Published in J Immunol Methods on April 22, 1985
Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med (1992) 10.08
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. J Exp Med (1988) 5.16
Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes. J Clin Invest (1987) 4.80
NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation. Biochem J (2007) 3.88
Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. J Exp Med (2001) 3.75
Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins. J Cell Biol (1989) 3.68
Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells. J Exp Med (1987) 2.97
Role of the adherence-promoting receptors, CR3, LFA-1, and p150,95, in binding of Histoplasma capsulatum by human macrophages. J Exp Med (1987) 2.87
Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J Exp Med (1989) 2.72
CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation. J Cell Biol (1994) 1.89
Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma. J Exp Med (1987) 1.85
A novel antioxidant gene from Mycobacterium tuberculosis. J Exp Med (1997) 1.52
Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine release. J Clin Invest (1995) 1.49
Tumor necrosis factor and CD11/CD18 (beta 2) integrins act synergistically to lower cAMP in human neutrophils. J Cell Biol (1990) 1.48
Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide. J Clin Invest (1989) 1.34
Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents. J Exp Med (1990) 1.29
Administration of recombinant interferon gamma to cancer patients enhances monocyte secretion of hydrogen peroxide. Proc Natl Acad Sci U S A (1985) 1.29
Hydrogen peroxide release by alveolar macrophages from sarcoid patients and by alveolar macrophages from normals after exposure to recombinant interferons alpha A, beta, and gamma and 1,25-dihydroxyvitamin D3. J Clin Invest (1987) 1.28
Leukocyte response integrin and integrin-associated protein act as a signal transduction unit in generation of a phagocyte respiratory burst. J Exp Med (1993) 1.26
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. J Exp Med (2005) 1.25
Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3). J Exp Med (1987) 1.16
Complementary roles for scavenger receptor A and CD36 of human monocyte-derived macrophages in adhesion to surfaces coated with oxidized low-density lipoproteins and in secretion of H2O2. J Exp Med (1998) 1.10
Analysis of the nonfunctional respiratory burst in murine Kupffer cells. J Exp Med (1988) 1.10
Toxicological investigations on silicon carbide. 2. In vitro cell tests and long term injection tests. Br J Ind Med (1993) 1.00
Involvement of hydrogen peroxide in the differentiation of clonal HD-11EM cells into osteoclast-like cells. J Cell Physiol (1998) 0.95
Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein. Proc Natl Acad Sci U S A (1986) 0.91
Effects of hyaluronic acid on macrophage phagocytosis and active oxygen release. Agents Actions (1993) 0.90
Serum amyloid P inhibits granulocyte adhesion. Fibrogenesis Tissue Repair (2013) 0.86
Evaluation of human monocyte oxidative metabolism utilizing a flow cytometric assay. Clin Exp Immunol (1989) 0.85
Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages. Infect Immun (2012) 0.84
Immune stimulatory and anti-tumour properties of haemin. Clin Exp Immunol (1993) 0.81
Virucidal effect of myeloperoxidase on human immunodeficiency virus type 1-infected T cells. Antimicrob Agents Chemother (1994) 0.79
Freshly isolated and cultured human monocytes obtained by plasmapheresis kill schistosomula of Schistosoma mansoni. Am J Pathol (1991) 0.77
Highly sensitive determination of hydrogen peroxide and glucose by fluorescence correlation spectroscopy. PLoS One (2011) 0.77
Lead inhibits oxidative metabolism of macrophages exposed to macrophage-activating factor. Biochem J (1989) 0.75
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol (1988) 14.21
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med (1983) 14.08
Secretory products of macrophages. J Clin Invest (1987) 10.33
Alterations of macrophage functions by mediators from lymphocytes. J Exp Med (1971) 7.95
Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci U S A (1997) 7.90
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med (1989) 7.72
Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res (1991) 6.99
Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering. J Exp Med (1977) 5.44
Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity. J Exp Med (1979) 5.38
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. J Exp Med (1988) 5.16
Hydrogen peroxide metabolism in human monocytes during differentiation in vitro. J Clin Invest (1981) 4.46
The macrophage as an effector cell. N Engl J Med (1980) 4.30
Local and systemic effects of intradermal recombinant interferon-gamma in patients with lepromatous leprosy. N Engl J Med (1986) 4.05
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proc Natl Acad Sci U S A (1991) 4.01
Characterization of a lymphocyte factor which alters macrophage functions. J Exp Med (1973) 3.98
Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma. J Immunol (1985) 3.85
Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates. J Exp Med (1979) 3.72
Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide. J Exp Med (1979) 3.61
Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. J Immunol (1990) 3.55
Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J (1991) 3.41
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J Biol Chem (1989) 3.31
Activation of human macrophages. Comparison of other cytokines with interferon-gamma. J Exp Med (1984) 3.02
Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. J Exp Med (1989) 2.99
Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med (1993) 2.98
A simple method for counting adherent cells: application to cultured human monocytes, macrophages and multinucleated giant cells. J Immunol Methods (1983) 2.75
Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A (1989) 2.59
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J (1991) 2.57
Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J Exp Med (1999) 2.51
Experimental visceral leishmaniasis: production of interleukin 2 and interferon-gamma, tissue immune reaction, and response to treatment with interleukin 2 and interferon-gamma. J Immunol (1987) 2.45
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine. J Biol Chem (1991) 2.38
Liver macrophages in murine listeriosis. Cell-mediated immunity is correlated with an influx of macrophages capable of generating reactive oxygen intermediates. J Exp Med (1985) 2.37
Lymphokines enhance the capacity of human monocytes to secret reactive oxygen intermediates. J Clin Invest (1982) 2.23
Cellular responses to the intradermal injection of recombinant human gamma-interferon in lepromatous leprosy patients. Am J Pathol (1987) 2.18
Murine Kupffer cells. Mononuclear phagocytes deficient in the generation of reactive oxygen intermediates. J Exp Med (1985) 2.03
Mechanisms of macrophage antimicrobial activity. Trans R Soc Trop Med Hyg (1983) 2.01
Glutathione metabolism as a determinant of therapeutic efficacy: a review. Cancer Res (1984) 1.98
Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med (1998) 1.96
Shared actions of endotoxin and taxol on TNF receptors and TNF release. Science (1990) 1.91
Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma. J Exp Med (1987) 1.85
A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Cancer Res (1999) 1.85
Trace levels of bacterial lipopolysaccharide prevent interferon-gamma or tumor necrosis factor-alpha from enhancing mouse peritoneal macrophage respiratory burst capacity. J Immunol (1987) 1.85
Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J Exp Med (1991) 1.83
Secretion of oxygen intermediates: role in effector functions of activated macrophages. Fed Proc (1982) 1.81
Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages. J Exp Med (1975) 1.77
Characterization of the nonphagocytic adherent cell from the peritoneal cavity of normal and BCG-treated mice. J Immunol (1977) 1.77
Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties. J Clin Invest (1990) 1.74
Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice. J Exp Med (1998) 1.74
Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria. Curr Opin Microbiol (2000) 1.73
Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis. J Exp Med (1981) 1.71
L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen. J Biol Chem (1990) 1.70
Phase I trial of recombinant interferon gamma in cancer patients. J Clin Oncol (1986) 1.68
Decreased phagocytosis by peritoneal macrophages from BCG-treated mice: induction of the phagocytic defect in normal macrophages with BCG in vitro. Cell Immunol (1977) 1.61
Secretion of pyruvate. An antioxidant defense of mammalian cells. J Exp Med (1987) 1.61
FAD and GSH participate in macrophage synthesis of nitric oxide. Biochem Biophys Res Commun (1990) 1.59
Suppression of macrophage oxidative metabolism by products of malignant and nonmalignant cells. J Exp Med (1982) 1.58
Enzymatic basis of macrophage activation. Kinetic analysis of superoxide production in lysates of resident and activated mouse peritoneal macrophages and granulocytes. J Biol Chem (1984) 1.54
Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: requirement for inducible and constitutive components. Biochem Biophys Res Commun (1989) 1.53
Macrophage oxygen-dependent antimicrobial activity. IV. Role of endogenous scavengers of oxygen intermediates. J Exp Med (1980) 1.44
Functional channel formation associated with cytotoxic T-cell granules. Proc Natl Acad Sci U S A (1986) 1.43
Macrophages rapidly internalize their tumor necrosis factor receptors in response to bacterial lipopolysaccharide. J Biol Chem (1989) 1.42
Antitumor effects of hydrogen peroxide in vivo. J Exp Med (1981) 1.41
Bacterial infection induces nitric oxide synthase in human neutrophils. J Clin Invest (1997) 1.40
Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide. Proc Natl Acad Sci U S A (1999) 1.40
Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes. Mol Endocrinol (1992) 1.35
Glutathione depletion sensitizes tumor cells to oxidative cytolysis. J Biol Chem (1982) 1.31
Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents. J Exp Med (1990) 1.29
Administration of recombinant interferon gamma to cancer patients enhances monocyte secretion of hydrogen peroxide. Proc Natl Acad Sci U S A (1985) 1.29
Hydrogen peroxide release by alveolar macrophages from sarcoid patients and by alveolar macrophages from normals after exposure to recombinant interferons alpha A, beta, and gamma and 1,25-dihydroxyvitamin D3. J Clin Invest (1987) 1.28
Resistance of human tumor cells in vitro to oxidative cytolysis. J Clin Invest (1985) 1.25
Suppression of macrophage antimicrobial activity by a tumor cell product. J Immunol (1983) 1.19
Role of oxygen in T cell-mediated cytolysis. J Immunol (1982) 1.18
Isolation of a subpopulation of adherent peritoneal cells with anti-tumour activity. Nature (1976) 1.16
Lipopolysaccharide-related stimuli induce expression of the secretory leukocyte protease inhibitor, a macrophage-derived lipopolysaccharide inhibitor. Infect Immun (1998) 1.16
Macrophage deactivation. Altered kinetic properties of superoxide-producing enzyme after exposure to tumor cell-conditioned medium. J Exp Med (1986) 1.10
Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection. J Virol (1998) 1.10
Elevation of IL-18 in human sepsis. J Clin Immunol (2000) 1.09
Subcellular location and properties of bactericidal factors from human neutrophils. J Exp Med (1986) 1.09
Hydrogen peroxide and cytolytic factor can interact synergistically in effecting cytolysis of neoplastic targets. J Immunol (1981) 1.08
Augmentation of spontaneous macrophage-mediated cytolysis by eosinophil peroxidase. J Exp Med (1982) 1.05
Secretion of toxic oxygen products by macrophages: regulatory cytokines and their effects on the oxidase. Ciba Found Symp (1986) 1.04
Adenosine regulates the respiratory burst of cytokine-triggered human neutrophils adherent to biologic surfaces. J Immunol (1989) 1.03
Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha. J Clin Invest (1995) 1.03
Effect of recombinant interferon-gamma on hydrogen peroxide-releasing capacity of monocyte-derived macrophages from patients with lepromatous leprosy. J Immunol (1986) 1.01
Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock. Mol Med (1999) 1.00
Taxol shares the ability of bacterial lipopolysaccharide to induce tyrosine phosphorylation of microtubule-associated protein kinase. J Immunol (1993) 0.96
Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia. Crit Care Med (2000) 0.96
Nitrite production by stimulated human polymorphonuclear leukocytes supplemented with azide and catalase. Biochem Biophys Res Commun (1993) 0.95
Peroxide and pteridine: a hypothesis on the regulation of macrophage antimicrobial activity by interferon gamma. Interferon (1986) 0.94
Inhibition of glutathione synthesis augments lysis of murine tumor cells by sulfhydryl-reactive antineoplastics. J Clin Invest (1983) 0.92
Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein. Proc Natl Acad Sci U S A (1986) 0.91
Release of arachidonate and reduction of oxygen. Independent metabolic bursts of the mouse peritoneal macrophage. J Biol Chem (1986) 0.89
Bacillus Calmette-Guérin-activated murine macrophages kill syngeneic melanoma cells under strict anaerobic conditions. J Exp Med (1984) 0.85
Relationship between extracellular stimulation of intracellular killing and oxygen-dependent microbicidal systems of monocytes. Infect Immun (1985) 0.85
Treatment of patients with chronic granulomatous disease with recombinant human interferon-gamma does not improve neutrophil oxidative metabolism, cytochrome b558 content or levels of four anti-microbial proteins. Clin Exp Immunol (1992) 0.85
Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both. Shock (1999) 0.84
Paradoxical preservation of a lipopolysaccharide response in C3H/HeJ macrophages: induction of matrix metalloproteinase-9. J Immunol (1999) 0.84
Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor-alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma. Blood (1994) 0.83
Macrophage activation: some questions. Ann Inst Pasteur Immunol (1986) 0.82