Published in Proc Natl Acad Sci U S A on October 03, 2016
MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells. Cell Death Discov (2017) 0.76
Ironing out how p53 regulates ferroptosis. Proc Natl Acad Sci U S A (2016) 0.75
On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci (2017) 0.75
How do we fit ferroptosis in the family of regulated cell death? Cell Death Differ (2017) 0.75
Autophagy and Ferroptosis - What's the Connection? Curr Pathobiol Rep (2017) 0.75
Surfing the p53 network. Nature (2000) 35.36
p53, the cellular gatekeeper for growth and division. Cell (1997) 31.04
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (1992) 25.54
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science (2004) 24.42
Blinded by the Light: The Growing Complexity of p53. Cell (2009) 17.75
Cancer. p53, guardian of the genome. Nature (1992) 16.36
Live or let die: the cell's response to p53. Nat Rev Cancer (2002) 15.06
TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell (2006) 11.85
Cancer cell metabolism: Warburg and beyond. Cell (2008) 11.80
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell (2012) 9.88
The first 30 years of p53: growing ever more complex. Nat Rev Cancer (2009) 8.00
Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell (2012) 6.31
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A (2010) 4.99
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96
Polyamines and cancer: old molecules, new understanding. Nat Rev Cancer (2004) 4.70
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell (2012) 4.37
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci U S A (2010) 4.18
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab (2008) 3.52
Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov (2007) 3.46
Polyamines as targets for therapeutic intervention. Annu Rev Pharmacol Toxicol (1995) 3.26
Regulation of ferroptotic cancer cell death by GPX4. Cell (2014) 2.78
The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res (2004) 2.56
Ferroptosis as a p53-mediated activity during tumour suppression. Nature (2015) 2.06
TIGAR is required for efficient intestinal regeneration and tumorigenesis. Dev Cell (2013) 2.03
Metabolic regulation by p53 family members. Cell Metab (2013) 2.00
p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa. Cell Rep (2013) 2.00
The natural polyamine spermine functions directly as a free radical scavenger. Proc Natl Acad Sci U S A (1998) 1.91
A tumour suppressor network relying on the polyamine-hypusine axis. Nature (2012) 1.85
Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator. Am J Physiol Endocrinol Metab (2008) 1.64
Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br J Pharmacol (1997) 1.35
Keeping an old friend under control: regulation of p53 stability. Mol Med Today (1998) 1.29
Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells. Proc Natl Acad Sci U S A (2013) 1.13
Identification of 5-fluorouracil-inducible target genes using cDNA microarray profiling. Cancer Res (2003) 1.08
Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors. Cancer Res (2002) 1.03
A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer. Clin Cancer Res (2003) 1.02
Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer. Clin Cancer Res (2002) 0.99
Cross-talk between reactive oxygen species and polyamines in regulation of ion transport across the plasma membrane: implications for plant adaptive responses. J Exp Bot (2014) 0.98
High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation. J Cell Biochem (2000) 0.94
Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies. Invest New Drugs (2001) 0.90
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. Invest New Drugs (1997) 0.89
p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation. J Biol Chem (2014) 0.86
Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury. Am J Physiol Gastrointest Liver Physiol (2012) 0.84
Overexpression of SSAT by DENSPM treatment induces cell detachment and apoptosis in glioblastoma. Oncol Rep (2011) 0.79