Published in J Clin Invest on July 01, 1985
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med (1989) 7.72
Inhibition of tumor growth by elimination of granulocytes. J Exp Med (1995) 2.65
Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol (2013) 2.31
Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest (1986) 2.09
Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer. Breast Cancer Res (2001) 1.97
Secretion of pyruvate. An antioxidant defense of mammalian cells. J Exp Med (1987) 1.61
Progression of human breast cancers to the metastatic state is linked to hydroxyl radical-induced DNA damage. Proc Natl Acad Sci U S A (1996) 1.59
Oxidant-induced DNA damage of target cells. J Clin Invest (1988) 1.56
A unified theory of carcinogenesis based on order-disorder transitions in DNA structure as studied in the human ovary and breast. Proc Natl Acad Sci U S A (1998) 1.16
Tumor progression to the metastatic state involves structural modifications in DNA markedly different from those associated with primary tumor formation. Proc Natl Acad Sci U S A (1996) 1.09
A journey in science: promise, purpose, privilege. Mol Med (2013) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med (1967) 16.75
Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem (1969) 15.62
Iodination of bacteria: a bactericidal mechanism. J Exp Med (1967) 10.30
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J Natl Cancer Inst (1977) 6.91
The assay of catalases and peroxidases. Methods Biochem Anal (1954) 6.25
Tissue fractionation studies. 17. Intracellular distribution of monoamine oxidase, aspartate aminotransferase, alanine aminotransferase, D-amino acid oxidase and catalase in rat-liver tissue. Biochem J (1964) 5.74
The reduction of cytochrome c by milk xanthine oxidase. J Biol Chem (1968) 4.72
Hydrogen peroxide metabolism in human monocytes during differentiation in vitro. J Clin Invest (1981) 4.46
Absence of HeLa cell contamination in 169 cell lines derived from human tumors. J Natl Cancer Inst (1977) 4.35
Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide. J Exp Med (1979) 3.61
Role of superoxide dismutase in cancer: a review. Cancer Res (1979) 3.34
Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells. J Clin Invest (1981) 2.97
A study of the inhibition of catalase by 3-amino-1:2:4:-triazole. Biochem J (1958) 2.88
Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment. J Clin Invest (1981) 2.50
Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues. Cancer Res (1982) 2.19
Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical. J Biol Chem (1981) 2.16
Autooxidation as a basis for altered function by polymorphonuclear leukocytes. Blood (1977) 2.10
Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide. J Clin Invest (1984) 1.94
Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals. J Biol Chem (1981) 1.88
Secretion of oxygen intermediates: role in effector functions of activated macrophages. Fed Proc (1982) 1.81
Peroxidase-mediated mammalian cell cytotoxicity. J Exp Med (1973) 1.77
Differential effects of hydrogen peroxide on indices of endothelial cell function. J Exp Med (1984) 1.72
Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis. J Exp Med (1981) 1.71
Protection of phagocytic leukocytes by endogenous glutathione: studies in a family with glutathione reductase deficiency. Blood (1979) 1.60
Monocyte and granulocyte-mediated tumor cell destruction. A role for the hydrogen peroxide-myeloperoxidase-chloride system. J Clin Invest (1982) 1.56
Purification and some properties of L-ascorbic-acid-specific peroxidase in Euglena gracilis Z. Arch Biochem Biophys (1980) 1.53
Quantitative and temporal characterization of the extracellular H2O2 pool generated by human neutrophils. J Biol Chem (1984) 1.53
Antitumor effects of hydrogen peroxide in vivo. J Exp Med (1981) 1.41
Peroxidative hemolysis of red blood cells from patients with abetalipoproteinemia (acanthocytosis). J Clin Invest (1967) 1.39
Glutathione depletion sensitizes tumor cells to oxidative cytolysis. J Biol Chem (1982) 1.31
Superoxide dismutase activity of normal murine liver, regenerating liver, and H6 hepatoma. J Natl Cancer Inst (1978) 1.27
Suppression of natural killing in vitro by monocytes and polymorphonuclear leukocytes: requirement for reactive metabolites of oxygen. J Clin Invest (1982) 1.25
Leukocyte-platelet interaction. Release of hydrogen peroxide by granulocytes as a modulator of platelet reactions. J Clin Invest (1976) 1.12
Hydrogen peroxide and cytolytic factor can interact synergistically in effecting cytolysis of neoplastic targets. J Immunol (1981) 1.08
Human monocyte-mediated tumor cytotoxicity. I. Demonstration of an oxygen-dependent myeloperoxidase-independent mechanism. J Immunol (1984) 1.06
Superoxide dismutase activity in WI-38 cell cultures: effects of age, trypsinization and SV-40 transformation. Physiol Chem Phys (1974) 0.97
Mechanisms of tumour cell destruction by PMA-activated human neutrophils. Immunology (1983) 0.97
Enzyme defense against reactive oxygen derivatives. II. Erythrocytes and tumor cells. Mol Cell Biochem (1976) 0.94
Differential sensitivity of tumor cells to externally generated hydrogen peroxide. Role of glutathione and related enzymes. Cancer Biochem Biophys (1979) 0.94
Human B lymphocytes show greater susceptibility to H2O2 toxicity than T lymphocytes. J Immunol (1984) 0.93
Inhibition of glutathione synthesis augments lysis of murine tumor cells by sulfhydryl-reactive antineoplastics. J Clin Invest (1983) 0.92
The interaction of hydroxyl radicals with dimethylsulfoxide produces formaldehyde. FEBS Lett (1980) 0.91
Modification of superoxide dismutase in rat mammary carcinoma. Res Commun Chem Pathol Pharmacol (1977) 0.88
The effect of oxidant injury on the lymphocyte membrane and functions. J Lab Clin Med (1981) 0.88
Bacillus Calmette-Guérin-activated murine macrophages kill syngeneic melanoma cells under strict anaerobic conditions. J Exp Med (1984) 0.85
[Inbitition of lipid peroxidation and detoxification of lipoperoxides by protective enzyme systems (superoxide dismutase, glutathione peroxidase and glutathione reductase) during experimental neoplastic growth]. Dokl Akad Nauk SSSR (1976) 0.84
Use of an oxidase electrode to determine factors affecting the in vitro production of hydrogen peroxide by Ehrlich cells and 1-chloro-2, 4-dinitrobenzene. Biochem Pharmacol (1981) 0.80
An NADH coupled assay system for galactose oxidase. Anal Biochem (1978) 0.79
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol (1988) 14.21
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med (1983) 14.08
Secretory products of macrophages. J Clin Invest (1987) 10.33
Alterations of macrophage functions by mediators from lymphocytes. J Exp Med (1971) 7.95
Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci U S A (1997) 7.90
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med (1989) 7.72
Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res (1991) 6.99
Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering. J Exp Med (1977) 5.44
Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity. J Exp Med (1979) 5.38
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. J Exp Med (1988) 5.16
Hydrogen peroxide metabolism in human monocytes during differentiation in vitro. J Clin Invest (1981) 4.46
The macrophage as an effector cell. N Engl J Med (1980) 4.30
Local and systemic effects of intradermal recombinant interferon-gamma in patients with lepromatous leprosy. N Engl J Med (1986) 4.05
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proc Natl Acad Sci U S A (1991) 4.01
Characterization of a lymphocyte factor which alters macrophage functions. J Exp Med (1973) 3.98
Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma. J Immunol (1985) 3.85
Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates. J Exp Med (1979) 3.72
Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide. J Exp Med (1979) 3.61
Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. J Immunol (1990) 3.55
Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J (1991) 3.41
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J Biol Chem (1989) 3.31
Activation of human macrophages. Comparison of other cytokines with interferon-gamma. J Exp Med (1984) 3.02
Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. J Exp Med (1989) 2.99
Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med (1993) 2.98
A simple method for counting adherent cells: application to cultured human monocytes, macrophages and multinucleated giant cells. J Immunol Methods (1983) 2.75
Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A (1989) 2.59
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J (1991) 2.57
Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J Exp Med (1999) 2.51
A semi-automated micro-assay for H2O2 release by human blood monocytes and mouse peritoneal macrophages. J Immunol Methods (1985) 2.46
Experimental visceral leishmaniasis: production of interleukin 2 and interferon-gamma, tissue immune reaction, and response to treatment with interleukin 2 and interferon-gamma. J Immunol (1987) 2.45
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine. J Biol Chem (1991) 2.38
Liver macrophages in murine listeriosis. Cell-mediated immunity is correlated with an influx of macrophages capable of generating reactive oxygen intermediates. J Exp Med (1985) 2.37
Lymphokines enhance the capacity of human monocytes to secret reactive oxygen intermediates. J Clin Invest (1982) 2.23
Cellular responses to the intradermal injection of recombinant human gamma-interferon in lepromatous leprosy patients. Am J Pathol (1987) 2.18
Murine Kupffer cells. Mononuclear phagocytes deficient in the generation of reactive oxygen intermediates. J Exp Med (1985) 2.03
Mechanisms of macrophage antimicrobial activity. Trans R Soc Trop Med Hyg (1983) 2.01
Glutathione metabolism as a determinant of therapeutic efficacy: a review. Cancer Res (1984) 1.98
Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med (1998) 1.96
Shared actions of endotoxin and taxol on TNF receptors and TNF release. Science (1990) 1.91
Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma. J Exp Med (1987) 1.85
A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Cancer Res (1999) 1.85
Trace levels of bacterial lipopolysaccharide prevent interferon-gamma or tumor necrosis factor-alpha from enhancing mouse peritoneal macrophage respiratory burst capacity. J Immunol (1987) 1.85
Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J Exp Med (1991) 1.83
Secretion of oxygen intermediates: role in effector functions of activated macrophages. Fed Proc (1982) 1.81
Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages. J Exp Med (1975) 1.77
Characterization of the nonphagocytic adherent cell from the peritoneal cavity of normal and BCG-treated mice. J Immunol (1977) 1.77
Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties. J Clin Invest (1990) 1.74
Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice. J Exp Med (1998) 1.74
T cell assays and MIATA: the essential minimum for maximum impact. Immunity (2012) 1.74
Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria. Curr Opin Microbiol (2000) 1.73
Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis. J Exp Med (1981) 1.71
L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen. J Biol Chem (1990) 1.70
Phase I trial of recombinant interferon gamma in cancer patients. J Clin Oncol (1986) 1.68
Decreased phagocytosis by peritoneal macrophages from BCG-treated mice: induction of the phagocytic defect in normal macrophages with BCG in vitro. Cell Immunol (1977) 1.61
Secretion of pyruvate. An antioxidant defense of mammalian cells. J Exp Med (1987) 1.61
FAD and GSH participate in macrophage synthesis of nitric oxide. Biochem Biophys Res Commun (1990) 1.59
Suppression of macrophage oxidative metabolism by products of malignant and nonmalignant cells. J Exp Med (1982) 1.58
Enzymatic basis of macrophage activation. Kinetic analysis of superoxide production in lysates of resident and activated mouse peritoneal macrophages and granulocytes. J Biol Chem (1984) 1.54
Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: requirement for inducible and constitutive components. Biochem Biophys Res Commun (1989) 1.53
Macrophage oxygen-dependent antimicrobial activity. IV. Role of endogenous scavengers of oxygen intermediates. J Exp Med (1980) 1.44
Functional channel formation associated with cytotoxic T-cell granules. Proc Natl Acad Sci U S A (1986) 1.43
Macrophages rapidly internalize their tumor necrosis factor receptors in response to bacterial lipopolysaccharide. J Biol Chem (1989) 1.42
Antitumor effects of hydrogen peroxide in vivo. J Exp Med (1981) 1.41
Bacterial infection induces nitric oxide synthase in human neutrophils. J Clin Invest (1997) 1.40
Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide. Proc Natl Acad Sci U S A (1999) 1.40
Minimal information about T cell assays: the process of reaching the community of T cell immunologists in cancer and beyond. Cancer Immunol Immunother (2010) 1.36
Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes. Mol Endocrinol (1992) 1.35
Glutathione depletion sensitizes tumor cells to oxidative cytolysis. J Biol Chem (1982) 1.31
Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents. J Exp Med (1990) 1.29
Administration of recombinant interferon gamma to cancer patients enhances monocyte secretion of hydrogen peroxide. Proc Natl Acad Sci U S A (1985) 1.29
Hydrogen peroxide release by alveolar macrophages from sarcoid patients and by alveolar macrophages from normals after exposure to recombinant interferons alpha A, beta, and gamma and 1,25-dihydroxyvitamin D3. J Clin Invest (1987) 1.28
Suppression of macrophage antimicrobial activity by a tumor cell product. J Immunol (1983) 1.19
Electron microscope observations of African swine fever virus in tissue culture cells. Virology (1966) 1.19
Role of oxygen in T cell-mediated cytolysis. J Immunol (1982) 1.18
Isolation of a subpopulation of adherent peritoneal cells with anti-tumour activity. Nature (1976) 1.16
Lipopolysaccharide-related stimuli induce expression of the secretory leukocyte protease inhibitor, a macrophage-derived lipopolysaccharide inhibitor. Infect Immun (1998) 1.16
Macrophage deactivation. Altered kinetic properties of superoxide-producing enzyme after exposure to tumor cell-conditioned medium. J Exp Med (1986) 1.10
Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection. J Virol (1998) 1.10
Elevation of IL-18 in human sepsis. J Clin Immunol (2000) 1.09
Subcellular location and properties of bactericidal factors from human neutrophils. J Exp Med (1986) 1.09
Immunologic relationship between rinderpest and peste des petits ruminants viruses. Proc Annu Meet U S Anim Health Assoc (1975) 1.09
Hydrogen peroxide and cytolytic factor can interact synergistically in effecting cytolysis of neoplastic targets. J Immunol (1981) 1.08
Augmentation of spontaneous macrophage-mediated cytolysis by eosinophil peroxidase. J Exp Med (1982) 1.05
Secretion of toxic oxygen products by macrophages: regulatory cytokines and their effects on the oxidase. Ciba Found Symp (1986) 1.04
Adenosine regulates the respiratory burst of cytokine-triggered human neutrophils adherent to biologic surfaces. J Immunol (1989) 1.03
Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha. J Clin Invest (1995) 1.03
Effect of recombinant interferon-gamma on hydrogen peroxide-releasing capacity of monocyte-derived macrophages from patients with lepromatous leprosy. J Immunol (1986) 1.01
Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock. Mol Med (1999) 1.00
Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia. Crit Care Med (2000) 0.96
Taxol shares the ability of bacterial lipopolysaccharide to induce tyrosine phosphorylation of microtubule-associated protein kinase. J Immunol (1993) 0.96
Nitrite production by stimulated human polymorphonuclear leukocytes supplemented with azide and catalase. Biochem Biophys Res Commun (1993) 0.95
Peroxide and pteridine: a hypothesis on the regulation of macrophage antimicrobial activity by interferon gamma. Interferon (1986) 0.94
African swine fever: comparison of four serotests on porcine serums in Spain. Am J Vet Res (1974) 0.93
Inhibition of glutathione synthesis augments lysis of murine tumor cells by sulfhydryl-reactive antineoplastics. J Clin Invest (1983) 0.92
Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein. Proc Natl Acad Sci U S A (1986) 0.91
Release of arachidonate and reduction of oxygen. Independent metabolic bursts of the mouse peritoneal macrophage. J Biol Chem (1986) 0.89