Published in Cell on May 13, 2010
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Female sex bias in human embryonic stem cell lines. Stem Cells Dev (2011) 0.99
Primed pluripotent cell lines derived from various embryonic origins and somatic cells in pig. PLoS One (2013) 0.99
Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem Cell Reports (2014) 0.98
Reactivation of the inactive X chromosome in development and reprogramming. Cell Mol Life Sci (2012) 0.98
X-chromosome inactivation in rett syndrome human induced pluripotent stem cells. Front Psychiatry (2012) 0.97
Lineage-specific function of the noncoding Tsix RNA for Xist repression and Xi reactivation in mice. Genes Dev (2011) 0.96
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Oxygen levels that optimize TSC culture are identified by maximizing growth rates and minimizing stress. Placenta (2011) 0.95
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Establishment of LIF-dependent human iPS cells closely related to basic FGF-dependent authentic iPS cells. PLoS One (2012) 0.88
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Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts. J Neurosci Methods (2013) 0.83
Demarcation of stable subpopulations within the pluripotent hESC compartment. PLoS One (2013) 0.83
Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels. PLoS One (2013) 0.83
HIF hits Wnt in the stem cell niche. Nat Cell Biol (2010) 0.83
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Comparative study of hematopoietic differentiation between human embryonic stem cell lines. PLoS One (2011) 0.82
Systematic optimization of human pluripotent stem cells media using Design of Experiments. Sci Rep (2015) 0.82
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CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes. Sci Rep (2014) 0.81
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Regulation of X-chromosome dosage compensation in human: mechanisms and model systems. Philos Trans R Soc Lond B Biol Sci (2017) 0.80
Genetic and epigenetic X-chromosome variations in a parthenogenetic human embryonic stem cell line. J Assist Reprod Genet (2010) 0.80
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
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Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
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Mediator and cohesin connect gene expression and chromatin architecture. Nature (2010) 14.34
BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell (2011) 14.34
Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science (2008) 13.79
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol (2009) 12.40
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
Control of pancreas and liver gene expression by HNF transcription factors. Science (2004) 12.05
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c-Myc regulates transcriptional pause release. Cell (2010) 11.64
Divergent transcription from active promoters. Science (2008) 11.03
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell (2008) 10.68
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev (2002) 10.06
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell (2005) 9.84
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Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell (2013) 9.55
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DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04
Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med (2004) 8.89
Induction of tumors in mice by genomic hypomethylation. Science (2003) 8.86
Direct cell reprogramming is a stochastic process amenable to acceleration. Nature (2009) 8.71
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res (2005) 8.69
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (2003) 8.48
c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2007) 8.46
Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell (2013) 8.37
Transcriptional amplification in tumor cells with elevated c-Myc. Cell (2012) 8.24
YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell (2013) 7.99
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A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol (2008) 7.91
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52
Super-enhancers in the control of cell identity and disease. Cell (2013) 7.50
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39
Chromatin immunoprecipitation and microarray-based analysis of protein location. Nat Protoc (2006) 7.29
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17
Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell (2011) 7.03
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol Cell (2010) 6.88
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A (2006) 6.80
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Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis (2006) 6.64
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56
Computational discovery of gene modules and regulatory networks. Nat Biotechnol (2003) 6.55
Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays. Nat Genet (2004) 6.33
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Chromosomal instability and tumors promoted by DNA hypomethylation. Science (2003) 6.02
Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature (2007) 5.81
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Profiling critical cancer gene mutations in clinical tumor samples. PLoS One (2009) 5.63
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Human macrophage activation programs induced by bacterial pathogens. Proc Natl Acad Sci U S A (2002) 5.18
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Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A (2010) 5.00