Published in EMBO J on December 20, 1986
A phylogenetic analysis of the mycoplasmas: basis for their classification. J Bacteriol (1989) 6.66
High-frequency plastid transformation in tobacco by selection for a chimeric aadA gene. Proc Natl Acad Sci U S A (1993) 4.40
Versatility of aminoglycosides and prospects for their future. Clin Microbiol Rev (2003) 3.72
A functional pseudoknot in 16S ribosomal RNA. EMBO J (1991) 3.59
Antibiotic resistance mutations in the chloroplast 16S and 23S rRNA genes of Chlamydomonas reinhardtii: correlation of genetic and physical maps of the chloroplast genome. Genetics (1989) 2.41
Streptomycin resistance in mycobacteria. Antimicrob Agents Chemother (1994) 2.40
Genetic alterations in streptomycin-resistant Mycobacterium tuberculosis: mapping of mutations conferring resistance. Antimicrob Agents Chemother (1994) 2.23
A mutation in the 530 loop of Escherichia coli 16S ribosomal RNA causes resistance to streptomycin. Nucleic Acids Res (1988) 2.13
Mutations in eukaryotic 18S ribosomal RNA affect translational fidelity and resistance to aminoglycoside antibiotics. EMBO J (1994) 2.08
Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2). J Bacteriol (1996) 2.03
Interaction of antibiotics with A- and P-site-specific bases in 16S ribosomal RNA. EMBO J (1991) 1.96
Chloroplast ribosomes and protein synthesis. Microbiol Rev (1994) 1.65
Structural basis for selectivity and toxicity of ribosomal antibiotics. EMBO Rep (2001) 1.61
Substitution of an invariant nucleotide at the base of the highly conserved '530-loop' of 15S rRNA causes suppression of yeast mitochondrial ochre mutations. Nucleic Acids Res (1989) 1.59
Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations. Appl Environ Microbiol (2001) 1.33
Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus. Appl Environ Microbiol (2003) 1.22
Molecular evolution of Mycoplasma capricolum subsp. capripneumoniae strains, based on polymorphisms in the 16S rRNA genes. J Bacteriol (1998) 1.20
Aminoglycoside resistance with homogeneous and heterogeneous populations of antibiotic-resistant ribosomes. Antimicrob Agents Chemother (2001) 1.14
In vitro selection and characterization of streptomycin-binding RNAs: recognition discrimination between antibiotics. RNA (1998) 1.13
Streptomycin inhibits splicing of group I introns by competition with the guanosine substrate. Nucleic Acids Res (1991) 1.11
Mutations conferring aminoglycoside and spectinomycin resistance in Borrelia burgdorferi. Antimicrob Agents Chemother (2006) 1.06
Mutations in the 915 region of Escherichia coli 16S ribosomal RNA reduce the binding of streptomycin to the ribosome. Nucleic Acids Res (1991) 1.05
Alterations in ribosomal protein RPS28 can diversely affect translational accuracy in Saccharomyces cerevisiae. Genetics (1995) 0.88
Ribosomes of the extremely thermophilic eubacterium Thermotoga maritima are uniquely insensitive to the miscoding-inducing action of aminoglycoside antibiotics. J Bacteriol (1988) 0.86
Genetic and comparative analyses reveal an alternative secondary structure in the region of nt 912 of Escherichia coli 16S rRNA. Proc Natl Acad Sci U S A (1995) 0.86
Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects. J Antibiot (Tokyo) (2016) 0.80
The conserved 900 stem/loop region in Escherichia coli 16S ribosomal RNA is not required for protein synthesis. Nucleic Acids Res (1989) 0.78
The mthA mutation conferring low-level resistance to streptomycin enhances antibiotic production in Bacillus subtilis by increasing the S-adenosylmethionine pool size. J Bacteriol (2014) 0.78
Thermoadaptation-directed enzyme evolution in an error-prone thermophile derived from Geobacillus kaustophilus HTA426. Appl Environ Microbiol (2014) 0.76
A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51
Selective extraction of polyoma DNA from infected mouse cell cultures. J Mol Biol (1967) 106.91
Hybridization of synthetic oligodeoxyribonucleotides to phi chi 174 DNA: the effect of single base pair mismatch. Nucleic Acids Res (1979) 14.12
Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA. Nucleic Acids Res (1982) 13.52
The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic polyribonucleotides. Proc Natl Acad Sci U S A (1961) 11.56
Construction and fine mapping of recombinant plasmids containing the rrnB ribosomal RNA operon of E. coli. Plasmid (1981) 9.00
Isolation and characterization of ribonuclease I mutants of Escherichia coli. J Mol Biol (1966) 8.60
Sequence of the 16S Ribosomal RNA from Halobacterium volcanii, an Archaebacterium. Science (1983) 5.66
Identification and functional characterization of the protein controlled by the streptomycin-resistant locus in E. coli. Nature (1969) 5.47
Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli. Nucleic Acids Res (1984) 3.94
The nucleotide sequence of the 17S ribosomal RNA gene of Tetrahymena thermophila and the identification of point mutations resulting in resistance to the antibiotics paromomycin and hygromycin. J Biol Chem (1985) 3.04
Ribosomal proteins. 33. Location of amino-acid replacements in protein S12 isolated from Escherichia coli mutants resistant to streptomycin. J Mol Biol (1972) 2.94
Identification of the paromomycin-resistance mutation in the 15 S rRNA gene of yeast mitochondria. J Biol Chem (1982) 2.70
Refined secondary structure models for the 16S and 23S ribosomal RNA of Escherichia coli. Nucleic Acids Res (1983) 2.38
Erythromycin resistance due to a mutation in a ribosomal RNA operon of Escherichia coli. Proc Natl Acad Sci U S A (1982) 1.73
Accurate and efficient in vitro splicing of purified precursor RNAs specified by early region 2 of the adenovirus 2 genome. Nucleic Acids Res (1983) 1.63
Streptomycin preferentially perturbs ribosomal proofreading. Mol Gen Genet (1984) 1.49
Streptomycin-resistance of Euglena gracilis chloroplasts: identification of a point mutation in the 16S rRNA gene in an invariant position. Nucleic Acids Res (1985) 1.46
The attachment site of streptomycin to the 30S ribosomal subunit. Proc Natl Acad Sci U S A (1972) 1.33
Cyclic blockade of initiation sites by streptomycin-damaged ribosomes in Escherichia coli: an explanation for dominance of sensitivity. J Mol Biol (1973) 1.22
Nature of phenotypic masking exhibited by drug-dependent streptomycin A mutants of Escherichia coli. J Mol Biol (1971) 1.14
Evidence for functional interaction between domains II and V of 23S ribosomal RNA from an erythromycin-resistant mutant. Proc Natl Acad Sci U S A (1985) 1.13
Three-dimensional arrangement of the Escherichia coli 16 S ribosomal RNA. J Mol Biol (1985) 1.13
Structural and functional analysis of Escherichia coli ribosomes containing small deletions around position 1760 in the 23S ribosomal RNA. Nucleic Acids Res (1984) 0.96
Cross-linking of streptomycin to the 30S subunit of Escherichia coli with phenyldiglyoxal. Biochemistry (1984) 0.89
Repair tracts in mismatched DNA heteroduplexes. Proc Natl Acad Sci U S A (1976) 5.88
Repair of defined single base-pair mismatches in Escherichia coli. Proc Natl Acad Sci U S A (1985) 3.88
Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins [see comment]. Nature (1998) 3.77
Mismatch repair in Escherichia coli. Annu Rev Genet (1986) 3.71
Characterization of a virtually full-length human immunodeficiency virus type 1 genome of a prevalent intersubtype (C/B') recombinant strain in China. J Virol (2000) 3.70
Nucleotide sequence of a Euglena gracilis chloroplast gene coding for the 16S rRNA: homologies to E. coli and Zea mays chloroplast 16S rRNA. Nucleic Acids Res (1982) 3.25
The genes for the ribosomal proteins S12 and S7 are clustered with the gene for the EF-Tu protein on the chloroplast genome of Euglena gracilis. Nucleic Acids Res (1984) 3.17
A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23. Nat Struct Biol (2001) 3.06
A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans. EMBO J (1995) 2.86
Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83
Nucleotide sequence of soybean chloroplast DNA regions which contain the psb A and trn H genes and cover the ends of the large single copy region and one end of the inverted repeats. Nucleic Acids Res (1983) 2.81
Predictors of automobile crashes and moving violations among elderly drivers. Ann Intern Med (1994) 2.63
Endocytosis in Chang liver cells. Quantitation by sucrose- 3 H uptake and inhibition by cytochalasin B. J Cell Biol (1971) 2.63
Sequencing of 16S--23S spacer in a ribosomal RNA operon of Euglena gracilis chloroplast DNA reveals two tRNA genes. Nature (1980) 2.29
Complete sequence of Euglena gracilis chloroplast DNA. Nucleic Acids Res (1993) 2.27
Identification of a region in the Pr55gag-polyprotein essential for HIV-1 particle formation. Virology (1993) 2.20
Cassini observes the active south pole of Enceladus. Science (2006) 2.15
Nucleotide sequence of a Euglena gracilis chloroplast genome region coding for the elongation factor Tu; evidence for a spliced mRNA. Nucleic Acids Res (1983) 2.15
Differential polymerase activity in avian and mammalian cells determines host range of influenza virus. J Virol (2007) 2.04
Reconstitution of a chloroplast protein import channel. EMBO J (1997) 2.03
Repair of a mismatch is influenced by the base composition of the surrounding nucleotide sequence. Genetics (1987) 2.03
Tumour necrosis factor-alpha induces ectopic activity in nociceptive primary afferent fibres. Neuroscience (1997) 2.00
Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas. Lancet (2001) 1.94
Involvement of Escherichia coli mismatch repair in DNA replication and recombination. Cold Spring Harb Symp Quant Biol (1984) 1.92
Cloning and characterization of a virtually full-length HIV type 1 genome from a subtype B'-Thai strain representing the most prevalent B-clade isolate in China. AIDS Res Hum Retroviruses (1998) 1.83
Multiple effects of codon usage optimization on expression and immunogenicity of DNA candidate vaccines encoding the human immunodeficiency virus type 1 Gag protein. J Virol (2001) 1.81
Proline residues in the HIV-1 NH2-terminal capsid domain: structure determinants for proper core assembly and subsequent steps of early replication. Virology (2000) 1.77
Mismatch repair of deaminated 5-methyl-cytosine. J Mol Biol (1987) 1.77
The importance of bacterial sepsis in intensive care unit patients with acquired immunodeficiency syndrome: implications for future care in the age of increasing antiretroviral resistance. Crit Care Med (2001) 1.72
Use of Doppler ultrasound in performing percutaneous cannulation of the radial artery. Crit Care Med (1990) 1.59
Potential regulation of gene expression in photosynthetic cells by redox and energy state: approaches towards better understanding. Ann Bot (2008) 1.58
Studies on drug monitoring in thrice and once daily treatment with aminoglycosides. Intensive Care Med (1993) 1.57
Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase. Nature (1999) 1.56
Tumor dedifferentiation: an important step in tumor invasion. Clin Exp Metastasis (1986) 1.54
Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors. Mol Cell Biol (2001) 1.53
Measurement of the forward-backward charge asymmetry in top-quark pair production. Phys Rev Lett (2008) 1.53
Origin of a chloroplast protein importer. Proc Natl Acad Sci U S A (1998) 1.51
Exploring the open pore of the potassium channel from Streptomyces lividans. FEBS Lett (1999) 1.50
Methyl-directed repair of frameshift mutations in heteroduplex DNA. Proc Natl Acad Sci U S A (1986) 1.48
Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis. Diabetologia (1995) 1.48
Effects of DNA methylation on mismatch repair, mutagenesis, and recombination in Escherichia coli. Curr Top Microbiol Immunol (1984) 1.47
Mismatch repair and recombination in E. coli. Cell (1987) 1.46
Streptomycin-resistance of Euglena gracilis chloroplasts: identification of a point mutation in the 16S rRNA gene in an invariant position. Nucleic Acids Res (1985) 1.46
[Absorption of ferrioxamine B by tomato plants]. Experientia (1964) 1.44
Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells. J Cell Physiol (1996) 1.43
A dominant trifluoperazine resistance gene from Saccharomyces cerevisiae has homology with F0F1 ATP synthase and confers calcium-sensitive growth. Mol Cell Biol (1988) 1.43
[The Würzburg polytrauma algorithm. Concept and first results of a sliding-gantry-based computer tomography diagnostic system]. Anaesthesist (2005) 1.41
[Anesthesia in cesarean section in the FRG in 1997. Results of a nationwide survey]. Anasthesiol Intensivmed Notfallmed Schmerzther (1998) 1.40
Improvement of myocardial blood flow to ischemic regions by angiotensin-converting enzyme inhibition with quinaprilat IV: a study using [15O] water dobutamine stress positron emission tomography. J Am Coll Cardiol (1999) 1.40
Anesthesia for cesarean section and acid aspiration prophylaxis: a German survey. Anesth Analg (1999) 1.39
Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris. Proc Natl Acad Sci U S A (1990) 1.39
Mismatch-stimulated killing. Proc Natl Acad Sci U S A (1986) 1.38
Isolation and characterization of an amino acid-selective channel protein present in the chloroplastic outer envelope membrane. Proc Natl Acad Sci U S A (1997) 1.35
Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats. J Cereb Blood Flow Metab (1994) 1.34
Progressive derangement of periinfarct viable tissue in ischemic stroke. J Cereb Blood Flow Metab (1992) 1.31
Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance. Am J Transplant (2009) 1.29
A new RNA-RNA crosslinking reagent and its application to ribosomal 5S RNA. Nucleic Acids Res (1978) 1.29
Endoscopic gastric submucosal transplantation of islets (ENDO-STI): technique and initial results in diabetic pigs. Am J Transplant (2009) 1.27
Influence of the GCGC discriminator motif introduced into the ribosomal RNA P2- and tac promoter on growth-rate control and stringent sensitivity. EMBO J (1989) 1.27
Violence and severe mental disorder in clinical and community populations: the effects of psychotic symptoms, comorbidity, and lack of treatment. Psychiatry (1997) 1.23
Vesta's shape and morphology. Science (2012) 1.23
Differentiation between Clostridium acidiurici and Clostridium cylindrosporum on the basis of specific metal requirements for formate dehydrogenase formation. Arch Microbiol (1977) 1.23
A ribonuclease-resistant region of 5S RNA and its relation to the RNA binding sites of proteins L18 and L25. Nucleic Acids Res (1979) 1.22
Chemical evidence for a codon-induced allosteric change in tRNALys involving the 7-methylguanosine residue 46. Eur J Biochem (1979) 1.22
Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reaction. Biotechnol Bioeng (1999) 1.19
Evidence for a regulatory function of the histone-like Escherichia coli protein H-NS in ribosomal RNA synthesis. Mol Microbiol (1994) 1.19
A structural model of 5S RNA from E. coli based on intramolecular crosslinking evidence. Nucleic Acids Res (1982) 1.17
Comparison of Escherichia coli tRNAPhe in the free state, in the ternary complex and in the ribosomal A and P sites by chemical probing. Eur J Biochem (1983) 1.16
Cassini Imaging Science: initial results on Phoebe and Iapetus. Science (2005) 1.16
Selenium requirement for active xanthine dehydrogenase from Clostridium acidiurici and Clostridium cylindrosporum. Arch Microbiol (1979) 1.16
The bacterial DNA-binding protein H-NS represses ribosomal RNA transcription by trapping RNA polymerase in the initiation complex. J Mol Biol (2000) 1.16
[Do female medical graduates have different views on professional work and workload compared to their male colleagues? Results of a multicenter postal survey in Germany]. Dtsch Med Wochenschr (2012) 1.16
Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris. Proc Natl Acad Sci U S A (1991) 1.16
Priming of strong, broad, and long-lived HIV type 1 p55gag-specific CD8+ cytotoxic T cells after administration of a virus-like particle vaccine in rhesus macaques. AIDS Res Hum Retroviruses (2000) 1.15
The integrity of the 25-S ribosomal RNA from Euglena gracilis 87-S ribosomes. Biochim Biophys Acta (1971) 1.15
An RNA core in the 30S ribosomal subunit of Escherichia coli and its structural and functional significance. Cell Biol Int Rep (1977) 1.15
Physical mapping of the ribosomal DNA region of Euglena gracilis chloroplast DNA. Eur J Biochem (1978) 1.14
Isolation and characterization of gmsti, a stress-inducible gene from soybean (Glycine max) coding for a protein belonging to the TPR (tetratricopeptide repeats) family. Plant Mol Biol (1995) 1.13
A rectifying ATP-regulated solute channel in the chloroplastic outer envelope from pea. EMBO J (1999) 1.13
A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin. Nat Med (2005) 1.12
Mismatch recognition in chromosomal interactions and speciation. Chromosoma (1993) 1.12
Competitive inhibition of human immunodeficiency virus type-1 protease by the Gag-Pol transframe protein. J Biol Chem (1999) 1.11
Isolation and characterization of Euglena gracilis cytoplasmic and chloroplast ribosomes and their ribosomal RNA components. Biochim Biophys Acta (1969) 1.11
N-Methyl-N'-nitro-N-nitrosoguanidine sensitivity of E. coli mutants deficient in DNA methylation and mismatch repair. Mol Gen Genet (1981) 1.11
Ion channel properties of the reconstituted chloroplast triose phosphate/phosphate translocator. J Biol Chem (1994) 1.10
A natural transactivation mutation in the thyroid hormone beta receptor: impaired interaction with putative transcriptional mediators. Proc Natl Acad Sci U S A (1997) 1.10
Ambulatory pacemaker surgery--medical and economical advantages. Pacing Clin Electrophysiol (1986) 1.09
Analysis of the Fis-dependent and Fis-independent transcription activation mechanisms of the Escherichia coli ribosomal RNA P1 promoter. Biochemistry (1992) 1.09
Measurement of the electron charge asymmetry in pp[over ]-->W+X-->enu+X events at sqrt[s]=1.96 TeV. Phys Rev Lett (2008) 1.09
Concerted action of multiple cis-acting sequences is required for Rev dependence of late human immunodeficiency virus type 1 gene expression. J Virol (2000) 1.08
Large non-homology in heteroduplex DNA is processed differently than single base pair mismatches. Mol Gen Genet (1987) 1.08
Solute pores, ion channels, and metabolite transporters in the outer and inner envelope membranes of higher plant plastids. Biochim Biophys Acta (2000) 1.07
Establishing the physician-patient relationship. J Dermatol Surg Oncol (1993) 1.07
Allele identification using immobilized mismatch binding protein: detection and identification of antibiotic-resistant bacteria and determination of sheep susceptibility to scrapie. Nucleic Acids Res (1997) 1.06
The importance of individual nucleotides for the structure and function of rRNA molecules in E. coli. A mutagenesis study. FEBS Lett (1986) 1.06