Cell Biol (1990) 2.32
ARF is required for maintenance of yeast Golgi and endosome structure and function. Mol Biol Cell (1998) 2.32
Alternative pathways for the sorting of soluble vacuolar proteins in yeast: a vps35 null mutant missorts and secretes only a subset of vacuolar hydrolases. Mol Biol Cell (1992) 2.32
GAL2 codes for a membrane-bound subunit of the galactose permease in Saccharomyces cerevisiae. J Bacteriol (1986) 2.30
A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast. Mol Biol Cell (1997) 2.24
Mutants of Saccharomyces cerevisiae that block intervacuole vesicular traffic and vacuole division and segregation. Proc Natl Acad Sci U S A (1990) 2.18
Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J (1999) 2.18
COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants. J Cell Biol (1997) 2.16
Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. Curr Biol (1999) 2.15
A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor. Mol Biol Cell (1997) 2.14
Protein traffic in the yeast endocytic and vacuolar protein sorting pathways. Curr Opin Cell Biol (1998) 2.13
Location, location, location: membrane targeting directed by PX domains. Science (2001) 2.09
Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol Biol Cell (2001) 1.99
Importance of secondary structure in the signal sequence for protein secretion. Proc Natl Acad Sci U S A (1983) 1.98
A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery. EMBO J (1991) 1.93
The AP-3 complex: a coat of many colours. Trends Cell Biol (1998) 1.92
Invertase beta-galactosidase hybrid proteins fail to be transported from the endoplasmic reticulum in Saccharomyces cerevisiae. Mol Cell Biol (1984) 1.91
D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport. J Bacteriol (1984) 1.89
In vitro reconstitution of intercompartmental protein transport to the yeast vacuole. J Cell Biol (1990) 1.85
Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery. Protein Sci (1999) 1.84
Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways. J Biol Chem (1999) 1.80
Clathrin-dependent localization of alpha 1,3 mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae. J Cell Biol (1994) 1.79
Phosphatidylinositol 3-phosphate recognition by the FYVE domain. Mol Cell (1999) 1.76
The class C Vps complex functions at multiple stages of the vacuolar transport pathway. Traffic (2001) 1.73
AtVPS34, a phosphatidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain. Proc Natl Acad Sci U S A (1994) 1.72
Yeast Gga coat proteins function with clathrin in Golgi to endosome transport. Mol Biol Cell (2001) 1.72
Formation of AP-3 transport intermediates requires Vps41 function. Nat Cell Biol (1999) 1.69
Molecular components of the signal sequence that function in the initiation of protein export. J Cell Biol (1982) 1.65
A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development. Mol Cell Biol (1995) 1.64
Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway. EMBO J (1993) 1.59
Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE. J Cell Biol (1998) 1.58
The yeast VPS17 gene encodes a membrane-associated protein required for the sorting of soluble vacuolar hydrolases. J Biol Chem (1993) 1.58
A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins. Mol Cell Biol (1996) 1.56