Published in Trends Biochem Sci on September 01, 1988
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Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell (1993) 2.40
CENP-E as an essential component of the mitotic checkpoint in vitro. Cell (2000) 2.40
cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment. Proc Natl Acad Sci U S A (1988) 2.38
Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A (1987) 2.36
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Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J Cell Biol (1992) 2.21
Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs. Cell (1987) 2.13
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res (2013) 2.12
Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proc Natl Acad Sci U S A (1995) 2.12
Identification of novel centromere/kinetochore-associated proteins using monoclonal antibodies generated against human mitotic chromosome scaffolds. J Cell Biol (1991) 2.10
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An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell (1996) 2.09
Sequences that confer beta-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a beta-tubulin mRNA. Cell (1987) 2.09
NuMA is required for the proper completion of mitosis. J Cell Biol (1993) 2.04
Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis. J Cell Biol (1994) 2.00
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Is apparent autoregulatory control of tubulin synthesis nontranscriptionally regulated? J Cell Biol (1983) 1.88
Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation. Proc Natl Acad Sci U S A (1989) 1.87
Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation. Mol Cell Biol (1987) 1.83
Neurofilaments are obligate heteropolymers in vivo. J Cell Biol (1993) 1.82
Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides. Mol Cell Biol (1988) 1.80
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Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products. Cell (1978) 1.73
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Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds. Hum Mol Genet (1999) 1.62
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The kinesin-like protein CENP-E is kinetochore-associated throughout poleward chromosome segregation during anaphase-A. J Cell Sci (1996) 1.59
A monoclonal antibody against the type II isotype of beta-tubulin. Preparation of isotypically altered tubulin. J Biol Chem (1988) 1.55
Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. Proc Natl Acad Sci U S A (1998) 1.55
Differential utilization of beta-tubulin isotypes in differentiating neurites. J Cell Biol (1989) 1.54
The multitubulin hypothesis revisited: what have we learned? J Cell Biol (1987) 1.50
Physical evidence for cotranslational regulation of beta-tubulin mRNA degradation. Mol Cell Biol (1992) 1.49
Regional modulation of neurofilament organization by myelination in normal axons. J Neurosci (1994) 1.49
Programmed expression of beta-tubulin genes during development and differentiation of the chicken. J Cell Biol (1984) 1.48
A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron (1994) 1.46
Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M. J Cell Biol (1990) 1.45
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A rapidly rearranging retrotransposon within the miniexon gene locus of Crithidia fasciculata. Mol Cell Biol (1990) 1.41
Subunit composition of neurofilaments specifies axonal diameter. J Cell Biol (1996) 1.39
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Characterization of DLC-A and DLC-B, two families of cytoplasmic dynein light chain subunits. Mol Biol Cell (1994) 1.33
The tubulins: from DNA to RNA to protein and back again. Cell (1983) 1.33
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Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons. J Cell Biol (1995) 1.25
Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber. J Cell Biol (1990) 1.24
Retention of autoregulatory control of tubulin synthesis in cytoplasts: demonstration of a cytoplasmic mechanism that regulates the level of tubulin expression. J Cell Biol (1985) 1.23
Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant. Proc Natl Acad Sci U S A (1998) 1.23
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Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M. J Biol Chem (1993) 1.21
Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants. Proc Natl Acad Sci U S A (1998) 1.21
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