Published in Proc Natl Acad Sci U S A on March 01, 1986
Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol Cell Biol (1987) 5.67
cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. Proc Natl Acad Sci U S A (1987) 2.97
A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. Mol Cell Biol (1990) 2.90
CENP-B: a major human centromere protein located beneath the kinetochore. J Cell Biol (1990) 2.55
Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster. EMBO J (1989) 2.54
N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts. Mol Cell Biol (1990) 2.24
v-maf, a viral oncogene that encodes a "leucine zipper" motif. Proc Natl Acad Sci U S A (1989) 2.24
A constitutive nucleolar protein identified as a member of the nucleoplasmin family. EMBO J (1987) 2.20
The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma. Proc Natl Acad Sci U S A (2005) 2.19
The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc. EMBO J (1989) 2.18
Neoplastic transformation by the human gene N-myc. Mol Cell Biol (1987) 2.17
Human proto-oncogene N-myc encodes nuclear proteins that bind DNA. Mol Cell Biol (1986) 2.15
Sequence conservation in the protein coding and intron regions of the engrailed transcription unit. EMBO J (1986) 2.05
The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication. Mol Cell Biol (1992) 2.00
Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.98
Sequences of the 5' portion of the human c-sis gene: characterization of the transcriptional promoter and regulation of expression of the protein product by 5' untranslated mRNA sequences. Nucleic Acids Res (1987) 1.91
Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity. Proc Natl Acad Sci U S A (1987) 1.82
Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing. Mol Cell Biol (1988) 1.78
myc boxes, which are conserved in myc family proteins, are signals for protein degradation via the proteasome. Mol Cell Biol (1998) 1.77
Neuroblastoma and MYCN. Cold Spring Harb Perspect Med (2013) 1.75
Structure and expression of the murine L-myc gene. EMBO J (1987) 1.64
The 5' splice site: phylogenetic evolution and variable geometry of association with U1RNA. Nucleic Acids Res (1989) 1.60
The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max(p20/22) in human neuroblastoma cells. EMBO J (1991) 1.52
Sequence analysis of the complete cDNA and encoded polypeptide for the Glued gene of Drosophila melanogaster. Proc Natl Acad Sci U S A (1987) 1.46
L-myc cooperates with ras to transform primary rat embryo fibroblasts. Mol Cell Biol (1988) 1.43
IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression. EMBO J (1989) 1.42
Alternative processing of RNA transcribed from NMYC. Mol Cell Biol (1987) 1.26
DNA-binding domain of human c-Myc produced in Escherichia coli. Mol Cell Biol (1989) 1.15
Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation. PLoS One (2009) 1.15
Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas. J Clin Invest (1991) 1.11
Tetranucleotide repeat polymorphism at the human N-MYC gene (MYCN). Nucleic Acids Res (1992) 1.06
Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells. J Virol (1991) 1.03
Amplified N-myc in human neuroblastoma cells is often arranged as clustered tandem repeats of differently recombined DNA. Mol Cell Biol (1989) 1.03
Isolation and characterization of s-myc, a member of the rat myc gene family. Proc Natl Acad Sci U S A (1989) 1.01
IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis. EMBO J (1990) 1.00
Modulation of N-myc expression alters the invasiveness of neuroblastoma. Clin Exp Metastasis (1997) 0.96
Isolation and structural analysis of a 1.2-megabase N-myc amplicon from a human neuroblastoma. Mol Cell Biol (1992) 0.95
Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene. Mol Cell Biol (1989) 0.94
Structure and expression of B-myc, a new member of the myc gene family. Mol Cell Biol (1988) 0.93
Complete nucleotide sequence and exon-intron boundaries of the 5' non-coding region of the mouse N-myc gene. Nucleic Acids Res (1988) 0.91
Sustained expression of the human protooncogene MYCN rescues rat embryo cells from senescence. Proc Natl Acad Sci U S A (1988) 0.89
The N-myc proto-oncogene and IGF-II growth factor mRNAs are expressed by distinct cells in human fetal kidney and brain. J Cell Biol (1989) 0.89
Expression of the woodchuck N-myc2 retroposon in brain and in liver tumors is driven by a cryptic N-myc promoter. Mol Cell Biol (1992) 0.85
Organization and expression of the chicken N-myc gene. Mol Cell Biol (1990) 0.84
Insertional activation of N-myc by endogenous Moloney-like murine retrovirus sequences in macrophage cell lines derived from myeloma cell line-macrophage hybrids. Mol Cell Biol (1989) 0.83
Nucleotide sequence of the woodchuck N-myc gene (WN-myc1). Nucleic Acids Res (1990) 0.82
High frequency of myelomonocytic tumors in aging E mu L-myc transgenic mice. J Exp Med (1992) 0.81
Subnuclear localization and antitransforming activity of N-myc:beta-galactosidase fusion proteins. Mol Cell Biol (1988) 0.81
N-myc gene expression and oncoprotein characterisation in medulloblastoma. Br J Cancer (1989) 0.81
MYCN, neuroblastoma and focal adhesion kinase (FAK). Front Biosci (Elite Ed) (2011) 0.76
Synthesis, characterization, and evaluation of a novel 99mTc(CO)3 pyrazolyl conjugate of a peptide nucleic acid sequence. J Biol Inorg Chem (2008) 0.76
Targeting focal adhesion kinase in neuroblastoma. Anticancer Agents Med Chem (2010) 0.75
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
New M13 vectors for cloning. Methods Enzymol (1983) 90.74
Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination. Proc Natl Acad Sci U S A (1983) 54.64
A system for shotgun DNA sequencing. Nucleic Acids Res (1981) 52.99
Improved estimation of secondary structure in ribonucleic acids. Nat New Biol (1973) 46.33
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids Res (1984) 39.52
A catalogue of splice junction sequences. Nucleic Acids Res (1982) 39.41
Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. Microbiol Rev (1983) 24.58
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (1984) 24.45
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature (1983) 19.76
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell (1983) 17.87
Cellular oncogenes and retroviruses. Annu Rev Biochem (1983) 10.65
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science (1984) 9.64
The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma. Cell (1983) 8.54
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature (1983) 8.18
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc Natl Acad Sci U S A (1983) 7.01
Onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient. Nature (1982) 6.78
Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation. Cell (1984) 6.53
Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature (1984) 6.23
Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line. Nature (1982) 6.11
Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature (1983) 5.97
Transcripts from the cellular homologs of retroviral oncogenes: distribution among chicken tissues. Mol Cell Biol (1982) 5.70
Nucleotide sequence of cloned cDNA of human c-myc oncogene. Nature (1983) 4.83
L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer. Nature (1985) 4.66
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture. Nature (1985) 4.31
Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell (1983) 4.13
Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29. Nature (1983) 4.06
Identification of nuclear proteins encoded by viral and cellular myc oncogenes. Nature (1984) 3.86
Proteins encoded by v-myc and c-myc oncogenes: identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines. Cell (1983) 3.79
Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus. Nature (1982) 3.64
Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma. Nature (1985) 3.50
Activation of the c-myc gene by translocation: a model for translational control. Proc Natl Acad Sci U S A (1983) 3.36
Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite. Nature (1984) 3.06
Expression and amplification of the N-myc gene in primary retinoblastoma. Nature (1984) 2.99
Activated expression of the N-myc gene in human neuroblastomas and related tumors. Science (1984) 2.46
N-myc can cooperate with ras to transform normal cells in culture. Proc Natl Acad Sci U S A (1985) 2.33
Spatial and temporal pattern of cellular myc oncogene expression in developing human placenta: implications for embryonic cell proliferation. Cell (1984) 1.99
Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma. Proc Natl Acad Sci U S A (1984) 1.99
Differential efficiencies of in vitro translation of mouse c-myc transcripts differing in the 5' untranslated region. Proc Natl Acad Sci U S A (1985) 1.94
Human oncogene locations and chromosome aberrations. Nature (1983) 1.79
Amplification, expression and rearrangement of c-myc and N-myc oncogenes in human lung cancer. Curr Top Microbiol Immunol (1984) 1.12
Nucleotide sequence of the 3' exon of the human N-myc gene. Nucleic Acids Res (1985) 0.92
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol (1985) 25.52
Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nat Med (2001) 16.65
Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA. Cell (1978) 13.33
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein. Cell (1978) 11.17
Correct integration of retroviral DNA in vitro. Cell (1987) 10.73
Cellular oncogenes and retroviruses. Annu Rev Biochem (1983) 10.65
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature (1976) 9.81
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science (1984) 9.64
Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature (1982) 9.12
A nucleoprotein complex mediates the integration of retroviral DNA. Genes Dev (1989) 8.80
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature (1983) 8.18
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. Proc Natl Acad Sci U S A (1989) 8.13
Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell (1999) 8.03
The molecular genetics of cancer. Science (1987) 7.64
Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proc Natl Acad Sci U S A (1979) 7.55
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell (1978) 7.46
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J Virol (1980) 7.37
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc Natl Acad Sci U S A (1983) 7.01
Analysis of avian leukosis virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumor state. Cell (1981) 6.98
Virus-specific ribonucleic acid in cells producing rous sarcoma virus: detection and characterization. J Virol (1972) 6.38
Standardized and simplified nomenclature for proteins common to all retroviruses. J Virol (1988) 6.31
Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell (1982) 6.19
Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature (1983) 5.97
CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem (1993) 5.81
Transcripts from the cellular homologs of retroviral oncogenes: distribution among chicken tissues. Mol Cell Biol (1982) 5.70
Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol Cell Biol (1987) 5.67
Retroviruses. Annu Rev Biochem (1978) 5.41
The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses. Cell (1977) 5.23
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. Nature (1980) 5.22
Viral oncogenes. Cell (1985) 5.20
Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev (1998) 5.14
Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses. J Mol Biol (1976) 5.07
The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membrane. Proc Natl Acad Sci U S A (1980) 4.99
Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J (1997) 4.99
The MYC protein activates transcription of the alpha-prothymosin gene. EMBO J (1991) 4.96
N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis. EMBO J (2001) 4.85
Nucleotide sequence of cloned cDNA of human c-myc oncogene. Nature (1983) 4.83
Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src). Proc Natl Acad Sci U S A (1981) 4.69
Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature (1989) 4.65
The low molecular weight RNAs of Rous sarcoma virus. I. The 4 S RNA. Virology (1970) 4.64
Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex. Science (1998) 4.57
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. Cell (1983) 4.53
Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet (1999) 4.48
Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates. Proc Natl Acad Sci U S A (1978) 4.47
c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature (2001) 4.46
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut (2004) 4.39
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture. Nature (1985) 4.31
Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts. Proc Natl Acad Sci U S A (1973) 4.19
A joint produce of the genes gag and pol of avian sarcoma virus: a possible precursor of reverse transcriptase. Cell (1977) 4.18
Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA. Cell (1977) 4.06
Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src). Proc Natl Acad Sci U S A (1981) 4.04
Kinetics of synthesis, structure and purification of avian sarcoma virus-specific DNA made in the cytoplasm of acutely infected cells. J Mol Biol (1978) 4.04
The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine. J Biol Chem (1980) 3.95
Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia. Proc Natl Acad Sci U S A (1983) 3.90
Transcription of DNA from the 70S RNA of Rous sarcoma virus. I. Identification of a specific 4S RNA which serves as primer. J Virol (1974) 3.90
A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle. Cell (1990) 3.87
Identification of nuclear proteins encoded by viral and cellular myc oncogenes. Nature (1984) 3.86
Nucleotide sequence of cloned unintegrated avian sarcoma virus DNA: viral DNA contains direct and inverted repeats similar to those in transposable elements. Proc Natl Acad Sci U S A (1981) 3.82
Computer-based screening system for patients at risk of hypothyroidism. Lancet (1969) 3.70
DNA and RNA from uninfected vertebrate cells contain nucleotide sequences related to the putative transforming gene of avian myelocytomatosis virus. J Virol (1979) 3.68
Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus. Nature (1975) 3.63
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Nature (1983) 3.56
Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus. Cell (1982) 3.53
Purification and characterization of the deoxyribonucleic acid polymerase associated with Rous sarcoma virus. Biochemistry (1972) 3.53
Daily requirement of oxygen to reverse pulmonary hypertension in patients with chronic bronchitis. Br Med J (1972) 3.43
Corrections to the nucleotide sequence of the src gene of Rous sarcoma virus. Nature (1983) 3.42
Transduction of a cellular oncogene: the genesis of Rous sarcoma virus. Proc Natl Acad Sci U S A (1983) 3.41
Production of mouse mammary tumor virus by cultured cells in the absence and presence of hormones: assay by molecular hybridization. Virology (1975) 3.40
A cellular protein that associates with the transforming protein of Rous sarcoma virus is also a heat-shock protein. Proc Natl Acad Sci U S A (1981) 3.32
RNA-directed DNA polymerase of Rous sarcoma virus: initiation of synthesis with 70 S viral RNA as template. J Mol Biol (1973) 3.32
The protein encoded by the human proto-oncogene c-myc. Proc Natl Acad Sci U S A (1984) 3.31
Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA. Proc Natl Acad Sci U S A (1977) 3.31
Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells). Proc Natl Acad Sci U S A (1972) 3.28
Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc Natl Acad Sci U S A (1999) 3.24
The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant. Mol Cell Biol (1988) 3.24
New method for oxygen therapy in the home using an oxygen concentrator. Br Med J (1973) 3.22
Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb. Cell (1989) 3.21
Appearance of virus-specific DNA in mammalian cells following transformation by Rous sarcoma virus. J Mol Biol (1973) 3.21
The product of the retroviral transforming gene v-myb is a truncated version of the protein encoded by the cellular oncogene c-myb. Cell (1983) 3.21
A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci U S A (1997) 3.20
Characterization of the low-molecular-weight RNAs associated with the 70S RNA of Rous sarcoma virus. J Virol (1973) 3.19
Proposal for naming host cell-derived inserts in retrovirus genomes. J Virol (1981) 3.18
The nucleotide sequence of an untranslated but conserved domain at the 3' end of the avian sarcoma virus genome. Nucleic Acids Res (1980) 3.16
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Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol Cell Biol (1993) 3.13
Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell (1997) 3.06
Reversal of pulmonary hypertension by prolonged oxygen administration to patients with chronic bronchitis. Circ Res (1968) 3.06
Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src. Cell (1984) 3.06
Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics (2001) 3.05
Molecular cloning of the avian erythroblastosis virus genome and recovery of oncogenic virus by transfection of chicken cells. J Virol (1980) 3.01
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Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by chicken c-myb gene. Cell (1984) 2.98
Molecular cloning of the avian myelocytomatosis virus genome and recovery of infectious virus by transfection of chicken cells. J Virol (1981) 2.95
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