Published in Annu Rev Cell Biol on January 01, 1987
Exon amplification: a strategy to isolate mammalian genes based on RNA splicing. Proc Natl Acad Sci U S A (1991) 3.43
Selection of splice sites in pre-mRNAs with short internal exons. Mol Cell Biol (1991) 3.02
Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. Proc Natl Acad Sci U S A (1991) 2.81
Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing. Mol Cell Biol (1991) 1.90
The rat alpha-tropomyosin gene generates a minimum of six different mRNAs coding for striated, smooth, and nonmuscle isoforms by alternative splicing. Mol Cell Biol (1988) 1.89
The contribution of exon-skipping events on chromosome 22 to protein coding diversity. Genome Res (2001) 1.83
Differential exon usage involving an unusual splicing mechanism generates at least eight types of NCAM cDNA in mouse brain. EMBO J (1989) 1.76
Multiple positive and negative 5' regulatory elements control the cell-type-specific expression of the embryonic skeletal myosin heavy-chain gene. Mol Cell Biol (1987) 1.73
A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. Mol Cell Biol (1996) 1.65
Identification of a novel neuronal C-SRC exon expressed in human brain. Mol Cell Biol (1990) 1.63
The concentration of B52, an essential splicing factor and regulator of splice site choice in vitro, is critical for Drosophila development. Mol Cell Biol (1994) 1.62
Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. Nucleic Acids Res (1993) 1.61
Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA. Biochem J (2002) 1.30
Cell type specific trans-acting factors are involved in alternative splicing of human fibronectin pre-mRNA. EMBO J (1989) 1.27
Intronic sequence with both negative and positive effects on the regulation of alternative transcripts of the chicken beta tropomyosin transcripts. Nucleic Acids Res (1992) 1.27
An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs. EMBO J (1990) 1.27
Potential for two isoforms of the A1 ribonucleoprotein in Xenopus laevis. Proc Natl Acad Sci U S A (1990) 1.20
Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain. Mol Cell Biol (1990) 1.12
Myosin light-chain 1/3 gene alternative splicing: cis regulation is based upon a hierarchical compatibility between splice sites. Mol Cell Biol (1990) 1.09
Challenges in design and characterization of ligand-targeted drug delivery systems. J Control Release (2012) 1.07
Cell-type-specific expression of alternatively spliced human fibronectin IIICS mRNAs. Mol Cell Biol (1990) 1.03
Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript. Biochem J (1993) 1.01
Accumulation of fetal fibronectin mRNAs during the development of rat cardiac hypertrophy induced by pressure overload. J Clin Invest (1991) 0.99
In vitro splicing of fibronectin pre-mRNAs. Nucleic Acids Res (1990) 0.94
A subfragment of the beta tropomyosin gene is alternatively spliced when transfected into differentiating muscle cells. Nucleic Acids Res (1989) 0.94
Alternative mRNA splicing generates multiple forms of peptidyl-glycine alpha-amidating monooxygenase in rat atrium. Proc Natl Acad Sci U S A (1989) 0.90
Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities. Proc Natl Acad Sci U S A (1991) 0.90
Intracellular traffic of newly synthesized proteins. Current understanding and future prospects. J Clin Invest (1989) 0.89
Alternative 5' splice site selection induced by heat shock. Mol Cell Biol (1994) 0.88
Production of rat soluble and membrane-bound catechol O-methyltransferase forms from bifunctional mRNAs. Biochem J (1993) 0.87
Regulation of acetylcholine receptor alpha subunit variants in human myasthenia gravis. Quantification of steady-state levels of messenger RNA in muscle biopsy using the polymerase chain reaction. J Clin Invest (1994) 0.87
Diversity of color vision: not all Australian marsupials are trichromatic. PLoS One (2010) 0.85
Multiple forms of chicken alpha 3(VI) collagen chain generated by alternative splicing in type A repeated domains. J Cell Biol (1990) 0.85
Relative exon affinities and suboptimal splice site signals lead to non-equivalence of two cassette exons. Nucleic Acids Res (1995) 0.84
Novel ZIP kinase isoform lacks leucine zipper. Arch Biochem Biophys (2006) 0.83
The related transcriptional enhancer factor-1 isoform, TEAD4(216), can repress vascular endothelial growth factor expression in mammalian cells. PLoS One (2012) 0.75
Bone marrow cells regenerate infarcted myocardium. Nature (2001) 21.24
Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med (2001) 10.03
Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A (2001) 7.19
Alternative splicing in the control of gene expression. Annu Rev Genet (1989) 6.18
Alternative splicing: a ubiquitous mechanism for the generation of multiple protein isoforms from single genes. Annu Rev Biochem (1987) 5.79
Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell (1993) 4.90
Transcriptional and posttranscriptional control of c-myc during myogenesis: its mRNA remains inducible in differentiated cells and does not suppress the differentiated phenotype. Mol Cell Biol (1986) 4.46
Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev (1991) 4.28
Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci U S A (1988) 4.23
Scanning from an independently specified branch point defines the 3' splice site of mammalian introns. Nature (1989) 4.18
Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev (1992) 4.10
Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated. J Biol Chem (1984) 4.01
Commitment, fusion and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis. Cell (1978) 3.96
Type beta transforming growth factor is an inhibitor of myogenic differentiation. Proc Natl Acad Sci U S A (1986) 3.83
Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev (1993) 3.63
Reversal of terminal differentiation and control of DNA replication: cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication. Cell (1993) 3.42
Moloney murine sarcoma proviral DNA is a transcriptional unit. Nature (1980) 3.13
Myocardial cell death in human diabetes. Circ Res (2000) 3.12
Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem. Proc Natl Acad Sci U S A (1984) 3.05
Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science (1994) 3.05
Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene. Cell (1985) 3.02
Scanning and competition between AGs are involved in 3' splice site selection in mammalian introns. Mol Cell Biol (1993) 2.98
Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy. Circ Res (2001) 2.89
Mutually exclusive splicing of alpha-tropomyosin exons enforced by an unusual lariat branch point location: implications for constitutive splicing. Cell (1989) 2.84
A muscle-specific enhancer is located at the 3' end of the myosin light-chain 1/3 gene locus. Genes Dev (1988) 2.71
All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner. Science (1986) 2.57
Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing. J Biol Chem (1984) 2.49
hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Mol Cell Biol (1993) 2.41
Reversibility of muscle differentiation in the absence of commitment: analysis of a myogenic cell line temperature-sensitive for commitment. Cell (1983) 2.37
Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. J Clin Invest (1987) 2.37
Molecular characterization of two myosin heavy chain genes expressed in the adult heart. Nature (1982) 2.28
Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells. Neuron (1990) 2.20
A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. Development (1993) 2.13
Incremental reductions of positive charge within the S4 region of a voltage-gated K+ channel result in corresponding decreases in gating charge. Neuron (1992) 2.09
MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proc Natl Acad Sci U S A (1993) 2.07
Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice. Genes Dev (1991) 2.07
Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD. Science (1994) 2.02
Complete nucleotide and encoded amino acid sequence of a mammalian myosin heavy chain gene. Evidence against intron-dependent evolution of the rod. J Mol Biol (1986) 1.97
Alpha-tropomyosin gene organization. Alternative splicing of duplicated isotype-specific exons accounts for the production of smooth and striated muscle isoforms. J Biol Chem (1987) 1.96
IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes (2001) 1.92
Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J (1994) 1.91
Co-expression of multiple myosin heavy chain genes, in addition to a tissue-specific one, in extraocular musculature. J Cell Biol (1985) 1.90
The rat alpha-tropomyosin gene generates a minimum of six different mRNAs coding for striated, smooth, and nonmuscle isoforms by alternative splicing. Mol Cell Biol (1988) 1.89
Angiotensin II induces c-fos mRNA in aortic smooth muscle. Role of Ca2+ mobilization and protein kinase C activation. J Biol Chem (1989) 1.83
Transcriptional and cell cycle-mediated regulation of myosin heavy chain gene expression during muscle cell differentiation. J Biol Chem (1983) 1.82
A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways. Mol Cell Biol (1991) 1.80
Complete amino acid sequence of canine cardiac calsequestrin deduced by cDNA cloning. J Biol Chem (1988) 1.75
Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome. Science (1983) 1.74
Characterization of sarcomeric myosin heavy chain genes. J Biol Chem (1983) 1.74
Multiple positive and negative 5' regulatory elements control the cell-type-specific expression of the embryonic skeletal myosin heavy-chain gene. Mol Cell Biol (1987) 1.73
Isolation and characterization of human myosin heavy chain genes. Proc Natl Acad Sci U S A (1983) 1.72
A novel mechanism of alternative RNA splicing for the developmentally regulated generation of troponin T isoforms from a single gene. Cell (1984) 1.71
Mapping and use of a sequence that targets DNA ligase I to sites of DNA replication in vivo. J Cell Biol (1997) 1.70
Cytoplasmic processing of myosin heavy chain messenger RNA: evidence provided by using a recombinant DNA plasmid. Proc Natl Acad Sci U S A (1980) 1.67
Developmentally induced, muscle-specific trans factors control the differential splicing of alternative and constitutive troponin T exons. Cell (1987) 1.67
Molecular cloning and characterization of the ryanodine receptor/junctional channel complex cDNA from skeletal muscle sarcoplasmic reticulum. Proc Natl Acad Sci U S A (1989) 1.67
Development and characterization of a cloned rat pulmonary arterial smooth muscle cell line that maintains differentiated properties through multiple subcultures. Circulation (1992) 1.61
Cloning and characterization of cDNA sequences corresponding to myosin light chains 1, 2, and 3, troponin-C, troponin-T, alpha-tropomyosin, and alpha-actin. J Biol Chem (1982) 1.58
Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death. Diabetes (2001) 1.53
Myosin light-chain 1 and 3 gene has two structurally distinct and differentially regulated promoters evolving at different rates. Mol Cell Biol (1985) 1.51
Overexpression of Gs alpha protein in the hearts of transgenic mice. J Clin Invest (1995) 1.50
Sarcomeric myosin heavy chain is coded by a highly conserved multigene family. Proc Natl Acad Sci U S A (1982) 1.50
Three types of muscle-specific gene expression in fusion-blocked rat skeletal muscle cells: translational control in EGTA-treated cells. Cell (1987) 1.50
Muscle is the major source of plasma gelsolin. J Biol Chem (1988) 1.47
A MyoD1-independent muscle-specific enhancer controls the expression of the beta-myosin heavy chain gene in skeletal and cardiac muscle cells. J Biol Chem (1991) 1.46
Molecular cloning and sequence analysis of smooth muscle calponin. J Biol Chem (1991) 1.45
Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications. J Cell Biol (1987) 1.35
Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development. Development (1992) 1.33
Cloning and characterization of mammalian myosin regulatory light chain (RLC) cDNA: the RLC gene is expressed in smooth, sarcomeric, and nonmuscle tissues. J Cell Biol (1987) 1.32
Slow myosin in developing rat skeletal muscle. J Cell Biol (1987) 1.28
Early expression of the different isoforms of the myocyte enhancer factor-2 (MEF2) protein in myogenic as well as non-myogenic cell lineages during mouse embryogenesis. Mech Dev (1996) 1.25
Alternative promoter and 5' exon generate a novel Gs alpha mRNA. J Biol Chem (1990) 1.23
Gating charge differences between two voltage-gated K+ channels are due to the specific charge content of their respective S4 regions. Neuron (1993) 1.22
Characterization of a developmentally regulated perinatal myosin heavy-chain gene expressed in skeletal muscle. J Biol Chem (1984) 1.22
Myocyte-specific enhancer factor 2 and thyroid hormone receptor associate and synergistically activate the alpha-cardiac myosin heavy-chain gene. Mol Cell Biol (1997) 1.21
Comparison of alpha-tropomyosin sequences from smooth and striated muscle. Nature (1985) 1.19
Canine ventricular myocytes possess a renin-angiotensin system that is upregulated with heart failure. Circ Res (2001) 1.19
Cardiac myocyte terminal differentiation. Potential for cardiac regeneration. Ann N Y Acad Sci (1995) 1.18
The expression of sarcomeric muscle-specific contractile protein genes in BC3H1 cells: BC3H1 cells resemble skeletal myoblasts that are defective for commitment to terminal differentiation. J Cell Biol (1989) 1.18
Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114. Proc Natl Acad Sci U S A (1994) 1.16
Homologous recombination in planta is stimulated in the absence of Rad50. EMBO Rep (2001) 1.15
Rules for the diagnosis of visceral situs, truncoconal morphologies, and ventricular inversions. Am Heart J (1972) 1.14
Experimental study of the formation of the bulboventricular loop in the chick. J Embryol Exp Morphol (1972) 1.14
Complete nucleotide sequence of the fast skeletal troponin T gene. Alternatively spliced exons exhibit unusual interspecies divergence. J Mol Biol (1986) 1.13
Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A. J Biol Chem (1996) 1.11
Inhibition of in vitro myogenic differentiation by cellular transcription factor E2F1. Cell Growth Differ (1995) 1.11
Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart. Proc Natl Acad Sci U S A (2001) 1.10
Resident cardiac stem cells. Cell Mol Life Sci (2007) 1.10
Transient induction of poly(A)-short myosin heavy chain messenger RNA during terminal differentiation of L6E9 myoblasts. J Mol Biol (1980) 1.10
Myosin light-chain 1/3 gene alternative splicing: cis regulation is based upon a hierarchical compatibility between splice sites. Mol Cell Biol (1990) 1.09
Regulation of lactate dehydrogenase levels in the mouse. J Biol Chem (1978) 1.08
Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium. J Clin Invest (1992) 1.06
Purification, characterization, and molecular cloning of a 60-kDa phosphoprotein in rabbit skeletal sarcoplasmic reticulum which is an isoform of phosphoglucomutase. J Biol Chem (1992) 1.06
Developmental and hormonal regulation of sarcomeric myosin heavy chain gene family. Circ Res (1987) 1.06
JE mRNA accumulates rapidly in aortic injury and in platelet-derived growth factor-stimulated vascular smooth muscle cells. Circ Res (1992) 1.06
Identification of a high molecular weight presumptive precursor to albumin mRNA in the nucleus of rat liver and hepatoma cell line H4AZC2. J Biol Chem (1978) 1.05
Characterization of cDNA and genomic sequences corresponding to an embryonic myosin heavy chain. J Biol Chem (1985) 1.04
Unco-ordinate regulation of ribosomal RNA and ribosomal protein synthesis during L6E9 myoblast differentiation. J Mol Biol (1980) 1.03
Inhibition of muscle differentiation by trypanosoma cruzi. Proc Natl Acad Sci U S A (1983) 1.02
Disuse and passive stretch cause rapid alterations in expression of developmental and adult contractile protein genes in skeletal muscle. Development (1990) 1.02