MicroRNA-34a suppresses colorectal cancer metastasis by regulating Notch signaling.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28781671)

Published in Oncol Lett on June 21, 2017

Authors

Xuemei Zhang1,2,3, Feiyan Ai1,2, Xiayu Li1,2, Li Tian1,2, Xiaoyan Wang1,2, Shourong Shen1,2, Fen Liu1,2

Author Affiliations

1: Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China.
2: Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha, Hunan 410008, P.R. China.
3: Cancer Research Institute, Central South University, Changsha, Hunan 410013, P.R. China.

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

Hallmarks of cancer: the next generation. Cell (2011) 140.01

Cancer statistics, 2012. CA Cancer J Clin (2012) 87.38

The functions of animal microRNAs. Nature (2004) 64.85

Cancer statistics, 2016. CA Cancer J Clin (2016) 32.95

Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature (2007) 21.53

The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72

Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell (2007) 14.58

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene (2007) 10.79

Retracted A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell (2009) 10.51

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med (2011) 6.85

MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene (2007) 6.55

The miR-34 family in cancer and apoptosis. Cell Death Differ (2009) 5.92

Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci U S A (2007) 5.50

Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J (2004) 4.77

p53 enters the microRNA world. Cancer Cell (2007) 3.78

MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res (2009) 3.57

MicroRNAs in cancer. Annu Rev Pathol (2013) 3.50

Recent insights into the role of Notch signaling in tumorigenesis. Blood (2005) 3.37

Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc Natl Acad Sci U S A (1995) 3.33

Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. Cancer Res (2010) 3.21

A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Mol Cancer Res (2008) 2.77

A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. Cell Stem Cell (2013) 2.68

Towards a pan-European consensus on the treatment of patients with colorectal liver metastases. Eur J Cancer (2006) 2.51

Notch tumor suppressor function. Oncogene (2008) 2.26

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest (2014) 2.01

MicroRNA regulation of cancer stem cells. Cancer Res (2011) 1.84

MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis (2010) 1.73

From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell (2014) 1.70

Colorectal cancer screening: prospects for molecular stool analysis. Nat Rev Cancer (2005) 1.64

miR-34: from bench to bedside. Oncotarget (2014) 1.59

MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1. Oncogene (2012) 1.54

Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence. Clin Cancer Res (2012) 1.50

Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PLoS One (2011) 1.48

Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS One (2012) 1.34

MicroRNA-34a: a potential therapeutic target in human cancer. Cell Death Dis (2014) 1.32

Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer. BMC Cancer (2012) 1.30

MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. Carcinogenesis (2011) 1.29

A miR-34a-SIRT6 axis in the squamous cell differentiation network. EMBO J (2013) 1.18

SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition. EMBO J (2013) 1.09

[2010 TNM system: on the 7th edition of TNM classification of malignant tumors]. Pathologe (2010) 1.07

microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer. Mol Cancer (2014) 1.05

MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme. Cancer Biol Ther (2011) 1.05

Current understanding of the molecular biology of pancreatic neuroendocrine tumors. J Natl Cancer Inst (2013) 0.96

Notch1 activation is a poor prognostic factor in patients with gastric cancer. Br J Cancer (2014) 0.95

miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment. Cell Rep (2014) 0.94

Functional role of miR-34 family in human cancer. Curr Drug Targets (2013) 0.88

NOTCH1 signaling contributes to cell growth, anti-apoptosis and metastasis in salivary adenoid cystic carcinoma. Oncotarget (2014) 0.86

Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS One (2013) 0.85