Published in EMBO J on July 01, 1988
Nucleotide excision repair in Escherichia coli. Microbiol Rev (1990) 3.39
Mechanisms of directed mutation. Genetics (1992) 2.92
RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage. Genetics (1997) 2.84
Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer (2012) 2.52
Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage. EMBO J (1990) 2.41
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Acad Sci U S A (1990) 2.14
Substrate spectrum of human excinuclease: repair of abasic sites, methylated bases, mismatches, and bulky adducts. Proc Natl Acad Sci U S A (1994) 1.94
Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation. Carcinogenesis (2009) 1.73
Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature (2009) 1.70
DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli. J Bacteriol (1994) 1.48
Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene. EMBO J (1991) 1.31
Contribution of base excision repair, nucleotide excision repair, and DNA recombination to alkylation resistance of the fission yeast Schizosaccharomyces pombe. J Bacteriol (2000) 1.19
Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium. J Bacteriol (1989) 1.04
Characterization of the mycobacterial NER system reveals novel functions of the uvrD1 helicase. J Bacteriol (2008) 0.93
Alkyltransferase-like proteins: molecular switches between DNA repair pathways. Cell Mol Life Sci (2010) 0.92
Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates. PLoS One (2007) 0.86
Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases. J Biol Chem (2009) 0.86
Stripped-down DNA repair in a highly reduced parasite. BMC Mol Biol (2007) 0.84
Defective repair of O6-methylguanine-DNA in primary Sjögren's syndrome patients predisposed to lymphoma. Ann Rheum Dis (1995) 0.84
Alkyltransferase-like protein (eATL) prevents mismatch repair-mediated toxicity induced by O6-alkylguanine adducts in Escherichia coli. Proc Natl Acad Sci U S A (2010) 0.81
Monoclonal antibody-based, selective isolation of DNA fragments containing an alkylated base to be quantified in defined gene sequences. Nucleic Acids Res (1991) 0.80
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea. Proc Natl Acad Sci U S A (1998) 0.79
Repair of O6-alkylguanines in the nuclear DNA of human lymphocytes and leukaemic cells: analysis at the single-cell level. Br J Cancer (1994) 0.79
Mutagenic frequencies of site-specifically located O6-methylguanine in wild-type Escherichia coli and in a strain deficient in ada-methyltransferase. J Bacteriol (1991) 0.75
Inducible Protective Processes in Animal Systems XIII: Comparative Analysis of Induction of Adaptive Response by EMS and MMS in Ehrlich Ascites Carcinoma Cells. Scientifica (Cairo) (2014) 0.75
Development of a novel site-specific mutagenesis assay using MALDI-ToF MS (SSMA-MS). Nucleic Acids Res (2006) 0.75
DNA repair enzymes. Annu Rev Biochem (1982) 6.68
A novel repair enzyme: UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region. Cell (1983) 5.74
A new pathway for DNA repair in Escherichia coli. Nature (1977) 5.37
Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue. J Biol Chem (1980) 4.16
In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome. Proc Natl Acad Sci U S A (1984) 4.09
Adaptation to alkylation resistance involves the induction of a DNA glycosylase. Nature (1982) 3.23
Repair of O6-methylguanine in adapted Escherichia coli. Proc Natl Acad Sci U S A (1978) 2.98
The intracellular signal for induction of resistance to alkylating agents in E. coli. Cell (1986) 2.77
Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli. EMBO J (1984) 2.77
Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase. J Biol Chem (1982) 2.56
An adaptive response of E. coli to low levels of alkylating agent: comparison with previously characterised DNA repair pathways. Mol Gen Genet (1977) 2.45
Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents. J Bacteriol (1979) 2.39
Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase. J Mol Biol (1980) 2.32
Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage. EMBO J (1984) 2.15
Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli. Biochem Biophys Res Commun (1980) 2.14
Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli. Nucleic Acids Res (1987) 2.07
Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase. EMBO J (1982) 2.03
Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli. Nucleic Acids Res (1985) 2.00
Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents. Proc Natl Acad Sci U S A (1984) 1.87
Structure of the uvrB gene of Escherichia coli. Homology with other DNA repair enzymes and characterization of the uvrB5 mutation. Nucleic Acids Res (1986) 1.85
Regulatory mechanisms for induction of synthesis of repair enzymes in response to alkylating agents: ada protein acts as a transcriptional regulator. Proc Natl Acad Sci U S A (1986) 1.84
Quantitation of the adaptive response to alkylating agents. Nature (1979) 1.80
Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis. Proc Natl Acad Sci U S A (1986) 1.45
Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes. Proc Natl Acad Sci U S A (1986) 1.45
Synthesis and characterization of a set of four dodecadeoxyribonucleoside undecaphosphates containing O6-methylguanine opposite adenine, cytosine, guanine, and thymine. Biochemistry (1984) 1.42
O6-methylguanine-DNA methyltransferase in wild-type and ada mutants of Escherichia coli. J Bacteriol (1982) 1.38
Structural studies of the O6meG.C interaction in the d(C-G-C-G-A-A-T-T-C-O6meG-C-G) duplex. Biochemistry (1986) 1.36
Structural studies of the O6meG.T interaction in the d(C-G-T-G-A-A-T-T-C-O6meG-C-G) duplex. Biochemistry (1986) 1.28
Immunological quantification by high-affinity antibodies of O6-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosourea. Cancer Res (1980) 1.13
A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA. J Mol Biol (1982) 1.09
Repair of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage by ABC excinuclease. J Bacteriol (1987) 1.05
Covalent carcinogenic O6-methylguanosine lesions in DNA. Structural studies of the O6 meG X A and O6meG X G interactions in dodecanucleotide duplexes. J Mol Biol (1986) 0.96
Regulation of expression of the cloned ada gene in Escherichia coli. Mutat Res (1985) 0.96
Immuno-slot-blot: a highly sensitive immunoassay for the quantitation of carcinogen-modified nucleosides in DNA. J Cancer Res Clin Oncol (1984) 0.96
Antibodies specific for DNA components structurally modified by chemical carcinogens. J Cancer Res Clin Oncol (1981) 0.95
Comparison of the relative mutagenicities of O-alkylthymines site-specifically incorporated into phi X174 DNA. J Biol Chem (1987) 0.92
Enzymatic elimination of O6-ethylguanine and stability of O4-ethylthymine in the DNA of malignant neural cell lines exposed to N-ethyl-N-nitrosourea in culture. Carcinogenesis (1986) 0.88
Human O6-alkylguanine-DNA alkyltransferase fails to repair O4-methylthymine and methyl phosphotriesters in DNA as efficiently as does the alkyltransferase from Escherichia coli. Carcinogenesis (1985) 0.87
Quantitation and visualization of alkyl deoxynucleosides in the DNA of mammalian cells by monoclonal antibodies. Environ Health Perspect (1985) 0.84
High-affinity monoclonal antibodies for the specific recognition and quantification of deoxynucleosides structurally modified by N-nitroso compounds. IARC Sci Publ (1984) 0.78
Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc Natl Acad Sci U S A (1974) 3.07
O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine. Proc Natl Acad Sci U S A (1984) 1.54
In vitro studies of cell proliferation in tumours. II. Characteristics of a standardised in vitro system for the measurement of 3H-thymidine incorporation into tissue explants. Eur J Cancer (1965) 1.43
Early mutation of the neu (erbB-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage. Proc Natl Acad Sci U S A (1991) 1.37
Neoplastic transformation of fetal rat brain cells in culture after exposure to ethylnitrosourea in vivo. J Natl Cancer Inst (1975) 1.26
Molecular and cellular mechanisms associated with pulse-carcinogenesis in the rat nerbous system by ethyinitrosourea: ethylation of nucleic acids and elimination rates of ethylated bases from the DNA of different tissues. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol (1974) 1.24
Oxygens in DNA are main targets for ethylnitrosourea in normal and xeroderma pigmentosum fibroblasts and fetal rat brain cells. Nature (1978) 1.23
Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status. Leukemia (2006) 1.22
O(6)-methyldeoxyguanosine in oesophageal DNA among individuals at high risk of oesophageal cancer. Int J Cancer (1985) 1.17
G to A polymorphism at amino acid codon 655 of the human erbB-2/HER2 gene. Nucleic Acids Res (1991) 1.15
Immunological quantification by high-affinity antibodies of O6-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosourea. Cancer Res (1980) 1.13
Threonyl-transfer ribonucleic acid synthetase from Escherichia coli: subunit structure and genetic analysis of the structural gene by means of a mutated enzyme and of a specialized transducing lambda bacteriophage. J Bacteriol (1977) 1.12
Ethylation of nucleic acids by ethylnitrosourea-1- 14 C in the fetal and adult rat. Cancer Res (1972) 1.11
1,N6-etheno-2'-deoxyadenosine and 3,N4-etheno-2'-deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride. Carcinogenesis (1989) 1.09
Liver carcinogenesis by diethylnitrosamine in the rat. Science (1966) 1.06
Alteration of structure of level of threonyl-tRNA-synthetase in Borrelidin resistant mutants of E. coli. FEBS Lett (1974) 1.06
Spleen-cell reactivity against transplanted neurogenic rat tumors induced by ethylnitrosourea: uncovering of tumor specificity after removal of complement-receptor-bearing lymphocytes. Int J Cancer (1975) 1.02
Hydrogen ion-mediated enhancement of cytotoxicity of bis-chloroethylating drugs in rat mammary carcinoma cells in vitro. Cancer Res (1989) 1.00
Allelic deletion mapping on chromosome 5 in human carcinomas. Oncogene (1996) 1.00
pH in human tumour xenografts: effect of intravenous administration of glucose. Br J Cancer (1993) 1.00
Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues. Cancer Res (1982) 0.98
Immuno-slot-blot: a highly sensitive immunoassay for the quantitation of carcinogen-modified nucleosides in DNA. J Cancer Res Clin Oncol (1984) 0.96
Antibodies specific for DNA components structurally modified by chemical carcinogens. J Cancer Res Clin Oncol (1981) 0.95
pH in human tumor xenografts and transplanted rat tumors: effect of insulin, inorganic phosphate, and m-iodobenzylguanidine. Cancer Res (1992) 0.95
Enzymatic removal of O6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethyl-N-nitrosourea in vivo. J Biol Chem (1988) 0.95
Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea. Proc Natl Acad Sci U S A (1990) 0.94
Proliferative parameters of mammalian cell systms and their rôle in tumor growth and carcinogenesis. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol (1972) 0.94
Characteristics of three nuclear emulsions for autoradiography at the electron microscope. Biophysik (1966) 0.93
Proton-mediated liberation of aldophosphamide from a nontoxic prodrug: a strategy for tumor-selective activation of cytocidal drugs. Cancer Res (1989) 0.93
Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain. Neuroscience (2010) 0.92
Wild type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells. Oncogene (1996) 0.92
Genetic analysis of mutations causing borrelidin resistance by overproduction of threonyl-transfer ribonucleic acid synthetase. J Bacteriol (1980) 0.92
Binding and repair of O6-ethylguanine in double-stranded oligodeoxynucleotides by recombinant human O6-alkylguanine-DNA alkyltransferase do not exhibit significant dependence on sequence context. Nucleic Acids Res (1996) 0.91
Chemical neuro-oncogenesis: role of structural DNA modifications, DNA repair and neural target cell population. Prog Exp Tumor Res (1984) 0.91
Role of DNA repair in carcinogen-induced ras mutation. Mutat Res (2000) 0.91
Non-coordinate regulation of enzymes involved in transfer RNA metabolism in Escherichia coli. Biochim Biophys Acta (1980) 0.91
pH distributions in transplanted neural tumors and normal tissues of BDIX rats as measured with pH microelectrodes. Cancer Res (1982) 0.91
DNA excision repair profiles of normal and leukemic human lymphocytes: functional analysis at the single-cell level. Cancer Res (1997) 0.90
Preferential retention of paternal alleles in human retinoblastoma: evidence for genomic imprinting. Cell Growth Differ (1990) 0.90
Immunoanalytical detection of O4-ethylthymine in liver DNA of individuals with or without malignant tumors. Cancer Res (1989) 0.89
Protection of cultured malignant cells from mitoxantrone cytotoxicity by low extracellular pH: a possible mechanism for chemoresistance in vivo. Eur J Cancer (1990) 0.89
Phenotypic properties of neoplastic cell lines developed from fetal rat brain cells in culture after exposure to ethylnitrosourea in vivo. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol (1977) 0.89
Elimination of O6-ethylguanine from the DNA of brain, liver, and other rat tissues exposed to ethylnitrosourea at different stages of prenatal development. Cancer Res (1983) 0.89
Neural cell surface differentiation antigen gp130(RB13-6) induces fibroblasts and glioma cells to express astroglial proteins and invasive properties. FASEB J (1999) 0.88
Proliferative properties of malignant cell populations cultured in intraperitoneal diffusion chambers. Eur J Cancer (1973) 0.88
Enzymatic elimination of O6-ethylguanine and stability of O4-ethylthymine in the DNA of malignant neural cell lines exposed to N-ethyl-N-nitrosourea in culture. Carcinogenesis (1986) 0.88
Reduction of intratumoral pH by the mitochondrial inhibitor m-iodobenzylguanidine and moderate hyperglycemia. Cancer Res (1994) 0.88
Newly established human retinoblastoma cell lines exhibit an "immortalized" but not an invasive phenotype in vitro. Int J Cancer (1990) 0.87
Three-dimensional imaging of nerve tissue by x-ray phase-contrast microtomography. Biophys J (1999) 0.87
Affinity purification and cDNA cloning of rat neural differentiation and tumor cell surface antigen gp130RB13-6 reveals relationship to human and murine PC-1. J Biol Chem (1995) 0.86
Differential formation and repair of the mutagenic DNA alkylation product O6-ethylguanine in transcribed and nontranscribed genes of the rat. J Biol Chem (1994) 0.86
Microsatellite instability and loss of heterozygosity at the hMLH1 locus on chromosome 3p21 occur in a subset of nonsmall cell lung carcinomas. Oncol Res (1996) 0.86
DNA sequence dependence of guanine-O6 alkylation by the N-nitroso carcinogens N-methyl- and N-ethyl-N-nitrosourea. Mutat Res (1991) 0.86
Cell proliferation in transplanted rat tumors: influence of the host immune system. Eur J Immunol (1972) 0.85
Alteration of the intracellular concentration of aminoacyl-tRNA synthetases and isoaccepting tRNAs during amino-acid limited growth in Escherichia coli. Eur J Biochem (1978) 0.85
Schwann cell lineage-specific neu (erbB-2) gene expression in the developing rat nervous system. Cell Growth Differ (1993) 0.85
"Tumour suppressor gene" concept of carcinogenesis. Lancet (1995) 0.84
Monoclonal antibody-based immunoassay for the determination of cellular enzymatic activity for repair of specific carcinogen-DNA adducts (O6-alkylguanine). Carcinogenesis (1990) 0.84
Electrophysiological properties of ethylnitrosourea-induced, neoplastic neurogenic rat cell lines cultured in vitro and in vivo. Cancer Res (1976) 0.84
Highly sensitive sites for guanine-O6 ethylation in rat brain DNA exposed to N-ethyl-N-nitrosourea in vivo. EMBO J (1984) 0.84
Formation and repair kinetics of Pt-(GpG) DNA adducts in extracted circulating tumour cells and response to platinum treatment. Br J Cancer (2013) 0.84
Quantitation and visualization of alkyl deoxynucleosides in the DNA of mammalian cells by monoclonal antibodies. Environ Health Perspect (1985) 0.84
In vitro differentiation of human retinoblastoma cells into neuronal phenotypes. Differentiation (1990) 0.82
Synchronisation in vivo: temporary inhibition of DNA synthesis in the rat embryo with hydroxyurea. Exp Cell Res (1971) 0.82
[Ethylation of guanine-N-7 in the nucleic acids of rat embryos and liver by ethylnitrosourea]. Z Naturforsch B (1971) 0.82
Quantification of specific DNA O-alkylation products in individual cells by monoclonal antibodies and digital imaging of intensified nuclear fluorescence. Carcinogenesis (1993) 0.82
Metabolic response of AH13r rat tumours to cyclophosphamide as monitored by pO2 and pH semi-microelectrodes. Eur J Cancer (1992) 0.82
Nigericin enhances mafosfamide cytotoxicity at low extracellular pH. Cancer Chemother Pharmacol (1991) 0.81
Ethylation of nucleophilic sites in DNA by N-ethyl-N-nitrosourea depends on chromatin structure and ionic strength. Mutat Res (1985) 0.81
Ethylnitrosourea-induced development of malignant schwannomas in the rat: two distinct loci on chromosome of 10 involved in tumor susceptibility and oncogenesis. Cancer Res (1999) 0.81
In vitro differentiation of neural progenitor cells from prenatal rat brain: common cell surface glycoprotein on three glial cell subsets. J Neurosci Res (1997) 0.81
Escherichia coli mutants overproducing phenylalanyl- and threonyl-tRNA synthetase. J Bacteriol (1979) 0.81
DNA repair and cellular resistance to alkylating agents in chronic lymphocytic leukemia. Clin Cancer Res (1997) 0.80
Monoclonal antibody-based, selective isolation of DNA fragments containing an alkylated base to be quantified in defined gene sequences. Nucleic Acids Res (1991) 0.80
[Cell proliferation in normal and malignant tissues: H3-thymidine incorporation in vitro under standard conditions]. Biophysik (1966) 0.80
Chemosensitisation of alkylating agents by pentoxifylline, O6-benzylguanine and ethacrynic acid in haematological malignancies. Anticancer Res (1994) 0.80
Effect of sorafenib combined with cytostatic agents on hepatoblastoma cell lines and xenografts. Br J Cancer (2012) 0.80
DNA damage and repair in mutagenesis and carcinogenesis: implications of structure-activity relationships for cross-species extrapolation. Mutat Res (1996) 0.80
Relevance of N-nitrosamines to esophageal cancer in China. J Cell Physiol Suppl (1986) 0.80
Change of isoaccepting threonyl-tRNA and contitutively increased level of threonyl-tRNA-synthetase in E. coli. FEBS Lett (1975) 0.80
Synchronisation in vivo: kinetics of a malignant cell system following temporary inhibition of DNA synthesis with hydroxyurea. Exp Cell Res (1970) 0.80
Monoclonal antibodies for the specific detection of 3-alkyladenines in nucleic acids and body fluids. Carcinogenesis (1990) 0.80
Recombinant human O6-alkylguanine-DNA alkyltransferase induces conformational change in bound DNA. FEBS Lett (1997) 0.80
Relevance of DNA repair to carcinogenesis and cancer therapy. Recent Results Cancer Res (1998) 0.80
Mutagenicities of N-nitrosodimethylamine and N-nitrosodiethylamine in Drosophila and their relationship to the levels of O-alkyl adducts in DNA. Mutat Res (1999) 0.80
Immunohistologic detection and phenotyping of neuroblastoma cells in bone marrow using cytoplasmic neuron specific enolase and cell surface antigens. Prog Clin Biol Res (1985) 0.79
Enzymatic synthesis of double-stranded DNA containing radioactively labeled O(6)-ethylguanine as the only modified base. Carcinogenesis (1981) 0.79
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea. Proc Natl Acad Sci U S A (1998) 0.79
Induction of the common fragile site FRA3B does not affect FHIT expression. Oncogene (2001) 0.79