Published in Cell Death Differ on October 06, 2017
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell (2009) 11.26
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol (2006) 10.55
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol (2006) 9.64
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell (2012) 6.56
Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell (2012) 6.31
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol (2010) 6.05
Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science (1991) 5.65
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc Natl Acad Sci U S A (2010) 5.59
Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med (1997) 5.53
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature (2014) 4.69
Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol (2014) 4.28
Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell (2003) 3.68
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab (2008) 3.52
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol (2013) 3.29
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity (2013) 3.15
Apoptosis in development. Nature (2000) 2.95
A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84
A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation. Proc Natl Acad Sci U S A (2001) 2.80
Regulation of ferroptotic cancer cell death by GPX4. Cell (2014) 2.78
Pore-forming activity and structural autoinhibition of the gasdermin family. Nature (2016) 2.71
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ (2014) 2.66
Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. Sci Signal (2010) 2.36
Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration. Dev Cell (2009) 2.33
Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res (2013) 2.26
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences. Cell (2017) 2.17
Free radical lipid peroxidation: mechanisms and analysis. Chem Rev (2011) 2.17
The role of iron and reactive oxygen species in cell death. Nat Chem Biol (2014) 2.10
Oxidative stress and covalent modification of protein with bioactive aldehydes. J Biol Chem (2008) 2.09
Ferroptosis as a p53-mediated activity during tumour suppression. Nature (2015) 2.06
Caspase substrates and cellular remodeling. Annu Rev Biochem (2011) 1.79
Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1. J Biol Chem (2008) 1.78
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol (2014) 1.76
An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model. Genes Dev (2016) 1.70
Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A (2014) 1.62
Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J Biol Chem (2003) 1.61
Neuroprotective properties of the natural vitamin E alpha-tocotrienol. Stroke (2005) 1.56
Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife (2014) 1.44
Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth. Nat Med (2016) 1.40
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell Res (2015) 1.37
Glutaminolysis and Transferrin Regulate Ferroptosis. Mol Cell (2015) 1.35
Effect of lipid peroxidation on the properties of lipid bilayers: a molecular dynamics study. Biophys J (2007) 1.35
Herpes simplex virus suppresses necroptosis in human cells. Cell Host Microbe (2015) 1.32
Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome. J Clin Immunol (2010) 1.28
Near death experiences: poxvirus regulation of apoptotic death. Virology (2006) 1.27
Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development. Cancer Res (2005) 1.26
Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance. Cell Death Differ (2013) 1.23
Cell signaling by protein carbonylation and decarbonylation. Antioxid Redox Signal (2010) 1.21
Ferroptosis: Death by Lipid Peroxidation. Trends Cell Biol (2015) 1.17
Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection? Prog Cardiovasc Dis (2010) 1.17
12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. J Neurochem (2009) 1.13
Interaction of the adenovirus 14.7-kDa protein with FLICE inhibits Fas ligand-induced apoptosis. J Biol Chem (1998) 1.13
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. EMBO J (2016) 1.13
YopK regulates the Yersinia pestis type III secretion system from within host cells. Mol Microbiol (2011) 1.11
Paraquat toxicity: proposed mechanism of action involving lipid peroxidation. Environ Health Perspect (1976) 1.10
Necrosis is associated with IL-6 production but apoptosis is not. Cell Signal (2005) 1.05
The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons. J Neurochem (1991) 1.04
Suppression of RIP3-dependent necroptosis by human cytomegalovirus. J Biol Chem (2015) 0.93
Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation. Cell Death Differ (2015) 0.93
H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. PLoS One (2012) 0.93
Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res (2016) 0.92
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol (2016) 0.91
Cellular protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity. Nat Commun (2014) 0.91
Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents. Biochem Pharmacol (1990) 0.91
Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes. Toxicol Appl Pharmacol (1980) 0.91
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol (2016) 0.91
Doxorubicin-induced carbonylation and degradation of cardiac myosin binding protein C promote cardiotoxicity. Proc Natl Acad Sci U S A (2014) 0.91
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci U S A (2016) 0.90
Heat stress induces ferroptosis-like cell death in plants. J Cell Biol (2017) 0.89
Cadmium toxicity: unique cytoprotective properties of alpha tocopheryl succinate in hepatocytes. Toxicology (1991) 0.89
Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death. ACS Chem Biol (2015) 0.89
The pantheon of the fallen: why are there so many forms of cell death? Trends Cell Biol (2012) 0.87
Phospholipid hydroperoxide accumulation in liver of rats intoxicated with carbon tetrachloride and its inhibition by dietary alpha-tocopherol. J Biochem (1990) 0.87
The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity. Chem Biol Interact (1985) 0.87
Lipid peroxidation in liver of rats administrated with methyl mercuric chloride. Biol Trace Elem Res (1996) 0.87
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop. Biochem J (2015) 0.85
Mechanisms of ferroptosis. Cell Mol Life Sci (2016) 0.84
6-Hydroxydopamine releases iron from ferritin and promotes ferritin-dependent lipid peroxidation. Biochem Pharmacol (1989) 0.84
Injury-induced asymmetric cell death as a driving force for head regeneration in Hydra. Dev Genes Evol (2012) 0.83
Inhibition of apoptosis by the gamma-herpesviruses. Int Rev Immunol (2003) 0.83
Effects of dietary alpha-tocopherol and beta-carotene on lipid peroxidation induced by methyl mercuric chloride in mice. Pharmacol Toxicol (1993) 0.82
Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: behavioral and biochemical evidence. Brain Res (1989) 0.82
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death. Trends Biochem Sci (2016) 0.81
Deferoxamine inhibits methyl mercury-induced increases in reactive oxygen species formation in rat brain. Toxicol Appl Pharmacol (1992) 0.81
Cephaloridine-induced lipid peroxidation initiated by reactive oxygen species as a possible mechanism of cephaloridine nephrotoxicity. Biochim Biophys Acta (1985) 0.81
Comparison of the protective effects of desferrioxamine and ICRF-187 against doxorubicin-induced toxicity in spontaneously hypertensive rats. Cancer Chemother Pharmacol (1994) 0.80
Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. Proc Natl Acad Sci U S A (2016) 0.80
Effect of iron chelators on paraquat toxicity in rats and alveolar type II cells. Am Rev Respir Dis (1992) 0.79
Evolutionary divergence of the necroptosis effector MLKL. Cell Death Differ (2016) 0.79
Lipid peroxidation, protein thiols and calcium homeostasis in bromobenzene-induced liver damage. Biochem Pharmacol (1987) 0.79
Stimulation of lipid peroxidation by methyl mercury in rats. Life Sci (1983) 0.79
An evolutionary perspective on the necroptotic pathway. Trends Cell Biol (2016) 0.79
Liposomal alpha-tocopherol alleviates the progression of paraquat-induced lung damage. J Drug Target (1995) 0.78
Identification of baicalein as a ferroptosis inhibitor by natural product library screening. Biochem Biophys Res Commun (2016) 0.78
Insane in the membrane: a structural perspective of MLKL function in necroptosis. Immunol Cell Biol (2017) 0.78
Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression. Cell Rep (2016) 0.78
Hepatic lipid peroxidation in acute fatal human carbon tetrachloride poisoning. N Engl J Med (1968) 0.77
Evidence for the participation of activated oxygen species and the resulting peroxidation of lipids in the killing of cultured hepatocytes by aryl halides. Toxicol Appl Pharmacol (1990) 0.77
U0126 protects cells against oxidative stress independent of its function as a MEK inhibitor. ACS Chem Neurosci (2015) 0.77
Lipid peroxidation in rat adrenal glands after administration cadmium and role of essential metals. J Toxicol Environ Health A (2001) 0.77
A real-time fluorometric method for the simultaneous detection of cell death type and rate. Nat Protoc (2016) 0.77
Initiation and execution mechanisms of necroptosis: an overview. Cell Death Differ (2017) 0.77
Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury. Cell Death Dis (2017) 0.76
A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress. Cell Death Differ (2016) 0.75
USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability. Oncogene (2016) 0.75
6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury. Sci Rep (2017) 0.75
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death. Nat Cell Biol (2017) 0.75
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death. Nat Commun (2022) 0.75