Published in Nature on December 15, 1988
Characterization of junD: a new member of the jun proto-oncogene family. EMBO J (1989) 3.55
CBP-induced stimulation of c-Fos activity is abrogated by E1A. EMBO J (1995) 3.22
Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun. Mol Cell Biol (1994) 3.15
Asymmetrical recognition of the palindromic AP1 binding site (TRE) by Fos protein complexes. EMBO J (1989) 2.98
A conserved retina-specific gene encodes a basic motif/leucine zipper domain. Proc Natl Acad Sci U S A (1992) 2.79
mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element. Mol Cell Biol (1990) 2.38
Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen. J Clin Invest (1991) 2.28
v-maf, a viral oncogene that encodes a "leucine zipper" motif. Proc Natl Acad Sci U S A (1989) 2.24
Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site. EMBO J (1990) 2.21
The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N-myc. EMBO J (1989) 2.18
Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements. Mol Cell Biol (1990) 2.16
Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation. EMBO J (1990) 2.11
Characterization of the sequence-specific interaction of mouse c-myb protein with DNA. EMBO J (1990) 2.05
Recombinant 43-kDa USF binds to DNA and activates transcription in a manner indistinguishable from that of natural 43/44-kDa USF. Mol Cell Biol (1991) 2.04
Evolutionarily conserved Ets family members display distinct DNA binding specificities. J Exp Med (1992) 2.04
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. Proc Natl Acad Sci U S A (1992) 1.97
Intracellular leucine zipper interactions suggest c-Myc hetero-oligomerization. Mol Cell Biol (1991) 1.84
The basic region of Fos mediates specific DNA binding. EMBO J (1989) 1.75
Transcriptional control of the Saccharomyces cerevisiae PGK gene by RAP1. Mol Cell Biol (1989) 1.74
The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43. Mol Cell Biol (1990) 1.74
Osteoblasts are target cells for transformation in c-fos transgenic mice. J Cell Biol (1993) 1.70
Phosphorylation and calcium binding properties of an Arabidopsis GF14 brain protein homolog. Plant Cell (1994) 1.61
Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation. Proc Natl Acad Sci U S A (1990) 1.60
ras-induced neuronal differentiation of PC12 cells: possible involvement of fos and jun. Mol Cell Biol (1989) 1.59
An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins. Proc Natl Acad Sci U S A (1991) 1.54
Evolution of gene networks by gene duplications: a mathematical model and its implications on genome organization. Proc Natl Acad Sci U S A (1994) 1.52
Ionizing radiation regulates expression of the c-jun protooncogene. Proc Natl Acad Sci U S A (1990) 1.50
A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras. EMBO J (1991) 1.46
c-Fos-induced activation of a TATA-box-containing promoter involves direct contact with TATA-box-binding protein. Mol Cell Biol (1994) 1.42
Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinases. Mol Cell Biol (1995) 1.42
The nuclear protooncogenes c-jun and c-fos as regulators of DNA replication. Proc Natl Acad Sci U S A (1991) 1.40
In vitro posttranslational modification of lamin B cloned from a human T-cell line. Mol Cell Biol (1990) 1.40
Transcriptional activation and repression by cellular DNA-binding protein C/EBP. J Virol (1990) 1.35
Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei. Proc Natl Acad Sci U S A (1990) 1.32
Positive regulation of jun/AP-1 by E1A. Mol Cell Biol (1991) 1.32
Identification of C/EBP basic region residues involved in DNA sequence recognition and half-site spacing preference. Mol Cell Biol (1993) 1.29
A gene family for acidic ribosomal proteins in Schizosaccharomyces pombe: two essential and two nonessential genes. Mol Cell Biol (1990) 1.28
c-myc, c-fos, and c-jun regulation in the regenerating livers of normal and H-2K/c-myc transgenic mice. Mol Cell Biol (1990) 1.27
An inhibitor domain in c-Fos regulates activation domains containing the HOB1 motif. EMBO J (1995) 1.23
The leucine zipper of c-Myc is required for full inhibition of erythroleukemia differentiation. Mol Cell Biol (1990) 1.23
Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C. Mol Cell Biol (1990) 1.22
Transactivation and transformation by Myb are negatively regulated by a leucine-zipper structure. Proc Natl Acad Sci U S A (1992) 1.21
Production of the CYS3 regulator, a bZIP DNA-binding protein, is sufficient to induce sulfur gene expression in Neurospora crassa. Mol Cell Biol (1992) 1.18
Trans-dominant negative mutants of Fos and Jun. Proc Natl Acad Sci U S A (1990) 1.18
Evidence that xeroderma pigmentosum cells from complementation group E are deficient in a homolog of yeast photolyase. Mol Cell Biol (1989) 1.17
Glucocorticoid-induced leucine zipper (GILZ)/NF-kappaB interaction: role of GILZ homo-dimerization and C-terminal domain. Nucleic Acids Res (2006) 1.15
Functional cooperativity between two TPA responsive elements in undifferentiated F9 embryonic stem cells. EMBO J (1990) 1.13
Dimerization of leucine zippers analyzed by random selection. Nucleic Acids Res (1993) 1.12
Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis. J Virol (2005) 1.12
Gene regulation by tyrosine kinases: src protein activates various promoters, including c-fos. Mol Cell Biol (1989) 1.11
Domain swapping reveals the modular nature of Fos, Jun, and CREB proteins. Mol Cell Biol (1990) 1.09
Characterization of Neurospora CPC1, a bZIP DNA-binding protein that does not require aligned heptad leucines for dimerization. Mol Cell Biol (1991) 1.09
Transformation by Fos proteins requires a C-terminal transactivation domain. Mol Cell Biol (1993) 1.06
Downregulation of c-Jun expression by transcription factor C/EBPalpha is critical for granulocytic lineage commitment. Mol Cell Biol (2002) 1.05
Adherence-dependent increase in human monocyte PDGF(B) mRNA is associated with increases in c-fos, c-jun, and EGR2 mRNA. J Cell Biol (1990) 1.03
Altered gene transcription after burn injury results in depressed T-lymphocyte activation. Ann Surg (1994) 1.03
Conserved enhancer and silencer elements responsible for differential Adh transcription in Drosophila cell lines. Mol Cell Biol (1990) 1.02
Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes. Biochem J (1993) 1.02
Restraint-induced fra-2 and c-fos expression in the rat forebrain: relationship to stress duration. Neuroscience (2007) 1.01
Strong and prolonged induction of c-jun and c-fos proto-oncogenes by photodynamic therapy. Br J Cancer (1996) 1.00
Transcription factor AP-1 modulates the activity of the human foamy virus long terminal repeat. J Virol (1991) 1.00
The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein. Nucleic Acids Res (1990) 0.99
Differential expression of jun and fos genes during differentiation of mouse P19 embryonal carcinoma cells. Nucleic Acids Res (1990) 0.99
Characterization of nuclear proteins that bind the EFII enhancer sequence in the Rous sarcoma virus long terminal repeat. J Virol (1992) 0.98
CREB regulation of cellular cyclic AMP-responsive and adenovirus early promoters. J Virol (1990) 0.96
Myristylation alters DNA-binding activity and transactivation of FBR (gag-fos) protein. Mol Cell Biol (1991) 0.95
Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene. Mol Cell Biol (1989) 0.94
Coupled and uncoupled induction of fos and jun transcription by different second messengers in cells of hematopoietic origin. Nucleic Acids Res (1990) 0.92
Proto-oncogene FosB: the amino terminus encodes a regulatory function required for transformation. Mol Cell Biol (1993) 0.91
Unusual c-fos induction upon chromaffin PC12 differentiation by sodium butyrate: loss of fos autoregulatory function. Nucleic Acids Res (1990) 0.91
Multiple components are required for sequence recognition of the AP1 site in the gibbon ape leukemia virus enhancer. Mol Cell Biol (1989) 0.90
Phosphorylation within the MafA N terminus regulates C-terminal dimerization and DNA binding. J Biol Chem (2010) 0.90
TPA can overcome the requirement for EIa and together act synergistically in stimulating expression of the adenovirus EIII promoter. EMBO J (1989) 0.89
A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3' enhancer. EMBO J (1996) 0.86
Characterization of the mouse junD promoter--high basal level activity due to an octamer motif. EMBO J (1991) 0.86
Characterization and purification of human fos protein generated in insect cells with a baculoviral expression vector. J Virol (1990) 0.86
Induction of junB expression, but not c-jun, by granulocyte colony-stimulating factor or macrophage colony-stimulating factor in the proliferative response of human myeloid leukemia cells. J Clin Invest (1992) 0.83
The dyad palindromic glutathione transferase P enhancer binds multiple factors including AP1. Nucleic Acids Res (1992) 0.83
Uptake of pathogenic intracellular bacteria into human and murine macrophages downregulates the eukaryotic 26S protease complex ATPase gene. Infect Immun (1997) 0.82
Single strand binding protein specific for the polyoma early-coding strand of PEA1 (AP1) regulatory sequence. Nucleic Acids Res (1991) 0.82
Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes. Biochem J (1991) 0.82
Correlation of c-fos/c-jun expression with histiocytic differentiation in Hodgkin's Reed-Sternberg cells. Examination in HDLM-1 subclones with spontaneous differentiation. Am J Pathol (1992) 0.81
A 69-base-pair monkey DNA sequence enhances simian virus 40 replication and transcription through multiple motifs. J Virol (1990) 0.81
Interferon-gamma induces the expression of immediate early genes c-fos and c-jun in astrocytes. Immunology (1997) 0.80
Extended life span of human endometrial stromal cells transfected with cloned origin-defective, temperature-sensitive simian virus 40. J Virol (1991) 0.79
Products of the fos and jun proto-oncogenes bind cooperatively to the AP1 DNA recognition sequence. Environ Health Perspect (1990) 0.78
KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. Oncogene (2016) 0.78
c-fos oncogene underexpression in salivary gland tumors as measured by in situ hybridization. Am J Pathol (1993) 0.77
Rapid induction of the c-jun protooncogene in the avian oviduct by the antiestrogen tamoxifen. Proc Natl Acad Sci U S A (1991) 0.77
Analysis of CYS3 regulator function in Neurospora crassa by modification of leucine zipper dimerization specificity. Nucleic Acids Res (1995) 0.77
Inhibitory effect of myristylation on transrepression by FBR (Gag-Fos) protein. Mol Cell Biol (1992) 0.77
Nucleotide sequence of the quail c-jun protooncogene. Nucleic Acids Res (1989) 0.75
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science (1996) 28.95
Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science (1996) 12.23
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A (1996) 9.15
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature (1985) 8.36
Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene. Mol Cell Biol (1985) 7.49
The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J Virol (1996) 6.62
Development of a self-inactivating lentivirus vector. J Virol (1998) 6.60
Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science (1999) 6.20
FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA. J Virol (1982) 6.11
Gene therapy -- promises, problems and prospects. Nature (1997) 6.02
Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini. Cell (1983) 5.79
Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell (1990) 5.59
c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene. Cell (1984) 5.55
Nucleotide sequence of the genome of a murine sarcoma virus. Cell (1981) 5.48
Induction of proto-oncogene JUN/AP-1 by serum and TPA. Nature (1988) 5.18
Viral and cellular fos proteins: a comparative analysis. Cell (1984) 4.89
Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor. Science (1984) 4.87
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. Nature (1986) 4.70
Expression of cellular oncogenes in human malignancies. Science (1984) 4.48
Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature (1982) 4.44
Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein. Proc Natl Acad Sci U S A (1983) 4.38
Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet (1997) 4.26
The reverse transcriptase. Biochim Biophys Acta (1977) 4.16
Transcriptional autoregulation of the proto-oncogene fos. Nature (1988) 4.10
Long terminal repeat of murine retroviral DNAs: sequence analysis, host-proviral junctions, and preintegration site. J Virol (1982) 4.06
Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus. Nature (1981) 4.05
In vitro synthesis of DNA complementary to rabbit reticulocyte 10S RNA. Nat New Biol (1972) 4.01
Identification of a nuclear receptor that is activated by farnesol metabolites. Cell (1995) 3.92
Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Proc Natl Acad Sci U S A (1995) 3.90
fos-associated cellular p39 is related to nuclear transcription factor AP-1. Cell (1988) 3.82
Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation. Cell (1985) 3.81
Transcriptional activation by BRCA1. Nature (1996) 3.64
Functional antagonism between c-Jun and MyoD proteins: a direct physical association. Cell (1992) 3.55
Structure of Moloney murine leukemia viral DNA: nucleotide sequence of the 5' long terminal repeat and adjacent cellular sequences. Proc Natl Acad Sci U S A (1980) 3.53
The rel-associated pp40 protein prevents DNA binding of Rel and NF-kappa B: relationship with I kappa B beta and regulation by phosphorylation. Genes Dev (1991) 3.52
Analysis of the env gene of a molecularly cloned and biologically active Moloney mink cell focus-forming proviral DNA. J Virol (1982) 3.40
Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci U S A (1997) 3.40
Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol (1997) 3.37
Studies on reverse transcriptase of RNA tumor viruses III. Properties of purified Moloney murine leukemia virus DNA polymerase and associated RNase H. J Virol (1975) 3.31
A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT. Proc Natl Acad Sci U S A (1983) 3.31
Covalently linked RNA-DNA molecule as initial product of RNA tumour virus DNA polymerase. Nat New Biol (1971) 3.27
I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B family. Cell (1992) 3.25
c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A (1988) 3.24
Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc Natl Acad Sci U S A (2001) 3.24
Autoregulation of I kappa B alpha activity. Proc Natl Acad Sci U S A (1994) 3.24
Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science (1999) 3.10
Two base changes restore infectivity to a noninfectious molecular clone of Moloney murine leukemia virus (pMLV-1). J Virol (1984) 3.09
Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene. Proc Natl Acad Sci U S A (1985) 2.95
Regulated mRNA stability. Annu Rev Genet (1990) 2.93
IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev (1999) 2.92
Nucleotide sequence of Moloney leukemia virus: 3' end reveals details of replications, analogy to bacterial transposons, and an unexpected gene. Proc Natl Acad Sci U S A (1980) 2.90
Viral and cellular fos proteins are complexed with a 39,000-dalton cellular protein. Mol Cell Biol (1985) 2.86
Retinoic acid is a negative regulator of AP-1-responsive genes. Proc Natl Acad Sci U S A (1991) 2.85
Nuclear proto-oncogenes fos and jun. Annu Rev Cell Biol (1990) 2.82
Heteroduplex analysis of the sequence relations between the RNAs of mink cell focus-inducing and murine leukemia viruses. J Virol (1978) 2.79
Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells. Science (1984) 2.75
Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. J Natl Cancer Inst (1998) 2.75
Induction of the proto-oncogene fos by nerve growth factor. Proc Natl Acad Sci U S A (1985) 2.74
M-MuLV-induced leukemogenesis: integration and structure of recombinant proviruses in tumors. Cell (1981) 2.65
c-rel activates but v-rel suppresses transcription from kappa B sites. Proc Natl Acad Sci U S A (1991) 2.65
Gene therapy: trials and tribulations. Nat Rev Genet (2000) 2.62
Studies on the reverse transcriptase of RNA tumor viruses. Structural relatedness of two subunits of avian RNA tumor viruses. Proc Natl Acad Sci U S A (1974) 2.60
Cationic liposome-mediated RNA transfection. Proc Natl Acad Sci U S A (1989) 2.55
Structure of the FBJ murine osteosarcoma virus genome: molecular cloning of its associated helper virus and the cellular homolog of the v-fos gene from mouse and human cells. Mol Cell Biol (1983) 2.53
Expression of a retrovirus encoding human HPRT in mice. Science (1984) 2.48
Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo. Proc Natl Acad Sci U S A (2001) 2.48
The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain. Mol Cell Biol (1990) 2.47
Modification of fos proteins: phosphorylation of c-fos, but not v-fos, is stimulated by 12-tetradecanoyl-phorbol-13-acetate and serum. Mol Cell Biol (1987) 2.40
Identification of a transcriptional enhancer element upstream from the proto-oncogene fos. Science (1985) 2.39
Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element. Genes Dev (1988) 2.38
mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element. Mol Cell Biol (1990) 2.38
Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. Proc Natl Acad Sci U S A (1991) 2.34
Gene therapy via primary myoblasts: long-term expression of factor IX protein following transplantation in vivo. Proc Natl Acad Sci U S A (1992) 2.30
Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors: role of ankyrin repeats in the inhibition of DNA binding activity. Proc Natl Acad Sci U S A (1992) 2.29
Detection of a transforming gene product in cells transformed by Moloney murine sarcoma virus. Cell (1982) 2.27
A factor IX-deficient mouse model for hemophilia B gene therapy. Proc Natl Acad Sci U S A (1997) 2.22
Identification of a RNA polymerase II initiation site in the long terminal repeat of Moloney murine leukemia viral DNA. Proc Natl Acad Sci U S A (1981) 2.16
Transcription of c-onc genes c-rasKi and c-fms during mouse development. Mol Cell Biol (1983) 2.14
Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B. Proc Natl Acad Sci U S A (1994) 2.12
Sustained expression of therapeutic level of factor IX in hemophilia B dogs by AAV-mediated gene therapy in liver. Mol Ther (2000) 2.12
Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation. EMBO J (1990) 2.11
Molecular cloning of unintegrated and a portion of integrated moloney murine leukemia viral DNA in bacteriophage lambda. J Virol (1980) 2.10
Role of Rel/NF-kappaB transcription factors during the outgrowth of the vertebrate limb. Nature (1998) 2.08
Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. EMBO J (1983) 2.08
Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins. Genes Dev (1989) 2.06
Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts. J Cell Biol (2000) 2.04
BRCA1 is a cell cycle-regulated nuclear phosphoprotein. Proc Natl Acad Sci U S A (1997) 2.02
Identification and molecular cloning of Moloney mouse sarcoma virus-specific sequences from uninfected mouse cells. Proc Natl Acad Sci U S A (1980) 1.98
Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev (2000) 1.96
Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells. Cancer Res (1997) 1.96
Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappa B. Nature (1993) 1.94
Sustained correction of bleeding disorder in hemophilia B mice by gene therapy. Proc Natl Acad Sci U S A (1999) 1.90