Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP.

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Published in Stem Cells Int on July 19, 2017

Authors

Jarmon G Lees1,2, David K Gardner1,2, Alexandra J Harvey1,2

Author Affiliations

1: School of BioSciences, University of Melbourne, Parkville, VIC 3010, Australia.
2: ARC Special Research Initiative, Stem Cells Australia, Melbourne, VIC, Australia.

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Oxygen consumption and energy metabolism of the early mouse embryo. Mol Reprod Dev (1996) 1.14