Published in J Exp Med on March 16, 1998
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc Natl Acad Sci U S A (2000) 7.39
Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Mol Med (2006) 2.27
Pathogenesis of malaria and clinically similar conditions. Clin Microbiol Rev (2004) 1.87
Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency. Am J Pathol (2002) 1.78
Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice. J Exp Med (1998) 1.74
Insight into oxidative stress in varicocele-associated male infertility: part 1. Nat Rev Urol (2012) 1.52
Impaired liver regeneration in inducible nitric oxide synthasedeficient mice. Proc Natl Acad Sci U S A (1998) 1.44
Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. J Exp Med (1999) 1.38
New perspectives on central and peripheral immune responses to acute traumatic brain injury. J Neuroinflammation (2012) 1.34
NF-kappaB and AP-1 activation by nitric oxide attenuated apoptotic cell death in RAW 264.7 macrophages. Mol Biol Cell (1999) 1.33
The multiplex function of nitric oxide in (auto)immunity. J Exp Med (1998) 1.29
Arginase I expression and activity in human mononuclear cells after injury. Ann Surg (2001) 1.25
A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks. PLoS One (2011) 1.24
Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice. J Clin Invest (1999) 1.21
Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice. PLoS One (2011) 1.20
The role of estrogen and receptor agonists in maintaining organ function after trauma-hemorrhage. Shock (2009) 1.19
Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice. J Clin Invest (2001) 1.12
Hypothermia in bleeding trauma: a friend or a foe? Scand J Trauma Resusc Emerg Med (2009) 1.11
The acute inflammatory response in trauma / hemorrhage and traumatic brain injury: current state and emerging prospects. Libyan J Med (2009) 1.08
Herbal medicinal products target defined biochemical and molecular mediators of inflammatory autoimmune arthritis. Bioorg Med Chem (2010) 1.05
Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury. Am J Pathol (2009) 1.05
Emerging concepts on the anti-inflammatory actions of carbon monoxide-releasing molecules (CO-RMs). Med Gas Res (2012) 0.98
Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation. Immunology (1998) 0.96
Nitric oxide and redox regulation in the liver: part II. Redox biology in pathologic hepatocytes and implications for intervention. J Surg Res (2009) 0.94
Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PLoS One (2008) 0.93
Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway. Ann Surg (2007) 0.93
Myocardial cytokine IL-8 and nitric oxide synthase activity during and after resuscitation: preliminary observations in regards to post-resuscitation myocardial dysfunction. Resuscitation (2008) 0.92
Lack of inducible NO synthase reduces oxidative stress and enhances cardiac response to isoproterenol in mice with deoxycorticosterone acetate-salt hypertension. Hypertension (2005) 0.90
Inducible nitric oxide synthase contributes to immune dysfunction following trauma. Shock (2012) 0.89
Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats. J Physiol (2002) 0.88
Initial resuscitation of hemorrhagic shock. World J Emerg Surg (2006) 0.88
Receptor-mediated phagocytosis of rat macrophages is regulated differentially for opsonized particles and non-opsonized particles containing beta-glucan. Immunology (2001) 0.88
Acute alcohol intoxication reduces mortality, inflammatory responses and hepatic injury after haemorrhage and resuscitation in vivo. Br J Pharmacol (2012) 0.88
Regulation of human immunodeficiency virus type 1 replication in human T lymphocytes by nitric oxide. J Virol (2001) 0.87
Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats. Eur J Nutr (2011) 0.86
Beta2-adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-kappaB activation through beta-arrestin 2. Immunology (2008) 0.86
The role of estrogen receptor subtypes in ameliorating hepatic injury following trauma-hemorrhage. J Hepatol (2007) 0.86
Akt-mediated signaling is induced by cytokines and cyclic adenosine monophosphate and suppresses hepatocyte inducible nitric oxide synthase expression independent of MAPK P44/42. Biochim Biophys Acta (2010) 0.86
Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. Int J Clin Exp Med (2008) 0.86
Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for nuclear factor-kappaB. Crit Care (2002) 0.86
Activation of nuclear factor kappaB and induction of inducible nitric oxide synthase by Ureaplasma urealyticum in macrophages. Infect Immun (2000) 0.86
Activation of macrophage nuclear factor-kappa B and induction of inducible nitric oxide synthase by LPS. Respir Res (2002) 0.85
Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines. J Cancer Res Clin Oncol (2014) 0.84
Role of nitric oxide in inflammation and tissue injury during endotoxemia and hemorrhagic shock. Environ Health Perspect (1998) 0.84
Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes. Nitric Oxide (2008) 0.83
Cytoprotective effects of a cyclic RGD peptide in steatotic liver cold ischemia and reperfusion injury. Am J Transplant (2009) 0.83
Inhibition of NOS-2 expression in macrophages through the inactivation of NF-kappaB by andalusol. Br J Pharmacol (1999) 0.82
17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-α increase, and caspase-3 activation. Cell Biosci (2011) 0.82
Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses. J Leukoc Biol (2009) 0.82
IL-6-mediated activation of Stat3α prevents trauma/hemorrhagic shock-induced liver inflammation. PLoS One (2011) 0.82
Insulin inhibits hepatocyte iNOS expression induced by cytokines by an Akt-dependent mechanism. Am J Physiol Gastrointest Liver Physiol (2011) 0.82
Role of estrogen receptor subtypes in estrogen-induced organ-specific vasorelaxation after trauma-hemorrhage. Am J Physiol Heart Circ Physiol (2008) 0.81
Nitrosative and oxidative stresses contribute to post-ischemic liver injury following severe hemorrhagic shock: the role of hypoxemic resuscitation. PLoS One (2012) 0.81
Myeloid knockout of HIF-1 α does not markedly affect hemorrhage/resuscitation-induced inflammation and hepatic injury. Mediators Inflamm (2014) 0.81
Hepatoprotective Activity of the Total Saponins from Actinidia valvata Dunn Root against Carbon Tetrachloride-Induced Liver Damage in Mice. Evid Based Complement Alternat Med (2012) 0.81
Triggering receptor expressed on myeloid cells-1 as a new therapeutic target during inflammatory diseases. Self Nonself (2010) 0.81
Stimulation of Wnt/β-catenin signaling pathway with Wnt agonist reduces organ injury after hemorrhagic shock. J Trauma Acute Care Surg (2015) 0.79
Which gender is better positioned in the process of liver surgery? Male or female? Surg Today (2007) 0.79
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. Mediators Inflamm (2014) 0.79
Resveratrol decreases nitric oxide production by hepatocytes during inflammation. Surgery (2015) 0.78
Hemostatic properties of a venomic protein in rat organ trauma. Exp Mol Pathol (2009) 0.78
Acute ethanol gavage attenuates hemorrhage/resuscitation-induced hepatic oxidative stress in rats. Oxid Med Cell Longev (2012) 0.78
Inducible Nitric Oxide Synthase (iNOS) Is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking. Stem Cell Rev (2016) 0.77
Teratogenic effects of long term consumption of potassium benzoate on eye development in BALB/c fetal mice. Iran J Basic Med Sci (2013) 0.75
Teratogenic effects of long term consumption of potassium benzoate on eye development in BALB/c fetal mice. Iran J Basic Med Sci (2013) 0.75
Blood autotransfusion outcomes compared with Ringer lactate infusion in dogs with hemorrhagic shock induced by controlled bleeding. J Res Med Sci (2011) 0.75
Evaluating the potential role of nitric oxide as a mediator of hydrostatic edema mediated intestinal contractile dysfunction. J Surg Res (2010) 0.75
New progress in roles of nitric oxide during hepatic ischemia reperfusion injury. World J Gastroenterol (2017) 0.75
Inhibition of BTK protects lungs from trauma-hemorrhagic shock-induced injury in rats. Mol Med Rep (2017) 0.75
Enhancing or eliminating signals for cell survival to treat disease. Trans Am Clin Climatol Assoc (2006) 0.75
Induced nitric oxide (NO) synthesis in heterologous nephrotoxic nephritis; effects of selective inhibition in neutrophil-dependent glomerulonephritis. Clin Exp Immunol (1999) 0.75
The Role of NIGMS P50 Sponsored Team Science in Our Understanding of Multiple Organ Failure. J Trauma Acute Care Surg (2017) 0.75
Analysis of immunohistochemical expression of inducible nitric oxide synthase for the evaluation of agonal time in forensic medicine. Int J Legal Med (2016) 0.75
Preliminary profiling of blood transcriptome in a rat model of hemorrhagic shock. Exp Biol Med (Maywood) (2017) 0.75
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
Nitric oxide as a secretory product of mammalian cells. FASEB J (1992) 13.38
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell (1995) 7.13
Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science (1996) 6.70
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell (1994) 6.45
A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science (1993) 4.65
The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J (1990) 4.28
Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity (1997) 4.19
Cytokine signaling through nonreceptor protein tyrosine kinases. Science (1995) 3.16
An essential role for free radicals and derived species in signal transduction. FASEB J (1997) 2.50
Type 1 interferon (IFNalpha/beta) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity (1998) 2.22
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem (1994) 2.13
A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction. J Biol Chem (1997) 2.08
Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proc Natl Acad Sci U S A (1993) 1.96
The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock (1996) 1.78
Redox regulation of cell signalling. Nature (1996) 1.72
Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells. J Biol Chem (1989) 1.60
Differential activation of mitogen-activated protein kinases by nitric oxide-related species. J Biol Chem (1996) 1.40
Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells. Blood (1996) 1.29
Effect of hemorrhagic shock on bacterial translocation, intestinal morphology, and intestinal permeability in conventional and antibiotic-decontaminated rats. Crit Care Med (1990) 1.22
Invited opinion: role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury. Shock (1994) 1.18
Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression. J Clin Invest (1997) 1.04
Molecular cloning of a cDNA encoding an inducible calmodulin-dependent nitric-oxide synthase from rat liver and its expression in COS 1 cells. Eur J Biochem (1993) 1.03
Bacterial translocation in trauma patients. J Trauma (1991) 1.02
Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia. Nitric Oxide (1997) 0.96
Granulocyte colony-stimulating factor rapidly activates a distinct STAT-like protein in normal myeloid cells. Blood (1995) 0.95
Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice. J Exp Med (1995) 0.94
Hemorrhagic shock induces G-CSF expression in bronchial epithelium. Am J Physiol (1997) 0.93
Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury. Shock (1995) 0.90
Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase. Arch Orthop Trauma Surg (1997) 0.87
Activation of STAT proteins in the lung of rats following resuscitation from hemorrhagic shock. Arch Orthop Trauma Surg (1998) 0.82
Hepatic inducible nitric oxide synthase: regulation and function. Biochem Soc Trans (1995) 0.80
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol (1988) 14.21
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med (1983) 14.08
Secretory products of macrophages. J Clin Invest (1987) 10.33
Alterations of macrophage functions by mediators from lymphocytes. J Exp Med (1971) 7.95
Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci U S A (1997) 7.90
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med (1989) 7.72
The Structured Clinical Interview for DSM-III-R (SCID). II. Multisite test-retest reliability. Arch Gen Psychiatry (1992) 7.36
Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res (1991) 6.99
Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering. J Exp Med (1977) 5.44
Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity. J Exp Med (1979) 5.38
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. J Exp Med (1988) 5.16
Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst (1998) 5.05
Hydrogen peroxide metabolism in human monocytes during differentiation in vitro. J Clin Invest (1981) 4.46
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med (2000) 4.40
The macrophage as an effector cell. N Engl J Med (1980) 4.30
Local and systemic effects of intradermal recombinant interferon-gamma in patients with lepromatous leprosy. N Engl J Med (1986) 4.05
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proc Natl Acad Sci U S A (1991) 4.01
Characterization of a lymphocyte factor which alters macrophage functions. J Exp Med (1973) 3.98
Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma. J Immunol (1985) 3.85
Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates. J Exp Med (1979) 3.72
Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res (1993) 3.62
Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide. J Exp Med (1979) 3.61
Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. J Immunol (1990) 3.55
Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J Exp Med (1992) 3.42
Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J (1991) 3.41
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J Biol Chem (1989) 3.31
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci U S A (1993) 3.24
Inflammation, immunoregulation, and inducible nitric oxide synthase. J Leukoc Biol (1993) 3.07
Activation of human macrophages. Comparison of other cytokines with interferon-gamma. J Exp Med (1984) 3.02
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. J Clin Invest (1998) 3.01
Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. J Exp Med (1989) 2.99
Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med (1993) 2.98
Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J Biol Chem (1997) 2.89
Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus. Gastroenterology (1999) 2.75
A simple method for counting adherent cells: application to cultured human monocytes, macrophages and multinucleated giant cells. J Immunol Methods (1983) 2.75
Prospective study of blunt aortic injury: Multicenter Trial of the American Association for the Surgery of Trauma. J Trauma (1997) 2.60
Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A (1989) 2.59
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J (1991) 2.57
Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J Immunol (1987) 2.54
Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J Exp Med (1999) 2.51
Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. J Exp Med (1989) 2.49
A semi-automated micro-assay for H2O2 release by human blood monocytes and mouse peritoneal macrophages. J Immunol Methods (1985) 2.46
Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci U S A (1993) 2.46
Experimental visceral leishmaniasis: production of interleukin 2 and interferon-gamma, tissue immune reaction, and response to treatment with interleukin 2 and interferon-gamma. J Immunol (1987) 2.45
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine. J Biol Chem (1991) 2.38
Liver macrophages in murine listeriosis. Cell-mediated immunity is correlated with an influx of macrophages capable of generating reactive oxygen intermediates. J Exp Med (1985) 2.37
Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene. J Biol Chem (1998) 2.35
Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg (1991) 2.24
Lymphokines enhance the capacity of human monocytes to secret reactive oxygen intermediates. J Clin Invest (1982) 2.23
Type 1 interferon (IFNalpha/beta) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity (1998) 2.22
Cellular responses to the intradermal injection of recombinant human gamma-interferon in lepromatous leprosy patients. Am J Pathol (1987) 2.18
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res (1998) 2.15
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology. Ann Surg Oncol (2006) 2.13
Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores. Biophys J (2005) 2.09
Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol (1991) 2.07
New insights into the regulation of inducible nitric oxide synthesis. Am J Physiol (1994) 2.06
Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J Biol Chem (1992) 2.03
Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway . Prostate (2000) 2.03
Murine Kupffer cells. Mononuclear phagocytes deficient in the generation of reactive oxygen intermediates. J Exp Med (1985) 2.03
Mechanisms of macrophage antimicrobial activity. Trans R Soc Trop Med Hyg (1983) 2.01
Glutathione metabolism as a determinant of therapeutic efficacy: a review. Cancer Res (1984) 1.98
Shared actions of endotoxin and taxol on TNF receptors and TNF release. Science (1990) 1.91
Blastomycosis: a new endemic focus in Canada. Can Med Assoc J (1983) 1.88
Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation. Biochem Biophys Res Commun (1997) 1.87
Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant (2008) 1.86
Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma. J Exp Med (1987) 1.85
A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Cancer Res (1999) 1.85
Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest (1998) 1.85
Trace levels of bacterial lipopolysaccharide prevent interferon-gamma or tumor necrosis factor-alpha from enhancing mouse peritoneal macrophage respiratory burst capacity. J Immunol (1987) 1.85
Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J Biol Chem (1997) 1.83
Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J Exp Med (1991) 1.83
Secretion of oxygen intermediates: role in effector functions of activated macrophages. Fed Proc (1982) 1.81
Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock. Am J Physiol Cell Physiol (2001) 1.81
Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages. J Exp Med (1975) 1.77
Characterization of the nonphagocytic adherent cell from the peritoneal cavity of normal and BCG-treated mice. J Immunol (1977) 1.77
Attenuation of myocardial ischemia/reperfusion injury by superinduction of inducible nitric oxide synthase. Circulation (2000) 1.76
Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine. J Immunol (1990) 1.76
The differentiation of Trichophyton rubrum and T. mentagrophytes by use of Christensen's urea broth. Can J Microbiol (1971) 1.75
Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties. J Clin Invest (1990) 1.74
Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice. J Exp Med (1998) 1.74
Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis. Ann Surg (1990) 1.74
Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria. Curr Opin Microbiol (2000) 1.73
Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis. J Exp Med (1981) 1.71
Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter. Proc Natl Acad Sci U S A (1996) 1.71
L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen. J Biol Chem (1990) 1.70
Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents. Gastroenterology (2000) 1.69
Phase I trial of recombinant interferon gamma in cancer patients. J Clin Oncol (1986) 1.68
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci U S A (1996) 1.68
Molecular biology of nitric oxide synthases. Cancer Metastasis Rev (1998) 1.66
Trauma center maturation: quantification of process and outcome. Ann Surg (1999) 1.64
Traumatic aortic rupture: diagnosis and management. Ann Thorac Surg (1998) 1.64
Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene. J Biol Chem (1994) 1.64
Nitric oxide as a bifunctional regulator of apoptosis. Circ Res (1999) 1.63
Decreased phagocytosis by peritoneal macrophages from BCG-treated mice: induction of the phagocytic defect in normal macrophages with BCG in vitro. Cell Immunol (1977) 1.61
Secretion of pyruvate. An antioxidant defense of mammalian cells. J Exp Med (1987) 1.61
Impaired wound healing and angiogenesis in eNOS-deficient mice. Am J Physiol (1999) 1.60
FAD and GSH participate in macrophage synthesis of nitric oxide. Biochem Biophys Res Commun (1990) 1.59