Antigen processing and intracellular Ia. Possible roles of endocytosis and protein synthesis in Ia function.

PubWeight™: 1.84‹?› | Rank: Top 3%

🔗 View Article (PMID 2909613)

Published in J Immunol on January 01, 1989

Authors

C V Harding1, E R Unanue

Author Affiliations

1: Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.

Articles citing this

Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J Exp Med (1995) 6.62

end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae. J Cell Biol (1993) 5.22

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain. J Exp Med (1990) 2.39

Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells. J Cell Biol (1992) 1.86

Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA. J Exp Med (1998) 1.65

Functional and ultrastructural evidence for intracellular formation of major histocompatibility complex class II-peptide complexes during antigen processing. Proc Natl Acad Sci U S A (1990) 1.60

Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes. J Exp Med (1995) 1.57

Effects of pH and polysaccharides on peptide binding to class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A (1991) 1.49

Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturation. J Exp Med (2001) 1.37

Hypoexpression of major histocompatibility complex molecules on Legionella pneumophila phagosomes and phagolysosomes. Infect Immun (1993) 1.35

Turnover of Ia-peptide complexes is facilitated in viable antigen-presenting cells: biosynthetic turnover of Ia vs. peptide exchange. Proc Natl Acad Sci U S A (1989) 1.31

Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein. J Exp Med (1997) 1.30

Mouse B lymphocyte specific endocytosis and recycling of MHC class II molecules. EMBO J (1990) 1.12

Modulation of antigen processing and presentation by covalently linked complement C3b fragment. Immunology (1995) 1.08

Kinetics of antigenic peptide binding to the class II major histocompatibility molecule I-Ad. Proc Natl Acad Sci U S A (1991) 1.08

Enhanced antigen presentation in the absence of the invariant chain endosomal localization signal. J Exp Med (1993) 0.96

Role of phagosomes and major histocompatibility complex class II (MHC-II) compartment in MHC-II antigen processing of Mycobacterium tuberculosis in human macrophages. Infect Immun (2006) 0.96

Demonstration of MHC class II-restricted cytotoxic T lymphocytes in mice against herpes simplex virus. Immunology (1990) 0.96

Constitutive endocytosis and recycling of major histocompatibility complex class II glycoproteins in human B-lymphoblastoid cells. Immunology (1992) 0.92

Cellular mechanisms of antigen processing and the function of class I and II major histocompatibility complex molecules. Cell Regul (1990) 0.92

Calcium response of helper T lymphocytes to antigen-presenting cells in a single-cell assay. Biophys J (1995) 0.90

Endocytosis and recycling of the complex between CD23 and HLA-DR in human B cells. Immunology (2001) 0.88

Harnessing nanoparticles for immune modulation. Trends Immunol (2015) 0.88

Class II antigens on dendritic cells from the synovial fluids of patients with inflammatory arthritis. Clin Exp Immunol (1989) 0.85

The relationship between antigen concentration, antigen internalization, and antigenic complexes: modeling insights into antigen processing and presentation. J Cell Biol (1990) 0.84

T cells specific for alpha-beta interface regions of hemoglobin recognize the isolated subunit but not the tetramer and indicate presentation without processing. Proc Natl Acad Sci U S A (1989) 0.81

Articles by these authors

(truncated to the top 100)

Binding of immunogenic peptides to Ia histocompatibility molecules. Nature (1985) 8.39

Requirement of thymus (T) lymphocytes for resistance to listeriosis. J Exp Med (1972) 8.25

Immunoglobulins on the surface of lymphocytes. I. Distribution and quantitation. J Exp Med (1971) 8.22

Antigen-presenting function of the macrophage. Annu Rev Immunol (1984) 7.83

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci U S A (1993) 6.33

Immunoglobulins on the surface of lymphocytes. II. The bone marrow as the main source of lymphocytes with detectable surface-bound immunoglobulin. J Exp Med (1971) 5.43

Critical role of determinant presentation in the induction of specific responses in immunocompetent lymphocytes. J Exp Med (1973) 5.30

Ligand-induced movement of lymphocyte membrane macromolecules. I. Analysis by immunofluorescence and ultrastructural radioautography. J Exp Med (1972) 5.01

Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells. Proc Natl Acad Sci U S A (1982) 4.85

The regulatory role of macrophages in antigenic stimulation. Part Two: symbiotic relationship between lymphocytes and macrophages. Adv Immunol (1981) 4.72

Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice. J Immunol (1989) 4.70

The regulatory role of macrophages in antigenic stimulation. Adv Immunol (1972) 4.69

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature (1990) 4.59

The basis for the immunoregulatory role of macrophages and other accessory cells. Science (1987) 4.51

Membrane and cytoplasmic changes in B lymphocytes induced by ligand-surface immunoglobulin interaction. Adv Immunol (1976) 4.18

Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial stimuli. Infect Immun (1991) 4.18

Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes. J Immunol (1981) 3.94

Prostaglandins modulate macrophage Ia expression. Nature (1982) 3.83

Experimental glomerulonephritis: immunological events and pathogenetic mechanisms. Adv Immunol (1967) 3.83

Activated macrophages induce vascular proliferation. Nature (1977) 3.74

Antigen presentation: comments on its regulation and mechanism. J Immunol (1984) 3.68

Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production. J Immunol (1982) 3.61

A T cell-independent mechanism of macrophage activation by interferon-gamma. J Immunol (1987) 3.55

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma. J Immunol (1994) 3.50

Natural immunity: a T-cell-independent pathway of macrophage activation, defined in the scid mouse. Immunol Rev (1991) 3.49

Regulation of macrophage populations. I. Preferential induction of Ia-rich peritoneal exudates by immunologic stimuli. J Immunol (1980) 3.46

Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas. J Immunol (1984) 3.41

Identification of a membrane-associated interleukin 1 in macrophages. Proc Natl Acad Sci U S A (1985) 3.39

Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice. Infect Immun (1993) 3.38

Interleukin 1 is processed and released during apoptosis. Proc Natl Acad Sci U S A (1991) 3.09

Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope. Nature (1987) 3.08

A mononuclear cell component in experimental immunological glomerulonephritis. J Exp Med (1978) 3.02

Macrophage-T cell interactions involving Listeria monocytogenes--role of the H-2 gene complex. J Immunol (1979) 2.93

Persistence of immunogenicity of antigen after uptake by macrophages. J Exp Med (1968) 2.93

Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc Natl Acad Sci U S A (1997) 2.89

Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. J Immunol (1993) 2.73

The costimulatory function of antigen-presenting cells. Immunol Today (1990) 2.71

The binding of clathrin triskelions to membranes from coated vesicles. Cell (1981) 2.70

The immune response of mice to antigen in macrophages. Immunology (1968) 2.67

An ultrastructural study of lymphocytes with surface-bound immunoglobulin. J Exp Med (1972) 2.65

Two distinct mechanisms for redistribution of lymphocyte surface macromolecules. I. Relationship to cytoplasmic myosin. J Cell Biol (1978) 2.54

The modulation of lymphocyte functions by molecules secreted by macrophages. I. Description and partial biochemical analysis. J Exp Med (1975) 2.54

Presentation of Listeria monocytogenes to CD8+ T cells requires secretion of hemolysin and intracellular bacterial growth. J Immunol (1990) 2.54

Regulation of macrophage Ia expression in mice with severe combined immunodeficiency: induction of Ia expression by a T cell-independent mechanism. J Immunol (1986) 2.51

Ligand-induced movement of lymphocyte membrane macromolecules. II. Mapping of surface moieties. J Exp Med (1972) 2.49

Antigen binding and capping by lymphocytes of genetic nonresponder mice. J Exp Med (1972) 2.46

The regulation of lymphocyte functions by the macrophage. Immunol Rev (1978) 2.43

Processing of lysozyme by macrophages: identification of the determinant recognized by two T-cell hybridomas. Proc Natl Acad Sci U S A (1984) 2.40

Demonstration of a soluble mediator that induces exudates rich in Ia-positive macrophages. J Exp Med (1980) 2.38

Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA. Proc Natl Acad Sci U S A (1988) 2.26

Antigenic competition at the level of peptide-Ia binding. Proc Natl Acad Sci U S A (1986) 2.23

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells. Proc Natl Acad Sci U S A (1988) 2.21

Redistribution of myosin accompanying capping of surface Ig. J Exp Med (1977) 2.18

Stimulation of nonlymphoid mesenchymal cell proliferation by a macrophage-derived growth factor. J Immunol (1981) 2.18

Secretory function of mononuclear phagocytes: a review. Am J Pathol (1976) 2.12

An inhibitor of cell proliferation released by cultures of macrophages. Proc Natl Acad Sci U S A (1974) 2.11

Reduction of disulfide bonds within lysosomes is a key step in antigen processing. J Immunol (1991) 2.08

The immunogenicity of antigen bound to the plasma membrane of macrophages. J Exp Med (1970) 2.08

Ligand-induced movement of lymphocyte membrane macromolecules. 3. Relationship between the formation and fate of anti-Ig-surface Ig complexes and cell metabolism. J Exp Med (1973) 2.08

A defect in the antigen-presenting function of macrophages from neonatal mice. Nature (1979) 2.07

Interleukin 1 participates in the development of anti-Listeria responses in normal and SCID mice. Proc Natl Acad Sci U S A (1992) 2.06

A role of macrophages in the stimulation of immune responses by adjuvants. J Immunol (1969) 2.06

Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells. Nature (1975) 2.04

Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell. Nature (1994) 2.02

Induction of cytocidal macrophages after in vitro interactions between Listeria-immune T cells and macrophages--role of H-2. J Immunol (1979) 2.00

Immunity to Listeria infection. Curr Opin Immunol (2000) 1.97

The specific binding of Listeria monocytogenes-immune T lymphocytes to macrophages. I. Quantitation and role of H-2 gene products. J Exp Med (1979) 1.97

Cutting edge: paradigm revisited: antibody provides resistance to Listeria infection. J Immunol (1999) 1.96

Persistence of antigen on the surface of macrophages. Nature (1969) 1.95

Distribution of actin in spreading macrophages: a comparative study on living and fixed cells. J Cell Biol (1983) 1.95

Properties and some uses of anti-macrophage antibodies. Nature (1968) 1.94

Listeria monocytogenes induces apoptosis of infected hepatocytes. J Immunol (1996) 1.94

Receptor-mediated inactivation of early B lymphocytes. Nature (1975) 1.90

Experimental allergic glomerulonephritis induced in the rabbit with heterologous renal antigens. J Exp Med (1967) 1.90

Redistribution and fate of Ig complexes on surface of B lymphocytes: functional implications and mechanisms. Transplant Rev (1973) 1.88

IA antigens and antigen-presenting function of thymic macrophages. J Immunol (1980) 1.87

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. J Immunol (1996) 1.87

Intracellular antibody neutralizes Listeria growth. Immunity (2001) 1.86

Anti-Ig-triggered movements of lymphocytes-specificity and lack of evidence for directional migration. J Immunol (1975) 1.82

Characterization and quantitation of peptide-MHC complexes produced from hen egg lysozyme using a monoclonal antibody. Immunity (1997) 1.82

Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells. Cell (1991) 1.81

Effects of bacterial products on lymphocytes and macrophages: their possible role in natural resistance to listeria infetion in mice. J Immunol (1974) 1.79

Synthesis and release of thymidine by macrophages. J Immunol (1977) 1.77

Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice. Immunity (2000) 1.77

Experimental allergic glomerulonephritis induced in the rabbit with homologous renal antigens. J Exp Med (1967) 1.76

Inhibition of surface capping of macromolecules by local anaesthetics and tranquillisers. Nature (1974) 1.75

Calcium-sensitive modulation of Ig capping: evidence supporting a cytoplasmic control of ligand-receptor complexes. J Exp Med (1976) 1.75

Endocytosis by lymphocytes of complexes of anti-Ig with membrane-bound Ig. J Immunol (1972) 1.73

Characterization of resident glomerular cells in the rat expressing Ia determinants and manifesting genetically restricted interactions with lymphocytes. J Clin Invest (1981) 1.72

Thymus dependency of the immune response to hemocyanin: an evaluation of the role of macrophages in thymectomized mice. J Immunol (1970) 1.71

The function of macrophages in the immune response. Semin Hematol (1970) 1.71

Secretion of mediators following T lymphocyte-macrophage interaction is regulated by the major histocompatibility complex. Proc Natl Acad Sci U S A (1977) 1.68

Specificity of the T cell receptor: two different determinants are generated by the same peptide and the I-Ak molecule. J Immunol (1985) 1.67

Development of B lymphocytes. I. Cell populations and a critical event during ontogeny. J Immunol (1975) 1.65

Monoclonal antibodies to murine IL-1 alpha. Production, characterization, and inhibition of membrane-associated IL-1 activity. J Immunol (1988) 1.63

Antigen-presenting function of alveolar macrophages: uptake and presentation of Listeria monocytogenes. J Immunol (1981) 1.62

Quantitative analysis of the T cell repertoire that escapes negative selection. Immunity (1999) 1.61

Ligand-induced association of surface immunoglobulin with the detergent-insoluble cytoskeletal matrix of the B lymphocyte. J Immunol (1982) 1.61

Functional and ultrastructural evidence for intracellular formation of major histocompatibility complex class II-peptide complexes during antigen processing. Proc Natl Acad Sci U S A (1990) 1.60

Functional and structural studies on clathrin triskelions and baskets. Cold Spring Harb Symp Quant Biol (1982) 1.59