Published in Proc Natl Acad Sci U S A on December 01, 1990
O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis. Proc Natl Acad Sci U S A (1993) 1.07
Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors. Proc Natl Acad Sci U S A (1996) 0.94
Transcriptional bypass of regioisomeric ethylated thymidine lesions by T7 RNA polymerase and human RNA polymerase II. Nucleic Acids Res (2014) 0.86
Formation and persistence of 8-oxoguanine in rat lung cells as an important determinant for tumor formation following particle exposure. Environ Health Perspect (1997) 0.85
Monoclonal antibody-based, selective isolation of DNA fragments containing an alkylated base to be quantified in defined gene sequences. Nucleic Acids Res (1991) 0.80
Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes. Proc Natl Acad Sci U S A (1992) 0.80
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea. Proc Natl Acad Sci U S A (1998) 0.79
N -ethyl- N -nitrosourea induces retinal photoreceptor damage in adult rats. J Toxicol Pathol (2012) 0.76
A simple, rapid, and sensitive DNA assay procedure. Anal Biochem (1980) 23.88
A new pathway for DNA repair in Escherichia coli. Nature (1977) 5.37
Transformation of mammalian cells by avian myelocytomatosis virus and avian erythroblastosis virus. Virology (1979) 4.66
Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature (1984) 4.38
Regulation and expression of the adaptive response to alkylating agents. Annu Rev Biochem (1988) 4.32
Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc Natl Acad Sci U S A (1974) 3.07
Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis. Proc Natl Acad Sci U S A (1985) 3.01
Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA. Nature (1979) 2.81
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains. Nature (1980) 2.30
Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine. Proc Natl Acad Sci U S A (1990) 2.19
Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant rats. Nature (1966) 2.17
Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli. Nucleic Acids Res (1987) 2.07
A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography. Carcinogenesis (1980) 1.98
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells. Nature (1980) 1.86
Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines. Nature (1981) 1.72
A system in mouse liver for the repair of O6-methylguanine lesions in methylated DNA. Nucleic Acids Res (1981) 1.56
O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine. Proc Natl Acad Sci U S A (1984) 1.54
cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells. J Biol Chem (1990) 1.43
Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis (1986) 1.40
The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis. Mutat Res (1985) 1.39
Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA. J Mol Biol (1990) 1.38
Oxygens in DNA are main targets for ethylnitrosourea in normal and xeroderma pigmentosum fibroblasts and fetal rat brain cells. Nature (1978) 1.23
Interindividual variation in the activity of O6-methyl guanine-DNA methyltransferase and uracil-DNA glycosylase in human organs. Carcinogenesis (1983) 1.18
Increased O6-alkylguanine alkyltransferase activity in Chinese hamster V79 cells following selection with chloroethylating agents. Carcinogenesis (1988) 1.17
O6-alkylguanine-DNA alkyltransferase activity in human brain and brain tumors. Carcinogenesis (1984) 1.14
Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase. Proc Natl Acad Sci U S A (1989) 1.14
Immunological quantification by high-affinity antibodies of O6-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosourea. Cancer Res (1980) 1.13
Cell specificity in hepatocarcinogenesis: preferential accumulation of O6-methylguanine in target cell DNA during continuous exposure to rats to 1,2-dimethylhydrazine. Cancer Res (1982) 0.97
Immuno-slot-blot: a highly sensitive immunoassay for the quantitation of carcinogen-modified nucleosides in DNA. J Cancer Res Clin Oncol (1984) 0.96
DNA-carcinogen interaction: covalent DNA-adducts of benzo(a)pyrene 7,8-dihydrodiol 9,10-epoxides studied by biochemical and biophysical techniques. Q Rev Biophys (1989) 0.93
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents. Proc Natl Acad Sci U S A (1985) 0.88
Enzymatic elimination of O6-ethylguanine and stability of O4-ethylthymine in the DNA of malignant neural cell lines exposed to N-ethyl-N-nitrosourea in culture. Carcinogenesis (1986) 0.88
Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO cells. Carcinogenesis (1989) 0.87
Properties and assay of mammalian O6-alkylguanine-DNA alkyltransferase. Pharmacol Ther (1987) 0.87
Cloning and expression of the Bacillus subtilis methyltransferase gene in Escherichia coli ada- cells. Mutat Res (1989) 0.87
Specific DNA repair mechanisms may protect some human tumor cells from DNA interstrand crosslinking by chloroethylnitrosoureas but not from crosslinking by other anti-tumor alkylating agents. Carcinogenesis (1985) 0.85
Monoclonal antibody-based immunoassay for the determination of cellular enzymatic activity for repair of specific carcinogen-DNA adducts (O6-alkylguanine). Carcinogenesis (1990) 0.84
Coregulation of the human O6-methylguanine-DNA methyltransferase with two unrelated genes that are closely linked. Cancer Res (1990) 0.84
Quantitation and visualization of alkyl deoxynucleosides in the DNA of mammalian cells by monoclonal antibodies. Environ Health Perspect (1985) 0.84
Enzymatic elimination of O6-ethylguanine from the DNA of ethylnitrosourea-exposed normal and malignant rat brain cells grown under cell culture versus in vivo conditions. Int J Cancer (1988) 0.78
DNA ethylation in hamster tissues during subchronic diethylnitrosamine administration and in the hamster trachea after acute diethylnitrosamine administration. Carcinogenesis (1986) 0.77
When do carcinogen-treated 10T1/2 cells acquire the commitment to form transformed foci? Nature (1982) 0.77
Acquisition of resistance to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride in V79 cells through increased removal of O6-alkylguanine. Jpn J Cancer Res (1987) 0.77
Differential capacities for DNA repair in Clara cells, alveolar type II cells and macrophages of rabbit lung. Carcinogenesis (1985) 0.76
Alkylation of DNA in F344 rat thymus following administration of 1-n-propyl-1-nitrosourea in vivo and comparison of O6-alkylguanine DNA alkyltransferase activity in thymus from F344 and Long-Evans rats in vitro. Carcinogenesis (1988) 0.76
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol (1991) 8.60
Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc Natl Acad Sci U S A (1974) 3.07
Involvement of histone H1 in the organization of the chromosome fiber. Proc Natl Acad Sci U S A (1977) 2.59
O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine. Proc Natl Acad Sci U S A (1984) 1.54
Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair. EMBO J (1988) 1.51
Induction of differentiation in normal human keratinocytes by adenovirus-mediated introduction of the eta and delta isoforms of protein kinase C. Mol Cell Biol (1998) 1.50
In vitro studies of cell proliferation in tumours. II. Characteristics of a standardised in vitro system for the measurement of 3H-thymidine incorporation into tissue explants. Eur J Cancer (1965) 1.43
Early mutation of the neu (erbB-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage. Proc Natl Acad Sci U S A (1991) 1.37
The chromosome fiber: evidence for an ordered superstructure of nucleosomes. Chromosoma (1977) 1.35
Cleavage and binding of a DNA fragment containing a single 8-oxoguanine by wild type and mutant FPG proteins. Nucleic Acids Res (1993) 1.30
Neoplastic transformation of fetal rat brain cells in culture after exposure to ethylnitrosourea in vivo. J Natl Cancer Inst (1975) 1.26
Molecular and cellular mechanisms associated with pulse-carcinogenesis in the rat nerbous system by ethyinitrosourea: ethylation of nucleic acids and elimination rates of ethylated bases from the DNA of different tissues. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol (1974) 1.24
Oxygens in DNA are main targets for ethylnitrosourea in normal and xeroderma pigmentosum fibroblasts and fetal rat brain cells. Nature (1978) 1.23
O(6)-methyldeoxyguanosine in oesophageal DNA among individuals at high risk of oesophageal cancer. Int J Cancer (1985) 1.17
G to A polymorphism at amino acid codon 655 of the human erbB-2/HER2 gene. Nucleic Acids Res (1991) 1.15
Immunological quantification by high-affinity antibodies of O6-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosourea. Cancer Res (1980) 1.13
Ethylation of nucleic acids by ethylnitrosourea-1- 14 C in the fetal and adult rat. Cancer Res (1972) 1.11
1,N6-etheno-2'-deoxyadenosine and 3,N4-etheno-2'-deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride. Carcinogenesis (1989) 1.09
Liver carcinogenesis by diethylnitrosamine in the rat. Science (1966) 1.06
Spleen-cell reactivity against transplanted neurogenic rat tumors induced by ethylnitrosourea: uncovering of tumor specificity after removal of complement-receptor-bearing lymphocytes. Int J Cancer (1975) 1.02
Allelic deletion mapping on chromosome 5 in human carcinomas. Oncogene (1996) 1.00
Hydrogen ion-mediated enhancement of cytotoxicity of bis-chloroethylating drugs in rat mammary carcinoma cells in vitro. Cancer Res (1989) 1.00
pH in human tumour xenografts: effect of intravenous administration of glucose. Br J Cancer (1993) 1.00
Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues. Cancer Res (1982) 0.98
Formamidopyrimidine DNA glycosylase in the yeast Saccharomyces cerevisiae. Nucleic Acids Res (1994) 0.98
Developmental regulation and tissue distribution of the liver transcription factor LFB1 (HNF1) in Xenopus laevis. Mol Cell Biol (1993) 0.98
Immuno-slot-blot: a highly sensitive immunoassay for the quantitation of carcinogen-modified nucleosides in DNA. J Cancer Res Clin Oncol (1984) 0.96
Antibodies specific for DNA components structurally modified by chemical carcinogens. J Cancer Res Clin Oncol (1981) 0.95
pH in human tumor xenografts and transplanted rat tumors: effect of insulin, inorganic phosphate, and m-iodobenzylguanidine. Cancer Res (1992) 0.95
Enzymatic removal of O6-ethylguanine from mitochondrial DNA in rat tissues exposed to N-ethyl-N-nitrosourea in vivo. J Biol Chem (1988) 0.95
Proliferative parameters of mammalian cell systms and their rôle in tumor growth and carcinogenesis. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol (1972) 0.94
Characteristics of three nuclear emulsions for autoradiography at the electron microscope. Biophysik (1966) 0.93
Proton-mediated liberation of aldophosphamide from a nontoxic prodrug: a strategy for tumor-selective activation of cytocidal drugs. Cancer Res (1989) 0.93
N-methyl-N-nitrosourea-induced mutations in human cells. Effects of the transcriptional activity of the target gene. J Mol Biol (1992) 0.93
Neutrophils cause oxidative DNA damage in alveolar epithelial cells. Free Radic Biol Med (1999) 0.92
Wild type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells. Oncogene (1996) 0.92
Urinary excretion of 3-methyladenine and 3-ethyladenine after controlled exposure to tobacco smoke. Carcinogenesis (1995) 0.92
Chemical neuro-oncogenesis: role of structural DNA modifications, DNA repair and neural target cell population. Prog Exp Tumor Res (1984) 0.91
Role of DNA repair in carcinogen-induced ras mutation. Mutat Res (2000) 0.91
Binding and repair of O6-ethylguanine in double-stranded oligodeoxynucleotides by recombinant human O6-alkylguanine-DNA alkyltransferase do not exhibit significant dependence on sequence context. Nucleic Acids Res (1996) 0.91
pH distributions in transplanted neural tumors and normal tissues of BDIX rats as measured with pH microelectrodes. Cancer Res (1982) 0.91
Hornerin, a novel profilaggrin-like protein and differentiation-specific marker isolated from mouse skin. J Biol Chem (2001) 0.90
Localization of amplitude-modulated high-frequency noise. J Acoust Soc Am (2000) 0.90
DNA excision repair profiles of normal and leukemic human lymphocytes: functional analysis at the single-cell level. Cancer Res (1997) 0.90
Histone H1 involvement in the structure of the chromosome fiber. Cold Spring Harb Symp Quant Biol (1978) 0.90
Preferential retention of paternal alleles in human retinoblastoma: evidence for genomic imprinting. Cell Growth Differ (1990) 0.90
Immunoanalytical detection of O4-ethylthymine in liver DNA of individuals with or without malignant tumors. Cancer Res (1989) 0.89
Protection of cultured malignant cells from mitoxantrone cytotoxicity by low extracellular pH: a possible mechanism for chemoresistance in vivo. Eur J Cancer (1990) 0.89
Phenotypic properties of neoplastic cell lines developed from fetal rat brain cells in culture after exposure to ethylnitrosourea in vivo. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol (1977) 0.89
Elimination of O6-ethylguanine from the DNA of brain, liver, and other rat tissues exposed to ethylnitrosourea at different stages of prenatal development. Cancer Res (1983) 0.89
Neural cell surface differentiation antigen gp130(RB13-6) induces fibroblasts and glioma cells to express astroglial proteins and invasive properties. FASEB J (1999) 0.88
Reduction of intratumoral pH by the mitochondrial inhibitor m-iodobenzylguanidine and moderate hyperglycemia. Cancer Res (1994) 0.88
Proliferative properties of malignant cell populations cultured in intraperitoneal diffusion chambers. Eur J Cancer (1973) 0.88
Enzymatic elimination of O6-ethylguanine and stability of O4-ethylthymine in the DNA of malignant neural cell lines exposed to N-ethyl-N-nitrosourea in culture. Carcinogenesis (1986) 0.88
Growth and differentiation properties of normal and transformed human keratinocytes in organotypic culture. Jpn J Cancer Res (1994) 0.87
Newly established human retinoblastoma cell lines exhibit an "immortalized" but not an invasive phenotype in vitro. Int J Cancer (1990) 0.87
Three-dimensional imaging of nerve tissue by x-ray phase-contrast microtomography. Biophys J (1999) 0.87
Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D. J Cell Sci (1999) 0.87
Affinity purification and cDNA cloning of rat neural differentiation and tumor cell surface antigen gp130RB13-6 reveals relationship to human and murine PC-1. J Biol Chem (1995) 0.86
Differential formation and repair of the mutagenic DNA alkylation product O6-ethylguanine in transcribed and nontranscribed genes of the rat. J Biol Chem (1994) 0.86
Microsatellite instability and loss of heterozygosity at the hMLH1 locus on chromosome 3p21 occur in a subset of nonsmall cell lung carcinomas. Oncol Res (1996) 0.86
DNA sequence dependence of guanine-O6 alkylation by the N-nitroso carcinogens N-methyl- and N-ethyl-N-nitrosourea. Mutat Res (1991) 0.86
Cell proliferation in transplanted rat tumors: influence of the host immune system. Eur J Immunol (1972) 0.85
Schwann cell lineage-specific neu (erbB-2) gene expression in the developing rat nervous system. Cell Growth Differ (1993) 0.85
"Tumour suppressor gene" concept of carcinogenesis. Lancet (1995) 0.84
Quantitation and visualization of alkyl deoxynucleosides in the DNA of mammalian cells by monoclonal antibodies. Environ Health Perspect (1985) 0.84
Electrophysiological properties of ethylnitrosourea-induced, neoplastic neurogenic rat cell lines cultured in vitro and in vivo. Cancer Res (1976) 0.84
Highly sensitive sites for guanine-O6 ethylation in rat brain DNA exposed to N-ethyl-N-nitrosourea in vivo. EMBO J (1984) 0.84
Monoclonal antibody-based immunoassay for the determination of cellular enzymatic activity for repair of specific carcinogen-DNA adducts (O6-alkylguanine). Carcinogenesis (1990) 0.84
Why are human cells resistant to malignant cell transformation in vitro? Jpn J Cancer Res (1993) 0.83
Synchronisation in vivo: temporary inhibition of DNA synthesis in the rat embryo with hydroxyurea. Exp Cell Res (1971) 0.82
Metabolic response of AH13r rat tumours to cyclophosphamide as monitored by pO2 and pH semi-microelectrodes. Eur J Cancer (1992) 0.82
In vitro differentiation of human retinoblastoma cells into neuronal phenotypes. Differentiation (1990) 0.82
Quantification of specific DNA O-alkylation products in individual cells by monoclonal antibodies and digital imaging of intensified nuclear fluorescence. Carcinogenesis (1993) 0.82
[Ethylation of guanine-N-7 in the nucleic acids of rat embryos and liver by ethylnitrosourea]. Z Naturforsch B (1971) 0.82
Nigericin enhances mafosfamide cytotoxicity at low extracellular pH. Cancer Chemother Pharmacol (1991) 0.81
Ethylnitrosourea-induced development of malignant schwannomas in the rat: two distinct loci on chromosome of 10 involved in tumor susceptibility and oncogenesis. Cancer Res (1999) 0.81
Ethylation of nucleophilic sites in DNA by N-ethyl-N-nitrosourea depends on chromatin structure and ionic strength. Mutat Res (1985) 0.81
In vitro differentiation of neural progenitor cells from prenatal rat brain: common cell surface glycoprotein on three glial cell subsets. J Neurosci Res (1997) 0.81
[Experimental infection of mice, gerbils, and rats with mycoplasms from canine pericardium and cardial value (author's transl)]. Zentralbl Bakteriol Orig A (1977) 0.80
Increased cytotoxicity of 1-(2-chloroethyl)-1-nitroso-3(4-methyl)-cyclohexylurea by pretreatment with O6-methylguanine in resistant but not in sensitive human melanoma cells. J Cancer Res Clin Oncol (1987) 0.80
DNA repair and cellular resistance to alkylating agents in chronic lymphocytic leukemia. Clin Cancer Res (1997) 0.80
Chemosensitisation of alkylating agents by pentoxifylline, O6-benzylguanine and ethacrynic acid in haematological malignancies. Anticancer Res (1994) 0.80
Synchronisation in vivo: kinetics of a malignant cell system following temporary inhibition of DNA synthesis with hydroxyurea. Exp Cell Res (1970) 0.80
Monoclonal antibodies for the specific detection of 3-alkyladenines in nucleic acids and body fluids. Carcinogenesis (1990) 0.80
Relevance of N-nitrosamines to esophageal cancer in China. J Cell Physiol Suppl (1986) 0.80
Recombinant human O6-alkylguanine-DNA alkyltransferase induces conformational change in bound DNA. FEBS Lett (1997) 0.80
The expression of fragile X chromosomes in members of the same family at different times of examination. Hum Genet (1982) 0.80
[Cell proliferation in normal and malignant tissues: H3-thymidine incorporation in vitro under standard conditions]. Biophysik (1966) 0.80
Monoclonal antibody-based, selective isolation of DNA fragments containing an alkylated base to be quantified in defined gene sequences. Nucleic Acids Res (1991) 0.80
DNA damage and repair in mutagenesis and carcinogenesis: implications of structure-activity relationships for cross-species extrapolation. Mutat Res (1996) 0.80