Published in J Exp Med on July 26, 2017
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov (2008) 7.64
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature (2005) 7.18
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol (2003) 7.06
Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol (2003) 6.95
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83
A PCR primer bank for quantitative gene expression analysis. Nucleic Acids Res (2003) 6.76
Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol (2009) 6.10
Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc Natl Acad Sci U S A (1996) 4.69
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med (2008) 4.24
The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol (2008) 4.09
Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol (2014) 3.77
A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity (2004) 3.76
Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells. Immunity (2013) 3.51
Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D. Nat Immunol (2008) 3.14
Effect of NKG2D ligand expression on host immune responses. Immunol Rev (2010) 3.08
Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol (1996) 2.98
Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat Immunol (2015) 2.73
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science (2014) 2.59
Oncogenic stress sensed by the immune system: role of natural killer cell receptors. Nat Rev Immunol (2009) 2.44
Characteristics of natural killer cells in the murine intestinal epithelium and lamina propria. J Exp Med (1982) 2.12
Paneth cells as a site of origin for intestinal inflammation. Nature (2013) 2.09
Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol (2004) 1.96
Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness. Nat Immunol (2013) 1.88
CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells. Eur J Immunol (2009) 1.83
Immortalization of mouse intestinal epithelial cells by the SV40-large T gene. Phenotypic and immune characterization of the MODE-K cell line. J Immunol Methods (1993) 1.72
Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells. J Immunol (2003) 1.72
Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D. J Immunol (2007) 1.71
Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. J Immunol (2010) 1.60
Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria. Immunity (2015) 1.41
Quantification of crypt and stem cell evolution in the normal and neoplastic human colon. Cell Rep (2014) 1.30
Paneth cells and innate mucosal immunity. Curr Opin Gastroenterol (2010) 1.30
NKG2D Receptor and Its Ligands in Host Defense. Cancer Immunol Res (2015) 1.25
Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature (2014) 1.23
Resistance to cutaneous graft-vs.-host disease is not induced in T cell receptor delta gene-mutant mice. J Exp Med (1996) 1.11
Human small-intestinal epithelium contains functional natural killer lymphocytes. Gastroenterology (2003) 1.05
Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection. Int Immunol (2007) 1.05
Altered distribution of mucosal NK cells during HIV infection. Mucosal Immunol (2011) 1.04
An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity. Mucosal Immunol (2010) 1.03
Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease. Gut (2013) 1.02
A subset of IL-10-producing gammadelta T cells protect the liver from Listeria-elicited, CD8(+) T cell-mediated injury. Eur J Immunol (2008) 1.01
Role of NKT cells in the digestive system. III. Role of NKT cells in intestinal immunity. Am J Physiol Gastrointest Liver Physiol (2007) 0.95
NK cells and type 1 innate lymphoid cells: partners in host defense. Nat Immunol (2016) 0.94
Involvement of endoplasmic reticulum stress in inflammatory bowel disease: a different implication for colonic and ileal disease? PLoS One (2011) 0.92
Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death. Autophagy (2012) 0.92
The unfolded protein response and its role in intestinal homeostasis and inflammation. Exp Cell Res (2011) 0.91
CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. J Exp Med (2011) 0.88
The unfolded protein response in immunity and inflammation. Nat Rev Immunol (2016) 0.86
Post-transcriptional regulation of ULBP1 ligand for the activating immunoreceptor NKG2D involves 3' untranslated region. Hum Immunol (2011) 0.85
A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells. Elife (2015) 0.83
Value of concomitant endoscopic balloon dilation for intestinal stricture during long-term infliximab therapy in patients with Crohn's disease. Dig Endosc (2012) 0.81
Anti-NKG2D monoclonal antibody (NNC0142-0002) in active Crohn's disease: a randomised controlled trial. Gut (2016) 0.77
Toll-like receptor 4 engagement contributes to expression of NKG2D ligands by renal tubular epithelial cells. Nephrol Dial Transplant (2011) 0.76
Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci (2015) 1.71
NK cells and type 1 innate lymphoid cells: partners in host defense. Nat Immunol (2016) 0.94
C13orf31 (FAMIN) is a central regulator of immunometabolic function. Nat Immunol (2016) 0.90
A distinct innate lymphoid cell population regulates tumor-associated T cells. Nat Med (2017) 0.79
Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection. J Exp Med (2016) 0.78
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis. J Exp Med (2017) 0.75
Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection. J Immunol (2017) 0.75
Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy. Cell Death Dis (2022) 0.75
In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Sci Signal (2017) 0.75
Tetramer Immunization and Selection Followed by CELLISA Screening to Generate Monoclonal Antibodies against the Mouse Cytomegalovirus m12 Immunoevasin. J Immunol (2020) 0.75
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity. Nat Immunol (2019) 0.75
Cutting Edge: IL-2-Induced Expression of the Amino Acid Transporters SLC1A5 and CD98 Is a Prerequisite for NKG2D-Mediated Activation of Human NK Cells. J Immunol (2017) 0.75