Origins and implications of pluripotent stem cell variability and heterogeneity.

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Deconstructing transcriptional heterogeneity in pluripotent stem cells. Nature (2014) 1.91

Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nat Med (2016) 1.32

Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells. Nucleic Acids Res (2014) 1.26

Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCs. PLoS Genet (2016) 1.19

Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly. Nat Struct Mol Biol (2015) 1.19

Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells. Nat Methods (2015) 1.04

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Cell therapy for type 1 diabetes. QJM (2014) 0.99

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Ectopic transplantation sites for cell-based therapy. Curr Opin Organ Transplant (2014) 0.90

Natural underlying mtDNA heteroplasmy as a potential source of intra-person hiPSC variability. EMBO J (2016) 0.89

Concise review: pluripotent stem cell-based regenerative applications for failing β-cell function. Stem Cells Transl Med (2014) 0.88

Single-cell analysis of transcription kinetics across the cell cycle. Elife (2016) 0.88

MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency. Cell Stem Cell (2016) 0.87

Mathematical approaches to modeling development and reprogramming. Proc Natl Acad Sci U S A (2014) 0.87

The implementation of novel collaborative structures for the identification and resolution of barriers to pluripotent stem cell translation. Stem Cells Dev (2013) 0.86

Advancing stem cell therapy from bench to bedside: lessons from drug therapies. J Transl Med (2014) 0.85

Familial Alzheimer's disease modelling using induced pluripotent stem cell technology. World J Stem Cells (2014) 0.84

TeratoScore: Assessing the Differentiation Potential of Human Pluripotent Stem Cells by Quantitative Expression Analysis of Teratomas. Stem Cell Reports (2015) 0.83

Endogenous WNT signaling regulates hPSC-derived neural progenitor cell heterogeneity and specifies their regional identity. Stem Cell Reports (2014) 0.83

Fast and efficient multitransgenic modification of human pluripotent stem cells. Hum Gene Ther Methods (2014) 0.82

Collective dynamics of stem cell populations. Proc Natl Acad Sci U S A (2014) 0.82

Single-Cell XIST Expression in Human Preimplantation Embryos and Newly Reprogrammed Female Induced Pluripotent Stem Cells. Stem Cells (2015) 0.82

Cell Cycle-Driven Heterogeneity: On the Road to Demystifying the Transitions between "Poised" and "Restricted" Pluripotent Cell States. Stem Cells Int (2015) 0.81

Human induced hepatic lineage-oriented stem cells: autonomous specification of human iPS cells toward hepatocyte-like cells without any exogenous differentiation factors. PLoS One (2015) 0.80

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Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells. PLoS One (2015) 0.78

Cell fusion enhances mesendodermal differentiation of human induced pluripotent stem cells. Stem Cells Dev (2014) 0.78

Computational analysis of signaling patterns in single cells. Semin Cell Dev Biol (2014) 0.78

Directed differentiation of pluripotent stem cells to kidney cells. Semin Nephrol (2014) 0.78

Stem cells and the evolving notion of cellular identity. Philos Trans R Soc Lond B Biol Sci (2015) 0.78

Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse. PLoS One (2015) 0.78

Selective microRNA-Offset RNA expression in human embryonic stem cells. PLoS One (2015) 0.78

Technology advancement for integrative stem cell analyses. Tissue Eng Part B Rev (2014) 0.77

A new route to human embryonic stem cells. Nat Med (2013) 0.77

Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71. Sci Rep (2015) 0.77

Hand-held and integrated single-cell pipettes. J Am Chem Soc (2014) 0.77

Cancer stem cell signaling pathways. Medicine (Baltimore) (2016) 0.77

Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia. Sci Rep (2015) 0.77

Quantitative Analysis of Robustness of Dynamic Response and Signal Transfer in Insulin mediated PI3K/AKT Pathway. Comput Chem Eng (2014) 0.76

Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation. Elife (2015) 0.76

Computational Tools for Stem Cell Biology. Trends Biotechnol (2016) 0.76

Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. Mol Brain (2016) 0.76

Epigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation. Int J Obes (Lond) (2015) 0.76

Enhancing mammary differentiation by overcoming lineage-specific epigenetic modification and signature gene expression of fibroblast-derived iPSCs. Cell Death Dis (2014) 0.75

Trace elements during primordial plexiform network formation in human cerebral organoids. PeerJ (2017) 0.75

Selective de-repression of germ cell-specific genes in mouse embryonic fibroblasts in a permissive epigenetic environment. Sci Rep (2016) 0.75

A metric and workflow for quality control in the analysis of heterogeneity in phenotypic profiles and screens. Methods (2015) 0.75

Molecular characterisation of stromal populations derived from human embryonic stem cells: Similarities to immortalised bone marrow derived stromal stem cells. Bone Rep (2015) 0.75

The silver lining of induced pluripotent stem cell variation. Stem Cell Investig (2016) 0.75

Epigenetic Research in Neuropsychiatric Disorders: the "Tissue Issue". Curr Behav Neurosci Rep (2016) 0.75

Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines. Sci Rep (2016) 0.75

Understanding development and stem cells using single cell-based analyses of gene expression. Development (2017) 0.75

Reprogramming by lineage specifiers: blurring the lines between pluripotency and differentiation. Curr Opin Genet Dev (2014) 0.75

Neural stem and progenitor cell fate transition requires regulation of Musashi1 function. BMC Dev Biol (2015) 0.75

Dynamic Heterogeneity of Brachyury in Mouse Epiblast Stem Cells Mediates Distinct Response to Extrinsic Bone Morphogenetic Protein (BMP) Signaling. J Biol Chem (2016) 0.75

Expandable and Rapidly Differentiating Human Induced Neural Stem Cell Lines for Multiple Tissue Engineering Applications. Stem Cell Reports (2016) 0.75

A Blueprint for a Synthetic Genetic Feedback Controller to Reprogram Cell Fate. Cell Syst (2017) 0.75

Donor Dependent Variations in Hematopoietic Differentiation among Embryonic and Induced Pluripotent Stem Cell Lines. PLoS One (2016) 0.75

Co-fabrication of chitosan and epoxy photoresist to form microwell arrays with permeable hydrogel bottoms. Biomaterials (2015) 0.75

Stem Cell Extracellular Vesicles: Extended Messages of Regeneration. Annu Rev Pharmacol Toxicol (2016) 0.75

Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP. Stem Cells Int (2017) 0.75

Biologically Relevant Heterogeneity: Metrics and Practical Insights. SLAS Discov (2017) 0.75

An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells. NPJ Syst Biol Appl (2017) 0.75

Activation of Lineage Regulators and Transposable Elements across a Pluripotent Spectrum. Stem Cell Reports (2017) 0.75

Manufacturing Cell Therapies Using Engineered Biomaterials. Trends Biotechnol (2017) 0.75

Nanog Dynamics in Mouse Embryonic Stem Cells: Results from Systems Biology Approaches. Stem Cells Int (2017) 0.75

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42

Embryonic stem cell lines derived from human blastocysts. Science (1998) 65.53

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80

Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93

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Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58

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An extended transcriptional network for pluripotency of embryonic stem cells. Cell (2008) 14.64

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Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94

New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature (2007) 13.54

BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell (2003) 13.47

Nanog safeguards pluripotency and mediates germline development. Nature (2007) 13.01

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15

Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature (2007) 11.72

Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24

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Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev (1998) 8.51

Copy number variation and selection during reprogramming to pluripotency. Nature (2011) 8.24

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell (2011) 8.21

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Naive and primed pluripotent states. Cell Stem Cell (2009) 7.15

Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature (2010) 7.05

Control of the embryonic stem cell state. Cell (2011) 6.89

Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell (2011) 6.82

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The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Nat Cell Biol (2006) 5.74

FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development (2007) 5.62

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Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. Cell Stem Cell (2011) 3.31

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Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol (2011) 3.25

MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell (2010) 3.18

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Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature (2010) 2.36

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