Published in Int J Biol Sci on January 21, 2009
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell (2010) 5.40
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun (2010) 2.97
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab (2010) 2.89
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell (2011) 2.73
p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54
Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci (2014) 2.37
SIRT1: recent lessons from mouse models. Nat Rev Cancer (2010) 2.07
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem (2010) 1.86
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest (2011) 1.80
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem (2010) 1.65
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. Mol Cell (2011) 1.55
SIRT1 and p53, effect on cancer, senescence and beyond. Biochim Biophys Acta (2010) 1.46
Resveratrol: French paradox revisited. Front Pharmacol (2012) 1.40
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys (2010) 1.34
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc Natl Acad Sci U S A (2010) 1.30
SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta (2011) 1.28
Peptide switch is essential for Sirt1 deacetylase activity. Mol Cell (2011) 1.26
Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells. Int J Biol Sci (2010) 1.24
MicroRNA Regulation of SIRT1. Front Physiol (2012) 1.21
Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. Int J Biol Sci (2010) 1.16
Sirtuins and disease: the road ahead. Front Pharmacol (2012) 1.15
Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem (2012) 1.13
Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis. Antioxid Redox Signal (2013) 1.09
Down-regulation of mir-221 and mir-222 restrain prostate cancer cell proliferation and migration that is partly mediated by activation of SIRT1. PLoS One (2014) 1.06
Energy restriction as an antitumor target of thiazolidinediones. J Biol Chem (2010) 1.06
Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol (2015) 1.03
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol (2011) 1.03
The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis. Front Oncol (2012) 1.01
SIRT1: Regulator of p53 Deacetylation. Genes Cancer (2013) 1.01
Histone modifications in senescence-associated resistance to apoptosis by oxidative stress. Redox Biol (2013) 0.98
Mammalian Sirt1: insights on its biological functions. Cell Commun Signal (2011) 0.98
p30 DBC is a potential regulator of tumorigenesis. Cell Cycle (2009) 0.95
Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer. Oncotarget (2013) 0.95
Peroxisome proliferator activated receptor α ligands as anticancer drugs targeting mitochondrial metabolism. Curr Pharm Biotechnol (2013) 0.95
KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair. PLoS One (2015) 0.94
High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients. Sci Rep (2014) 0.93
SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer. Cancer Med (2014) 0.93
Deacetylation by SIRT1 Reprograms Inflammation and Cancer. Genes Cancer (2013) 0.92
Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma. BMC Cancer (2014) 0.92
Sirtuins, metabolism, and cancer. Front Pharmacol (2012) 0.91
SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells. Oncotarget (2014) 0.90
Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation. Genes Dis (2014) 0.90
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis. Transl Cancer Res (2012) 0.90
Dual role of SIRT1 in UVB-induced skin tumorigenesis. Oncogene (2014) 0.89
Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. Genes Cancer (2013) 0.88
Sirt1 is a tumor promoter in lung adenocarcinoma. Oncol Lett (2014) 0.88
Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3β Signaling Pathway and Promotes Hepatocellular Injury. J Biol Chem (2015) 0.87
Novel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach. Oncotarget (2014) 0.87
Systemic regulation of mammalian ageing and longevity by brain sirtuins. Nat Commun (2014) 0.87
Sirtuins, bioageing, and cancer. J Aging Res (2011) 0.86
Resveratrol (trans-3,5,4'-trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF-κB. Mol Nutr Food Res (2011) 0.86
"Micromanaging" metabolic syndrome. Cell Cycle (2011) 0.86
The role of dietary histone deacetylases (HDACs) inhibitors in health and disease. Nutrients (2014) 0.85
The controversial role of Sirtuins in tumorigenesis - SIRT7 joins the debate. Cell Res (2012) 0.85
The molecular genetics of sirtuins: association with human longevity and age-related diseases. Int J Mol Epidemiol Genet (2010) 0.85
SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation. Int J Biol Sci (2013) 0.84
Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase. Biochem J (2013) 0.84
Medicinal chemistry of the epigenetic diet and caloric restriction. Curr Med Chem (2013) 0.83
SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer. Cell Death Dis (2015) 0.83
SIRT1 inhibits the mouse intestinal motility and epithelial proliferation. Am J Physiol Gastrointest Liver Physiol (2011) 0.83
Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis. Int J Clin Exp Med (2015) 0.81
SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing. Int J Biol Sci (2014) 0.81
The sirtuins in the pathogenesis of cancer. Clin Epigenetics (2010) 0.81
Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells. BMC Cancer (2015) 0.80
Sirtuin functions and modulation: from chemistry to the clinic. Clin Epigenetics (2016) 0.80
Resveratrol differentially regulates NAMPT and SIRT1 in Hepatocarcinoma cells and primary human hepatocytes. PLoS One (2014) 0.80
The role of p53 in cancer drug resistance and targeted chemotherapy. Oncotarget (2016) 0.79
A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells. Anticancer Res (2016) 0.79
Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death. Cell Death Dis (2014) 0.79
The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal (2014) 0.79
Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylases. Oncogene (2014) 0.79
SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of "cancer cells with neural stemness" in a p53-dependent manner. Neuro Oncol (2014) 0.79
The role of SIRT1 in cancer: the saga continues. Am J Pathol (2014) 0.78
Biochemistry. Red wine, toast of the town (again). Science (2013) 0.78
Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. Cell Cycle (2012) 0.78
Bisindole-PBD regulates breast cancer cell proliferation via SIRT-p53 axis. Cancer Biol Ther (2015) 0.78
Role of the CacyBP/SIP protein in gastric cancer. Oncol Lett (2015) 0.78
Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders. Clin Transl Med (2016) 0.77
Sirt1 and cell migration. Cell Adh Migr (2010) 0.77
Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1. Oncotarget (2016) 0.77
SIRT1 at the crossroads of AKT1 and ERβ in malignant pleural mesothelioma cells. Oncotarget (2016) 0.77
SRT1720 induces lysosomal-dependent cell death of breast cancer cells. Mol Cancer Ther (2014) 0.77
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer. Clin Exp Metastasis (2015) 0.76
Protein mislocalization: mechanisms, functions and clinical applications in cancer. Biochim Biophys Acta (2014) 0.76
AAV8-mediated Sirt1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease. Mol Ther Methods Clin Dev (2014) 0.76
Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells. Sci Rep (2015) 0.76
miRNA regulation of Sirtuin-1 expression in human astrocytoma. Oncol Lett (2016) 0.76
Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions. Cell Rep (2015) 0.76
Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress. Cell Death Dis (2015) 0.76
Expression of the significance of silent information regulator type-1 in Angioimmunoblastic T-cell lymphoma is greater association with tumorigenesis and has strong implications for adverse prognosis. Cell Cycle (2016) 0.75
SIRT1 promotes metastasis of human osteosarcoma cells. Oncotarget (2016) 0.75
Nucleus or cytoplasm? The mysterious case of SIRT1's subcellular localization. Cell Cycle (2016) 0.75
Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging. Sci Rep (2016) 0.75
Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL). Cancer Biol Ther (2016) 0.75
Advances in epigenetic glioblastoma therapy. Oncotarget (2017) 0.75
Tumor-associated NADH oxidase (tNOX)-NAD+-sirtuin 1 axis contributes to oxaliplatin-induced apoptosis of gastric cancer cells. Oncotarget (2017) 0.75
AAV-mediated Sirt1 overexpression in skeletal muscle activates oxidative capacity but does not prevent insulin resistance. Mol Ther Methods Clin Dev (2016) 0.75
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21
The Sir2 family of protein deacetylases. Annu Rev Biochem (2004) 9.28
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev (2006) 8.48
Sir2 links chromatin silencing, metabolism, and aging. Genes Dev (2000) 5.95
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab (2008) 5.44
Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A (2008) 5.21
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene (2000) 4.90
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
DBC1 is a negative regulator of SIRT1. Nature (2008) 4.66
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science (2004) 4.61
The age of cancer. Nature (2000) 4.32
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene (2007) 3.85
SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One (2008) 3.66
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet (2006) 3.54
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell (2008) 3.38
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell (2008) 3.32
BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res (2006) 3.29
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One (2008) 3.25
SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res (2007) 2.98
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res (2008) 2.97
Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res (2005) 2.94
Sirtuins--novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov (2008) 2.89
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
Mutations that increase the life span of C. elegans inhibit tumor growth. Science (2006) 2.48
SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42
Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia (2005) 2.15
Function of the SIRT1 protein deacetylase in cancer. Biotechnol J (2007) 1.88
The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells. Mol Cancer Res (2003) 1.85
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet (2003) 1.77
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. Arch Dermatol Res (2006) 1.73
A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells. Biochem Biophys Res Commun (2008) 1.52
SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity. J Cell Physiol (2007) 1.36
Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem J (2007) 1.36
SirT1 fails to affect p53-mediated biological functions. Aging Cell (2006) 1.33
SIRT1: tumor promoter or tumor suppressor? Med Hypotheses (2006) 1.33
Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction. Mech Ageing Dev (2005) 1.30
SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Mol Cancer Res (2008) 1.30
Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem (2008) 1.27
Obesity hormone leptin: a new target in breast cancer? Breast Cancer Res (2007) 1.10
BRCA1 and acetyl-CoA carboxylase: the metabolic syndrome of breast cancer. Mol Carcinog (2008) 1.08
Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations. Hum Mol Genet (2008) 1.01
Knockout mouse models and mammary tumorigenesis. Semin Cancer Biol (2001) 0.93