Published in Cell on May 01, 1980
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med (1989) 11.36
Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc. Proc Natl Acad Sci U S A (1987) 7.38
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J (1996) 6.66
Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. Nucleic Acids Res (1984) 6.56
A human beta-actin expression vector system directs high-level accumulation of antisense transcripts. Proc Natl Acad Sci U S A (1987) 6.36
Sequences responsible for intracellular localization of beta-actin messenger RNA also affect cell phenotype. J Cell Biol (1994) 6.33
Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells. EMBO J (1985) 6.31
Structure and expression of the human gene encoding major heat shock protein HSP70. Mol Cell Biol (1985) 4.79
The nucleotide sequence of the chick cytoplasmic beta-actin gene. Nucleic Acids Res (1983) 4.62
Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution. Mol Cell Biol (1983) 4.01
Actin gene expression visualized in chicken muscle tissue culture by using in situ hybridization with a biotinated nucleotide analog. Proc Natl Acad Sci U S A (1982) 4.00
The complete nucleotide sequence of the chick a-actin gene and its evolutionary relationship to the actin gene family. Nucleic Acids Res (1982) 3.76
Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc Natl Acad Sci U S A (1987) 3.74
vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J (1989) 3.67
Human immunodeficiency virus type 1 negative factor is a transcriptional silencer. Proc Natl Acad Sci U S A (1989) 3.65
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions. Nat Rev Mol Cell Biol (2011) 3.53
HeLa cell beta-tubulin gene transcription is stimulated by adenovirus 5 in parallel with viral early genes by an E1a-dependent mechanism. Mol Cell Biol (1984) 3.44
Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Proc Natl Acad Sci U S A (1990) 3.40
The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs. Mol Cell Biol (1986) 3.36
Growth-related changes in specific mRNAs of cultured mouse cells. Proc Natl Acad Sci U S A (1983) 3.35
Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development. Proc Natl Acad Sci U S A (1986) 3.34
Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A. J Exp Med (1986) 3.24
Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin. Proc Natl Acad Sci U S A (1986) 3.21
The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J (1990) 3.21
Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes. Mol Cell Biol (1997) 3.21
Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro. J Cell Biol (1986) 3.20
Identification of two human beta-tubulin isotypes. Mol Cell Biol (1983) 3.15
Sequence of an expressed human beta-tubulin gene containing ten Alu family members. Nucleic Acids Res (1984) 3.08
Specific stimulation of actin gene transcription by epidermal growth factor and cycloheximide. Proc Natl Acad Sci U S A (1984) 3.00
Quantitative analysis of in situ hybridization methods for the detection of actin gene expression. Nucleic Acids Res (1985) 3.00
Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein. Proc Natl Acad Sci U S A (1984) 2.98
The two beta-tubulin genes of Chlamydomonas reinhardtii code for identical proteins. Mol Cell Biol (1984) 2.98
IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J (1994) 2.89
Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. Mol Cell Biol (1983) 2.85
The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAs. Mol Cell Biol (1992) 2.83
Continued expression of a poly(A)+ transcript of herpes simplex virus type 1 in trigeminal ganglia of latently infected mice. J Virol (1987) 2.78
Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J (1990) 2.75
Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes. Proc Natl Acad Sci U S A (1986) 2.71
Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J Clin Invest (1987) 2.70
The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor. Mol Cell Biol (1994) 2.69
Skeletal muscle actin mRNA. Characterization of the 3' untranslated region. Nucleic Acids Res (1981) 2.67
p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. Proc Natl Acad Sci U S A (1998) 2.65
Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix. Proc Natl Acad Sci U S A (1984) 2.64
Isolation and characterization of human actin genes. Proc Natl Acad Sci U S A (1981) 2.56
Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes. Nucleic Acids Res (1986) 2.54
Isolation and characterization of multiple human genes homologous to the oncogenes of avian erythroblastosis virus. EMBO J (1983) 2.52
Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments. Proc Natl Acad Sci U S A (1984) 2.51
Poly(A) RNA codistribution with microfilaments: evaluation by in situ hybridization and quantitative digital imaging microscopy. J Cell Biol (1992) 2.49
In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis. J Cell Biol (1989) 2.47
Serotype-specific glycoprotein of simian 11 rotavirus: coding assignment and gene sequence. Proc Natl Acad Sci U S A (1983) 2.46
Nucleotide sequence of a macronuclear DNA molecule coding for alpha-tubulin from the ciliate Stylonychia lemnae. Special codon usage: TAA is not a translation termination codon. Nucleic Acids Res (1985) 2.43
Gene expression in rat brain. Nucleic Acids Res (1983) 2.40
Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein. EMBO J (1989) 2.39
Dependence of liver-specific transcription on tissue organization. Mol Cell Biol (1985) 2.38
Regulation of human histone gene expression during the HeLa cell cycle requires protein synthesis. Mol Cell Biol (1984) 2.38
Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A (1987) 2.36
A polymer-dependent increase in phosphorylation of beta-tubulin accompanies differentiation of a mouse neuroblastoma cell line. J Cell Biol (1985) 2.35
Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas. Mol Cell Biol (1986) 2.34
Cardiac actin is the major actin gene product in skeletal muscle cell differentiation in vitro. Mol Cell Biol (1984) 2.33
Human cytoplasmic actin proteins are encoded by a multigene family. Mol Cell Biol (1982) 2.33
Induction of B2 RNA polymerase III transcription by heat shock: enrichment for heat shock induced sequences in rodent cells by hybridization subtraction. Nucleic Acids Res (1986) 2.31
Coordinate regulation of the four tubulin genes of Chlamydomonas reinhardi. Nucleic Acids Res (1982) 2.31
The genes coding for the cytoskeletal proteins actin and vimentin in warm-blooded vertebrates. EMBO J (1982) 2.30
alpha-skeletal and alpha-cardiac actin genes are coexpressed in adult human skeletal muscle and heart. Mol Cell Biol (1983) 2.29
Transcriptional and posttranscriptional regulation of tumor necrosis factor gene expression in human monocytes. J Clin Invest (1988) 2.29
Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells. EMBO J (1992) 2.28
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes. Proc Natl Acad Sci U S A (1988) 2.27
Expression and regulation of chicken actin genes introduced into mouse myogenic and nonmyogenic cells. Proc Natl Acad Sci U S A (1984) 2.26
Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes. Nucleic Acids Res (1990) 2.24
Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice. Proc Natl Acad Sci U S A (1985) 2.22
Influenza virus gene expression: control mechanisms at early and late times of infection and nuclear-cytoplasmic transport of virus-specific RNAs. J Virol (1987) 2.21
Temporal and tissue-specific expression of mouse ets genes. Proc Natl Acad Sci U S A (1987) 2.20
The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development. EMBO J (1991) 2.20
Macrophage colony-stimulating factor gene expression in vascular cells and in experimental and human atherosclerosis. Am J Pathol (1992) 2.19
Inhibition of protein synthesis stabilizes histone mRNA. Mol Cell Biol (1984) 2.14
The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology. Mol Cell Biol (1991) 2.11
Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis. J Clin Invest (1996) 2.10
Ionizing radiation induces expression and binding activity of the nuclear factor kappa B. J Clin Invest (1991) 2.08
Functional diversity of gro gene expression in human fibroblasts and mammary epithelial cells. Proc Natl Acad Sci U S A (1988) 2.07
Production of tumor necrosis factor/cachectin by human T cell lines and peripheral blood T lymphocytes stimulated by phorbol myristate acetate and anti-CD3 antibody. J Exp Med (1988) 2.05
Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes. J Cell Biol (1984) 2.05
Human eosinophils express transforming growth factor alpha. J Exp Med (1990) 2.04
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity. Proc Natl Acad Sci U S A (2004) 2.04
Vaccinia virus induces cellular mRNA degradation. J Virol (1983) 2.02
Growth-dependent expression of dihydrofolate reductase mRNA from modular cDNA genes. Mol Cell Biol (1983) 2.02
Expression of the ERBB3 gene product in breast cancer. Br J Cancer (1992) 2.01
Beta-actin mRNA localization is regulated by signal transduction mechanisms. J Cell Biol (1994) 2.01
Chromatin structure of transcriptionally competent and repressed genes. EMBO J (1990) 1.98
Induction of the TRPM-2 gene in cells undergoing programmed death. Mol Cell Biol (1989) 1.98
Metabolism and expression of RNA polymerase II transcripts in influenza virus-infected cells. Mol Cell Biol (1984) 1.97
Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha). Mol Cell Biol (1990) 1.96
Genetics of microtubule systems. J Cell Biol (1984) 1.94
Regulation of tubulin and actin mRNA production in rat brain: expression of a new beta-tubulin mRNA with development. Mol Cell Biol (1983) 1.94
Isolation and characterization of a human collagen alpha 1(I)-like gene from a cosmid library. Nucleic Acids Res (1982) 1.94
Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma. Proc Natl Acad Sci U S A (1986) 1.93
Nitric oxide produced during murine listeriosis is protective. Infect Immun (1994) 1.93
Rapid identification of Leishmania species by specific hybridization of kinetoplast DNA in cutaneous lesions. Proc Natl Acad Sci U S A (1982) 1.92
Isolation of human cDNA clones of ski and the ski-related gene, sno. Nucleic Acids Res (1989) 1.91
Sequence of contactin, a 130-kD glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous system. J Cell Biol (1988) 1.91
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. J Biol Chem (1977) 72.51
Cyclin is degraded by the ubiquitin pathway. Nature (1991) 17.93
Rat insulin genes: construction of plasmids containing the coding sequences. Science (1977) 17.05
A protein factor essential for microtubule assembly. Proc Natl Acad Sci U S A (1975) 15.35
Polymorphic DNA region adjacent to the 5' end of the human insulin gene. Proc Natl Acad Sci U S A (1981) 12.86
High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment. Nucleic Acids Res (1984) 10.40
Cyclin synthesis drives the early embryonic cell cycle. Nature (1989) 9.73
Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell (1986) 8.87
The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature (1989) 8.69
Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes. Nature (1984) 8.65
How proteolysis drives the cell cycle. Science (1996) 8.59
Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements. Science (1985) 8.44
A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell (1995) 8.34
Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev (1996) 8.28
CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Cell (1997) 8.08
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell (1999) 8.07
The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences. Nature (1982) 7.47
Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms. Nature (1969) 6.98
Cyclin activation of p34cdc2. Cell (1990) 6.87
Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell (1998) 6.69
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev (2000) 6.43
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin. Science (1970) 6.39
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science (2003) 6.35
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell (1991) 6.32
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron (1997) 6.16
Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature (1979) 6.10
Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science (1999) 6.07
Isolation and characterization of a cloned rat insulin gene. Cell (1979) 6.05
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron (1995) 6.03
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev (1998) 5.96
Bioenergetics and kinetics of microtubule and actin filament assembly-disassembly. Int Rev Cytol (1982) 5.93
Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature (1986) 5.90
Sequence of the human insulin gene. Nature (1980) 5.76
Dominoes and clocks: the union of two views of the cell cycle. Science (1989) 5.74
Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. Nature (1981) 5.65
Filament organization revealed in platinum replicas of freeze-dried cytoskeletons. J Cell Biol (1980) 5.61
CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature (1992) 5.54
Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science (1997) 5.40
Structure of yeast phenylalanine-tRNA genes: an intervening DNA segment within the region coding for the tRNA. Proc Natl Acad Sci U S A (1978) 5.29
Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol Cell (1998) 5.28
Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science (1998) 5.23
Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol Biol Cell (1992) 5.11
A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell (1996) 5.10
Mitosis in transition. Cell (1994) 5.03
Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J Cell Biol (1991) 5.02
Polewards chromosome movement driven by microtubule depolymerization in vitro. Nature (1988) 4.97
Ribosomal RNA genes of Saccharomyces cerevisiae. I. Physical map of the repeating unit and location of the regions coding for 5 S, 5.8 S, 18 S, and 25 S ribosomal RNAs. J Biol Chem (1977) 4.76
Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen. Proc Natl Acad Sci U S A (1986) 4.73
A structural scaffolding of intermediate filaments in health and disease. Science (1998) 4.70
Specific nucleolar and nucleoplasmic RNA polymerases. Proc Natl Acad Sci U S A (1970) 4.63
Isolation of RNA using guanidinium salts. Methods Enzymol (1987) 4.62
Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J Mol Biol (1977) 4.60
Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen. J Cell Biol (1987) 4.50
Homology requirements for recombination in Escherichia coli. Proc Natl Acad Sci U S A (1985) 4.46
Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol (1977) 4.42
Implications of treadmilling for the stability and polarity of actin and tubulin polymers in vivo. J Cell Biol (1980) 4.39
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature (2007) 4.31
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. Cell (1991) 4.31
Evolutionary history of a multigene family: an expressed human beta-tubulin gene and three processed pseudogenes. Cell (1983) 4.26
Dual inhibition of sister chromatid separation at metaphase. Cell (2001) 4.23
CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. EMBO J (1991) 4.22
Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation. J Cell Biol (1985) 4.21
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science (1997) 4.19
Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. Science (1992) 4.17
Role of phosphorylation in p34cdc2 activation: identification of an activating kinase. Mol Biol Cell (1992) 4.17
Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J (1993) 4.10
Ribosomal RNA genes of Saccharomyces cerevisiae. II. Physical map and nucleotide sequence of the 5 S ribosomal RNA gene and adjacent intergenic regions. J Biol Chem (1977) 4.03
CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat Cell Biol (2000) 3.96
A human hepatitis B viral enhancer element. EMBO J (1985) 3.94
Waiting for anaphase: Mad2 and the spindle assembly checkpoint. Cell (2000) 3.88
Gamma-tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation. Nature (1992) 3.87
Synthesis and assembly of hepatitis B virus surface antigen particles in yeast. Nature (1982) 3.82
Unpolymerized tubulin modulates the level of tubulin mRNAs. Cell (1981) 3.78
Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin. Nature (1985) 3.75
Redesigning trypsin: alteration of substrate specificity. Science (1985) 3.70
Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C. Cell (1990) 3.67
Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol Cell (2000) 3.65
Cloning of hormone genes from a mixture of cDNA molecules. Methods Enzymol (1979) 3.62
Microtubules from mammalian brain: some properties of their depolymerization products and a proposed mechanism of assembly and disassembly. Proc Natl Acad Sci U S A (1974) 3.59
Properties of the depolymerization products of microtubules from mammalian brain. Biochemistry (1974) 3.58
Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin. Nature (1988) 3.57
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature (1995) 3.56
Analysis of the regions flanking the human insulin gene and sequence of an Alu family member. Nucleic Acids Res (1980) 3.55
Insulin-like growth factor II receptor as a multifunctional binding protein. Nature (1987) 3.52
A cytoplasmic chaperonin that catalyzes beta-actin folding. Cell (1992) 3.50
Sequence of the human somatostatin I gene. Science (1984) 3.48
Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning. Biochemistry (1987) 3.48
Tubulin genes are tandemly linked and clustered in the genome of trypanosoma brucei. Cell (1983) 3.40
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. J Cell Biol (2000) 3.39
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc Natl Acad Sci U S A (1994) 3.36