Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.

PubWeight™: 4.28‹?› | Rank: Top 1%

🔗 View Article (PMID 1906036)

Published in Genes Dev on July 01, 1991

Authors

J G Patton1, S A Mayer, P Tempst, B Nadal-Ginard

Author Affiliations

1: Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, Boston, Massachusetts.

Articles citing this

(truncated to the top 100)

A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein. Proc Natl Acad Sci U S A (1993) 4.71

Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol Cell Biol (2000) 4.12

Polypyrimidine tract binding protein antagonizes exon definition. Mol Cell Biol (2001) 4.10

MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Genes Dev (2007) 4.01

hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res (1992) 3.89

RNA-protein interactions in regulation of picornavirus RNA translation. Microbiol Rev (1996) 3.36

Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J (1994) 3.35

Polypyrimidine tract binding protein modulates efficiency of polyadenylation. Mol Cell Biol (2004) 3.28

A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction. EMBO J (1994) 3.17

Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mol Cell Biol (1993) 3.16

Scanning and competition between AGs are involved in 3' splice site selection in mammalian introns. Mol Cell Biol (1993) 2.98

The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream. Mol Cell Biol (1997) 2.93

Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry. Proc Natl Acad Sci U S A (1996) 2.82

Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro. Mol Cell Biol (1992) 2.66

Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA. Mol Cell Biol (1998) 2.59

unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA. Genes Dev (1999) 2.59

Interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation. J Virol (1995) 2.57

The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms. Genes Dev (1998) 2.56

A perinucleolar compartment contains several RNA polymerase III transcripts as well as the polypyrimidine tract-binding protein, hnRNP I. J Cell Biol (1995) 2.53

RNA annealing activities in HeLa nuclei. EMBO J (1994) 2.35

Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. EMBO J (2000) 2.33

The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5' nontranslated region. J Virol (1994) 2.29

Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome. J Virol (1997) 2.28

PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae. Mol Cell Biol (1993) 2.19

The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute. RNA (1998) 2.19

Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon. RNA (1998) 2.18

The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites. Proc Natl Acad Sci U S A (1994) 2.14

An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein. Mol Cell Biol (2000) 2.08

Functional analysis of the polypyrimidine tract in pre-mRNA splicing. Nucleic Acids Res (1997) 2.05

Functional characterization of SR and SR-related genes in Caenorhabditis elegans. EMBO J (2000) 2.05

Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon. Mol Cell Biol (1999) 2.05

Direct interactions between pre-mRNA and six U2 small nuclear ribonucleoproteins during spliceosome assembly. Mol Cell Biol (1994) 2.03

Polypyrimidine tract binding protein functions as a repressor to regulate alternative splicing of alpha-actinin mutally exclusive exons. Mol Cell Biol (1999) 2.02

The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. Nucleic Acids Res (1994) 2.01

Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB). RNA (2001) 1.98

Polypyrimidine-tract binding protein (PTB) is necessary, but not sufficient, for efficient internal initiation of translation of human rhinovirus-2 RNA. RNA (1999) 1.98

Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J (1994) 1.91

Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner. Mol Cell Biol (2003) 1.82

Purification of splicing factor SF1, a heat-stable protein that functions in the assembly of a presplicing complex. Mol Cell Biol (1992) 1.79

Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB. RNA (1999) 1.78

The spliceosome assembly pathway in mammalian extracts. Mol Cell Biol (1992) 1.78

Translation of polioviral mRNA is inhibited by cleavage of polypyrimidine tract-binding proteins executed by polioviral 3C(pro). J Virol (2002) 1.77

A role for the GSG domain in localizing Sam68 to novel nuclear structures in cancer cell lines. Mol Biol Cell (1999) 1.76

Translation of CUG- but not AUG-initiated forms of human fibroblast growth factor 2 is activated in transformed and stressed cells. J Cell Biol (1996) 1.73

Human genomic sequences that inhibit splicing. Mol Cell Biol (2000) 1.73

Location of the internal ribosome entry site in the 5' non-coding region of the immunoglobulin heavy-chain binding protein (BiP) mRNA: evidence for specific RNA-protein interactions. Nucleic Acids Res (1997) 1.70

The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing. EMBO J (2003) 1.68

Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold. EMBO J (2000) 1.67

PSF and p54nrb bind a conserved stem in U5 snRNA. RNA (2002) 1.66

The dynamic organization of the perinucleolar compartment in the cell nucleus. J Cell Biol (1997) 1.64

Two different sequence elements within exon 4 are necessary for calcitonin-specific splicing of the human calcitonin/calcitonin gene-related peptide I pre-mRNA. Mol Cell Biol (1994) 1.64

Determination of functional domains in polypyrimidine-tract-binding protein. Biochem J (1998) 1.63

Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site. J Virol (1995) 1.63

Phosphorylation of human hnRNP protein A1 abrogates in vitro strand annealing activity. Nucleic Acids Res (1993) 1.62

Specific interaction of polypyrimidine tract-binding protein with the extreme 3'-terminal structure of the hepatitis C virus genome, the 3'X. J Virol (1997) 1.61

Polypyrimidine tract sequences direct selection of alternative branch sites and influence protein binding. Nucleic Acids Res (1994) 1.58

Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex. Br J Cancer (2014) 1.56

Isolation of a mammalian homologue of a fission yeast differentiation regulator. Mol Cell Biol (1999) 1.49

The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins. Nucleic Acids Res (1993) 1.48

Combinatorial control of a neuron-specific exon. RNA (1999) 1.48

Transient expression of cellular polypyrimidine-tract binding protein stimulates cap-independent translation directed by both picornaviral and flaviviral internal ribosome entry sites In vivo. Mol Cell Biol (2000) 1.47

Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Nucleic Acids Res (2007) 1.47

Autoregulation of poly(A)-binding protein synthesis in vitro. Nucleic Acids Res (1995) 1.47

Nuclear RNP complex assembly initiates cytoplasmic RNA localization. J Cell Biol (2004) 1.44

Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase. Mol Cell Biol (2005) 1.42

Interaction of hnRNP A1 with snRNPs and pre-mRNAs: evidence for a possible role of A1 RNA annealing activity in the first steps of spliceosome assembly. Nucleic Acids Res (1992) 1.39

Vertebrate mRNAs with a 5'-terminal pyrimidine tract are candidates for translational repression in quiescent cells: characterization of the translational cis-regulatory element. Mol Cell Biol (1994) 1.39

A pyrimidine-rich exonic splicing suppressor binds multiple RNA splicing factors and inhibits spliceosome assembly. Proc Natl Acad Sci U S A (1998) 1.37

The use of antibodies to the polypyrimidine tract binding protein (PTB) to analyze the protein components that assemble on alternatively spliced pre-mRNAs that use distant branch points. RNA (1998) 1.35

Evidence for an RNA chaperone function of polypyrimidine tract-binding protein in picornavirus translation. RNA (2005) 1.35

Attenuating mutations in the poliovirus 5' untranslated region alter its interaction with polypyrimidine tract-binding protein. J Virol (1997) 1.29

A polypyrimidine tract binding protein, pumpkin RBP50, forms the basis of a phloem-mobile ribonucleoprotein complex. Plant Cell (2009) 1.29

Polypyrimidine tract-binding protein binds to the leader RNA of mouse hepatitis virus and serves as a regulator of viral transcription. J Virol (1999) 1.28

Intronic sequence with both negative and positive effects on the regulation of alternative transcripts of the chicken beta tropomyosin transcripts. Nucleic Acids Res (1992) 1.27

Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells. Biochem J (1993) 1.27

Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression. Mol Cell Biol (2003) 1.25

Regulation of expression by promoters versus internal ribosome entry site in the 5'-untranslated sequence of the human cyclin-dependent kinase inhibitor p27kip1. Nucleic Acids Res (2005) 1.24

In vivo splicing of the beta tropomyosin pre-mRNA: a role for branch point and donor site competition. Mol Cell Biol (1992) 1.24

trans complementation by RNA of defective foot-and-mouth disease virus internal ribosome entry site elements. J Virol (1994) 1.23

Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2. Crit Rev Biochem Mol Biol (2012) 1.20

Functional analysis of a C. elegans trans-splice acceptor. Nucleic Acids Res (1993) 1.19

Identification of two proteins that bind to a pyrimidine-rich sequence in the 3'-untranslated region of GAP-43 mRNA. Nucleic Acids Res (1997) 1.19

Identification of two RNA-binding proteins in Balbiani ring premessenger ribonucleoprotein granules and presence of these proteins in specific subsets of heterogeneous nuclear ribonucleoprotein particles. Mol Cell Biol (1996) 1.19

RNA binding activity of heterodimeric splicing factor U2AF: at least one RS domain is required for high-affinity binding. Mol Cell Biol (1998) 1.15

Smooth muscle alternative splicing induced in fibroblasts by heterologous expression of a regulatory gene. EMBO J (1996) 1.15

Sequence of the polypyrimidine tract of the 3'-terminal 3' splicing signal can affect intron-dependent pre-mRNA processing in vivo. Nucleic Acids Res (1996) 1.14

Encephalomyocarditis virus internal ribosomal entry site RNA-protein interactions. J Virol (1994) 1.14

Absence of internal ribosome entry site-mediated tissue specificity in the translation of a bicistronic transgene. J Virol (1999) 1.13

Activation of alpha-tropomyosin exon 2 is regulated by the SR protein 9G8 and heterogeneous nuclear ribonucleoproteins H and F. Mol Cell Biol (2006) 1.12

Antisense probes targeted to an internal domain in U2 snRNP specifically inhibit the second step of pre-mRNA splicing. Nucleic Acids Res (1992) 1.12

Nucleocytoplasmic shuttling of polypyrimidine tract-binding protein is uncoupled from RNA export. Mol Biol Cell (2001) 1.12

Regulation of BRCA1 transcription by specific single-stranded DNA binding factors. Mol Cell Biol (2003) 1.10

Polypyrimidine track-binding protein binding downstream of caspase-2 alternative exon 9 represses its inclusion. J Biol Chem (2000) 1.09

Drosophila polypyrimidine-tract binding protein (PTB) functions specifically in the male germline. EMBO J (2003) 1.08

Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner. J Biol Chem (2008) 1.07

The conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF 65) is essential in vivo but dispensable for activity in vitro. RNA (2004) 1.06

Genetic selection for balanced retroviral splicing: novel regulation involving the second step can be mediated by transitions in the polypyrimidine tract. Mol Cell Biol (1995) 1.04

Alternative splicing: functional diversity among voltage-gated calcium channels and behavioral consequences. Biochim Biophys Acta (2012) 1.04

Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. Mol Cell Biol (2000) 1.04

Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements. J Virol (1995) 1.03

Articles by these authors

Bone marrow cells regenerate infarcted myocardium. Nature (2001) 21.24

SNAP receptors implicated in vesicle targeting and fusion. Nature (1993) 18.57

Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med (2001) 10.03

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol (2001) 9.82

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell (1994) 9.48

Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell (1990) 9.24

A cellular gene encodes scrapie PrP 27-30 protein. Cell (1985) 8.86

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell (1994) 8.71

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev (1999) 7.58

Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A (2001) 7.19

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science (1998) 6.79

DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell (1991) 6.63

Alternative splicing in the control of gene expression. Annu Rev Genet (1989) 6.18

RSC, an essential, abundant chromatin-remodeling complex. Cell (1996) 6.17

Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell (1997) 5.83

Alternative splicing: a ubiquitous mechanism for the generation of multiple protein isoforms from single genes. Annu Rev Biochem (1987) 5.79

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet (1999) 5.61

Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science (2001) 5.25

COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A (2001) 5.19

Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell (2001) 5.04

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell (1997) 4.99

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell (1993) 4.90

Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage. Neurology (2006) 4.88

A human telomeric protein. Science (1995) 4.77

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature (1993) 4.68

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem (1999) 4.56

Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell (1999) 4.49

A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell (1994) 4.47

Transcriptional and posttranscriptional control of c-myc during myogenesis: its mRNA remains inducible in differentiated cells and does not suppress the differentiated phenotype. Mol Cell Biol (1986) 4.46

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature (1999) 4.40

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci U S A (1992) 4.32

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci U S A (1988) 4.23

Electrographic seizures and periodic discharges after intracerebral hemorrhage. Neurology (2007) 4.22

Scanning from an independently specified branch point defines the 3' splice site of mammalian introns. Nature (1989) 4.18

Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev (1992) 4.10

Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated. J Biol Chem (1984) 4.01

Commitment, fusion and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis. Cell (1978) 3.96

I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell (1995) 3.95

A Drosophila Polycomb group complex includes Zeste and dTAFII proteins. Nature (2001) 3.90

Type beta transforming growth factor is an inhibitor of myogenic differentiation. Proc Natl Acad Sci U S A (1986) 3.83

A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell (1999) 3.80

SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell (1998) 3.76

Rel-associated pp40: an inhibitor of the rel family of transcription factors. Science (1991) 3.76

Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysis. J Chromatogr A (1998) 3.64

Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev (1993) 3.63

Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology (2004) 3.60

Reversal of terminal differentiation and control of DNA replication: cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication. Cell (1993) 3.42

Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits. EMBO J (1992) 3.33

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature (1996) 3.29

Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Proc Natl Acad Sci U S A (1998) 3.18

Moloney murine sarcoma proviral DNA is a transcriptional unit. Nature (1980) 3.13

Myocardial cell death in human diabetes. Circ Res (2000) 3.12

A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J (2000) 3.11

Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem. Proc Natl Acad Sci U S A (1984) 3.05

Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science (1994) 3.05

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell (1997) 3.03

Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene. Cell (1985) 3.02

FK506 binding protein associated with the calcium release channel (ryanodine receptor). J Biol Chem (1992) 3.02

Scanning and competition between AGs are involved in 3' splice site selection in mammalian introns. Mol Cell Biol (1993) 2.98

The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev (1998) 2.91

Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. Proc Natl Acad Sci U S A (1991) 2.89

Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science (2002) 2.89

Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy. Circ Res (2001) 2.89

Mutually exclusive splicing of alpha-tropomyosin exons enforced by an unusual lariat branch point location: implications for constitutive splicing. Cell (1989) 2.84

Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol (1999) 2.76

Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Mol Cell (1999) 2.76

The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor. Mol Cell Biol (1994) 2.71

A muscle-specific enhancer is located at the 3' end of the myosin light-chain 1/3 gene locus. Genes Dev (1988) 2.71

Immobilized gallium(III) affinity chromatography of phosphopeptides. Anal Chem (1999) 2.70

Delayed posthypoxic demyelination. Association with arylsulfatase A deficiency and lactic acidosis on proton MR spectroscopy. Neurology (1997) 2.66

A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev (1998) 2.63

The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A (1993) 2.63

A novel Rad24 checkpoint protein complex closely related to replication factor C. Curr Biol (2000) 2.59

Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. Nucleic Acids Res (1994) 2.58

All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner. Science (1986) 2.57

Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing. J Biol Chem (1984) 2.49

Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem (2000) 2.47

Protein folding in the central cavity of the GroEL-GroES chaperonin complex. Nature (1996) 2.46

hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Mol Cell Biol (1993) 2.41

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39

Reversibility of muscle differentiation in the absence of commitment: analysis of a myogenic cell line temperature-sensitive for commitment. Cell (1983) 2.37

Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. J Clin Invest (1987) 2.37

Effect of cisternal and ventricular blood on risk of delayed cerebral ischemia after subarachnoid hemorrhage: the Fisher scale revisited. Stroke (2001) 2.33

A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control. Mol Cell (2001) 2.30

Molecular characterization of two myosin heavy chain genes expressed in the adult heart. Nature (1982) 2.28

Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke (2001) 2.26

An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding. Proc Natl Acad Sci U S A (1995) 2.26

Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells. Neuron (1990) 2.20

Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. J Biol Chem (1997) 2.17

A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. Development (1993) 2.13

Interleukin-3 signals through multiple isoforms of Stat5. EMBO J (1995) 2.12

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A (2008) 2.10

Incremental reductions of positive charge within the S4 region of a voltage-gated K+ channel result in corresponding decreases in gating charge. Neuron (1992) 2.09

MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proc Natl Acad Sci U S A (1993) 2.07

Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice. Genes Dev (1991) 2.07

Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). Mol Cell Biol (2002) 2.06

Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell (1999) 2.04

Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD. Science (1994) 2.02