Published in N Engl J Med on December 03, 1970
Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria). Proc Natl Acad Sci U S A (1974) 1.51
Glutathione biosynthesis in human erythrocytes. I. Identification of the enzymes of glutathione synthesis in hemolysates. J Clin Invest (1971) 1.20
Biochemical assessment of red blood cells during storage by (1)H nuclear magnetic resonance spectroscopy. Identification of a biomarker of their level of protection against oxidative stress. Blood Transfus (2014) 1.01
Biochemical heterogeneity in glutathione synthetase deficiency. J Clin Invest (1978) 0.99
Glutathione synthesis in human erythrocytes. II. Purification and properties of the enzymes of glutathione biosynthesis. J Clin Invest (1971) 0.94
Erythrocyte glutathione synthetase deficiency leads not only to glutathione but also to glutathione-S-transferase deficiency. J Clin Invest (1986) 0.85
Wandering through the laboratory. J Biol Chem (2010) 0.75
Glutathione synthetase deficiency: a family report. J R Soc Med (1994) 0.75
STUDIES IN IRON TRANSPORTATION AND METABOLISM. IV. OBSERVATIONS ON THE ABSORPTION OF IRON FROM THE GASTRO-INTESTINAL TRACT. J Clin Invest (1939) 10.38
Acetylation of prostaglandin synthase by aspirin. Proc Natl Acad Sci U S A (1975) 4.92
ABSORPTION OF FERROUS AND FERRIC RADIOACTIVE IRON BY HUMAN SUBJECTS AND BY DOGS. J Clin Invest (1944) 4.15
Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci U S A (1998) 4.07
The metabolism of phosphoinositide-derived messenger molecules. Science (1986) 3.58
Diglyceride lipase: a pathway for arachidonate release from human platelets. Proc Natl Acad Sci U S A (1979) 3.48
The binding of thrombin to the surface of human platelets. J Biol Chem (1974) 3.41
The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein. J Clin Invest (1975) 3.40
STUDIES IN IRON TRANSPORTATION AND METABOLISM. III. THE NORMAL FLUCTUATIONS OF SERUM AND "EASILY SPLIT-OFF" BLOOD IRON IN INDIVIDUAL SUBJECTS. J Clin Invest (1939) 3.29
A thrombin-sensitive protein of human platelet membranes. Proc Natl Acad Sci U S A (1971) 2.97
SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase. Proc Natl Acad Sci U S A (1998) 2.73
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1996) 2.68
Fraud in medical research. Presidential address delivered before the 74th annual meeting of the American Society for Clinical Investigation, Washington, DC, 8 May 1982. J Clin Invest (1982) 2.62
Properties of the factor Xa binding site on human platelets. J Biol Chem (1978) 2.59
Sickle-cell anemia and other hemoglobinopathies. Procedures and strategy for screening employing spots of blood on filter paper as specimens. N Engl J Med (1973) 2.57
Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate. J Biol Chem (1985) 2.55
Isolation and properties of a thrombin-sensitive protein of human platelets. J Biol Chem (1972) 2.54
Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest (1978) 2.40
Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. Proc Natl Acad Sci U S A (1991) 2.35
Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin. Biochem Biophys Res Commun (1977) 2.30
Protein kinase C phosphorylates human platelet inositol trisphosphate 5'-phosphomonoesterase, increasing the phosphatase activity. Cell (1986) 2.15
Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma. Lancet (1972) 2.13
Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. Proc Natl Acad Sci U S A (1991) 2.04
Interaction of coagulation factor Xa with human platelets. Proc Natl Acad Sci U S A (1977) 2.03
Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells. J Biol Chem (1985) 1.98
Structure and function of thrombomodulin: a natural anticoagulant. Blood (1990) 1.96
Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody. J Clin Invest (1980) 1.95
Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta. J Cell Biol (1985) 1.92
Isolation of human platelets and platelet surface membranes. Methods Enzymol (1974) 1.91
Acetyl coenzyme A carboxylase. The roles of synthesis and degradation in regulation of enzyme levels in rat liver. J Biol Chem (1969) 1.91
The synthesis of sulfated dextran beads for isolation of human plasma coagulation factors II, IX, and X. Anal Biochem (1980) 1.89
The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1995) 1.87
Thrombin-induced protein phosphorylation in human platelets. J Clin Invest (1975) 1.76
Structure and function of the acyl carrier protein. Fed Proc (1967) 1.76
Phosphoinositide interconversion in thrombin-stimulated human platelets. J Biol Chem (1985) 1.74
Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. Biochemistry (1987) 1.72
Purification and characterization of human coagulation factor V. J Biol Chem (1981) 1.67
Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. J Biol Chem (1989) 1.67
Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions. J Clin Invest (1977) 1.63
Lipid metabolism in human platelets. II. De novo phospholipid synthesis and the effect of thrombin on the pattern of synthesis. J Clin Invest (1969) 1.62
Purification and properties of human coagulation factor VII. J Biol Chem (1980) 1.61
The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. J Biol Chem (1997) 1.60
Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes. J Biol Chem (1984) 1.60
Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate. J Biol Chem (1983) 1.59
The binding of phytohemagglutinins to human platelet plasma membranes. J Biol Chem (1972) 1.59
The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase. J Biol Chem (2000) 1.58
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Curr Biol (1996) 1.57
Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate. J Biol Chem (1998) 1.56
The measurement of thrombin in clotting blood by radioimmunoassay. J Clin Invest (1976) 1.56
Characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblasts. Cell (1979) 1.55
Production of phosphoinositide-derived messengers. Cell (1984) 1.54
The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. J Biol Chem (1995) 1.54
Identification and properties of two distinct phosphatidylinositol-specific phospholipase C enzymes from sheep seminal vesicular glands. J Biol Chem (1982) 1.54
Pathway for inositol 1,3,4-trisphosphate and 1,4-bisphosphate metabolism. Proc Natl Acad Sci U S A (1987) 1.53
Primary structure of the major beta-chain of rat haemoglobins. Biochem J (1978) 1.52
Isolation and characterization of thrombomodulin from human placenta. J Biol Chem (1984) 1.50
Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes. Proc Natl Acad Sci U S A (1985) 1.49
Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. Proc Natl Acad Sci U S A (1995) 1.47
Arachidonate metabolism in vascular disorders. J Clin Invest (1983) 1.43
Patients with congenital factor V deficiency have decreased factor Xa binding sites on their platelets. J Clin Invest (1978) 1.42
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes. J Biol Chem (1987) 1.41
Thrombin-induced hydrolysis of phosphatidylinositol in human platelets. J Biol Chem (1980) 1.39
Prevention of thrombosis in patients on hemodialysis by low-dose aspirin. N Engl J Med (1979) 1.39
Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J Neurosci Res (2001) 1.38
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+. J Biol Chem (1987) 1.38
Properties of type II inositol polyphosphate 5-phosphatase. J Biol Chem (1995) 1.38
Discovery of an arachidonoyl coenzyme A synthetase in human platelets. J Biol Chem (1982) 1.36
Acyl carrier protein. VII. The primary structure of the substrate-binding site. J Biol Chem (1965) 1.35
The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell (2000) 1.34
The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. J Biol Chem (1988) 1.34
Hypercalcemia associated with chronic lymphocytic leukemia. Arch Intern Med (1979) 1.33
Inositol hexakisphosphate binds to clathrin assembly protein 3 (AP-3/AP180) and inhibits clathrin cage assembly in vitro. J Biol Chem (1995) 1.32
Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules. J Biol Chem (1997) 1.32
The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate. J Biol Chem (1987) 1.32
Inhibition of human platelet aggregation by monovalent antifibrinogen antibody fragments. J Clin Invest (1975) 1.32
Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme. J Biol Chem (1996) 1.30
Lack of covalent modification of prostaglandin synthetase (cyclo-oxygenase) by indomethacin. Prostaglandins (1977) 1.30
The effects of mepacrine and p-bromophenacyl bromide on arachidonic acid release in human platelets. Arch Biochem Biophys (1982) 1.29
The regulation of fatty acid biosynthesis in rat hepatomas. J Biol Chem (1968) 1.29
Factor Va-dependent binding of factor Xa to human platelets. J Biol Chem (1980) 1.28
Pseudohypoxemia secondary to leukemia and thrombocytosis. N Engl J Med (1979) 1.28
Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. J Biol Chem (1991) 1.27
Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts. J Biol Chem (1986) 1.25
Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography. J Biol Chem (1994) 1.25
The effects of thrombin on adenyl cyclase activity and a membrane protein from human platelets. J Clin Invest (1972) 1.24
Induction of the platelet release reaction by phytohemagglutinin. J Clin Invest (1974) 1.23
Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder. Blood (1979) 1.20
Glutathione biosynthesis in human erythrocytes. I. Identification of the enzymes of glutathione synthesis in hemolysates. J Clin Invest (1971) 1.20
The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages. Curr Biol (1998) 1.19
Decreased complement mediated binding of antibody/3H-dsDNA immune complexes to the red blood cells of patients with systemic lupus erythematosus, rheumatoid arthritis, and hematologic malignancies. Arthritis Rheum (1983) 1.19
Intestinal infarction caused by paroxysmal nocturnal hemoglobinuria. Am J Hematol (1984) 1.19
Phosphatidylinositol signalling reactions. Semin Cell Dev Biol (1998) 1.18
Properties of inositol polyphosphate 1-phosphatase. J Biol Chem (1988) 1.17
Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets. J Biol Chem (1989) 1.17
Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin. Proc Natl Acad Sci U S A (1978) 1.17
Lymphocyte subsets in normal bone marrow. Blood (1986) 1.17
Thrombomodulin is present in human plasma and urine. J Clin Invest (1985) 1.17
Fatty acid biosynthesis and the role of the acyl carrier protein. Adv Lipid Res (1967) 1.17
Diverse proteins homologous to inositol monophosphatase. FEBS Lett (1991) 1.16