Published in J Virol on December 01, 1986
N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl. EMBO J (1989) 3.55
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src. Mol Cell Biol (1990) 2.39
Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src. Mol Cell Biol (1992) 2.06
Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants. J Virol (1989) 1.95
Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions. J Cell Biol (1991) 1.82
Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants. J Virol (1986) 1.64
The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels. Mol Cell Biol (1992) 1.55
A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell. Proc Natl Acad Sci U S A (1987) 1.51
Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain. Mol Cell Biol (1990) 1.45
Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein. Mol Cell Biol (1989) 1.25
Structural differences between repressed and derepressed forms of p60c-src. Mol Cell Biol (1989) 1.23
The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation. J Virol (1987) 1.20
Biological and biochemical properties of the c-src+ gene product overexpressed in chicken embryo fibroblasts. Mol Cell Biol (1989) 1.16
A single point mutation has pleiotropic effects on pp60v-src function. J Virol (1988) 1.14
Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions. Proc Natl Acad Sci U S A (2010) 1.07
Mutations in the SH3 domain of the src oncogene which decrease association of phosphatidylinositol 3'-kinase activity with pp60v-src and alter cellular morphology. J Virol (1992) 1.05
Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation. Mol Cell Biol (1991) 1.03
Biochemical properties of p60v-src mutants that induce different cell transformation parameters. J Virol (1986) 1.03
Down regulation by p60v-src of genes specifically expressed and developmentally regulated in postmitotic quail neuroretina cells. Mol Cell Biol (1990) 0.95
Transformation of chicken embryo fibroblast cells by avian retroviruses containing the human Fyn gene and its mutated genes. Mol Cell Biol (1990) 0.89
Analysis of p60v-src mutants carrying lesions involved in temperature sensitivity. J Virol (1987) 0.83
Rous sarcoma virus mutant dlPA105 induces different transformed phenotypes in quail embryonic fibroblasts and neuroretina cells. J Virol (1987) 0.83
Activation of YRP kinase by v-Src and protein kinase C-mediated signal transduction pathways. Proc Natl Acad Sci U S A (1995) 0.78
Nucleotide sequence of Rous sarcoma virus. Cell (1983) 17.80
Protein-tyrosine kinases. Annu Rev Biochem (1985) 14.83
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature (1976) 9.81
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J Virol (1980) 7.37
Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus. Cell (1983) 7.37
Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. Proc Natl Acad Sci U S A (1975) 6.59
A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation. Mol Cell Biol (1984) 6.40
Rapid transformation of cells by Rous sarcoma virus. Proc Natl Acad Sci U S A (1969) 5.27
Recovery of avian sarcoma virus from tumors induced by transformation-defective mutants. J Exp Med (1977) 4.79
An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins. Nature (1985) 4.06
Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src). Proc Natl Acad Sci U S A (1981) 4.04
Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts. Proc Natl Acad Sci U S A (1984) 3.70
Local mutagenesis of Rous sarcoma virus: the major sites of tyrosine and serine phosphorylation of pp60src are dispensable for transformation. Cell (1983) 3.46
Corrections to the nucleotide sequence of the src gene of Rous sarcoma virus. Nature (1983) 3.42
DNA sequence of the viral and cellular src gene of chickens. 1. Complete nucleotide sequence of an EcoRI fragment of recovered avian sarcoma virus which codes for gp37 and pp60src. J Virol (1982) 3.35
Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src. Cell (1984) 3.06
Temperature-sensitive avian sarcoma viruses: a physiological comparison of twenty mutants. Virology (1973) 2.88
Nucleotide sequence of avian sarcoma virus UR2 and comparison of its transforming gene with other members of the tyrosine protein kinase oncogene family. J Virol (1985) 2.88
Activation of the transforming potential of p60c-src by a single amino acid change. Proc Natl Acad Sci U S A (1986) 2.70
Fine structural mapping of a critical NH2-terminal region of p60src. Proc Natl Acad Sci U S A (1985) 2.53
Processing of p60v-src to its myristylated membrane-bound form. Mol Cell Biol (1985) 2.41
N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene. Mol Cell Biol (1985) 2.32
Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells. Proc Natl Acad Sci U S A (1984) 2.30
Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins. J Biol Chem (1984) 1.90
Molecular cloning of avian sarcoma virus closed circular DNA: structural and biological characterization of three recombinant clones. J Virol (1980) 1.80
Distinguishable transformation-defective phenotypes among temperature-sensitive mutants of Rous sarcoma virus. J Virol (1977) 1.79
Role of p60src kinase activity in the induction of neuroretinal cell proliferation by rous sarcoma virus. J Virol (1982) 1.64
Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants. J Virol (1986) 1.64
Biological properties of "partial" transformation mutants of Rous sarcoma virus and characterization of their pp60src kinase. J Virol (1981) 1.58
Dissociation of transformation parameters using temperature-conditional mutants of Rous sarcoma virus. Cell (1979) 1.52
Small deletion in src of Rous sarcoma virus modifying transformation phenotypes: identification of 207-nucleotide deletion and its smaller product with protein kinase activity. J Virol (1983) 1.48
Expression of viral oncogenes in differentiating chick embryo neuroretinal cells infected with avian tumor viruses. Cold Spring Harb Symp Quant Biol (1980) 1.42
Transformation of chick embryo neuroretinal cells by Rous sarcoma virus in vitro: induction of cell proliferation. Science (1974) 1.40
Functional domains of the pp60v-src protein as revealed by analysis of temperature-sensitive Rous sarcoma virus mutants. Mol Cell Biol (1984) 1.35
Two independent mutations are required for temperature-sensitive cell transformation by a Rous sarcoma virus temperature-sensitive mutant. J Virol (1985) 1.25
A transformation defective mutant of Rous sarcoma virus inducing chick embryo neuroretinal cell proliferation. Virology (1978) 1.17
Four Rous sarcoma virus mutants which affect transformed cell morphology exhibit altered src gene products. Virology (1981) 1.10
Polymerase-defective mutant of the Bryan high-titer strain of Rous sarcoma virus. Nucleic Acids Res (1986) 1.08
Biochemical properties of p60v-src mutants that induce different cell transformation parameters. J Virol (1986) 1.03
Lack of induction of neuroretinal cell proliferation by Rous sarcoma virus variants that carry the c-src gene. Mol Cell Biol (1985) 0.95
Role of the mitogenic property and kinase activity of p60src in tumor formation by Rous sarcoma virus. J Virol (1984) 0.92
Stimulation of growth rate of chondrocytes by Rous sarcoma virus is not coordinated with other expressions of the src gene phenotype. J Virol (1980) 0.84
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol (2000) 9.85
STATs in oncogenesis. Oncogene (2000) 8.60
Identification of a ten-amino acid proline-rich SH3 binding site. Science (1993) 8.05
The effects of reciprocal changes in temperature on the transformed state of cells infected with a rous sarcoma virus mutant. Virology (1971) 7.83
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity (1999) 7.78
Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus. Cell (1983) 7.37
A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation. Mol Cell Biol (1984) 6.40
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science (1995) 6.28
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature (1995) 6.20
A novel viral oncogene with structural similarity to phospholipase C. Nature (1988) 5.84
Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet (1983) 5.64
Rapid transformation of cells by Rous sarcoma virus. Proc Natl Acad Sci U S A (1969) 5.27
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol (1994) 5.02
Recovery of avian sarcoma virus from tumors induced by transformation-defective mutants. J Exp Med (1977) 4.79
A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group. N Engl J Med (2000) 4.73
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature (1990) 4.69
Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. Science (1992) 4.57
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature (1992) 4.46
Genetic recombination with avian tumor virus. Virology (1972) 4.23
Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol (1998) 4.22
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell (2000) 4.21
Cell transformation by the viral src oncogene. Annu Rev Cell Biol (1987) 4.18
Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses. Cell (1982) 4.06
An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins. Nature (1985) 4.06
Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein. Science (1985) 3.97
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene (2001) 3.96
Aberrant expression of HLA-DR antigen on thyrocytes in Graves' disease: relevance for autoimmunity. Lancet (1983) 3.85
Characterization of protein kinase activity associated with the transforming gene product of Fujinami sarcoma virus. Cell (1980) 3.82
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest (2001) 3.79
STAT proteins: novel molecular targets for cancer drug discovery. Oncogene (2000) 3.75
Location of envelope-specific and sarcoma-specific oligonucleotides on RNA of Schmidt-Ruppin Rous sarcoma virus. Proc Natl Acad Sci U S A (1976) 3.73
Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts. Proc Natl Acad Sci U S A (1984) 3.70
Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. Science (1990) 3.67
Cellular information in the genome of recovered avian sarcoma virus directs the synthesis of transforming protein. Proc Natl Acad Sci U S A (1979) 3.66
Proteins of helper-dependent RSV. Virology (1971) 3.62
Transformation by Rous sarcoma virus induces a novel gene with homology to a mitogenic platelet protein. Cell (1987) 3.50
Local mutagenesis of Rous sarcoma virus: the major sites of tyrosine and serine phosphorylation of pp60src are dispensable for transformation. Cell (1983) 3.46
A cell-associated factor essential for formation of an infectious form of Rous sarcoma virus. Proc Natl Acad Sci U S A (1970) 3.43
Low level of cellular protein phosphorylation by nontransforming overproduced p60c-src. Mol Cell Biol (1985) 3.39
Recombination between viral and cellular sequences generates transforming sarcoma virus. Proc Natl Acad Sci U S A (1978) 3.38
Isolation of defective mutant of avian sarcoma virus. Proc Natl Acad Sci U S A (1973) 3.38
DNA sequence of the viral and cellular src gene of chickens. 1. Complete nucleotide sequence of an EcoRI fragment of recovered avian sarcoma virus which codes for gp37 and pp60src. J Virol (1982) 3.35
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis. Proc Natl Acad Sci U S A (2001) 3.29
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem (2001) 3.27
DNA in uninfected and virus-infected cells complementary to avian tumor virus RNA. Proc Natl Acad Sci U S A (1971) 3.25
Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc Natl Acad Sci U S A (1996) 3.18
Viral and cellular src genes contribute to the structure of recovered avian sarcoma virus transforming protein. Cell (1981) 3.12
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc Natl Acad Sci U S A (1999) 3.10
Recovery of a new virus from apparently normal chick cells by infection with avian tumor viruses. Proc Natl Acad Sci U S A (1970) 2.99
Analysis of a functional change in membrane in the process of cell transformation by Rous sarcoma virus; alteration in the characteristics of sugar transport. Virology (1970) 2.94
A putative modular domain present in diverse signaling proteins. Cell (1993) 2.90
Determining factor in the capacity of Rous sarcoma virus to induce tumors in mammals. Proc Natl Acad Sci U S A (1966) 2.86
Detection of avian tumor virus RNA in uninfected chicken embryo cells. J Virol (1973) 2.85
Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. J Biol Chem (2001) 2.85
Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet (1999) 2.84
Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein. Mol Cell Biol (1986) 2.84
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol (2001) 2.81
Association of the polyomavirus middle-T antigen with c-yes protein. Nature (1987) 2.78
Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem (1996) 2.77
Activation of the transforming potential of p60c-src by a single amino acid change. Proc Natl Acad Sci U S A (1986) 2.70
Cellular sequences related to three new onc genes of avian sarcoma virus (fps, yes, and ros) and their expression in normal and transformed cells. J Virol (1982) 2.69
c-Abl kinase regulates the protein binding activity of c-Crk. EMBO J (1994) 2.68
Characterization of the transforming gene of Fujinami sarcoma virus. Proc Natl Acad Sci U S A (1980) 2.68
Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest (1993) 2.64
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol Cell (1999) 2.64
Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ (1997) 2.63
A type of chick embryo cell that fails to support formation of infectious RSV. Virology (1970) 2.63
In vitro transcription from the adenovirus 2 major late promoter utilizing templates truncated at promoter-proximal sites. J Biol Chem (1984) 2.58
Fine structural mapping of a critical NH2-terminal region of p60src. Proc Natl Acad Sci U S A (1985) 2.53
Homology exists among the transforming sequences of avian and feline sarcoma viruses. Proc Natl Acad Sci U S A (1980) 2.50
BRCA1 regulates p53-dependent gene expression. Proc Natl Acad Sci U S A (1998) 2.50
Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity. Proc Natl Acad Sci U S A (1990) 2.48
Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. Mol Cell Biol (1993) 2.47
Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes (1999) 2.47
DNA sequence of the viral and cellular src gene of chickens. II. Comparison of the src genes of two strains of avian sarcoma virus and of the cellular homolog. J Virol (1982) 2.46
Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins. Mol Cell Biol (1995) 2.44
Phosphorylation of cellular proteins in Rous sarcoma virus-infected cells: analysis by use of anti-phosphotyrosine antibodies. Mol Cell Biol (1988) 2.44
Transformation-defective mutants of Rous sarcoma virus with src gene deletions of varying length. J Virol (1977) 2.43
Microinjection analysis of envelope-glycoprotein messenger activities of avian leukosis viral RNAs. Proc Natl Acad Sci U S A (1977) 2.42
Processing of p60v-src to its myristylated membrane-bound form. Mol Cell Biol (1985) 2.41
Isolation and characterization of fra-2, an additional member of the fos gene family. Proc Natl Acad Sci U S A (1990) 2.40
Only membrane-associated RSV src proteins have amino-terminally bound lipid. Nature (1983) 2.37
RNA of replication-defective strains of Rous sarcoma virus. Proc Natl Acad Sci U S A (1975) 2.37
Existence and expression of tumor virus genes in chick embryo cells. Virology (1972) 2.36