PubRank

R Jove

Author PubWeight™ 135.89‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 STATs in oncogenesis. Oncogene 2000 8.60
2 Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999 7.78
3 Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 1995 6.28
4 Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol 1998 4.22
5 Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene 2001 3.96
6 Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest 2001 3.79
7 STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 2000 3.75
8 Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis. Proc Natl Acad Sci U S A 2001 3.29
9 Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem 2001 3.27
10 Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet 1999 2.84
11 AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol 2001 2.81
12 Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ 1997 2.63
13 In vitro transcription from the adenovirus 2 major late promoter utilizing templates truncated at promoter-proximal sites. J Biol Chem 1984 2.58
14 Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system. J Biol Chem 1993 2.17
15 Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo. Cancer Res 1999 2.09
16 Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling. Oncogene 2000 2.06
17 Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. Cancer Res 1997 1.97
18 Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein. Mol Cell Biol 1999 1.80
19 Activation of STAT transcription factors in oncogenic tyrosine kinase signaling. J Biomed Sci 1998 1.77
20 Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region. Cell 1987 1.71
21 Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs. Cell 1984 1.69
22 Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants. J Virol 1986 1.64
23 AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. Cancer Res 1998 1.61
24 Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity. J Biol Chem 2000 1.61
25 Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential. Oncogene 1997 1.48
26 The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase. J Biol Chem 1997 1.45
27 Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system. J Biol Chem 1992 1.42
28 Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors. Oncogene 1999 1.41
29 Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters. J Virol 1986 1.38
30 Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils. J Immunol 2001 1.32
31 STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells. Blood 1999 1.29
32 Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase. J Immunol 1997 1.28
33 Role of the cytoplasmic tyrosines of beta 1A integrins in transformation by v-src. Proc Natl Acad Sci U S A 2001 1.28
34 Characterization of avian and viral p60src proteins expressed in yeast. Proc Natl Acad Sci U S A 1987 1.28
35 Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway. J Biol Chem 1998 1.27
36 STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription. Curr Opin Oncol 1999 1.24
37 Constitutive activation of JAK1 in Src-transformed cells. J Biol Chem 1997 1.23
38 Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest. Cancer Res 2001 1.22
39 The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival. Leukemia 2010 1.20
40 The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation. J Virol 1987 1.20
41 Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity. Oncogene 2000 1.16
42 GTPase-activating protein interactions with the viral and cellular Src kinases. Proc Natl Acad Sci U S A 1991 1.11
43 Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck. J Virol 1997 1.11
44 Raf-1 N-terminal sequences necessary for Ras-Raf interaction and signal transduction. Mol Cell Biol 1995 1.09
45 Transcription initiation by RNA polymerase II is inhibited by S-adenosylhomocysteine. Proc Natl Acad Sci U S A 1982 1.07
46 Molecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein. Mol Cell Biol 1991 1.05
47 Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines. Blood 1999 1.03
48 Biochemical properties of p60v-src mutants that induce different cell transformation parameters. J Virol 1986 1.03
49 The pyrido[2,3-d]pyrimidine derivative PD180970 inhibits p210Bcr-Abl tyrosine kinase and induces apoptosis of K562 leukemic cells. Cancer Res 2000 1.00
50 Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules. Somat Cell Mol Genet 1993 0.99
51 A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase. J Biol Chem 1995 0.98
52 Expression, purification and characterization of recombinant mitogen-activated protein kinase kinases. Biochem J 1994 0.97
53 Elevated c-Src protein expression is an early event in colonic neoplasia. Lab Invest 1998 0.97
54 Functional mapping of the N-terminal regulatory domain in the human Raf-1 protein kinase. J Biol Chem 1995 0.97
55 Activation of extracellular signal-regulated kinase (ERK) by mitogenic stimuli is repressed in v-Src-transformed cells. Cell Growth Differ 1997 0.96
56 Two SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase-activating protein. J Biol Chem 1995 0.96
57 Activation of STAT3 by the c-Fes protein-tyrosine kinase. J Biol Chem 1998 0.96
58 The protein-protein complex between pp60v-src and hsp90 is stabilized by molybdate, vanadate, tungstate, and an endogenous cytosolic metal. J Biol Chem 1992 0.95
59 Lack of induction of neuroretinal cell proliferation by Rous sarcoma virus variants that carry the c-src gene. Mol Cell Biol 1985 0.95
60 Regulation of the junB gene by v-src. Mol Cell Biol 1992 0.94
61 Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential. Cell Growth Differ 1997 0.93
62 The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class. J Biol Chem 1994 0.92
63 Regulation of glucocorticoid receptor function through assembly of a receptor-heat shock protein complex. Ann N Y Acad Sci 1993 0.90
64 Attenuation of serum inducibility of immediate early genes by oncoproteins in tyrosine kinase signaling pathways. Mol Cell Biol 1993 0.90
65 The Src-family kinase Lck can induce STAT3 phosphorylation and DNA binding activity. Cell Signal 1999 0.88
66 The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck. J Biol Chem 1995 0.88
67 Localization of the viral and cellular Src kinases to perinuclear vesicles in fibroblasts. Cell Growth Differ 1992 0.86
68 Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells. Clin Cancer Res 2001 0.85
69 Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors. Leukemia 2002 0.85
70 Dissociation of mitogen-activated protein kinase activation from the oxidative burst in differentiated HL-60 cells and human neutrophils. J Biol Chem 1995 0.83
71 Transcription of methylated eukaryotic viral genes in a soluble in vitro system. Nucleic Acids Res 1984 0.83
72 Analysis of p60v-src mutants carrying lesions involved in temperature sensitivity. J Virol 1987 0.83
73 Direct radioimmunoassay of nuclear 3,5,3' triiodothyronine in rat anterior pituitary. J Clin Invest 1980 0.83
74 Activated Src tyrosine kinase phosphorylates Tyr-457 of bovine GTPase-activating protein (GAP) in vitro and the corresponding residue of rat GAP in vivo. J Biol Chem 1992 0.82
75 Drug resistance in multiple myeloma: approaches to circumvention. Semin Oncol 1999 0.82
76 SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis 2013 0.81
77 Reconstitution of interactions between the Src tyrosine kinases and Ras GTPase-activating protein using a baculovirus expression system. J Biol Chem 1992 0.80
78 N-terminal sequences contained in the Src homology 2 and 3 domains of p120 GTPase-activating protein are required for full catalytic activity toward Ras. J Biol Chem 1996 0.80
79 Differential regulation of neurofibromin and p120 GTPase-activating protein by nutritionally relevant fatty acids. Nutr Cancer 1998 0.80
80 RNA polymerase II terminates transcription in vitro in the SV40 origin region. Nucleic Acids Res 1987 0.79
81 Tyrosine phosphorylation of Ras GTPase-activating protein stabilizes its association with p62 at membranes of v-Src transformed cells. J Biol Chem 1993 0.79
82 Constitutive RelB activation in v-Src-transformed fibroblasts: requirement for IkappaB degradation. J Cell Biochem 1999 0.77
83 Effect of intravenous propranolol on QT interval. Br Heart J 1980 0.76
84 Prostate adenocarcinoma: cellular and molecular abnormalities. Cancer Control 2002 0.76
85 Inhibition of neurofibromin and p120 GTPase activating protein (GAP) by dietary fatty acids. Adv Exp Med Biol 1999 0.75
86 Proximal promoter region of the junB gene mediates attenuation of serum inducibility in Src-transformed cells. Cell Growth Differ 1995 0.75