Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen.

PubWeight™: 2.89‹?› | Rank: Top 1%

🔗 View Article (PMID 3112582)

Published in Nature on September 18, 1987

Authors

D Gay, P Maddon, R Sekaly, M A Talle, M Godfrey, E Long, G Goldstein, L Chess, R Axel, J Kappler

Articles citing this

Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism. EMBO J (1988) 3.98

Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding. J Exp Med (1990) 3.01

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase. Proc Natl Acad Sci U S A (1989) 2.70

Soluble CD4 enhances simian immunodeficiency virus SIVagm infection. J Virol (1990) 1.79

CD4+ lymphocyte function with early human immunodeficiency virus infection. Proc Natl Acad Sci U S A (1989) 1.78

Structure and expression of the human and mouse T4 genes. Proc Natl Acad Sci U S A (1987) 1.77

Overproduction and dissection of proteins by the expression-cassette polymerase chain reaction. Proc Natl Acad Sci U S A (1990) 1.77

Depletion of the surface CD4 molecule by the envelope protein of human immunodeficiency virus expressed in a human CD4+ monocytoid cell line. J Virol (1989) 1.73

Structural analysis of the human immunodeficiency virus-binding domain of CD4. Epitope mapping with site-directed mutants and anti-idiotypes. J Exp Med (1989) 1.60

CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migration. J Exp Med (1991) 1.58

CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice. J Exp Med (1992) 1.54

Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells. EMBO J (1989) 1.53

Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. J Exp Med (1992) 1.48

Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation. Genome Biol (2016) 1.48

Antibody to adhesion molecule LFA-1 enhances plasma neutralization of human immunodeficiency virus type 1. J Virol (1995) 1.43

The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection. Microbiol Rev (1995) 1.34

Human T-cell receptor (TCR) alpha/beta + CD4-CD8- T cells express oligoclonal TCRs, share junctional motifs across TCR V beta-gene families, and phenotypically resemble memory T cells. Proc Natl Acad Sci U S A (1993) 1.32

Double-negative (CD4-CD8-) lymphocytes bearing T-cell receptor alpha and beta chains in normal human skin. Proc Natl Acad Sci U S A (1989) 1.27

The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses. J Exp Med (1988) 1.26

Direct evidence for binding of CD8 to HLA class I antigens. J Exp Med (1989) 1.24

Human immunodeficiency virus infection is efficiently mediated by a glycolipid-anchored form of CD4. Proc Natl Acad Sci U S A (1990) 1.22

Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruzi. J Exp Med (1992) 1.20

Class II MHC molecules and the HIV gp 120 envelope protein interact with functionally distinct regions of the CD4 molecule. EMBO J (1989) 1.20

Analysis of HLA-DR glycoproteins by DNA-mediated gene transfer. Definition of DR2 beta gene products and antigen presentation to T cell clones from leprosy patients. J Exp Med (1988) 1.18

Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway. Mol Cell Biol (1996) 1.17

Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain. Proc Natl Acad Sci U S A (1988) 1.17

Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor. J Exp Med (1998) 1.16

Human eosinophils express CD4 protein and bind human immunodeficiency virus 1 gp120. J Exp Med (1989) 1.16

Molecular dynamics in the membranes of helper T cells. Proc Natl Acad Sci U S A (1988) 1.12

An idiotypic network model of AIDS immunopathogenesis. Proc Natl Acad Sci U S A (1991) 1.12

Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity. Proc Natl Acad Sci U S A (1991) 1.09

Role of CD4 in thymocyte selection and maturation. J Exp Med (1989) 1.08

Using a baculovirus display library to identify MHC class I mimotopes. Proc Natl Acad Sci U S A (2005) 1.07

Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage. J Exp Med (1996) 1.07

Human immunodeficiency virus type 1 gp120 mimics a hidden monomorphic epitope borne by class I major histocompatibility complex heavy chains. J Exp Med (1991) 1.04

Equivalence of human and mouse CD4 in enhancing antigen responses by a mouse class II-restricted T cell hybridoma. J Exp Med (1989) 1.04

Association of p56lck with the cytoplasmic domain of CD4 modulates HIV-1 expression. EMBO J (1994) 1.04

Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A (1990) 1.03

High level of surface CD4 prevents stable human immunodeficiency virus infection of T-cell transfectants. J Virol (1992) 1.03

Repression of human immunodeficiency virus type 1 long terminal repeat-driven gene expression by binding of the virus to its primary cellular receptor, the CD4 molecule. J Virol (1996) 1.02

Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. J Clin Invest (1990) 1.02

Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals. Proc Natl Acad Sci U S A (1990) 1.01

The T-cell accessory molecule CD4 recognizes a monomorphic determinant on isolated Ia. Proc Natl Acad Sci U S A (1988) 1.01

Species specificity and augmentation of responses to class II major histocompatibility complex molecules in human CD4 transgenic mice. J Exp Med (1992) 0.95

Structural requirements for pairing of alpha and beta chains in HLA-DR and HLA-DP molecules. J Exp Med (1990) 0.95

Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma. J Exp Med (1988) 0.94

Detection of CD4+ T cells harboring human immunodeficiency virus type 1 DNA by flow cytometry using simultaneous immunophenotyping and PCR-driven in situ hybridization: evidence of epitope masking of the CD4 cell surface molecule in vivo. J Virol (1995) 0.92

PKC-θ is a drug target for prevention of T cell-mediated autoimmunity and allograft rejection. Endocr Metab Immune Disord Drug Targets (2010) 0.90

Differences in affinity of anti-CD4 monoclonal antibodies predict their effects on syncytium induction by human immunodeficiency virus. Immunology (1990) 0.89

Modulation of WC1, a lineage-specific cell surface molecule of gamma/delta T cells augments cellular proliferation. Immunology (1996) 0.89

Phase 1 study of recombinant human CD4-immunoglobulin G therapy of patients with AIDS and AIDS-related complex. Antimicrob Agents Chemother (1991) 0.88

Functional interaction between human histocompatibility leukocyte antigen (HLA) class II and mouse CD4 molecule in antigen recognition by T cells in HLA-DR and DQ transgenic mice. J Exp Med (1994) 0.88

The protein tyrosine kinase p56lck is required for triggering NF-kappaB activation upon interaction of human immunodeficiency virus type 1 envelope glycoprotein gp120 with cell surface CD4. J Virol (1998) 0.87

Expression of CD4 in transgenic mice alters the specificity of CD8 cells for allogeneic major histocompatibility complex. Proc Natl Acad Sci U S A (1991) 0.86

HLA-DR polymorphism affects the interaction with CD4. J Exp Med (1995) 0.84

Functional phenotype of synovial monocytes modulating inflammatory T-cell responses in rheumatoid arthritis (RA). PLoS One (2014) 0.84

Human dendritic cells stimulate allogeneic T cells in the absence of IL-1. Immunology (1989) 0.83

Effect of recombinant soluble CD4 on human peripheral blood lymphocyte responses in vitro. J Clin Invest (1988) 0.83

The CD4 molecule is not always required for the T cell response to bacterial enterotoxins. J Exp Med (1991) 0.82

Protective versus pathogenic anti-CD4 immunity: insights from the study of natural resistance to HIV infection. J Transl Med (2009) 0.82

A cDNA encoding feline CD4 has a unique repeat sequence downstream of the V-like region. Immunology (1992) 0.82

Design and synthesis of a CD4 beta-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes. Proc Natl Acad Sci U S A (1992) 0.81

Cutting Edge: Chronic NF-κB Activation in CD4+ T Cells in Rheumatoid Arthritis Is Genetically Determined by HLA Risk Alleles. J Immunol (2015) 0.81

CD4-Ia interactions can occur in the absence of T-cell receptor/antigen-Ia recognition. Immunology (1989) 0.80

Analysis of recombinant human tumour necrosis factor-alpha-induced CD4 expression on human eosinophils. Immunology (1996) 0.80

Role of CD4 molecule in the induction of interleukin 2 and interleukin 2 receptor in class II major histocompatibility complex-restricted antigen-specific T helper clones. T cell receptor/CD3 complex transmits CD4-dependent and CD4-independent signals. J Clin Invest (1992) 0.79

Inhibitory activity of HIV envelope gp120 dominates over its antigenicity for human T cells. Clin Exp Immunol (1992) 0.79

Anti-L3T4 antibody inhibits the lysis of H-2 class II antigen-negative target cells by L3T4+ cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1988) 0.79

Evaluation of serum levels of soluble CD4, CD8 and beta 2-microglobulin in visceral human leishmaniasis. Clin Exp Immunol (1994) 0.79

The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling. Immunol Lett (2012) 0.78

Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. Clin Exp Immunol (1998) 0.76

Increased, durable B-cell and ADCC Responses Associated with T-helper Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site. J Virol (2017) 0.75

Development of the cell contact-mediated accessory function for T-cell proliferation in a human promyelocytic leukaemia cell line, HL-60, by 1,25-dihydroxyvitamin D3. Immunology (1992) 0.75

Articles by these authors

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell (1986) 22.26

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci U S A (1979) 21.22

Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell (1978) 19.44

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell (1977) 18.95

A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell (1991) 18.19

Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell (1981) 12.73

The staphylococcal enterotoxins and their relatives. Science (1990) 11.99

Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci U S A (1980) 11.23

Intragenic DNA spacers interrupt the ovalbumin gene. Proc Natl Acad Sci U S A (1978) 11.03

Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol Rev (1983) 10.81

Monoclonal antibodies defining distinctive human T cell surface antigens. Science (1979) 10.50

Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci U S A (1979) 10.28

Chromatographic purification of tetramethylrhodamine-immune globulin conjugates and their use in the cellular localization of rabbit gamma-globulin polypeptide chains. J Immunol (1965) 8.88

Visualizing an olfactory sensory map. Cell (1996) 8.79

Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies. Proc Natl Acad Sci U S A (1983) 8.57

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J Exp Med (1983) 7.55

Interaction of Staphylococcus aureus toxin "superantigens" with human T cells. Proc Natl Acad Sci U S A (1989) 7.48

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell (1985) 7.16

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing. J Exp Med (1983) 6.97

A monoclonal antibody reactive with human peripheral blood monocytes. J Immunol (1980) 6.96

Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet (1981) 6.62

A spatial map of olfactory receptor expression in the Drosophila antenna. Cell (1999) 6.42

A soluble form of CD4 (T4) protein inhibits AIDS virus infection. Nature (1988) 6.39

The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell (1978) 6.38

Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science (2000) 6.22

A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J Immunol (1979) 6.08

A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2. J Immunol (1980) 6.05

Allelic inactivation regulates olfactory receptor gene expression. Cell (1994) 5.93

Fluorescent antibody staining. 3. Preparation of fluorescein-isothiocyanate-labeled antibodies. J Immunol (1965) 5.82

A novel ras-related gene family. Cell (1985) 5.81

Further characterization of the human inducer T cell subset defined by monoclonal antibody. J Immunol (1979) 5.63

Immunologic functions of isolated human lymphocyte subpopulations. I. Quantitative isolation of human T and B cells and response to mitogens. J Immunol (1974) 5.50

An olfactory sensory map in the fly brain. Cell (2000) 5.29

Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei. Proc Natl Acad Sci U S A (1976) 5.27

Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression. J Exp Med (1979) 5.19

Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin 1. J Exp Med (1986) 5.17

Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell (1984) 5.12

A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature (1982) 5.12

A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature (1986) 4.95

A novel family of genes encoding putative pheromone receptors in mammals. Cell (1995) 4.88

Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature (1990) 4.81

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes. Nature (1991) 4.77

Topographic organization of sensory projections to the olfactory bulb. Cell (1994) 4.74

A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell (2001) 4.64

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype. J Exp Med (1984) 4.29

Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines. J Immunol (1983) 4.28

T cells compete for access to antigen-bearing antigen-presenting cells. J Exp Med (2000) 4.16

Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity (1998) 4.15

Interleukin-induced increase in Ia expression by normal mouse B cells. J Exp Med (1984) 4.14

Distribution of Ia-like molecules on the surface of normal and leukemic human cells. Proc Natl Acad Sci U S A (1976) 4.05

The T cell receptor. Science (1987) 4.00

Transforming DNA integrates into the host chromosome. Cell (1981) 3.98

Type I interferons keep activated T cells alive. J Exp Med (1999) 3.98

Synthesis of globin ribonucleic acid from duck-reticulocyte chromatin in vitro. Proc Natl Acad Sci U S A (1973) 3.93

The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes. Cell (1985) 3.91

Superantigens and their potential role in human disease. Adv Immunol (1993) 3.88

Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus. EMBO J (1988) 3.82

Altering genotype and phenotype by DNA-mediated gene transfer. Science (1980) 3.82

Integration, transcription, and control of a Drosophila heat shock gene in mouse cells. Proc Natl Acad Sci U S A (1981) 3.70

The role of the T cell receptor in positive and negative selection of developing T cells. Science (1990) 3.64

Use of monoclonal antibodies to T-cell subsets for immunologic monitoring and treatment in recipients of renal allografts. N Engl J Med (1981) 3.63

Immunohistologic abnormalities of the microfibrillar-fiber system in the Marfan syndrome. N Engl J Med (1990) 3.63

Reactivity of Langerhans cells with hybridoma antibody. Proc Natl Acad Sci U S A (1981) 3.62

The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product. J Exp Med (1983) 3.54

AIDS--an immunologic reevaluation. N Engl J Med (1984) 3.53

Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proc Natl Acad Sci U S A (1979) 3.53

Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell (1993) 3.53

Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1987) 3.50

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas. Proc Natl Acad Sci U S A (1982) 3.41

Transformation of mammalian cells with an amplifiable dominant-acting gene. Proc Natl Acad Sci U S A (1980) 3.39

Studies on mediator production by highly purified human T and B lymphocytes. J Exp Med (1974) 3.38

Participation of monocyte-macrophages and lymphocytes in the production of a factor that stimulates collagenase and prostaglandin release by rheumatoid synovial cells. J Clin Invest (1979) 3.34

The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells. J Exp Med (1990) 3.31

Specific sites of interaction between histones and DNA in chromatin. Proc Natl Acad Sci U S A (1974) 3.25

Cleavage of DNA in nuclei and chromatin with staphylococcal nuclease. Biochemistry (1975) 3.20

Superantigens interact with MHC class II molecules outside of the antigen groove. Cell (1990) 3.20

Analysis of DNA of isolated chromatin subunits. Proc Natl Acad Sci U S A (1975) 3.17

Self-regulation of procoagulant events on the endothelial cell surface. J Exp Med (1985) 3.16

An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro. Proc Natl Acad Sci U S A (1999) 3.15

Does OKT3 monoclonal antibody react with an antigen-recognition structure on human T cells? Proc Natl Acad Sci U S A (1981) 3.09

Autoimmune disease: why and where it occurs. Nat Med (2001) 3.04

The repertoire of T cells shaped by a single MHC/peptide ligand. Cell (1996) 3.04

Concanavalin A-inducible, interleukin-2-producing T cell hybridoma. J Exp Med (1980) 3.02

Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science (1988) 3.02

Mice deficient in G(olf) are anosmic. Neuron (1998) 3.00

Production of soluble MHC class II proteins with covalently bound single peptides. Nature (1994) 2.98

Simple and rapid measurement of human T lymphocytes and their subclasses in peripheral blood. Proc Natl Acad Sci U S A (1980) 2.96

Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative T-T interactions in the immunoregulation of B cell differentiation. J Immunol (1980) 2.93

Primary structure of human T-cell receptor alpha-chain. Nature (1985) 2.93

A maternally inherited superantigen encoded by a mammary tumour virus. Nature (1991) 2.92

HIV infection does not require endocytosis of its receptor, CD4. Cell (1988) 2.88

Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity (1999) 2.84

Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens. J Exp Med (1982) 2.81